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Xiao Zhu
Pharmaceutical Sciences
Fudan University
Shanghai
Language: English, Chinese
Pharmacokinetics
Pharmacodynamics
Population
Quantitative
Systems
Receptor
Theory
Modeling
Analysis
Integration
Areas of Focus
- Population Pharmacokinetics and Pharmacodynamics
- Quantitative Systems Pharmacology
- Receptor Theory
Work Experience
- 2021/07 – Present - Fudan University - Young Researcher
- 2020/03 – 2021/06 - Murdoch Children's Research Institute - Honorary Fellow
- 2019/11 – 2020/12 - Otago Quantitative Pharmacology Group - Postdoctoral Fellow
- 2019/06 – 2019/10 - Otago Quantitative Pharmacology Group - Assistant Research Fellow
- 2015/10 – 2016/02 - GlaxoSmithKline China Shanghai R&D Center - Intern
Academic Background & Achievements
- 2016/03 – 2019/05 PhD in Quantitative Pharmacology: University of Otago
- 2012/08 – 2015/09 Master in Pharmacy: Chinese University of Hong Kong
- 2015/02 – 2015/07 Exchange Student: Peking University/Pfizer Quantitative Pharmacology Teaching Center
- 2008/09 – 2012/07 Bachelor in Pharmacy: Fudan University
- Selected for Shanghai 'Overseas High-Level Talent Introduction Program'
- Selected for 'University Young Talent Recruitment Program'
Publications
- A kinetic model for positive allosteric modulator (PAM)-antagonists for the type 1 cannabinoid receptor (CB1), Liang Yang; Xiao Zhu*; David B Finlay; Hayley Green; Michelle Glass; Stephen B Duffull, 2023
- Intra-operative Definition of Glioma Infiltrative Margins by Visualizing Immunosuppressive Tumor-Associated Macrophages, Chong Cao; Hang Yin; Biao Yang; Qi Yue; Guoqing Wu; Meng Gu; Yuwen Zhang; Yang Fan; Xiaoyan Dong; Ting Wang; Cong Wang; Xiao Zhu*; Ying Mao*; Xiao-Yong Zhang*; Zuhai Lei*; Cong Li*, 2023
- Escitalopram population pharmacokinetics and remedial strategies based on CYP2C19 phenotype, Xin Liu; Gehang Ju; Xinyi Huang; Wenyu Yang; Lulu Chen; Chao Li; Qingfeng He; Nuo Xu; Xiao Zhu*; Dongsheng Ouyang*, 2023
- Population pharmacokinetics and toxicity correlation analysis of free and liposome-encapsulated doxorubicin in Chinese patients with advanced breast cancer, Gaoqi Xu#; Dihong Yang#; Chaoneng He; Like Zhong; Junfeng Zhu; Qi Shu; Haiying Ding; Wenxiu Xin; Yinghui Tong; Xiao Zhu*; Luo Fang*, 2023
- Establishment and Evaluation of a Parametric Population Pharmacokinetic Model Repository for Ganciclovir and Valganciclovir, Wenyu Yang#; Wenyao Mak#; Amanda Gwee; Meng Gu; Yue Wu; Yufei Shi; Qingfeng He; Xiaoqiang Xiang; Bing Han*; Xiao Zhu*, 2023
- Population pharmacokinetics of buprenorphine and naloxone sublingual combination in Chinese healthy volunteers and patients with opioid use disorder: Model-based dose optimization, Meng Gu#; An-Ning Li#; Wen-Yao Mak; Fang Dong; Nuo Xu; Jing-Ye Zhang; Yu-Fei Shi; Nan Zheng; Zhi-Jia Tang; Qing-Feng He; Can-Jun Ruan; Wei Guo; Xiao-Qiang Xiang; Chuan-Yue Wang*; Bing Han*; Xiao Zhu*, 2023
- Population pharmacokinetics of Amisulpride in Chinese patients with schizophrenia with external validation: the impact of renal function, Anning Li #; Wen Yao Mak; Tingyi Ruan; Fang Dong; Nan Zheng; Meng Gu; Wei Guo; Jingye Zhang; Haoxuan Cheng; Canjun Ruan; Yufei Shi; Yannan Zang; Xuequan Zhu; Qingfeng He; Xiaoqiang Xiang; Gang Wang*; Xiao Zhu*, 2023
- Escitalopram Personalized Dosing: A Population Pharmacokinetics Repository Method, Xin Liu; Gehang Ju; Wenyu Yang; Lulu Chen; Nuo Xu; Qingfeng He; Xiao Zhu*; Dongsheng Ouyang*, 2023
- Identifying a therapeutic target for vancomycin against staphylococci in young infants, Amanda Gwee; Stephen B. Duffull; Andrew J. Daley; Michelle Lim; Susie Germano; Hajira Bilal; Samantha Hall; Nigel Curtis; Xiao Zhu*, 2022
- Impact of Hospital Characteristics and Governance Structure on the Adoption of Tracking Technologies for Clinical and Supply Chain Use: Longitudinal Study of US Hospitals, Xiao Zhu#; Youyou Tao#; Ruilin Zhu*; Dezhi Wu; Wai-Kit Ming, 2022
- Model-Informed Drug Development of New Cefoperazone Sodium and Sulbactam Sodium Combination (3:1): Pharmacokinetic/Pharmacodynamic Analysis and Antibacterial Efficacy Against Enterobacteriaceae, Xi-Wei Ji#; Yun Li; Feng Xue; Isabelle Hui San Kuan; Qing-Feng He; Xiang-Rui Meng; Xiao-Qiang Xiang; Yi-Min Cui; Bo Zheng*; Xiao Zhu*, 2022
- Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling, Xiao Zhu*; David B. Finlay; Michelle Glass; Stephen B. Duffull, 2020
- Model-free and kinetic modelling approaches for characterising non-equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors, Xiao Zhu*; David B. Finlay; Michelle Glass; Stephen B. Duffull, 2019
- An evaluation of the operational model when applied to quantify functional selectivity, Xiao Zhu*; David B. Finlay; Michelle Glass; Stephen B. Duffull, 2018
- Model-informed drug development of benapenem: Pharmacokinetic/Pharmacodynamic cutoff value determination and antibacterial efficacy against enterobacteriaceae, Xi-Wei Ji; Feng Xue; Zi-Sheng Kang; Wei Zhong; Isabelle Hui-San Kuan; Xi-Ping Yang; Xiao Zhu*; Yun Li; Yuan Lv, 2020
- Mechanistic Pharmacokinetic/Pharmacodynamic Model of Sunitinib and Dopamine in MCF-7/Adr Xenografts: Linking Cellular Heterogeneity to Tumour Burden, Siyuan Wang#; Xiao Zhu#; Mengyi Han; Fangran Hao; Wei Lu; Tianyan Zhou*, 2020
- Understanding the association between metformin plasma concentrations and lactate, Isabelle H. S. Kuan; Daniel F. B. Wright; Stephen B. Duffull; Xiao Zhu*, 2020
- Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID‐19, Ricardo Peña-Silva; Stephen B. Duffull; Andrew C. Steer; Sandra X. Jaramillo-Rincon; Amanda Gwee; Xiao Zhu*, 2020
- An intact model for quantifying functional selectivity, Xiao Zhu*; David B. Finlay; Michelle Glass; Stephen B. Duffull, 2019
- An Agent-Based Approach to Dynamically Represent the Pharmacokinetic Properties of Baicalein, Xiao Zhu; Jianyuan Deng; Zhong Zuo; Tai Ning Lam*, 2016
- Foretinib Is Effective against Triple-Negative Breast Cancer Cells MDA-MB-231 In Vitro and In Vivo by Down-Regulating p-MET/HGF Signaling, Xi-Wei Ji; Xiang-Rui Meng; Qing-Feng He; Xiao-Qiang Xiang; Yufei Shi*; Xiao Zhu*, 2023
- Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview, Qiu-Yu Jia#; Qing-Feng He#; Li Yao; Min Li; Jia-Ying Lin; Zhi-Jia Tang; Xiao Zhu*; Xiao-Qiang Xiang*, 2022
- Individualized vancomycin dosing in infants: prospective evaluation of an online dose calculator, Amanda L Wilkins; Tony Lai; Xiao Zhu; Srinivas Bolisetty; Roberto Chiletti; Noel Cranswick; Kaya Gardiner; Rodney Hunt; Atul Malhotra; Brendan McMullan; Bhavesh Mehta; Joanna Michalowski; Himanshu Popat; Meredith Ward; Stephen Duffull; Nigel Curtis; Amanda Gwee*, 2023
- Prediction of Drug-Drug Interactions with Ensartinib as a Time-Dependent CYP3A Inhibitor Using Physiologically Based Pharmacokinetic Model, Xiaowen Wang; Yiqun Yu; Hongrui Liu; Fengjiao Bu; Chunying Shen; Qingfeng He; Xiao Zhu; Pin Jiang; Bing Han*; Xiaoqiang Xiang*, 2023
- Evaluating the impact of co-administered drug and disease on ripretinib exposure: A physiologically-based pharmacokinetic modeling
Awards
- 2022: Member of Fudan University's 'Zhong Yang-style Teaching Team'
- 2022: Selected for Shanghai 'University Young Talent Recruitment Program'
- 2021: Selected for Shanghai 'Overseas High-Level Talent Introduction Program'
- 2020: National Excellent Self-Financed International Student Scholarship
- 2019: ASCEPT New Zealand Fred Fastier Prize
- 2019: ASCEPT and PAGANZ Student Travel Grants
- 2019: International Society of Pharmacometrics (ISoP) Student Prize for pharmacometrics, PAGANZ Meeting 2019, Auckland, New Zealand
- 2019: Best Research Paper of 2018, University of Otago School of Pharmacy
