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Dan Hu
Medical School
Wuhan University
Hubei
Language: English, Chinese
Electrophysiology
Arrhythmia
Cardiac Electrobiology
Epidemiology
Heart Failure
Cardiomyopathy
Myocardial Infarction
Sudden Cardiac Death
Drug Development
Genetics
Areas of Focus
- Clinical and translational cardiology, specifically in the area of electrophysiology and arrhythmia
- Cardiac electrobiology, epidemiology, risk stratification, and treatment of heart failure, arrhythmia, cardiomyopathy, myocardial infarction, and sudden cardiac death
- Drug development and therapy. Cardiac pharmacology in animal model, stem cell model, cell lines, and patients. Device implantation and ablation of arrhythmia
- Molecular genetics and mutation analysis of the basis for cardiac arrhythmias, cardiomyopathy, and sudden cardiac death
- Molecular and cellular characteristics of action potential and ion channels in heart, and the characteristics and underlying mechanism of ECG markers, such as J wave, T wave, U wave and QT interval, and possible therapy
- Gene expression and modulation in human and animal models with cardiac arrhythmias
- Stem cells and iPSC cells
Work Experience
- 2003.07-2004.08: Attending Physician, Cardiovascular Department, Renmin Hospital, Wuhan University
- 2004.09-2018.08: Postdoctoral Researcher, Assistant, Associate Professor, SCRO Chair, Director of CLIA-certified Genetic Testing Lab, United States
- 2018.09-present: Professor, Chief Physician, Cardiovascular Department, Renmin Hospital, Wuhan University
Academic Background & Achievements
- 1993-1998: Bachelor of Clinical Medicine, Wuhan University
- 1998-2000: Master of Internal Medicine, Wuhan University
- 2000-2003: PhD in Internal Medicine, Wuhan University
- Published over 140 academic papers, H-index=37, citations over 3900
Publications
- Advances in basic and translational research in atrial fibrillation, Hu D, Barajas-Martinez H, Zhang ZH, Duan HY, Zhao QY, Bao MW, Du YM, Burashnikov A, Monasky MM, Pappone C, Huang CX, Antzelevitch C and Jiang H, 2023
- Clinical characteristics and electrophysiologic properties of SCN5A variants in fever-induced Brugada syndrome, Chen GX, Barajas-Martínez H, Ciconte G, Wu CI, Monasky MM, Xia H, Li B, Capra JA, Guo K, Zhang ZH, Chen X, Yang B, Jiang H, Tse G, Mak CM, Aizawa Y, Gollob MH, Antzelevitch C, Wilde AAM, Pappone C and Hu D, 2023
- Functional identification of hot-spot mutations in cardiac calcium channel genes associated with the J wave syndromes, Zeng B, Zhang X, Schimpf R, Powers A, Glikson M, Antzelevitch C, Hu D and Barajas-Martinez H, 2023
- Abrogation of CC Chemokine Receptor 9 Ameliorates Ventricular Electrical Remodeling in Mice After Myocardial Infarction, Huang Y, Ding HS, Song T, Chen YT, Wang T, Tang YH, Barajas-Martinez H, Huang CX and Hu D, 2021
- Clinical and Functional Genetic Characterization of the Role of Cardiac Calcium Channel Variants in the Early Repolarization Syndrome, Chen X, Barajas-Martínez H, Xia H, Zhang Z, Chen G, Yang B, Jiang H, Antzelevitch C and Hu D, 2021
- Clinical characteristics, risk factors, and cardiac manifestations of cancer patients with COVID-19, Huang Y, Hu Z, Hu D, Quan Z, Zhou X, Fan G, Chen X, Liu X, Zhang Z, Chen G, Wu Y, Zhang F, Mao C, Xia H, Liang J, Yang B, Jiang H, Huang C, Barajas-Martínez H and Hu D, 2021
- Common variants in SCN10A gene associated with Brugada syndrome, Huang Y, Chen XM, Barajas-Martinez H, Jiang H, Antzelevitch C and Hu D, 2021
- Distinct Features of Probands With Early Repolarization and Brugada Syndromes Carrying SCN5A Pathogenic Variants, Zhang ZH, Barajas-Martínez H, Xia H, Li B, Capra JA, Clatot J, Chen GX, Chen X, Yang B, Jiang H, Tse G, Aizawa Y, Gollob MH, Scheinman M, Antzelevitch C and Hu D, 2021
- Identification, clinical manifestation and structural mechanisms of mutations in AMPK associated cardiac glycogen storage disease, Hu D, Hu D, Liu L, Barr D, Liu Y, Balderrabano-Saucedo N, Wang B, Zhu F, Xue Y, Wu S, Song B, McManus H, Murphy K, Loes K, Adler A, Monserrat L, Antzelevitch C, Gollob MH, Elliott PM and Barajas-Martinez H, 2020
- The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism, Liu X, Qu C, Shi S, Ye T, Wang L, Liu S, Zhang C, Liang J, Hu D and Yang B, 2019
- Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome, Hu D, Barajas-Martínez H, Pfeiffer R, Dezi F, Pfeiffer J, Buch T, Betzenhauser MJ, Belardin
Awards
- 2022: Top Ten Original Research in the Field of Arrhythmias in China (2019-2021)
- 2021: Cardiovascular Research Young Scholar Award - Clinical First Place at HRS 2021
- 2020: Anti-Epidemic Hero, Wuhan University Renmin Hospital
- 2019: Advanced Individual in Teaching, Wuhan University Renmin Hospital
- 2018: Outstanding Contribution Award, Heart Rhythm Journal
- 2017: AF Awareness Award, Heart Rhythm Society
- 2016: Spokesperson for HRS and the Journal
- 2015: Travel Award, FIT Learning Annex at the ACC Annual Meeting
- 2014: Travel Award, FIT Learning Annex at the ACC Annual Meeting
- 2013: Young Scholar Award Champion, American Heart Association
- 2013: Innovative Abstract Award, Heart Rhythm Society Annual Meeting
- 2007: Gordon K. Moe Young Scholar Award, Cardiac Electrophysiology Society
- 2003: Gengshan Scholarship, Wuhan University (First Recipient)
