Professor | Bin Ji | Asia Growth Partners

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Name	Bin Ji
Contact Information	binji@fudan.edu.cn
Language ability	Chinese, Japanese, English
Province	Shanghai

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Name

Bin Ji

Contact Information

binji@fudan.edu.cn

Language ability

Chinese, Japanese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1989.09 – 1993.07 Bachelor: Shanghai Medical University, School of Pharmacy 1998.04 – 2000.03 Master: Chiba University, School of Pharmacy, Clinical Pharmacy 2000.04 – 2003.03 Doctorate: Chiba University, School of Pharmacy, Clinical Pharmacy
Work Experience	2003.04 – 2005.03 Japan Atomic Energy Agency, Brain Function Imaging Research Division, Postdoctoral Researcher 2005.04 – 2021.03 Japan Atomic Energy Agency, Brain Function Imaging Research Division, Chief Researcher 2021.04 – Present Fudan University, School of Pharmacy, Researcher

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1989.09 – 1993.07 Bachelor: Shanghai Medical University, School of Pharmacy
1998.04 – 2000.03 Master: Chiba University, School of Pharmacy, Clinical Pharmacy
2000.04 – 2003.03 Doctorate: Chiba University, School of Pharmacy, Clinical Pharmacy

Work Experience

2003.04 – 2005.03 Japan Atomic Energy Agency, Brain Function Imaging Research Division, Postdoctoral Researcher
2005.04 – 2021.03 Japan Atomic Energy Agency, Brain Function Imaging Research Division, Chief Researcher
2021.04 – Present Fudan University, School of Pharmacy, Researcher

Areas of Focus	Development of PET/SPECT/MRI molecular probes for central nervous system diseases (Alzheimer's disease, Parkinson's disease, epilepsy), kidney diseases (diabetic nephropathy), and tumors (breast cancer) Investigation of the mechanisms of the development of the aforementioned diseases using PET/SPECT/MRI molecular probes
Publications	PET imaging of colony-stimulating factor 1 receptor: a head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey, Zhou, X. Y., Ji, B.(Co-first author), Seki, C., Nagai, Y., Minamimoto, T., Fujinaga, M., Zhang, M. R., Saito, T., Saido, T. C., Suhara, T., Kimura, Y., and Higuchi, M., 2023 Distinct microglial response against Alzheimer’s pathologies characterized by P2Y12 receptor, Maeda, J., Minamihisamatsu, T., Shimojo, M., Ono, M., Minatohara, K., Takuwa, H., Takado, Y., Ji, B., Zhang, M. R., Suhara, T., Sahara, N., and Higuchi, M., 2023 Detection of Alzheimer’s Disease-related Neuroinflammation by a PET Ligand Selective for Glial Versus Vascular Translocator Protein, Ji, B.*, Ono, M., Yamasaki, T., Fujinaga, M., Zhang, M. R., Seki, C., Aoki, I., Kito, S., Sawada, M., Suhara, T., Sahara, N., and Higuchi, M., 2023 In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell-derived neural stem/progenitor cells transplantation, Tanimoto, Y., Yamasaki, T., Nagoshi, N., Nishiyama, Y., Nori, S., Nishimura, S., Iida, T., Ozaki, M., Tsuji, O., Ji, B., Aoki, I., Jinzaki, M., Matsumoto, M., Fujibayashi, Y., Zhang, M. R., Nakamura, M., and Okano, H., 2020 Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice, Takeuchi, H., Imamura, K., Ji, B., Tsukita, K., Enami, T., Takao, K., Miyakawa, T., Hasegawa, M., Sahara, N., Iwata, N., Inoue, M., Hara, H., Tabira, T., Ono, M., Trojanowski, J. Q., Lee, V. M., Takahashi, R., Suhara, T., Higuchi, M., and Inoue, H., 2020 Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys, Nagai, Y., Miyakawa, N., Takuwa, H., Hori, Y., Oyama, K., Ji, B., Takahashi, M., Huang, X. P., Slocum, S. T., DiBerto, J. F., Xiong, Y., Urushihata, T., Hirabayashi, T., Fujimoto, A., Mimura, K., English, J. G., Liu, J., Inoue, K. I., Kumata, K., Seki, C., Ono, M., Shimojo, M., Zhang, M. R., Tomita, Y., Nakahara, J., Suhara, T., Takada, M., Higuchi, M., Jin, J., Roth, B. L., and Minamimoto, T., 2020 In vivo positron emission tomography imaging of mitochondrial abnormalities in a mouse model of tauopathy, Barron, A. M., Ji, B., Fujinaga, M., Zhang, M. R., Suhara, T., Sahara, N., Aoki, I., Tsukada, H., and Higuchi, M., 2020 Regulation of Anxiety and Depression by Mitochondrial Translocator Protein-Mediated Steroidogenesis: the Role of Neurons, Barron, A. M., Higuchi, M., Hattori, S., Kito, S., Suhara, T., and Ji, B., 2020 Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia, Lu, Y., Guo, Z., Zhang, Y., Li, C., Zhang, Y., Guo, Q., Chen, Q., Chen, X., He, X., Liu, L., Ruan, C., Sun, T., Ji, B., Lu, W., and Jiang, C., 2019 Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models, Ni, R., Ji, B., Ono, M., Sahara, N., Zhang, M. R., Aoki, I., Nordberg, A., Suhara, T., and Higuchi, M., 2018 In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510, Ishikawa, A., Tokunaga, M., Maeda, J., Minamihisamatsu, T., Shimojo, M., Takuwa, H., Ono, M., Ni, R., Hirano, S., Kuwabara, S., Ji, B., Zhang, M. R., Aoki, I., Suhara, T., Higuchi, M., and Sahara, N., 2018 Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male, Barron, A. M., Ji, B., Kito, S., Suhara, T., and Higuchi, M., 2018 Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies, Ono, M., Sahara, N., Kumata, K., Ji, B., Ni, R., Koga, S., Dickson, D. W., Trojanowski, J. Q., Lee, V. M., Yoshida, M., Hozumi, I., Yoshiyama, Y., van Swieten, J. C., Nordberg, A., Suhara, T., Zhang, M. R., and Higuchi, M., 2017 PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation, Nagai, Y., Kikuchi, E., Lerchner, W., Inoue, K. I., Ji, B., Eldridge, M. A., Kaneko, H., Kimura, Y., Oh-Nishi, A., Hori, Y., Kato, Y., Hirabayashi, T., Fujimoto, A., Kumata, K., Zhang, M. R., Aoki, I., Suhara, T., Higuchi, M., Takada, M., Richmond, B. J., and Minamimoto, T., 2016 Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice, Liu, Y., An, S., Li, J., Kuang, Y., He, X., Guo, Y., Ma, H., Zhang, Y., Ji, B., and Jiang, C., 2016 Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors, Ji, B., Kaneko, H., Minamimoto, T., Inoue, H., Takeuchi, H., Kumata, K., Zhang, M. R., Aoki, I., Seki, C., Ono, M., Tokunaga, M., Tsukamoto, S., Tanabe, K., Shin, R. M., Minamihisamatsu, T., Kito, S., Richmond, B. J., Suhara, T., and Higuchi, M., 2016 In vivo imaging of neuroinflammation in Alzheimer’s disease, Higuchi, M., B., J., Maeda, J., Sahara, N., and Suhara, T., 2016 Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value, Eldridge, M. A., Lerchner, W., Saunders, R. C., Kaneko, H., Krausz, K. W., Gonzalez, F. J., Ji, B., Higuchi, M., Minamimoto, T., and Richmond, B. J., 2016 Assessment of neuroinflammation in a mouse model of obesity and beta-amyloidosis using PET, Barron, A. M., Tokunaga, M., Zhang, M. R., Ji, B., Suhara, T., and Higuchi, M., 2016 [18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain, Tiwari, A. K., Ji, B.(co-first author), Yui, J., Fujinaga, M., Yamasaki, T., Xie, L., Luo, R., Shimoda, Y., Kumata, K., Zhang, Y., Hatori, A., Maeda, J., Higuchi, M., Wang, F., and Zhang, M. R., 2015 Distinct binding of amyloid imaging ligands to unique amyloid-beta deposited in the presubiculum of Alzheimer's disease, Ji, B., Chen, C. J., Bando, K., Ashino, H., Shiraishi, H., Sano, H., Kasahara, H., Minamizawa, T., Yamada, K., Ono, M., Zhang, M. R., Seki, C., Farde, L., Suhara, T., and Higuchi, M., 2015 In vivo SPECT imaging of amyloid-beta deposition with radioiodinated imidazo[1,2-a]pyridine derivative DRM106 in a mouse model of Alzheimer's disease, Chen, C. J., Bando, K., Ashino, H., Taguchi, K., Shiraishi, H., Shima, K., Fujimoto, O., Kitamura, C., Matsushima, S., Uchida, K., Nakahara, Y., Kasahara, H., Minamizawa, T., Jiang, C., Zhang, M. R., Ono, M., Tokunaga, M., Suhara, T., Higuchi, M., Yamada, K., and Ji, B., 2015

Areas of Focus

Development of PET/SPECT/MRI molecular probes for central nervous system diseases (Alzheimer's disease, Parkinson's disease, epilepsy), kidney diseases (diabetic nephropathy), and tumors (breast cancer)
Investigation of the mechanisms of the development of the aforementioned diseases using PET/SPECT/MRI molecular probes

Publications

PET imaging of colony-stimulating factor 1 receptor: a head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey, Zhou, X. Y., Ji, B.(Co-first author), Seki, C., Nagai, Y., Minamimoto, T., Fujinaga, M., Zhang, M. R., Saito, T., Saido, T. C., Suhara, T., Kimura, Y., and Higuchi, M., 2023
Distinct microglial response against Alzheimer’s pathologies characterized by P2Y12 receptor, Maeda, J., Minamihisamatsu, T., Shimojo, M., Ono, M., Minatohara, K., Takuwa, H., Takado, Y., Ji, B., Zhang, M. R., Suhara, T., Sahara, N., and Higuchi, M., 2023
Detection of Alzheimer’s Disease-related Neuroinflammation by a PET Ligand Selective for Glial Versus Vascular Translocator Protein, Ji, B.*, Ono, M., Yamasaki, T., Fujinaga, M., Zhang, M. R., Seki, C., Aoki, I., Kito, S., Sawada, M., Suhara, T., Sahara, N., and Higuchi, M., 2023
In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell-derived neural stem/progenitor cells transplantation, Tanimoto, Y., Yamasaki, T., Nagoshi, N., Nishiyama, Y., Nori, S., Nishimura, S., Iida, T., Ozaki, M., Tsuji, O., Ji, B., Aoki, I., Jinzaki, M., Matsumoto, M., Fujibayashi, Y., Zhang, M. R., Nakamura, M., and Okano, H., 2020
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice, Takeuchi, H., Imamura, K., Ji, B., Tsukita, K., Enami, T., Takao, K., Miyakawa, T., Hasegawa, M., Sahara, N., Iwata, N., Inoue, M., Hara, H., Tabira, T., Ono, M., Trojanowski, J. Q., Lee, V. M., Takahashi, R., Suhara, T., Higuchi, M., and Inoue, H., 2020
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys, Nagai, Y., Miyakawa, N., Takuwa, H., Hori, Y., Oyama, K., Ji, B., Takahashi, M., Huang, X. P., Slocum, S. T., DiBerto, J. F., Xiong, Y., Urushihata, T., Hirabayashi, T., Fujimoto, A., Mimura, K., English, J. G., Liu, J., Inoue, K. I., Kumata, K., Seki, C., Ono, M., Shimojo, M., Zhang, M. R., Tomita, Y., Nakahara, J., Suhara, T., Takada, M., Higuchi, M., Jin, J., Roth, B. L., and Minamimoto, T., 2020
In vivo positron emission tomography imaging of mitochondrial abnormalities in a mouse model of tauopathy, Barron, A. M., Ji, B., Fujinaga, M., Zhang, M. R., Suhara, T., Sahara, N., Aoki, I., Tsukada, H., and Higuchi, M., 2020
Regulation of Anxiety and Depression by Mitochondrial Translocator Protein-Mediated Steroidogenesis: the Role of Neurons, Barron, A. M., Higuchi, M., Hattori, S., Kito, S., Suhara, T., and Ji, B., 2020
Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia, Lu, Y., Guo, Z., Zhang, Y., Li, C., Zhang, Y., Guo, Q., Chen, Q., Chen, X., He, X., Liu, L., Ruan, C., Sun, T., Ji, B., Lu, W., and Jiang, C., 2019
Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models, Ni, R., Ji, B., Ono, M., Sahara, N., Zhang, M. R., Aoki, I., Nordberg, A., Suhara, T., and Higuchi, M., 2018
In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510, Ishikawa, A., Tokunaga, M., Maeda, J., Minamihisamatsu, T., Shimojo, M., Takuwa, H., Ono, M., Ni, R., Hirano, S., Kuwabara, S., Ji, B., Zhang, M. R., Aoki, I., Suhara, T., Higuchi, M., and Sahara, N., 2018
Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male, Barron, A. M., Ji, B., Kito, S., Suhara, T., and Higuchi, M., 2018
Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies, Ono, M., Sahara, N., Kumata, K., Ji, B., Ni, R., Koga, S., Dickson, D. W., Trojanowski, J. Q., Lee, V. M., Yoshida, M., Hozumi, I., Yoshiyama, Y., van Swieten, J. C., Nordberg, A., Suhara, T., Zhang, M. R., and Higuchi, M., 2017
PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation, Nagai, Y., Kikuchi, E., Lerchner, W., Inoue, K. I., Ji, B., Eldridge, M. A., Kaneko, H., Kimura, Y., Oh-Nishi, A., Hori, Y., Kato, Y., Hirabayashi, T., Fujimoto, A., Kumata, K., Zhang, M. R., Aoki, I., Suhara, T., Higuchi, M., Takada, M., Richmond, B. J., and Minamimoto, T., 2016
Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice, Liu, Y., An, S., Li, J., Kuang, Y., He, X., Guo, Y., Ma, H., Zhang, Y., Ji, B., and Jiang, C., 2016
Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors, Ji, B., Kaneko, H., Minamimoto, T., Inoue, H., Takeuchi, H., Kumata, K., Zhang, M. R., Aoki, I., Seki, C., Ono, M., Tokunaga, M., Tsukamoto, S., Tanabe, K., Shin, R. M., Minamihisamatsu, T., Kito, S., Richmond, B. J., Suhara, T., and Higuchi, M., 2016
In vivo imaging of neuroinflammation in Alzheimer’s disease, Higuchi, M., B., J., Maeda, J., Sahara, N., and Suhara, T., 2016
Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value, Eldridge, M. A., Lerchner, W., Saunders, R. C., Kaneko, H., Krausz, K. W., Gonzalez, F. J., Ji, B., Higuchi, M., Minamimoto, T., and Richmond, B. J., 2016
Assessment of neuroinflammation in a mouse model of obesity and beta-amyloidosis using PET, Barron, A. M., Tokunaga, M., Zhang, M. R., Ji, B., Suhara, T., and Higuchi, M., 2016
[18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain, Tiwari, A. K., Ji, B.(co-first author), Yui, J., Fujinaga, M., Yamasaki, T., Xie, L., Luo, R., Shimoda, Y., Kumata, K., Zhang, Y., Hatori, A., Maeda, J., Higuchi, M., Wang, F., and Zhang, M. R., 2015
Distinct binding of amyloid imaging ligands to unique amyloid-beta deposited in the presubiculum of Alzheimer's disease, Ji, B., Chen, C. J., Bando, K., Ashino, H., Shiraishi, H., Sano, H., Kasahara, H., Minamizawa, T., Yamada, K., Ono, M., Zhang, M. R., Seki, C., Farde, L., Suhara, T., and Higuchi, M., 2015
In vivo SPECT imaging of amyloid-beta deposition with radioiodinated imidazo[1,2-a]pyridine derivative DRM106 in a mouse model of Alzheimer's disease, Chen, C. J., Bando, K., Ashino, H., Taguchi, K., Shiraishi, H., Shima, K., Fujimoto, O., Kitamura, C., Matsushima, S., Uchida, K., Nakahara, Y., Kasahara, H., Minamizawa, T., Jiang, C., Zhang, M. R., Ono, M., Tokunaga, M., Suhara, T., Higuchi, M., Yamada, K., and Ji, B., 2015

Central Nervous System Alzheimer'S Disease Parkinson'S Disease Epilepsy Kidney Diseases Diabetic Nephropathy Tumors Breast Cancer Pet Spect

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