Professor | Lei Wang | Asia Growth Partners

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Name	Lei Wang
Contact Information	drwanglei@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

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Name

Lei Wang

Contact Information

drwanglei@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2006-2011: Bachelor of Clinical Medicine from Hubei Medical College 2011-2016: PhD in Surgery from Wuhan University Studied at the University of Pennsylvania, USA Published over 30 SCI papers with a total impact factor over 150 First author in more than 10 Chinese and core journals Holds three national patents
Work Experience	2016.07-2016.11: Resident Physician, Department of Urology, Renmin Hospital of Wuhan University 2016.12-2019.11: Attending Physician, Department of Urology, Renmin Hospital of Wuhan University 2019.12-2020.11: Associate Chief Physician, Department of Urology, Renmin Hospital of Wuhan University 2020.12-present: Associate Professor, Associate Chief Physician, Department of Urology, Renmin Hospital of Wuhan University
Awards	2019: Second Prize of Hubei Provincial Science and Technology Progress Award for 'Precision Medical Treatment of Prostate Cancer'

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2006-2011: Bachelor of Clinical Medicine from Hubei Medical College
2011-2016: PhD in Surgery from Wuhan University
Studied at the University of Pennsylvania, USA
Published over 30 SCI papers with a total impact factor over 150
First author in more than 10 Chinese and core journals
Holds three national patents

Work Experience

2016.07-2016.11: Resident Physician, Department of Urology, Renmin Hospital of Wuhan University
2016.12-2019.11: Attending Physician, Department of Urology, Renmin Hospital of Wuhan University
2019.12-2020.11: Associate Chief Physician, Department of Urology, Renmin Hospital of Wuhan University
2020.12-present: Associate Professor, Associate Chief Physician, Department of Urology, Renmin Hospital of Wuhan University

Awards

2019: Second Prize of Hubei Provincial Science and Technology Progress Award for 'Precision Medical Treatment of Prostate Cancer'

Areas of Focus	Molecular mechanisms and precision treatment of urinary tract tumors Molecular mechanisms and clinical research of acute and chronic renal injury
Publications	Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury, Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L, 2023 Predicting Lymph Node Metastasis Status from Primary Muscle-Invasive Bladder Cancer Histology Slides Using Deep Learning: A Retrospective Multicenter Study, Zheng Q, Jian J, Wang J, Wang K, Fan J, Xu H, Ni X, Yang S, Yuan J, Wu J, Jiao P, Yang R, Chen Z, Liu X, Wang L, 2023 β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells, Zhang Y, Mao H, Li Y, Xiong Y, Liu X, Wang L, Chen Z, 2023 Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway, Zhang B, Wan S, Liu H, Qiu Q, Chen H, Chen Z, Wang L, Liu X, 2022 Mitochondria-Targeted Antioxidant Mitoquinone Maintains Mitochondrial Homeostasis through the Sirt3-Dependent Pathway to Mitigate Oxidative Damage Caused by Renal Ischemia/Reperfusion, Mao H, Zhang Y, Xiong Y, Zhu Z, Wang L, Liu X, 2022 Lysine-specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4/NOX4 pathway in mice, Feng R, Xiong Y, Lei Y, Huang Q, Liu H, Zhao X, Chen Z, Chen H, Liu X, Wang L, Weng X, 2022 The LINC01929/miR-6875-5p/ADAMTS12 Axis in the ceRNA Network Regulates the Development of Advanced Bladder Cancer, Xiong Y, Pang M, Du Y, Yu X, Yuan J, Liu W, Wang L, Liu X, 2022 Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion Injury, Mao H, Wang L, Xiong Y, Jiang G, Liu X, 2022 Knockdown of TRIM8 Protects HK-2 Cells Against Hypoxia/Reoxygenation-Induced Injury by Inhibiting Oxidative Stress-Mediated Apoptosis and Pyroptosis via PI3K/Akt Signal Pathway, Zhang BH, Liu H, Yuan Y, Weng XD, Du Y, Chen H, Chen ZY, Wang L, Liu XH, 2021 RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2, Zhang J, Chen H, Weng X, Liu H, Chen Z, Huang Q, Wang L, Liu X, 2021 The Suppression of Pin1-Alleviated Oxidative Stress through the p38 MAPK Pathway in Ischemia- and Reperfusion-Induced Acute Kidney Injury, Zhao X, Wang D, Wan S, Liu X, Wang W, Wang L, 2021 Histone Methyltransferase G9a Promotes the Development of Renal Cancer through Epigenetic Silencing of Tumor Suppressor Gene SPINK5, Li RG, Deng H, Liu XH, Chen ZY, Wan SS, Wang L, 2021 The H3K9 histone methyltransferase G9a modulates renal ischemia reperfusion injury by targeting Sirt1, Liu H, Wang W, Weng X, Chen H, Chen Z, Du Y, Liu X, Wang L, 2021 TSPAN7 Exerts Anti-Tumor Effects in Bladder Cancer Through the PTEN/PI3K/AKT Pathway, Yu X, Li S, Pang M, Du Y, Xu T, Bai T, Yang K, Hu J, Zhu S, Wang L, Liu X, 2021 CBX7 suppression prevents ischemia-reperfusion injury-induced endoplasmic reticulum stress through the Nrf-2/HO-1 pathway, Zhang Y, Zhang JJ, Liu XH, Wang L, 2020 Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats, Zhang J, Wang L, Gong D, Yang Y, Liu X, Chen Z, 2020 Enhancer of zeste homolog 2 modulates oxidative stress-mediated pyroptosis in vitro and in a mouse kidney ischemia-reperfusion injury model, Liu H, Chen Z, Weng X, Chen H, Du Y, Diao C, Liu X, Wang L Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury, Diao C, Chen Z, Qiu T, Liu H, Yang Y, Liu X, Wu J, Wang L, 2019 Diabetes aggravates renal ischemia-reperfusion injury by repressing mitochondrial function and PINK1/Parkin-mediated mitophagy, Yang YY, Gong DJ, Zhang JJ, Liu XH, Wang L, 2019 Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress, Liu H, Wang L, Weng X, Chen H, Du Y, Diao C, Chen Z, Liu X, 2019

Areas of Focus

Molecular mechanisms and precision treatment of urinary tract tumors
Molecular mechanisms and clinical research of acute and chronic renal injury

Publications

Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury, Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L, 2023
Predicting Lymph Node Metastasis Status from Primary Muscle-Invasive Bladder Cancer Histology Slides Using Deep Learning: A Retrospective Multicenter Study, Zheng Q, Jian J, Wang J, Wang K, Fan J, Xu H, Ni X, Yang S, Yuan J, Wu J, Jiao P, Yang R, Chen Z, Liu X, Wang L, 2023
β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells, Zhang Y, Mao H, Li Y, Xiong Y, Liu X, Wang L, Chen Z, 2023
Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway, Zhang B, Wan S, Liu H, Qiu Q, Chen H, Chen Z, Wang L, Liu X, 2022
Mitochondria-Targeted Antioxidant Mitoquinone Maintains Mitochondrial Homeostasis through the Sirt3-Dependent Pathway to Mitigate Oxidative Damage Caused by Renal Ischemia/Reperfusion, Mao H, Zhang Y, Xiong Y, Zhu Z, Wang L, Liu X, 2022
Lysine-specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4/NOX4 pathway in mice, Feng R, Xiong Y, Lei Y, Huang Q, Liu H, Zhao X, Chen Z, Chen H, Liu X, Wang L, Weng X, 2022
The LINC01929/miR-6875-5p/ADAMTS12 Axis in the ceRNA Network Regulates the Development of Advanced Bladder Cancer, Xiong Y, Pang M, Du Y, Yu X, Yuan J, Liu W, Wang L, Liu X, 2022
Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion Injury, Mao H, Wang L, Xiong Y, Jiang G, Liu X, 2022
Knockdown of TRIM8 Protects HK-2 Cells Against Hypoxia/Reoxygenation-Induced Injury by Inhibiting Oxidative Stress-Mediated Apoptosis and Pyroptosis via PI3K/Akt Signal Pathway, Zhang BH, Liu H, Yuan Y, Weng XD, Du Y, Chen H, Chen ZY, Wang L, Liu XH, 2021
RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2, Zhang J, Chen H, Weng X, Liu H, Chen Z, Huang Q, Wang L, Liu X, 2021
The Suppression of Pin1-Alleviated Oxidative Stress through the p38 MAPK Pathway in Ischemia- and Reperfusion-Induced Acute Kidney Injury, Zhao X, Wang D, Wan S, Liu X, Wang W, Wang L, 2021
Histone Methyltransferase G9a Promotes the Development of Renal Cancer through Epigenetic Silencing of Tumor Suppressor Gene SPINK5, Li RG, Deng H, Liu XH, Chen ZY, Wan SS, Wang L, 2021
The H3K9 histone methyltransferase G9a modulates renal ischemia reperfusion injury by targeting Sirt1, Liu H, Wang W, Weng X, Chen H, Chen Z, Du Y, Liu X, Wang L, 2021
TSPAN7 Exerts Anti-Tumor Effects in Bladder Cancer Through the PTEN/PI3K/AKT Pathway, Yu X, Li S, Pang M, Du Y, Xu T, Bai T, Yang K, Hu J, Zhu S, Wang L, Liu X, 2021
CBX7 suppression prevents ischemia-reperfusion injury-induced endoplasmic reticulum stress through the Nrf-2/HO-1 pathway, Zhang Y, Zhang JJ, Liu XH, Wang L, 2020
Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats, Zhang J, Wang L, Gong D, Yang Y, Liu X, Chen Z, 2020
Enhancer of zeste homolog 2 modulates oxidative stress-mediated pyroptosis in vitro and in a mouse kidney ischemia-reperfusion injury model, Liu H, Chen Z, Weng X, Chen H, Du Y, Diao C, Liu X, Wang L
Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury, Diao C, Chen Z, Qiu T, Liu H, Yang Y, Liu X, Wu J, Wang L, 2019
Diabetes aggravates renal ischemia-reperfusion injury by repressing mitochondrial function and PINK1/Parkin-mediated mitophagy, Yang YY, Gong DJ, Zhang JJ, Liu XH, Wang L, 2019
Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress, Liu H, Wang L, Weng X, Chen H, Du Y, Diao C, Chen Z, Liu X, 2019

Urology Tumors Molecular Mechanisms Precision Treatment Renal Injury Clinical Research Kidney Cancer Bladder Cancer Prostate Cancer Renal Fibrosis

Weibing Zhang - Wuhan University

Zhonghua Yang - Wuhan University

Hu Dongliang - Wuhan University

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