Professor | Lei Lv | Asia Growth Partners

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Name	Lei Lv
Contact Information	lvlei@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Lei Lv

Contact Information

lvlei@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2000.09-2004.07 Bachelor's Degree: Fudan University, School of Life Sciences 2004.09-2007.07 Master's Degree: Fudan University, School of Life Sciences 2007.09-2010.07 PhD: Fudan University, Institute of Biomedical Sciences
Work Experience	2010.08-2012.06 - Fudan University, School of Basic Medical Sciences - Postdoctoral Researcher 2012.07-2013.03 - Shanghai Jiao Tong University School of Medicine, Xinhua Hospital - Clinical PI 2013.03-2017.06 - University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center - Postdoctoral Researcher 2017.06-Present - Fudan University, School of Basic Medical Sciences - Researcher
Awards	2018: First Prize of Shanghai Natural Science Award (Second Contributor) 2018: National Youth Distinguished Expert, Organization Department 2014: Second Prize of Ministry of Education Natural Science Award (Second Contributor) 2013: Shanghai Youth Science and Technology Star 2013: Excellent Doctoral Dissertation of Shanghai

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2000.09-2004.07 Bachelor's Degree: Fudan University, School of Life Sciences
2004.09-2007.07 Master's Degree: Fudan University, School of Life Sciences
2007.09-2010.07 PhD: Fudan University, Institute of Biomedical Sciences

Work Experience

2010.08-2012.06 - Fudan University, School of Basic Medical Sciences - Postdoctoral Researcher
2012.07-2013.03 - Shanghai Jiao Tong University School of Medicine, Xinhua Hospital - Clinical PI
2013.03-2017.06 - University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center - Postdoctoral Researcher
2017.06-Present - Fudan University, School of Basic Medical Sciences - Researcher

Awards

2018: First Prize of Shanghai Natural Science Award (Second Contributor)
2018: National Youth Distinguished Expert, Organization Department
2014: Second Prize of Ministry of Education Natural Science Award (Second Contributor)
2013: Shanghai Youth Science and Technology Star
2013: Excellent Doctoral Dissertation of Shanghai

Areas of Focus	Research on tumor metabolism regulation mechanisms Research on the interaction between metabolism and epigenetics Research on tumor immune regulation mechanisms and translational medicine
Publications	Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth, Lei Lv, Dong Li, Di Zhao, Ruiting Lin, Yajing Chu, Heng Zhang, Zhengyu Zha, Ying Liu, Zi Li, Yanping Xu, Gang Wang, Yiran Huang, Yue Xiong, Kun-Liang Guan, Qun-Ying Lei, 2011 Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization, Lei Lv, Yan-Ping Xu, Di Zhao, Fu-Long Li, Wei Wang, Naoya Sasaki, Ying Jiang, Xin Zhou, Ting-Ting Li, Kun-Liang Guan, Qun-Ying Lei and Yue Xiong, 2013 CRL4VprBP E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases, Tadashi Nakagawa, Lei Lv, Makiko NaKagawa, Yanbao Yu, Chao Yu, Ana C.D'Alessio, Keiko Nakayama, Heng-Yu Fan, Xian Chen and Yue Xiong, 2015 Vpr targets TET2 for degradation by CRL4VprBP E3 ligase to sustain IL-6 expression and enhance HIV-1 replication, Lei Lv, Qi Wang, Yanping Xu, Li-chung Tsao, Tadashi Nakagawa, Haitao Guo, Lishan Su and Yue Xiong, 2018 Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy, Yan-ping Xu, Lei Lv, Ying Liu, Matthew D. Smith, Wen-Cai Li, Xian-ming Tan, Meng Cheng, Zhijun Li, Michael Bovino, Jeffrey Aubé, and Yue Xiong, 2019 D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1, Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun Chen, Qun-Ying Lei, Song Zhang, Yanping Xu, Lei Lv, 2022 TET2 suppresses VHL-deficiency-driven clear cell renal cell carcinoma by targeting HIF signaling, Xinchao Zhang, Shuyan Li, Jing He, Yun-jie Jin, Ruonan Zhang, Wenjing Dong, Mingen Lin, Yajing Yang, Tongguan Tian, Yuefan Zhou, Yixin Xu, Qun-Ying Lei, Jing Zhang, Qing Zhang, Yanping Xu, Lei Lv, 2022

Areas of Focus

Research on tumor metabolism regulation mechanisms
Research on the interaction between metabolism and epigenetics
Research on tumor immune regulation mechanisms and translational medicine

Publications

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth, Lei Lv, Dong Li, Di Zhao, Ruiting Lin, Yajing Chu, Heng Zhang, Zhengyu Zha, Ying Liu, Zi Li, Yanping Xu, Gang Wang, Yiran Huang, Yue Xiong, Kun-Liang Guan, Qun-Ying Lei, 2011
Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization, Lei Lv, Yan-Ping Xu, Di Zhao, Fu-Long Li, Wei Wang, Naoya Sasaki, Ying Jiang, Xin Zhou, Ting-Ting Li, Kun-Liang Guan, Qun-Ying Lei and Yue Xiong, 2013
CRL4VprBP E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases, Tadashi Nakagawa, Lei Lv, Makiko NaKagawa, Yanbao Yu, Chao Yu, Ana C.D'Alessio, Keiko Nakayama, Heng-Yu Fan, Xian Chen and Yue Xiong, 2015
Vpr targets TET2 for degradation by CRL4VprBP E3 ligase to sustain IL-6 expression and enhance HIV-1 replication, Lei Lv, Qi Wang, Yanping Xu, Li-chung Tsao, Tadashi Nakagawa, Haitao Guo, Lishan Su and Yue Xiong, 2018
Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy, Yan-ping Xu, Lei Lv, Ying Liu, Matthew D. Smith, Wen-Cai Li, Xian-ming Tan, Meng Cheng, Zhijun Li, Michael Bovino, Jeffrey Aubé, and Yue Xiong, 2019
D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1, Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun Chen, Qun-Ying Lei, Song Zhang, Yanping Xu, Lei Lv, 2022
TET2 suppresses VHL-deficiency-driven clear cell renal cell carcinoma by targeting HIF signaling, Xinchao Zhang, Shuyan Li, Jing He, Yun-jie Jin, Ruonan Zhang, Wenjing Dong, Mingen Lin, Yajing Yang, Tongguan Tian, Yuefan Zhou, Yixin Xu, Qun-Ying Lei, Jing Zhang, Qing Zhang, Yanping Xu, Lei Lv, 2022

Tumor Metabolism Regulation Mechanisms Epigenetics Interaction Immune Translational Medicine Research

Shang Yongfeng - Peking University

Xian Wang - Peking University

Juan Feng - Peking University

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