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Qi-Liang Cai
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
Microenvironment
Virus
Carcinogenesis
Targeted Intervention
Drug Development
Hypoxia
Oncolytic Virus
Gene Delivery
Tumor Treatment
Vaccine Development
Areas of Focus
- Microenvironment and virus-induced host cell carcinogenesis mechanisms and targeted intervention drug development
- Hypoxic microenvironment stress response oncolytic virus, gene delivery system construction and its application in different tumor treatments and vaccine development
- Discovery of key host restriction factors (protein modification regulation) in acute (COVID-19) and chronic (herpes) viral infections
Work Experience
- 2004.10—2012.2 - University of Pennsylvania School of Medicine - Postdoctoral Researcher, Assistant Researcher
- 2012.05—Present - Fudan University Basic Medical Sciences - Researcher, PI
- 2019.10—Present - Department of Pathogen Biology, Ministry of Education/Health Commission Key Laboratory of Medical Molecular Virology - Deputy Director
- 2020.10—Present - Shared Instrumentation Platform Center, Basic Medical Sciences - Director
- 2021.04—Present - Shanghai Institute of Major Infectious Diseases and Biosafety - Dual-appointed PI, Director of Technical Support Center
Academic Background & Achievements
- 1995.09—2001.09 Degree: Biochemistry and Molecular Biology, Huazhong Agricultural University
- 2001.09—2004.07 Degree: Pathogen Biology, Chinese Academy of Medical Sciences/Peking Union Medical College
Publications
- A System Based on Novel Parainfluenza Virus PIV5-L for Efficient Gene Delivery of B-Lymphoma Cells, Liu X, Zheng L, Wang T, Li Y, Wu B, Du S, Zhu Q, Zhu C, Wang Y, Zhang R, Wei F, Cai Q, 2022
- A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry, Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R, 2021
- Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANA SIM-Associated Proteins in Hypoxia, Liu X, Gan J, Du S, Zhu C, Wang Y, Jia Y, Zhang D, Qu D, Wei F, Robertson ES, Cai Q, 2021
- Lactate induces production of the tRNAHis half to promote B-lymphoblastic cell proliferation, Mo X, Du S, Chen X, Wang Y, Liu X, Zhang C, Zhu C, Ding L, Li Y, Tong Y, Ju Q, Qu D, Tan F, Wei F, Cai Q, 2020
- Stub1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency, Wang Y, Du S, Zhu C, Wang C, Yu N, Lin Z, Gan J, Guo Y, Huang X, He Y, Robertson E, Qu D, Wei F, Cai Q, 2020
- Identification of viral SIM-SUMO2-interaction inhibitors for treating primary effusion lymphoma, Ding L, Zhu Q, Zhou F, Tan H, Xu W, Pan C, Zhu C, Wang Y, Zhang H, Fu W, Qian Z, Xu H, Wei F, Cai Q, 2019
- Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication, Wan C, Tai J, Zhang J, Guo Y, Zhu Q, Ling D, Gu F, Gan J, Zhu C, Wang Y, Liu S, Wei F, Cai Q, 2019
- Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis, Zhu Q, Ding L, Zi Z, Gao S, Wang C, Wang Y, Zhu C, Yuan Z, Wei F, Cai Q, 2019
- STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus, Gu F, Wang C, Wei F, Wang Y, Zhu Q, Ding L, Xu W, Zhu C, Cai C, Qian Z, Yuan Z, Robertson E, Cai Q, 2018
- Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth, Mo X, Wei F, Tong Y, Ding L, Zhu Q, Du S, Tan F, Zhu C, Wang Y, Yu Q, Liu Y, Robertson ES, Yuan Z, Cai Q, 2018
Awards
- 2013: New Century Excellent Talents by the Ministry of Education
