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Yang Li
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
Lysosomes
Homeostasis
Regulation
Small Molecules
Degradation
Protein Aggregates
Alzheimer'S Disease
Mechanisms
Screening
Function
Areas of Focus
- Revealing the regular changes of lysosomes and elucidating new mechanisms of lysosomal homeostasis regulation
- Screening small molecule compounds that enhance lysosomal degradation function and elucidating the mechanisms
- Elucidating the function of enhancing lysosomal degradation of toxic protein aggregates to improve Alzheimer's disease
Work Experience
- 2011-01 to 2017-10: Postdoctoral Researcher at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- 2017-11 to 2023-12: Young Researcher, Doctoral Supervisor at Department of Pharmacology, School of Basic Medical Sciences, Fudan University
- 2023-12 to present: Professor, Doctoral Supervisor at Department of Pharmacology, School of Basic Medical Sciences, Fudan University
Academic Background & Achievements
- 2002-09 to 2010-12: Peking University Health Science Center (8-year MD-PhD program)
- 2008-09 to 2009-12: University of Michigan (State-sponsored study abroad)
Publications
- Gut bacteria alleviate smoking-related NASH by degrading gut nicotine, Bo Chen, Lulu Sun, Guangyi Zeng, Zhe Shen, Kai Wang, Limin Yin, et al., Ming-Hua Zheng, Yang Li, Chaohui Yu, Frank J. Gonzalez, and Changtao Jiang, 2022
- Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer’s disease–like symptoms in mice, Limin Yin, Jianhui Zhou, Tianyou Li, Xinghua Wang, Wenlong Xue, Jie Zhang, Lingxi Lin, Ning Wang, Xinyi Kang, Yu Zhou, Hong Liu, Yang Li, 2022
- TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer’s disease-relevant phenotypes in mice, Tianyou Li, Limin Yin, Xinyi Kang, Wenlong Xue, Ning Wang, Jie Zhang, Ping Yuan, Lingxi Lin, Yang Li, 2022
- LYECs: lysosome-enhancing compounds as potential therapeutic approaches for Alzheimer’s disease, Limin Yin, Yu Zhou, Hong Liu, Yang Li, 2022
- Enhancement of lysosome biogenesis as a potential therapeutic approach for neurodegenerative diseases, Wenlong Xue, Yang Li, 2023
- 溶酶体生成的调控机制研究进展, 尹利敏，李洋, 2023
- C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, Yang Li, Yu Zhang, Meng Xu, Qiwen Gan, Xiao Ding, Kai Liu, Xuezhao Liu, Jingjing Liang, Xin Wang, Guihua Tang, Lingli Guo, Zhiyang Gao, Xiaojiang Hao, and Chonglin Yang, 2018
- Protein kinase C controls lysosome biogenesis independently of mTORC1, Yang Li, Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song, Lianwan Chen, Xiahe Huang, Xin Wang, Youli Jian, Guihua Tang, Changyong Tang, Yingtong Di, Shuzhen Mu, Xuezhao Liu, Kai Liu, Ting Li, Yingchun Wang, Long Miao, Weixiang Guo, Xiaojiang Hao, and Chonglin Yang, 2016
- The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy, Xuezhao Liu, Yang Li, Ruxiao Xing, Kai Liu, Qiwen Gan, Changyong Tang, Zhiyang Gao, Youli Jian, Shouqing Luo, Weixiang Guo, and Chonglin Yang, 2017
Awards
- Jilin Province Science and Technology Progress Award (Third Class, 2004)
- National Postdoctoral Science Foundation (Second Class, 2013)
- CAS 'Yihai Kerry' Excellent Postdoctoral Award (2017)
- Chinese Society for Cell Biology Excellent Young Paper Award (2017)
