Professor | Yichun Zhu | Asia Growth Partners

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Name	Yichun Zhu
Contact Information	nyczhu@shmu.edu.cn
Language ability	Chinese, German
Province	Shanghai

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Name

Yichun Zhu

Contact Information

nyczhu@shmu.edu.cn

Language ability

Chinese, German

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1981.09—1987.06 Bachelor's Degree: Shanghai Second Medical University 1992.06—1994.05 PhD in Pharmacology: Heidelberg University 2013 Selected for the National Hundred, Thousand, and Ten Thousand Talents Project and awarded the title of 'Outstanding Young and Middle-aged Expert with Outstanding Contributions' by the Ministry of Human Resources and Social Security of the People's Republic of China 2012 Shanghai Leading Talent, Organization Department of the CPC Shanghai Municipal Committee and Shanghai Municipal Human Resources and Social Security Bureau 2009 Shanghai Excellent Discipline Leader, Shanghai Science and Technology Commission 2008 National Science Fund for Distinguished Young Scholars, National Natural Science Foundation of China 2001 Ministry of Education Cross-Century Excellent Talent Training Program, Ministry of Education of the People's Republic of China 1998 Shanghai Shuguang Scholar, Shanghai Education Development Foundation
Work Experience	1994.05—1994.12 Postdoctoral Researcher in Pharmacology, Kiel University, Germany 1995.01—Present Lecturer, Associate Professor, Professor, Department of Physiology and Pathophysiology, Fudan University 2019.04—Present Head of the Department of Physiology and Pathophysiology, Fudan University
Awards	2011 Second Prize of the Natural Science Award, Ministry of Education of the People's Republic of China 2004 Second Prize of the Natural Science Award, Ministry of Education of the People's Republic of China 2013 Third Prize of the Chinese Medical Science and Technology Award, Chinese Medical Association 2008 Third Prize of the Chinese Medical Science and Technology Award, Chinese Medical Association 2010 Third Prize of the Shanghai Natural Science Award, Shanghai Municipal Government 2005 Third Prize of the Shanghai Science and Technology Progress Award, Shanghai Municipal Government 1998 Excellent Young Teacher of Shanghai Universities, Shanghai Municipal Education Commission 2008 WuXi AppTec Life Chemistry Research Award, WuXi AppTec New Drug Development Company 2003 Meiji Dairy Life Science Award, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences and Meiji Dairy Co., Ltd. 2000 Seventh Higher Education Young Teacher Award (Teaching Category), Fok Ying Tung Education Foundation

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1981.09—1987.06 Bachelor's Degree: Shanghai Second Medical University
1992.06—1994.05 PhD in Pharmacology: Heidelberg University
2013 Selected for the National Hundred, Thousand, and Ten Thousand Talents Project and awarded the title of 'Outstanding Young and Middle-aged Expert with Outstanding Contributions' by the Ministry of Human Resources and Social Security of the People's Republic of China
2012 Shanghai Leading Talent, Organization Department of the CPC Shanghai Municipal Committee and Shanghai Municipal Human Resources and Social Security Bureau
2009 Shanghai Excellent Discipline Leader, Shanghai Science and Technology Commission
2008 National Science Fund for Distinguished Young Scholars, National Natural Science Foundation of China
2001 Ministry of Education Cross-Century Excellent Talent Training Program, Ministry of Education of the People's Republic of China
1998 Shanghai Shuguang Scholar, Shanghai Education Development Foundation

Work Experience

1994.05—1994.12 Postdoctoral Researcher in Pharmacology, Kiel University, Germany
1995.01—Present Lecturer, Associate Professor, Professor, Department of Physiology and Pathophysiology, Fudan University
2019.04—Present Head of the Department of Physiology and Pathophysiology, Fudan University

Awards

2011 Second Prize of the Natural Science Award, Ministry of Education of the People's Republic of China
2004 Second Prize of the Natural Science Award, Ministry of Education of the People's Republic of China
2013 Third Prize of the Chinese Medical Science and Technology Award, Chinese Medical Association
2008 Third Prize of the Chinese Medical Science and Technology Award, Chinese Medical Association
2010 Third Prize of the Shanghai Natural Science Award, Shanghai Municipal Government
2005 Third Prize of the Shanghai Science and Technology Progress Award, Shanghai Municipal Government
1998 Excellent Young Teacher of Shanghai Universities, Shanghai Municipal Education Commission
2008 WuXi AppTec Life Chemistry Research Award, WuXi AppTec New Drug Development Company
2003 Meiji Dairy Life Science Award, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences and Meiji Dairy Co., Ltd.
2000 Seventh Higher Education Young Teacher Award (Teaching Category), Fok Ying Tung Education Foundation

Areas of Focus	Effects and mechanisms of active ingredients from natural plants on the cardiovascular system Mechanisms of cardiomyocyte apoptosis and new intervention approaches New approaches to promote microvascular angiogenesis in ischemic myocardium Regulation of the cardiovascular system and related ion channels by hydrogen sulfide Target molecules and mechanisms of hydrogen sulfide in the cardiovascular system
Publications	Advances in Hydrogen Sulfide Biology, Zhu YC (Editor), 2021 YB-1 recruits Drosha to promote splicing of pri-miR-192 to mediate the proangiogenic effects of H2S, Zhou Y, Li XH, Xue WL, Jin S, Li MY, Zhang CC, Yu B, Zhu L, Liang K, Chen Y, Tao BB, Zhu YZ, Wang MJ, Zhu YC, 2022 H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets, Liu HD, Zhang AJ, Xu JJ, Chen Y, Zhu YC, 2016 Hydrogen sulfide targets the Cys320/Cys529 motif in Kv4.2 to inhibit the Ito potassium channels in cardiomyocytes and regularizes fatal arrhythmia in myocardial infarction, Ma SF, Luo Y, Ding YJ, Chen Y, Pu SX, Wu HJ, Wang ZF, Tao BB, Wang WW, Zhu YC, 2015 Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na+/K+-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats, Ge SN, Zhao MM, Wu DD, Chen Y, Wang Y, Zhu JH, Cai WJ, Zhu YZ, Zhu YC, 2014 Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes, Xue R, Hao DD, Sun JP, Li WW, Zhao MM, Li XH, Chen Y, Zhu JH, Ding YJ, Liu J, Zhu YC, 2013 VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045–Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells, Tao BB, Liu SY, Zhang CC, Fu W, Cai WJ, Wang Y, Shen Q, Wang MJ, Chen Y, Zhang LJ, Zhu YZ, Zhu YC, 2013 The hydrogen sulfide donor NaHS promotes Angiogenesis in a rat model of hind limb ischemia, Wang MJ, Cai WJ, Li N, Ding YJ, Chen Y, Zhu YC, 2010 Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes, Sun YG, Cao YX, Wang WW, Ma SF, Yao T, Zhu YC, 2008 The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation, Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, Zhu YC, 2007

Areas of Focus

Effects and mechanisms of active ingredients from natural plants on the cardiovascular system
Mechanisms of cardiomyocyte apoptosis and new intervention approaches
New approaches to promote microvascular angiogenesis in ischemic myocardium
Regulation of the cardiovascular system and related ion channels by hydrogen sulfide
Target molecules and mechanisms of hydrogen sulfide in the cardiovascular system

Publications

Advances in Hydrogen Sulfide Biology, Zhu YC (Editor), 2021
YB-1 recruits Drosha to promote splicing of pri-miR-192 to mediate the proangiogenic effects of H2S, Zhou Y, Li XH, Xue WL, Jin S, Li MY, Zhang CC, Yu B, Zhu L, Liang K, Chen Y, Tao BB, Zhu YZ, Wang MJ, Zhu YC, 2022
H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets, Liu HD, Zhang AJ, Xu JJ, Chen Y, Zhu YC, 2016
Hydrogen sulfide targets the Cys320/Cys529 motif in Kv4.2 to inhibit the Ito potassium channels in cardiomyocytes and regularizes fatal arrhythmia in myocardial infarction, Ma SF, Luo Y, Ding YJ, Chen Y, Pu SX, Wu HJ, Wang ZF, Tao BB, Wang WW, Zhu YC, 2015
Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na+/K+-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats, Ge SN, Zhao MM, Wu DD, Chen Y, Wang Y, Zhu JH, Cai WJ, Zhu YZ, Zhu YC, 2014
Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes, Xue R, Hao DD, Sun JP, Li WW, Zhao MM, Li XH, Chen Y, Zhu JH, Ding YJ, Liu J, Zhu YC, 2013
VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045–Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells, Tao BB, Liu SY, Zhang CC, Fu W, Cai WJ, Wang Y, Shen Q, Wang MJ, Chen Y, Zhang LJ, Zhu YZ, Zhu YC, 2013
The hydrogen sulfide donor NaHS promotes Angiogenesis in a rat model of hind limb ischemia, Wang MJ, Cai WJ, Li N, Ding YJ, Chen Y, Zhu YC, 2010
Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes, Sun YG, Cao YX, Wang WW, Ma SF, Yao T, Zhu YC, 2008
The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation, Cai WJ, Wang MJ, Moore PK, Jin HM, Yao T, Zhu YC, 2007

Natural Plants Cardiovascular System Active Ingredients Mechanisms Cardiomyocyte Apoptosis Intervention Microvascular Angiogenesis Ischemic Myocardium Hydrogen Sulfide Ion Channels

Ning Lu - Fudan University

Xiaoqin Zhu - Guangzhou Medical University

Juan Feng - Peking University

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