Professor | Xiaoxing Xiong | Asia Growth Partners

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Name	Xiaoxing Xiong
Contact Information	xiaoxingxiong@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

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Name

Xiaoxing Xiong

Contact Information

xiaoxingxiong@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	1998-2003: Bachelor of Clinical Medicine from Nanchang University 2006-2008: Master of Clinical Medicine from Zhejiang University 2008-2011: PhD in Clinical Medicine from Zhejiang University Selected into Hubei's 'Chutian Scholar Program' in 2016 Received 'Hubei Province Outstanding Youth Fund' in 2017 Selected for 'Wuhan Young and Middle-aged Medical Talents Training Project' in 2018 Selected as 'Hubei Province Leading Talent (Young Leading Medical Talent First Level)' in 2019 Selected as 'Chutian Distinguished Professor' in Hubei Province in 2022
Work Experience	2011-2014: Postdoctoral Fellow, Assistant Researcher at Stanford University School of Medicine, Neurosurgery, Stroke Center 2015-2017: Associate Professor, Associate Chief Physician at Renmin Hospital of Wuhan University, Department of Neurosurgery 2017-present: Professor at Renmin Hospital of Wuhan University, Department of Neurosurgery
Awards	2020: Third Prize of Hubei Province Science and Technology Progress Award for 'Ischemic Brain Injury and Immune Regulation Mechanism and Prevention'

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

1998-2003: Bachelor of Clinical Medicine from Nanchang University
2006-2008: Master of Clinical Medicine from Zhejiang University
2008-2011: PhD in Clinical Medicine from Zhejiang University
Selected into Hubei's 'Chutian Scholar Program' in 2016
Received 'Hubei Province Outstanding Youth Fund' in 2017
Selected for 'Wuhan Young and Middle-aged Medical Talents Training Project' in 2018
Selected as 'Hubei Province Leading Talent (Young Leading Medical Talent First Level)' in 2019
Selected as 'Chutian Distinguished Professor' in Hubei Province in 2022

Work Experience

2011-2014: Postdoctoral Fellow, Assistant Researcher at Stanford University School of Medicine, Neurosurgery, Stroke Center
2015-2017: Associate Professor, Associate Chief Physician at Renmin Hospital of Wuhan University, Department of Neurosurgery
2017-present: Professor at Renmin Hospital of Wuhan University, Department of Neurosurgery

Awards

2020: Third Prize of Hubei Province Science and Technology Progress Award for 'Ischemic Brain Injury and Immune Regulation Mechanism and Prevention'

Areas of Focus	Research on immune mechanisms of stroke Application of molecular imaging and nanomaterials in brain diseases
Publications	An ultrasensitive fluorescent platform for monitoring GSH variation during ischemic stroke, Xiaoxing Xiong, Yingze Ye, Xiaoyang Gao, Hua Zhu, Wei Hu, Chunya Li, Zhihong Jian, Hongping Deng, Lijuan Gu, 2022 Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation, Jinchen Wang, Yi Zhong, Hua Zhu, Omer Kamal Mahgoub, Zhihong Jian, Lijuan Gu, Xiaoxing Xiong, 2022 ATG5 Knockdown Attenuates Ischemia‒Reperfusion Injury by Reducing Excessive Autophagy-Induced Ferroptosis, Hua Zhu, Yi Zhong, Ran Chen, Lei Wang, Yuntao Li, Zhihong Jian, Lijuan Gu, Xiaoxing Xiong, 2022 Small-Molecule Fluorophores for Near-Infrared IIb Imaging and ImageGuided Therapy of Vascular Diseases, Yang Li, Hua Zhu, Xiaobo Wang, Yan Cui1, Lijuan Gu, Xiaowen Hou, Mengting Guan, JunzhuWu, Yuling Xiao, Xiaoxing Xiong, Xianli Meng, Xuechuan Hong, 2022 Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis, Hua Zhu, Yonggang Zhang, Shi Feng, Yina Li, Yingze Ye, Zhihong Jian, Xiaoxing Xiong, Lijuan Gu, 2023 Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation Through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition, Zhu H, Jian Z, Zhong Y, Ye Y, Zhang Y, Hu X, Pu B, Gu L, Xiaoxing Xiong, 2021 The Involvement of Immune Cells Between Ischemic Stroke and Gut Microbiota, Bei Pu, Hua Zhu, Liang Wei, Lijuan Gu, Shenqi Zhang, Zhihong Jian, Xiaoxing Xiong, 2023 Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke, Xu Q, Zhao B, Ye Y, Li Y, Zhang Y, Xiong X, Gu L, 2021 Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway, Yingze Ye, Tong Jin, Xu Zhang, Zhi Zeng, Baixin Ye, Jinchen Wang, Yi Zhong, Xiaoxing Xiong, Lijuan Gu, 2019 The Involvement and Therapy Target of Immune Cells After Ischemic Stroke, Zhihong Jian, Rui Liu, Xiqun Zhu, Daniel Smerin, Yi Zhong, Lijuan Gu, Weirong Fang, Xiaoxing Xiong, 2019 Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy, Xingping Qin, Jing Cheng, Yi Zhong, Omer Kamal Mahgoub, Farhana Akter, Yanqin Fan, Mohammed Aldughaim, Qiurong Xie, Lingxia Qin, Lijuan Gu, Zhihong Jian, Xiaoxing Xiong, Renzhong Liu, 2019 Engineering chimeric antigen receptor-t cells for cancer treatment, Ye B, Stary CM, Li X, Gao Q, Kang C, Xiong X, 2018 High-throughput sequencing of the immune repertoire in oncology: Applications for clinical diagnosis, monitoring, and immunotherapies, Ye B, Smerin D, Gao Q, Kang C, Xiong X, 2018 Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke, Zhao L, Xiong Q, Stary CM, Mahgoub OK, Ye Y, Gu L, Xiong X, Zhu S, 2018 Gene Targets of CAR-T Cell Therapy for Glioblastoma, Chaoqun Wang, Yuntao Li, Lijuan Gu, Ran Chen, Hua Zhu, Xu Zhang, Yonggang Zhang, Shi Feng, Sheng Qiu, Zhihong Jian, Xiaoxing Xiong, 2023 Macrophage polarization in cerebral aneurysm: Perspectives and potential targets, Shao L, Qin X, Liu J, Jian Z, Xiong X, Liu R, 2017 Glycyrrhizin protects against focal cerebral ischemia via inhibition of t cell activity and hmgb1-mediated mechanisms, Xiong X, Gu L, Wang Y, Luo Y, Zhang H, Lee J, Krams S, Zhu S, Zhao H, 2016 The inflammasome as a target for pain therapy, Zhang H, Li F, Li WW, Stary C, Clark JD, Xu S, Xiong X, 2016 IL-4 is required for sex differences in vulnerability to focal ischemia in mice, Xiong X, Xu L, Wei L, White RE, Ouyang YB, Giffard RG, 2015 Pras40 plays a pivotal role in protecting against stroke by linking the akt and mtor pathways, Xiong X, Xie R, Zhang H, Gu L, Xie W, Cheng M, Jian Z, Kovacina K, Zhao H, 2014

Areas of Focus

Research on immune mechanisms of stroke
Application of molecular imaging and nanomaterials in brain diseases

Publications

An ultrasensitive fluorescent platform for monitoring GSH variation during ischemic stroke, Xiaoxing Xiong*, Yingze Ye, Xiaoyang Gao, Hua Zhu, Wei Hu, Chunya Li, Zhihong Jian, Hongping Deng, Lijuan Gu, 2022
Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation, Jinchen Wang, Yi Zhong, Hua Zhu, Omer Kamal Mahgoub, Zhihong Jian, Lijuan Gu, Xiaoxing Xiong*, 2022
ATG5 Knockdown Attenuates Ischemia‒Reperfusion Injury by Reducing Excessive Autophagy-Induced Ferroptosis, Hua Zhu, Yi Zhong, Ran Chen, Lei Wang, Yuntao Li, Zhihong Jian, Lijuan Gu, Xiaoxing Xiong*, 2022
Small-Molecule Fluorophores for Near-Infrared IIb Imaging and ImageGuided Therapy of Vascular Diseases, Yang Li, Hua Zhu, Xiaobo Wang, Yan Cui1, Lijuan Gu, Xiaowen Hou, Mengting Guan, JunzhuWu, Yuling Xiao, Xiaoxing Xiong*, Xianli Meng, Xuechuan Hong, 2022
Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis, Hua Zhu, Yonggang Zhang, Shi Feng, Yina Li, Yingze Ye, Zhihong Jian, Xiaoxing Xiong*, Lijuan Gu, 2023
Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation Through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition, Zhu H, Jian Z, Zhong Y, Ye Y, Zhang Y, Hu X, Pu B, Gu L, Xiaoxing Xiong*, 2021
The Involvement of Immune Cells Between Ischemic Stroke and Gut Microbiota, Bei Pu, Hua Zhu, Liang Wei, Lijuan Gu, Shenqi Zhang, Zhihong Jian, Xiaoxing Xiong*, 2023
Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke, Xu Q, Zhao B, Ye Y, Li Y, Zhang Y, Xiong X*, Gu L, 2021
Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway, Yingze Ye, Tong Jin, Xu Zhang, Zhi Zeng, Baixin Ye, Jinchen Wang, Yi Zhong, Xiaoxing Xiong*, Lijuan Gu*, 2019
The Involvement and Therapy Target of Immune Cells After Ischemic Stroke, Zhihong Jian, Rui Liu, Xiqun Zhu, Daniel Smerin, Yi Zhong, Lijuan Gu, Weirong Fang*, Xiaoxing Xiong*, 2019
Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy, Xingping Qin, Jing Cheng, Yi Zhong, Omer Kamal Mahgoub, Farhana Akter, Yanqin Fan, Mohammed Aldughaim, Qiurong Xie, Lingxia Qin, Lijuan Gu, Zhihong Jian, Xiaoxing Xiong*, Renzhong Liu*, 2019
Engineering chimeric antigen receptor-t cells for cancer treatment, Ye B, Stary CM, Li X, Gao Q, Kang C*, Xiong X*, 2018
High-throughput sequencing of the immune repertoire in oncology: Applications for clinical diagnosis, monitoring, and immunotherapies, Ye B, Smerin D, Gao Q, Kang C*, Xiong X*, 2018
Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke, Zhao L, Xiong Q, Stary CM, Mahgoub OK, Ye Y, Gu L, Xiong X*, Zhu S*, 2018
Gene Targets of CAR-T Cell Therapy for Glioblastoma, Chaoqun Wang, Yuntao Li, Lijuan Gu, Ran Chen, Hua Zhu, Xu Zhang, Yonggang Zhang, Shi Feng, Sheng Qiu, Zhihong Jian, Xiaoxing Xiong*, 2023
Macrophage polarization in cerebral aneurysm: Perspectives and potential targets, Shao L, Qin X, Liu J, Jian Z, Xiong X*, Liu R*, 2017
Glycyrrhizin protects against focal cerebral ischemia via inhibition of t cell activity and hmgb1-mediated mechanisms, Xiong X*, Gu L, Wang Y, Luo Y, Zhang H, Lee J, Krams S, Zhu S*, Zhao H*, 2016
The inflammasome as a target for pain therapy, Zhang H, Li F, Li WW, Stary C, Clark JD, Xu S*, Xiong X*, 2016
IL-4 is required for sex differences in vulnerability to focal ischemia in mice, Xiong X*, Xu L, Wei L, White RE, Ouyang YB, Giffard RG*, 2015
Pras40 plays a pivotal role in protecting against stroke by linking the akt and mtor pathways, Xiong X*, Xie R, Zhang H, Gu L, Xie W, Cheng M, Jian Z, Kovacina K, Zhao H*, 2014

Stroke Immune Mechanisms Central Nervous System Peripheral Immune System Molecular Imaging Nanomaterials Brain Diseases Ischemia Neurology Biomedical Engineering

Shenqi Zhang - Wuhan University

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Zhang Xin - Wuhan University

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