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Lei Wang
Medical School
Wuhan University
Hubei
Language: English, Chinese
Urology
Tumors
Molecular Mechanisms
Precision Treatment
Renal Injury
Clinical Research
Kidney Cancer
Bladder Cancer
Prostate Cancer
Renal Fibrosis
Areas of Focus
- Molecular mechanisms and precision treatment of urinary tract tumors
- Molecular mechanisms and clinical research of acute and chronic renal injury
Work Experience
- 2016.07-2016.11: Resident Physician, Department of Urology, Renmin Hospital of Wuhan University
- 2016.12-2019.11: Attending Physician, Department of Urology, Renmin Hospital of Wuhan University
- 2019.12-2020.11: Associate Chief Physician, Department of Urology, Renmin Hospital of Wuhan University
- 2020.12-present: Associate Professor, Associate Chief Physician, Department of Urology, Renmin Hospital of Wuhan University
Academic Background & Achievements
- 2006-2011: Bachelor of Clinical Medicine from Hubei Medical College
- 2011-2016: PhD in Surgery from Wuhan University
- Studied at the University of Pennsylvania, USA
- Published over 30 SCI papers with a total impact factor over 150
- First author in more than 10 Chinese and core journals
- Holds three national patents
Publications
- Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury, Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L, 2023
- Predicting Lymph Node Metastasis Status from Primary Muscle-Invasive Bladder Cancer Histology Slides Using Deep Learning: A Retrospective Multicenter Study, Zheng Q, Jian J, Wang J, Wang K, Fan J, Xu H, Ni X, Yang S, Yuan J, Wu J, Jiao P, Yang R, Chen Z, Liu X, Wang L, 2023
- β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells, Zhang Y, Mao H, Li Y, Xiong Y, Liu X, Wang L, Chen Z, 2023
- Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway, Zhang B, Wan S, Liu H, Qiu Q, Chen H, Chen Z, Wang L, Liu X, 2022
- Mitochondria-Targeted Antioxidant Mitoquinone Maintains Mitochondrial Homeostasis through the Sirt3-Dependent Pathway to Mitigate Oxidative Damage Caused by Renal Ischemia/Reperfusion, Mao H, Zhang Y, Xiong Y, Zhu Z, Wang L, Liu X, 2022
- Lysine-specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4/NOX4 pathway in mice, Feng R, Xiong Y, Lei Y, Huang Q, Liu H, Zhao X, Chen Z, Chen H, Liu X, Wang L, Weng X, 2022
- The LINC01929/miR-6875-5p/ADAMTS12 Axis in the ceRNA Network Regulates the Development of Advanced Bladder Cancer, Xiong Y, Pang M, Du Y, Yu X, Yuan J, Liu W, Wang L, Liu X, 2022
- Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion Injury, Mao H, Wang L, Xiong Y, Jiang G, Liu X, 2022
- Knockdown of TRIM8 Protects HK-2 Cells Against Hypoxia/Reoxygenation-Induced Injury by Inhibiting Oxidative Stress-Mediated Apoptosis and Pyroptosis via PI3K/Akt Signal Pathway, Zhang BH, Liu H, Yuan Y, Weng XD, Du Y, Chen H, Chen ZY, Wang L, Liu XH, 2021
- RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2, Zhang J, Chen H, Weng X, Liu H, Chen Z, Huang Q, Wang L, Liu X, 2021
- The Suppression of Pin1-Alleviated Oxidative Stress through the p38 MAPK Pathway in Ischemia- and Reperfusion-Induced Acute Kidney Injury, Zhao X, Wang D, Wan S, Liu X, Wang W, Wang L, 2021
- Histone Methyltransferase G9a Promotes the Development of Renal Cancer through Epigenetic Silencing of Tumor Suppressor Gene SPINK5, Li RG, Deng H, Liu XH, Chen ZY, Wan SS, Wang L, 2021
- The H3K9 histone methyltransferase G9a modulates renal ischemia reperfusion injury by targeting Sirt1, Liu H, Wang W, Weng X, Chen H, Chen Z, Du Y, Liu X, Wang L, 2021
- TSPAN7 Exerts Anti-Tumor Effects in Bladder Cancer Through the PTEN/PI3K/AKT Pathway, Yu X, Li S, Pang M, Du Y, Xu T, Bai T, Yang K, Hu J, Zhu S, Wang L, Liu X, 2021
- CBX7 suppression prevents ischemia-reperfusion injury-induced endoplasmic reticulum stress through the Nrf-2/HO-1 pathway, Zhang Y, Zhang JJ, Liu XH, Wang L, 2020
- Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats, Zhang J, Wang L, Gong D, Yang Y, Liu X, Chen Z, 2020
- Enhancer of zeste homolog 2 modulates oxidative stress-mediated pyroptosis in vitro and in a mouse kidney ischemia-reperfusion injury model, Liu H, Chen Z, Weng X, Chen H, Du Y, Diao C, Liu X, Wang L
- Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury, Diao C, Chen Z, Qiu T, Liu H, Yang Y, Liu X, Wu J, Wang L, 2019
- Diabetes aggravates renal ischemia-reperfusion injury by repressing mitochondrial function and PINK1/Parkin-mediated mitophagy, Yang YY, Gong DJ, Zhang JJ, Liu XH, Wang L, 2019
- Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress, Liu H, Wang L, Weng X, Chen H, Du Y, Diao C, Chen Z, Liu X, 2019
Awards
- 2019: Second Prize of Hubei Provincial Science and Technology Progress Award for 'Precision Medical Treatment of Prostate Cancer'
