Professor | Qi-Liang Cai | Asia Growth Partners

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Name	Qi-Liang Cai
Contact Information	qiliang@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Qi-Liang Cai

Contact Information

qiliang@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1995.09—2001.09 Degree: Biochemistry and Molecular Biology, Huazhong Agricultural University 2001.09—2004.07 Degree: Pathogen Biology, Chinese Academy of Medical Sciences/Peking Union Medical College
Work Experience	2004.10—2012.2 - University of Pennsylvania School of Medicine - Postdoctoral Researcher, Assistant Researcher 2012.05—Present - Fudan University Basic Medical Sciences - Researcher, PI 2019.10—Present - Department of Pathogen Biology, Ministry of Education/Health Commission Key Laboratory of Medical Molecular Virology - Deputy Director 2020.10—Present - Shared Instrumentation Platform Center, Basic Medical Sciences - Director 2021.04—Present - Shanghai Institute of Major Infectious Diseases and Biosafety - Dual-appointed PI, Director of Technical Support Center
Awards	2013: New Century Excellent Talents by the Ministry of Education

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1995.09—2001.09 Degree: Biochemistry and Molecular Biology, Huazhong Agricultural University
2001.09—2004.07 Degree: Pathogen Biology, Chinese Academy of Medical Sciences/Peking Union Medical College

Work Experience

2004.10—2012.2 - University of Pennsylvania School of Medicine - Postdoctoral Researcher, Assistant Researcher
2012.05—Present - Fudan University Basic Medical Sciences - Researcher, PI
2019.10—Present - Department of Pathogen Biology, Ministry of Education/Health Commission Key Laboratory of Medical Molecular Virology - Deputy Director
2020.10—Present - Shared Instrumentation Platform Center, Basic Medical Sciences - Director
2021.04—Present - Shanghai Institute of Major Infectious Diseases and Biosafety - Dual-appointed PI, Director of Technical Support Center

Awards

2013: New Century Excellent Talents by the Ministry of Education

Areas of Focus	Microenvironment and virus-induced host cell carcinogenesis mechanisms and targeted intervention drug development Hypoxic microenvironment stress response oncolytic virus, gene delivery system construction and its application in different tumor treatments and vaccine development Discovery of key host restriction factors (protein modification regulation) in acute (COVID-19) and chronic (herpes) viral infections
Publications	A System Based on Novel Parainfluenza Virus PIV5-L for Efficient Gene Delivery of B-Lymphoma Cells, Liu X, Zheng L, Wang T, Li Y, Wu B, Du S, Zhu Q, Zhu C, Wang Y, Zhang R, Wei F, Cai Q, 2022 A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry, Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R, 2021 Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANA SIM-Associated Proteins in Hypoxia, Liu X, Gan J, Du S, Zhu C, Wang Y, Jia Y, Zhang D, Qu D, Wei F, Robertson ES, Cai Q, 2021 Lactate induces production of the tRNAHis half to promote B-lymphoblastic cell proliferation, Mo X, Du S, Chen X, Wang Y, Liu X, Zhang C, Zhu C, Ding L, Li Y, Tong Y, Ju Q, Qu D, Tan F, Wei F, Cai Q, 2020 Stub1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency, Wang Y, Du S, Zhu C, Wang C, Yu N, Lin Z, Gan J, Guo Y, Huang X, He Y, Robertson E, Qu D, Wei F, Cai Q, 2020 Identification of viral SIM-SUMO2-interaction inhibitors for treating primary effusion lymphoma, Ding L, Zhu Q, Zhou F, Tan H, Xu W, Pan C, Zhu C, Wang Y, Zhang H, Fu W, Qian Z, Xu H, Wei F, Cai Q, 2019 Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication, Wan C, Tai J, Zhang J, Guo Y, Zhu Q, Ling D, Gu F, Gan J, Zhu C, Wang Y, Liu S, Wei F, Cai Q, 2019 Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis, Zhu Q, Ding L, Zi Z, Gao S, Wang C, Wang Y, Zhu C, Yuan Z, Wei F, Cai Q, 2019 STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus, Gu F, Wang C, Wei F, Wang Y, Zhu Q, Ding L, Xu W, Zhu C, Cai C, Qian Z, Yuan Z, Robertson E, Cai Q, 2018 Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth, Mo X, Wei F, Tong Y, Ding L, Zhu Q, Du S, Tan F, Zhu C, Wang Y, Yu Q, Liu Y, Robertson ES, Yuan Z, Cai Q, 2018

Areas of Focus

Microenvironment and virus-induced host cell carcinogenesis mechanisms and targeted intervention drug development
Hypoxic microenvironment stress response oncolytic virus, gene delivery system construction and its application in different tumor treatments and vaccine development
Discovery of key host restriction factors (protein modification regulation) in acute (COVID-19) and chronic (herpes) viral infections

Publications

A System Based on Novel Parainfluenza Virus PIV5-L for Efficient Gene Delivery of B-Lymphoma Cells, Liu X, Zheng L, Wang T, Li Y, Wu B, Du S, Zhu Q, Zhu C, Wang Y, Zhang R, Wei F, Cai Q, 2022
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry, Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R, 2021
Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANA SIM-Associated Proteins in Hypoxia, Liu X, Gan J, Du S, Zhu C, Wang Y, Jia Y, Zhang D, Qu D, Wei F, Robertson ES, Cai Q, 2021
Lactate induces production of the tRNAHis half to promote B-lymphoblastic cell proliferation, Mo X, Du S, Chen X, Wang Y, Liu X, Zhang C, Zhu C, Ding L, Li Y, Tong Y, Ju Q, Qu D, Tan F, Wei F, Cai Q, 2020
Stub1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency, Wang Y, Du S, Zhu C, Wang C, Yu N, Lin Z, Gan J, Guo Y, Huang X, He Y, Robertson E, Qu D, Wei F, Cai Q, 2020
Identification of viral SIM-SUMO2-interaction inhibitors for treating primary effusion lymphoma, Ding L, Zhu Q, Zhou F, Tan H, Xu W, Pan C, Zhu C, Wang Y, Zhang H, Fu W, Qian Z, Xu H, Wei F, Cai Q, 2019
Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication, Wan C, Tai J, Zhang J, Guo Y, Zhu Q, Ling D, Gu F, Gan J, Zhu C, Wang Y, Liu S, Wei F, Cai Q, 2019
Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis, Zhu Q, Ding L, Zi Z, Gao S, Wang C, Wang Y, Zhu C, Yuan Z, Wei F, Cai Q, 2019
STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus, Gu F, Wang C, Wei F, Wang Y, Zhu Q, Ding L, Xu W, Zhu C, Cai C, Qian Z, Yuan Z, Robertson E, Cai Q, 2018
Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth, Mo X, Wei F, Tong Y, Ding L, Zhu Q, Du S, Tan F, Zhu C, Wang Y, Yu Q, Liu Y, Robertson ES, Yuan Z, Cai Q, 2018

Microenvironment Virus Carcinogenesis Targeted Intervention Drug Development Hypoxia Oncolytic Virus Gene Delivery Tumor Treatment Vaccine Development

Jueyu Zhou - Southern Medical University

Yihong Peng - Peking University

Qingsong Hu - University of Science and Technology of China

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