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Xiaoqing Gan
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
Metabolism
Cell Signaling
Biochemistry
Molecular Biology
Cell Biology
Signal Transduction
Wnt Pathway
Runx2
Osteogenesis
Adipogenesis
Areas of Focus
- Cell Biology: Metabolism and Cell Signal Transduction
Work Experience
- 1996.07 - 1997.06 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Research Intern
- 1997.07 - 2000.06 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Research Assistant
- 2000.07 - 2000.04 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher
- 2008.05 - 2009.05 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Associate Researcher
- 2009.05 - 2013.03 - Yale University School of Medicine - Postdoctoral Fellow
- 2013.06 - Present - Fudan University, School of Basic Medical Sciences, Department of Biochemistry and Molecular Biology - Researcher
Academic Background & Achievements
- 1992.09 - 1996.07 Bachelor's in Biochemistry: East China University of Science and Technology
- 1999.09 - 2001.12 Master's in Biochemistry and Molecular Biology: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- 2002.09 - 2008.05 Ph.D. in Biochemistry and Molecular Biology: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
Publications
- FNDC5/irisin facilitates muscle−adipose−bone connectivity through ubiquitination- dependent activation of runt-related transcriptional factors RUNX1/2, He, X.Y., Hua, Y., Li, Q., Zhu, W., Pan, Y., Yang, Y.L., Li, X.Y., Wu, M.X., Wang, J.Y., Gan, X.Q., 2022
- Oligomerization of Frizzled and low-density lipoprotein receptor-related protein 5/6 initiates intracellular signaling for the canonical WNT/β-catenin pathway, Hua, Y., Yang, Y.L., Li, Q., He, X.Y., Zhu, W., Wang, J.Y., Gan. X.Q., 2018
- T Cell Factor 7 (TCF7)/TCF1 feedback controls osteocalcin signaling in brown adipocytes independent of Wnt/b-catenin pathway, Li, Q., Hua, Y., Yang, Y.L., He, X.Y., Zhu, W., Wang, J.Y., Gan. X.Q., 2018
- The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation, Zhu, W., He, X.Y., Hua, Y., Li, Q., Wang, J.Y., Gan. X.Q., 2017
- PRR5L degradation promotes mTORC2-mediated PKC- phosphorylation and cell migration downstream of G12, Gan. X.Q., Wang, J.Y., Wang, C., Sommer, E., Kozasa, T., Srinivasula, S., Alessi, D., Offermanns, S., Simon, M.I., Wu, D.Q., 2012
- Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3, 4, 5-trisphophate, Gan. X.Q., Wang, J.Y., Su, B., Wu, D.Q., 2011
- Nuclear Dishevelled, c-Jun, -Catenin and TCF form a complex leading to stabilization of -catenin/TCF interaction, Gan. X.Q., Wang, J.Y., Xi, Y., Wu, Z.L., Li, Y.P., Li, L., 2008
Awards
- 2014: Shanghai Pujiang Talent, Shanghai Science and Technology Commission
