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Xun Sun
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, English
Natural Compounds
Lead Optimization
Target Mechanisms
Clinical Targets
Anti-Tumor
Anti-Inflammatory
Anti-Drug-Resistant
Diversity Synthesis
Total Synthesis
Natural Product
Areas of Focus
- Optimization and discovery of active natural lead compounds and their functional target mechanisms
- Validation of potential clinical targets and development of new drugs for anti-tumor, anti-inflammatory immunity, and anti-drug-resistant bacteria
- Diversity synthesis methodology and total synthesis of natural product advantageous skeleton structures
Work Experience
- 2010.01-present - Fudan University, School of Pharmacy, Department of Natural Medicinal Chemistry - Professor, Doctoral Supervisor
- 2009.01-2010.01 - Fudan University, School of Pharmacy, Department of Natural Medicinal Chemistry - Professor, Master's Supervisor
- 2001.01-2010.01 - Fudan University, School of Pharmacy, Department of Natural Medicinal Chemistry - Associate Professor, Master's Supervisor
- 1997.07-2001.01 - Fudan University, School of Pharmacy, Department of Organic Chemistry - Associate Professor
- 2017.06-2019.09 - Fudan University, Shanghai Medical College - Vice Dean
- 2012.12-2017.06 - Fudan University, School of Pharmacy - Vice Dean of Research
- 2014.12-2015.10 - Fudan University, School of Pharmacy - Acting Dean
- 2009.01-2012.12 - Fudan University, School of Pharmacy - Vice Dean of Administration
Academic Background & Achievements
- 2000.09 – 2004.07 Ph.D. in Pharmaceutical Chemistry, Fudan University (Shanghai Medical University)
- 1994.09 - 1997.07 M.Sc. in Pharmaceutical Chemistry, Shanghai Medical University
- 1983.09 – 1987.06 B.Sc. in Chemistry, Nanchang University
Publications
- Discovery of First-in-Class TAK1–MKK3 Protein–Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production, Mei-Lin Tang, Haidong Li, Jin-Feng Ning, Xiaoyan Shen, Xun Sun, 2022
- Discovery of pyrimidine-bridged CA-4 CBSIs for the treatment of cervical cancer in combination with cisplatin with significantly reduced nephrotoxicity, Zhipeng Huo, Kunlin Liu, Xi Zhang, Yongxi Liang, Xun Sun, 2022
- Identification, Synthesis, and Comprehension of an Imidazole N-3 Regioisomeric Impurity of Olmesartan Medoxomil Key Intermediate, Jianwu Lu, Xiao Li, Shun Yuan, Yinquan Wang, Han Sun, Weizhao Weng, Yinfei Shi, Xiaoxu Wang, Kongcheng Huang, Xun Sun, Taizhi Wu, 2022
- Design, synthesis and biological evaluation of novel 5-methyl-2,4,5,6-tetrahydropyrrolo [3,4-c] pyrazole derivatives as potent potassium-competitive acid blockers, Wang Xianlian, Xu Yongmei, Zong Zaiwei, Cai Jinna, Chen Chunlin, Zhang Qingwei, Sun Xun, Li Jianqi, 2022
- A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis, Zheng-Nan Ren, Jun Yang, Meng-Ya Zhang, Yi-Wen Huang, Dong-Xiao Song, Xun Sun, Li-Long Pan, Jia Sun, 2022
- A Novel Resveratrol Analog Upregulates SIRT1 Expression and Ameliorates Neointima Formation, Baohui Yuan, He Liu, Xiaoliang Dong, Xiaohua Pan, Xun Sun, Jia Sun, Li-Long Pan, 2021
- Improved synthesis of cenobamate, Jiaxin Huang, Hongyi Wang, Zenong Wu, Xun Sun, Fuli Zhang, 2021
- LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors, Yi Zhao, Long An, Shupan Guo, Xiaoxing Huang, Huajie Tian, Li Liu, Tao Chen, Xun Sun, Qibing Mei, Rutao Wang, 2021
- TMSOTf-mediated approach to 1,3-oxazin-2-one skeleton through one-pot successive reduction-[4 + 2] cyclization process of imides with ynamides, Chen-Chen Zhang, Zhi-Peng Huo, Mei-Lin Tang, Yong-Xi Liang, Xun Sun, 2021
- A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine, Renwu Lia, Lingling Yan, Xun Sun, Weiping Zheng, 2020
- Study on the Total Synthesis of Resveratrol Dimers Quadrangularin A and Pallidol, Ji-lai Han, Mei-Lin Tang, Xun Sun, 2020
- A Concise Approach to N-substituted Rhodanines through a Base-assisted One-pot Coupling and Cyclization Process, Yongxi Liang, Mei-Lin Tang, Zhipeng Huo, Chenchen Zhang, Xun Sun, 2020
- Novel octapeptide-DTX prodrugs targeting MMP-7 as effective agents for the treatment of colorectal cancer with lower systemic toxicity, Zheng-Yu Liu, Mei-Lin Tang, Jin-Feng Ning, Yun-Peng Hao, Lu Zhou, Xun Sun, 2020
- Design, synthesis and biological evaluation of novel indone derivatives as selective ERβ modulators, Xi-Xi Liu, Mei-Lin Tang, Chen Zhong, Yun Tang, Jian-Ming Yu, Xun Sun, 2019
- Novel Mercapto Propionamide Derivatives with Potent New Delhi Metallo-β-Lactamase‑1 Inhibitory Activity and Low Toxicity, Zhi Meng, Mei-Lin Tang, Liting Yu, Yongxi Liang, Jilai Han, ChenChen Zhang, Fupin Hu, Jian-Ming Yu, Xun Sun, 2019
- Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes, Liting Yu, Mei-Lin Tang, Chang-Mei Si, Zhi Meng, Yongxi Liang, Jilai Han, Xun Sun, 2018
- Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis, Yong-Wei Jiang, Liang Xu, Wei Fu, Hua Lin, Jian-Ming Yu, Xun Sun, 2018
- Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors, Mingliang Wang, Yanjia Fang, Shoulai Gu, Fangfang Chen, Zhengjiang Zhu, Xun Sun, Jidong Zhu, 2017
- Divergent copper-mediated dimerization and hydroxylation of benzamides involving C–H bond functionalization, Mingliang Wang, Yimin Hu, Zhe Jiang, Hong C. Shen, Xun Sun, 2016
- Novel Fluorinated Docetaxel Analogue for Anti-hepatoma：Molecular Docking and Biological Evaluation, Yun-peng Hao, Zheng-yu Liu, Cheng Xie, Lu Zhou, Xun Sun, 2016
- Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents, Mei-Lin Tang, Chen Zhong, Zheng-Yu Liu, Peng Peng, Xin-Hua Liu, Xun Sun, 2016
- Differential metabolism of 3FDT and docetaxel in RLMs, rats, and HLMs, Mei-Lin Tang, Lu Zhou, Jun Chang, Zhuo-Han Hu, Yan Qin, Xun Sun, 2016
- Selective non-zinc binding MMP-2 inhibitors: novel benzamide Ilomastat analogs with anti-tumor metastasis, Jiao Song, Peng Peng, Jun Chang, Ming-Ming Liu, Jian-Ming Yu, Lu Zhou, Xun Sun, 2016
- Highly efficient synthesis of enantioenriched fully-substituted spirocyclohexane oxindoles via a Michael-Michael-aldol cascade reaction, Qiang-Sheng Sun, Hua Lin, Xun Sun, Xing-Wen Sun, 2016
- An enantioselective total synthesis of tubulysin V, Wei Tao, Wen Zhou, Zhu Zhou, Chang-Mei Si, Xun Sun, Bang-Guo Wei
Awards
- Shanghai Outstanding Academic Leader (2014)
- Shanghai Pharmaceutical Association Science and Technology Award Second Prize (2012)
- Fudan University March 8th Red Banner Holder
- Fudan University School of Pharmacy Dean's Award
- Fudan University School of Pharmacy 'My Favorite Teacher'
