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Ji-Yang Wang
Basic Medical Sciences
Fudan University
Shanghai
Language: Japanese, English, Chinese
Humoral Immunity
Immune Tolerance
Iga
Intestinal Secretion
Inflammatory Bowel Disease
Colorectal Cancer
Antibody Deficiency
Cellular Mechanisms
Molecular Mechanisms
Immune Regulation
Areas of Focus
- Regulation mechanisms of humoral immunity and immune tolerance
- Regulation of intestinal secretion of IgA and its role in inflammatory bowel disease and colorectal cancer
- Cellular and molecular mechanisms of antibody deficiency diseases
Work Experience
- 1990/04-1998/09 - Kyushu University - Assistant Professor
- 1991/10-1994/09 - University of Alabama - Research Assistant
- 1997/04-1997/09 - Harvard Medical School - Visiting Scholar
- 1998/10-2003/02 - Chiba Cancer Center - Chief Researcher
- 2003/03-2013/03 - RIKEN Research Center for Allergy and Immunology - Laboratory Head
- 2014/04-Present - Fudan University - Professor
Academic Background & Achievements
- 1980/04-1984/03 Bachelor: Hiroshima University, Japan
- 1984/04-1986/03 Master: Kwansei Gakuin University, Japan
- 1986/04-1990/03 PhD: Kyushu University, Japan
Publications
- RAG1 splicing mutation causes enhanced B-cell differentiation and autoantibody production, Min, Q.*, Meng, X.*, Zhou, Q.*, Wang, Y., Li, Y., Lai, N., Xiong, E., Wang, W., Yasuda, S., Yu, M., Zhang, H., Sun, J., Wang, X.#, Wang, J.-Y.#, 2021
- Effective and safe treatment of a novel IL2RA deficiency with rapamycin, Lai, N.*, Liu, L.*, Lin, L., Cui, C., Wang, Y., Min, Q., Xiong, E., Wang, W., Ying, W., Zhou, Q., Hou, J., Sun, J., Wang, J.-Y.#, and Wang, X., 2020
- MZB1 promotes the secretion of J chain-containing dimeric IgA and is critical for the suppression of gut inflammation, Xiong, E.*, Li, Y.*, Min, Q.*, Cui, C., Liu, J., Hong, R., Lai, N., Wang, Y., Sun, J., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. and Wang, J.-Y.#, 2019
- EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity, Li, Y.*, Takahashi, Y., Fujii, S., Zhou, Y., Hong, R., Suzuki, A., Tsubata, T., Hase, K.#, Wang, J.-Y.#, 2016
- Critical role of the IgM Fc receptor in IgM homeostasis, B cell survival and humoral immune responses, Ouchida, R., Mori, H., Hase, K., Takatsu, H., Kurosaki, T., Tokuhisa, T., Ohno, H. and Wang, J.-Y.#, 2012
Awards
- Asahi Science and Technology Award (1987): Detail
- Ito Research Award (1990): Detail
- Chiba Cancer Center Research Award (2000): Detail
- RIKEN International Cooperation Award (2004): Detail
- RIKEN Excellent Paper Award (2009): Detail
