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Zezhong Liu
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, English
Infectious Diseases
Prevention
Adjuvants
Vaccines
Coronavirus
Influenza
Enterovirus
Antiviral
Peptides
Antibodies
Areas of Focus
- Research on prevention strategies for emerging infectious diseases
- Research on new adjuvants
- Research on highly efficient broad-spectrum antiviral vaccines (coronavirus/influenza virus/enterovirus)
- Research on antiviral peptides and antibody drugs
Work Experience
- 2022.09 - Present - Fudan University, School of Pharmacy - Junior Researcher
- 2020.09 - 2022.08 - Fudan University, School of Basic Medical Sciences - Postdoctoral Researcher
Academic Background & Achievements
- 2017.09 – 2020.08 PhD: Fudan University, Pathogen Biology
- 2014.09 – 2017.07 Master's: Chinese Academy of Agricultural Sciences, Preventive Veterinary Medicine
- 2009.09 – 2014.07 Bachelor's: Northwest A&F University, Veterinary Medicine
Publications
- A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primates, Z. Liu, J. Zhou, X. Wang, W. Xu, Z. Teng, H. Chen, M. Chen, G. Zhang, Y. Wang, J. Huang, Q. Wang, S. Jiang, L. Lu, 2023
- Up or down: where comes Omicron?, Z. Liu, L. Lu, S. Jiang, 2022
- A Pan-sarbecovirus Vaccine Induces Highly Potent and Durable Neutralizing Antibody Responses in Non-human Primates against SARS-CoV-2 Omicron Variant, Z. Liu, JF. Chan, J. Zhou, M. Wang, Q. Wang, G. Zhang, W. Xu, KK. Chik, Y. Zhang, Y. Wang, KY. Yuen, L. Lu, S. Jiang, 2022
- A novel STING Agonist-Adjuvanted Pan-Sarbecovirus Vaccine Elicits Potent and Durable Neutralizing Antibody and T Cell Responses in Mice, Rabbits and NHPs, Z. Liu, J. Zhou, W. Xu, W. Deng, Y. Wang, M. Wang, Q. Wang, M. Hsieh, J. Dong, X. Wang, W. Huang, L. Xing, M. He, C. Tao, Y. Xie, Y. Zhang, Y. Wang, J. Zhao, Z. Yuan, C. Qin, S. Jiang, L. Lu, 2022
- An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope, Z. Liu, W. Xu, Z. Chen, W. Fu, W. Zhan, Y. Gao, J. Zhou, Y. Zhou, J. Wu, Q. Wang, X. Zhang, A. Hao, W. Wu, Q. Zhang, Y. Li, K. Fan, R. Chen, Q. Jiang, CT. Mayer, T. Schoofs, Y. Xie, S. Jiang, Y. Wen, Z. Yuan, K. Wang, L. Lu, L. Sun, Q. Wang, 2022
- Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo, Y. Fang, Z. Liu, Y. Qiu, J. Kong, Y. Fu, Y. Liu, C. Wang, J. Quan, Q. Wang, W. Xu, L. Yin, J. Cui, Y. Xu, S. Curry, S. Jiang, L. Lu, X. Zhou, 2021
- RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response, Z. Liu, W. Xu, S. Xia, C. Gu, X. Wang, Q. Wang, J. Zhou, Y. Wu, X. Cai, D. Qu, T. Ying, Y. Xie, L. Lu, Z. Yuan, S. Jiang, 2020
- A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases, J. Zhou, W. Xu, Z. Liu, C. Wang, S. Xia, Q. Lan, Y. Cai, S. Su, J. Pu, L. Xing, Y. Xie, L. Lu, S. Jiang, Q. Wang, 2022
- Enhancement versus neutralization by SARS-CoV-2 antibodies from a convalescent donor associates with distinct epitopes on the RBD, Y. Zhou, Z. Liu, S. Li, W. Xu, Q. Zhang, IT. Silva, C. Li, Y. Wu, Q. Jiang, Z. Liu, Q. Wang, Y. Guo, J. Wu, C. Gu, X. Cai, D. Qu, CT. Mayer, X. Wang, S. Jiang, T. Ying, Z. Yuan, Y. Xie, Y. Wen, L. Lu, Q. Wang, 2021
- Sodium Copper Chlorophyllin Is Highly Effective against Enterovirus (EV) A71 Infection by Blocking Its Entry into the Host Cell, Z. Liu, S. Xia, X. Wang, Q. Lan, P. Li, W. Xu, Q. Wang, L. Lu, S. Jiang, 2020
- Effect of Different Adjuvants on Immune Responses Elicited by Protein-Based Subunit Vaccines against SARS-CoV-2 and Its Delta Variant, N. Zhang, Q. Ji, Z. Liu, K. Tang, Y. Xie, K. Li, J. Zhou, S. Li, H. Shang, Z. Shi, T. Zheng, J. Yao, L. Lu, S. Yuan, S. Jiang, 2022
- Inefficiency of Sera from Mice Treated with Pseudotyped SARS-CoV to Neutralize 2019-nCoV Infection, Z. Liu, S. Xia, X. Wang, Q. Lan, W. Xu, Q. Wang, S. Jiang, L. Lu, 2020
- Chemiluminescence Immunoassay for the Detection of Antibodies against the 2C and 3ABC Nonstructural Proteins Induced by Infecting Pigs with Foot-and-Mouth Disease Virus, Z. Liu, J. Shao, F. Zhao, G. Zhou, S. Gao, W. Liu, J. Lv, X. Li, Y. Li, H. Chang, Y. Zhang, 2017
Awards
- 2023: National Youth Talent Program
- 2023: Shanghai Youth Science and Technology Star
