Professor | Zhentao Zhang | Asia Growth Partners

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Name	Zhentao Zhang
Contact Information	zhentaozhang@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

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Name

Zhentao Zhang

Contact Information

zhentaozhang@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2007-2010 PhD in Neurology, Tongji Medical College, Huazhong University of Science and Technology 2004-2007 Master's in Neurology, Tongji Medical College, Huazhong University of Science and Technology 1999-2004 Bachelor in Clinical Medicine, Weifang Medical University
Work Experience	2017-present Professor, Chief Physician at Department of Neurology, Renmin Hospital of Wuhan University 2016-2017 Professor, Associate Chief Physician at Department of Neurology, Renmin Hospital of Wuhan University 2015-2016 Assistant Professor at Emory University, USA 2012-2015 Postdoctoral Researcher at Emory University, USA 2010-2012 Attending Physician at Department of Neurology, Renmin Hospital of Wuhan University
Awards	National Talent Project National Outstanding Young Expert Special Government Allowance of the State Council National Excellent Youth Science Fund Hubei Province Outstanding Youth Science Fund

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2007-2010 PhD in Neurology, Tongji Medical College, Huazhong University of Science and Technology
2004-2007 Master's in Neurology, Tongji Medical College, Huazhong University of Science and Technology
1999-2004 Bachelor in Clinical Medicine, Weifang Medical University

Work Experience

2017-present Professor, Chief Physician at Department of Neurology, Renmin Hospital of Wuhan University
2016-2017 Professor, Associate Chief Physician at Department of Neurology, Renmin Hospital of Wuhan University
2015-2016 Assistant Professor at Emory University, USA
2012-2015 Postdoctoral Researcher at Emory University, USA
2010-2012 Attending Physician at Department of Neurology, Renmin Hospital of Wuhan University

Awards

National Talent Project
National Outstanding Young Expert
Special Government Allowance of the State Council
National Excellent Youth Science Fund
Hubei Province Outstanding Youth Science Fund

Areas of Focus	Parkinson's disease Alzheimer's disease
Publications	Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease, Pan L, Li C, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G, Zhang Z, 2022 Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease, Zhang G, Meng L, Wang Z, Peng Q, Chen G, Xiong J, Zhang Z, 2022 A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease, Meng L, Zou L, Xiong M, Chen J, Zhang X, Yu T, Li Y, Liu C, Chen G, Wang Z, Ye K, Zhang Z, 2022 Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease, Yan M, Xiong M, Dai L, Zhang X, Zha Y, Deng X, Yu Z, Zhang Z, 2022 δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease, Zhang Z, Li XG, Wang ZH, Song M, Yu SP, Kang SS, Liu X, Zhang Z, Xie M, Liu GP, Wang JZ, Ye K, 2021 A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease, Xiong M, Zou L, Meng L, Zhang X, Tian Y, Zhang G, Yang J, Chen G, Xiong J, Ye K, Zhang Z, 2021 Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction, Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J, Wang Z, Duong DM, Zhang Z, Cao X, Wang T, Tang L, Ye K, Zhang Z, 2021 Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease, Li Zou, Xingyu Zhang, Min Xiong, Lanxia Meng, Ye Tian, Lina Pan, Xin Yuan, Guiqin Chen, Zhihao Wang, Lihong Bu, Zhaohui Yao, Zhaohui Zhang, Keqiang Ye, Zhentao Zhang, 2021 Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets, Dai L, Zou L, Meng L, Qiang G, Yan M, Zhang Z, 2021 Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease, Jiaolong Yang, Shilin Luo, Jichun Zhang, Ting Yu, Zhihui Fu, Yongfa Zheng, Ximing Xu, Chaoyang Liu, Mingxia Fan, Zhentao Zhang, 2021 TREM2 Ectodomain and Its Soluble Form in Alzheimer's Disease, Yang J, Fu Z, Zhang X, Xiong M, Meng L, Zhang Z, 2020 δ-secretase in Neurodegenerative Diseases: Mechanisms, Regulators and Therapeutic Opportunities, Zhang Z, Tian Y, Ye K, 2020 What is strain in neurodegenerative diseases?, Tian Y, Meng L, Zhang Z, 2020 Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease, Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K, 2017 Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease, Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K, 2017 Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease, Zhang Z, Song M, Liu X, Su Kang S, Duong DM, Seyfried NT, Cao X, Cheng L, Sun YE, Ping Yu S, Jia J, Levey AI, Ye K, 2015 Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease, Zhang Z, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L, Sun YE, Yu SP, Levey AI, Ye K, 2014

Areas of Focus

Parkinson's disease
Alzheimer's disease

Publications

Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease, Pan L, Li C, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G, Zhang Z, 2022
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease, Zhang G, Meng L, Wang Z, Peng Q, Chen G, Xiong J, Zhang Z, 2022
A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease, Meng L, Zou L, Xiong M, Chen J, Zhang X, Yu T, Li Y, Liu C, Chen G, Wang Z, Ye K, Zhang Z, 2022
Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease, Yan M, Xiong M, Dai L, Zhang X, Zha Y, Deng X, Yu Z, Zhang Z, 2022
δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease, Zhang Z, Li XG, Wang ZH, Song M, Yu SP, Kang SS, Liu X, Zhang Z, Xie M, Liu GP, Wang JZ, Ye K, 2021
A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease, Xiong M, Zou L, Meng L, Zhang X, Tian Y, Zhang G, Yang J, Chen G, Xiong J, Ye K, Zhang Z, 2021
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction, Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J, Wang Z, Duong DM, Zhang Z, Cao X, Wang T, Tang L, Ye K, Zhang Z, 2021
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease, Li Zou, Xingyu Zhang, Min Xiong, Lanxia Meng, Ye Tian, Lina Pan, Xin Yuan, Guiqin Chen, Zhihao Wang, Lihong Bu, Zhaohui Yao, Zhaohui Zhang, Keqiang Ye, Zhentao Zhang, 2021
Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets, Dai L, Zou L, Meng L, Qiang G, Yan M, Zhang Z, 2021
Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease, Jiaolong Yang, Shilin Luo, Jichun Zhang, Ting Yu, Zhihui Fu, Yongfa Zheng, Ximing Xu, Chaoyang Liu, Mingxia Fan, Zhentao Zhang, 2021
TREM2 Ectodomain and Its Soluble Form in Alzheimer's Disease, Yang J, Fu Z, Zhang X, Xiong M, Meng L, Zhang Z, 2020
δ-secretase in Neurodegenerative Diseases: Mechanisms, Regulators and Therapeutic Opportunities, Zhang Z, Tian Y, Ye K, 2020
What is strain in neurodegenerative diseases?, Tian Y, Meng L, Zhang Z, 2020
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease, Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K, 2017
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease, Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K, 2017
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease, Zhang Z, Song M, Liu X, Su Kang S, Duong DM, Seyfried NT, Cao X, Cheng L, Sun YE, Ping Yu S, Jia J, Levey AI, Ye K, 2015
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease, Zhang Z, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L, Sun YE, Yu SP, Levey AI, Ye K, 2014

Neurodegeneration Parkinson'S Alzheimer'S Molecular Mechanisms Neuronal Degeneration Tau Protein Amyloid Neuroinflammation Synaptic Dysfunction Biomarkers

Hanxing Liu - Wuhan University

Zhaohui Zhang - Wuhan University

Jing Xiong - Wuhan University

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