Professor | Qiong Xie | Asia Growth Partners

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Name	Qiong Xie
Contact Information	qxie@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Qiong Xie

Contact Information

qxie@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1998.09 – 2002.06 Bachelor: Fudan University (formerly Shanghai Medical University), School of Pharmacy, Pharmacy 2002.09 – 2007.06 PhD: Fudan University, School of Pharmacy, Medicinal Chemistry Published over 70 research papers in domestic and international journals, including 26 as first or corresponding author Granted 5 international patents (USA, Japan, Europe) and 7 Chinese invention patents Participated in the development of anti-AD candidate drugs in two major national science and technology projects
Work Experience	2017.12 – Present - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Associate Professor 2010.11 – 2011.11 - University of Arizona, Department of Chemistry and Biochemistry - Visiting Scholar 2007.07 – 2017.12 - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Lecturer
Awards	2017 Shanghai Science and Technology Progress Award (First Prize) 2017 Chinese Medical Science and Technology Award (Second Prize) 2017 National College Pharmacy Professional Young Teacher Micro-Lecture Teaching Competition (Special Prize) 2017 National College Pharmacy Professional Young Teacher Teaching Ability Competition (First Prize) 2017 Fudan University School of Pharmacy 'Outstanding Undergraduate Teaching Individual' 2016-2017 Fudan University School of Pharmacy 'Dechuan Teaching Award' 2015 Shanghai Medical Science and Technology Award (Second Prize) 2014 Fudan University School of Pharmacy Young Teacher Lecture Competition (Second Prize) 2010 Shanghai Municipal Education Commission 'Morning Light Scholar'

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1998.09 – 2002.06 Bachelor: Fudan University (formerly Shanghai Medical University), School of Pharmacy, Pharmacy
2002.09 – 2007.06 PhD: Fudan University, School of Pharmacy, Medicinal Chemistry
Published over 70 research papers in domestic and international journals, including 26 as first or corresponding author
Granted 5 international patents (USA, Japan, Europe) and 7 Chinese invention patents
Participated in the development of anti-AD candidate drugs in two major national science and technology projects

Work Experience

2017.12 – Present - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Associate Professor
2010.11 – 2011.11 - University of Arizona, Department of Chemistry and Biochemistry - Visiting Scholar
2007.07 – 2017.12 - Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Lecturer

Awards

2017 Shanghai Science and Technology Progress Award (First Prize)
2017 Chinese Medical Science and Technology Award (Second Prize)
2017 National College Pharmacy Professional Young Teacher Micro-Lecture Teaching Competition (Special Prize)
2017 National College Pharmacy Professional Young Teacher Teaching Ability Competition (First Prize)
2017 Fudan University School of Pharmacy 'Outstanding Undergraduate Teaching Individual'
2016-2017 Fudan University School of Pharmacy 'Dechuan Teaching Award'
2015 Shanghai Medical Science and Technology Award (Second Prize)
2014 Fudan University School of Pharmacy Young Teacher Lecture Competition (Second Prize)
2010 Shanghai Municipal Education Commission 'Morning Light Scholar'

Areas of Focus	Research on small molecule drugs for inflammation and tumor immunity Research on drugs for neurodegenerative diseases and analgesics
Publications	Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists, Lixue Lu, Song Chen, Mingcheng Yu, Ronghui Zhou, Siqi Guo, Ji-an Chen, Haojie Wang, Shijie Chen, Cheng Luo, Qiong Xie, Yonghui Wang, 2023 Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity, Nannan Sun#, Mingcheng Yu#, Zhengyuan Jiang, Feng Yang, Lixue Lu, Yuehan Xia, Yunpeng Zhao, Yafei Huang, Song Chen, Shijie Chen, Cheng Luo, Yonghui Wang, Qiong Xie, 2023 Discovery of pyridinone derivatives as potent, selective, and orally bioavailable adenosine A2A receptor antagonists for cancer immunotherapy, Chenyu Zhu#, Shuyin Ze#, Ronghui Zhou#, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang, Weiqiang Lu, Qiong Xie, 2023 Design, synthesis, and bioevaluation of 2-aminopteridin- 7(8H)-one derivatives as novel potent adenosine A2A receptor antagonists for cancer immunotherapy, Fazhi Yu#, Chenyu Zhu#, Shuyin Ze, Haojie Wang, Xinyu Yang, Mingyao Liu, Qiong Xie, Weiqiang Lu, Yonghui Wang, 2022 Discovery of orally available retinoic acid receptor-related orphan receptor γ-t/dihydroorotate dehydrogenase dual inhibitors for the treatment of refractory inflammatory bowel disease, Ji-An Chen#, Hui Ma#, Zehui Liu#, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lu, Qiong Xie, Jin Huang, Yonghui Wang, 2022 Discovery of tert-amine-based RORγt agonists, Ruomeng Qiu#, Mingcheng Yu#, Juwen Gong, Jinlong Tian, Yafei Huang, Yonghui Wang, Qiong Xie, 2021 Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists, Yuehan Xia, Mingcheng Yu, Yunpeng Zhao, Li Xia, Yafei Huang, Nannan Sun, Meiqi Song, Huimin Guo, Yunyi Zhang, Di Zhu, Qiong Xie, Yonghui Wang, 2021 Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists, Nannan Sun#, Yafei Huang#, Mingcheng Yu, Yunpeng Zhao, Ji-An Chen, Chenyu Zhu, Meiqi Song, Huimin Guo, Qiong Xie, Yonghui Wang, 2020 Discovery of aryl-substituted indole and indoline derivatives as RORγt Agonists, Yan Zhu#, Nannan Sun#, Mingcheng Yu, Huimin Guo, Qiong Xie, Yonghui Wang*, 2019

Areas of Focus

Research on small molecule drugs for inflammation and tumor immunity
Research on drugs for neurodegenerative diseases and analgesics

Publications

Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists, Lixue Lu, Song Chen, Mingcheng Yu, Ronghui Zhou, Siqi Guo, Ji-an Chen, Haojie Wang, Shijie Chen, Cheng Luo, Qiong Xie*, Yonghui Wang*, 2023
Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity, Nannan Sun#, Mingcheng Yu#, Zhengyuan Jiang, Feng Yang, Lixue Lu, Yuehan Xia, Yunpeng Zhao, Yafei Huang, Song Chen, Shijie Chen, Cheng Luo, Yonghui Wang*, Qiong Xie*, 2023
Discovery of pyridinone derivatives as potent, selective, and orally bioavailable adenosine A2A receptor antagonists for cancer immunotherapy, Chenyu Zhu#, Shuyin Ze#, Ronghui Zhou#, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang*, Weiqiang Lu*, Qiong Xie*, 2023
Design, synthesis, and bioevaluation of 2-aminopteridin- 7(8H)-one derivatives as novel potent adenosine A2A receptor antagonists for cancer immunotherapy, Fazhi Yu#, Chenyu Zhu#, Shuyin Ze, Haojie Wang, Xinyu Yang, Mingyao Liu, Qiong Xie*, Weiqiang Lu*, Yonghui Wang*, 2022
Discovery of orally available retinoic acid receptor-related orphan receptor γ-t/dihydroorotate dehydrogenase dual inhibitors for the treatment of refractory inflammatory bowel disease, Ji-An Chen#, Hui Ma#, Zehui Liu#, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lu, Qiong Xie*, Jin Huang*, Yonghui Wang*, 2022
Discovery of tert-amine-based RORγt agonists, Ruomeng Qiu#, Mingcheng Yu#, Juwen Gong, Jinlong Tian, Yafei Huang, Yonghui Wang*, Qiong Xie*, 2021
Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists, Yuehan Xia, Mingcheng Yu, Yunpeng Zhao, Li Xia, Yafei Huang, Nannan Sun, Meiqi Song, Huimin Guo, Yunyi Zhang, Di Zhu, Qiong Xie*, Yonghui Wang*, 2021
Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists, Nannan Sun#, Yafei Huang#, Mingcheng Yu, Yunpeng Zhao, Ji-An Chen, Chenyu Zhu, Meiqi Song, Huimin Guo, Qiong Xie*, Yonghui Wang*, 2020
Discovery of aryl-substituted indole and indoline derivatives as RORγt Agonists, Yan Zhu#, Nannan Sun#, Mingcheng Yu, Huimin Guo, Qiong Xie*, Yonghui Wang*, 2019

Inflammation Tumor Immunity Small Molecule Drugs Neurodegenerative Diseases Analgesics Ache Inhibition Anti-Aβ Aggregation Rorγt Inverse Agonists Cancer Immunotherapy Drug Development

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