Professor | Yang Li | Asia Growth Partners

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Name	Yang Li
Contact Information	oceanyangli@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Yang Li

Contact Information

oceanyangli@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2002-09 to 2010-12: Peking University Health Science Center (8-year MD-PhD program) 2008-09 to 2009-12: University of Michigan (State-sponsored study abroad)
Work Experience	2011-01 to 2017-10: Postdoctoral Researcher at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences 2017-11 to 2023-12: Young Researcher, Doctoral Supervisor at Department of Pharmacology, School of Basic Medical Sciences, Fudan University 2023-12 to present: Professor, Doctoral Supervisor at Department of Pharmacology, School of Basic Medical Sciences, Fudan University
Awards	Jilin Province Science and Technology Progress Award (Third Class, 2004) National Postdoctoral Science Foundation (Second Class, 2013) CAS 'Yihai Kerry' Excellent Postdoctoral Award (2017) Chinese Society for Cell Biology Excellent Young Paper Award (2017)

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2002-09 to 2010-12: Peking University Health Science Center (8-year MD-PhD program)
2008-09 to 2009-12: University of Michigan (State-sponsored study abroad)

Work Experience

2011-01 to 2017-10: Postdoctoral Researcher at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
2017-11 to 2023-12: Young Researcher, Doctoral Supervisor at Department of Pharmacology, School of Basic Medical Sciences, Fudan University
2023-12 to present: Professor, Doctoral Supervisor at Department of Pharmacology, School of Basic Medical Sciences, Fudan University

Awards

Jilin Province Science and Technology Progress Award (Third Class, 2004)
National Postdoctoral Science Foundation (Second Class, 2013)
CAS 'Yihai Kerry' Excellent Postdoctoral Award (2017)
Chinese Society for Cell Biology Excellent Young Paper Award (2017)

Areas of Focus	Revealing the regular changes of lysosomes and elucidating new mechanisms of lysosomal homeostasis regulation Screening small molecule compounds that enhance lysosomal degradation function and elucidating the mechanisms Elucidating the function of enhancing lysosomal degradation of toxic protein aggregates to improve Alzheimer's disease
Publications	Gut bacteria alleviate smoking-related NASH by degrading gut nicotine, Bo Chen, Lulu Sun, Guangyi Zeng, Zhe Shen, Kai Wang, Limin Yin, et al., Ming-Hua Zheng, Yang Li, Chaohui Yu, Frank J. Gonzalez, and Changtao Jiang, 2022 Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer’s disease–like symptoms in mice, Limin Yin, Jianhui Zhou, Tianyou Li, Xinghua Wang, Wenlong Xue, Jie Zhang, Lingxi Lin, Ning Wang, Xinyi Kang, Yu Zhou, Hong Liu, Yang Li, 2022 TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer’s disease-relevant phenotypes in mice, Tianyou Li, Limin Yin, Xinyi Kang, Wenlong Xue, Ning Wang, Jie Zhang, Ping Yuan, Lingxi Lin, Yang Li, 2022 LYECs: lysosome-enhancing compounds as potential therapeutic approaches for Alzheimer’s disease, Limin Yin, Yu Zhou, Hong Liu, Yang Li, 2022 Enhancement of lysosome biogenesis as a potential therapeutic approach for neurodegenerative diseases, Wenlong Xue, Yang Li, 2023 溶酶体生成的调控机制研究进展, 尹利敏，李洋, 2023 C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, Yang Li, Yu Zhang, Meng Xu, Qiwen Gan, Xiao Ding, Kai Liu, Xuezhao Liu, Jingjing Liang, Xin Wang, Guihua Tang, Lingli Guo, Zhiyang Gao, Xiaojiang Hao, and Chonglin Yang, 2018 Protein kinase C controls lysosome biogenesis independently of mTORC1, Yang Li, Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song, Lianwan Chen, Xiahe Huang, Xin Wang, Youli Jian, Guihua Tang, Changyong Tang, Yingtong Di, Shuzhen Mu, Xuezhao Liu, Kai Liu, Ting Li, Yingchun Wang, Long Miao, Weixiang Guo, Xiaojiang Hao, and Chonglin Yang, 2016 The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy, Xuezhao Liu, Yang Li, Ruxiao Xing, Kai Liu, Qiwen Gan, Changyong Tang, Zhiyang Gao, Youli Jian, Shouqing Luo, Weixiang Guo, and Chonglin Yang, 2017

Areas of Focus

Revealing the regular changes of lysosomes and elucidating new mechanisms of lysosomal homeostasis regulation
Screening small molecule compounds that enhance lysosomal degradation function and elucidating the mechanisms
Elucidating the function of enhancing lysosomal degradation of toxic protein aggregates to improve Alzheimer's disease

Publications

Gut bacteria alleviate smoking-related NASH by degrading gut nicotine, Bo Chen, Lulu Sun, Guangyi Zeng, Zhe Shen, Kai Wang, Limin Yin, et al., Ming-Hua Zheng, Yang Li, Chaohui Yu, Frank J. Gonzalez, and Changtao Jiang, 2022
Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer’s disease–like symptoms in mice, Limin Yin, Jianhui Zhou, Tianyou Li, Xinghua Wang, Wenlong Xue, Jie Zhang, Lingxi Lin, Ning Wang, Xinyi Kang, Yu Zhou, Hong Liu, Yang Li, 2022
TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer’s disease-relevant phenotypes in mice, Tianyou Li, Limin Yin, Xinyi Kang, Wenlong Xue, Ning Wang, Jie Zhang, Ping Yuan, Lingxi Lin, Yang Li, 2022
LYECs: lysosome-enhancing compounds as potential therapeutic approaches for Alzheimer’s disease, Limin Yin, Yu Zhou, Hong Liu, Yang Li, 2022
Enhancement of lysosome biogenesis as a potential therapeutic approach for neurodegenerative diseases, Wenlong Xue, Yang Li, 2023
溶酶体生成的调控机制研究进展, 尹利敏，李洋, 2023
C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, Yang Li, Yu Zhang, Meng Xu, Qiwen Gan, Xiao Ding, Kai Liu, Xuezhao Liu, Jingjing Liang, Xin Wang, Guihua Tang, Lingli Guo, Zhiyang Gao, Xiaojiang Hao, and Chonglin Yang, 2018
Protein kinase C controls lysosome biogenesis independently of mTORC1, Yang Li, Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song, Lianwan Chen, Xiahe Huang, Xin Wang, Youli Jian, Guihua Tang, Changyong Tang, Yingtong Di, Shuzhen Mu, Xuezhao Liu, Kai Liu, Ting Li, Yingchun Wang, Long Miao, Weixiang Guo, Xiaojiang Hao, and Chonglin Yang, 2016
The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy, Xuezhao Liu, Yang Li, Ruxiao Xing, Kai Liu, Qiwen Gan, Changyong Tang, Zhiyang Gao, Youli Jian, Shouqing Luo, Weixiang Guo, and Chonglin Yang, 2017

Lysosomes Homeostasis Regulation Small Molecules Degradation Protein Aggregates Alzheimer'S Disease Mechanisms Screening Function

Ma Rong Fang - Zhejiang University

Xu Zhiqing - Capital Medical University

He Guiqiong - Chongqing Medical University

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