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Zhengxing Lian
Animal Science and Technology
China Agricultural University
Beijing
Language: Chinese, English
Animal Genetics
Molecular Breeding
Cellular Engineering
Transgenic Animals
Crispr/Cas9
Gene Editing
Disease Resistance
Brucellosis
Tlr4 Gene
Embryonic Stem Cells
Areas of Focus
- Animal Molecular and Cellular Engineering Breeding
Work Experience
- 2003/07-present: Professor, Department of Animal Genetics and Breeding, China Agricultural University
- 1996/07-2003/07: Associate Professor, Department of Animal Genetics and Breeding, China Agricultural University
- 1989/07-1992/07: Lecturer, Department of Animal Genetics and Breeding, Northeast Agricultural University
- 2008/01-2008/12: Visiting Scholar, Institute of Animal Health, UK
- 2000/01-2000/04: Collaborative Researcher, French National Institute for Agricultural Research (INRA)
Academic Background & Achievements
- 1992/09-1996/06: PhD in Animal Genetics and Breeding, Northeast Agricultural University
- 1986/09-1989/06: Master's in Animal Husbandry, Northeast Agricultural College
- 1982/09-1986/06: Bachelor's in Animal Husbandry, Northeast Agricultural College
Publications
- Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning., Yu D, Wang J, Zou H, Feng T, Chen L, Li J, Qi X, Li Z, Duan X, Xu C, Zhang L, Long X, Lan J, Chen C, Wang C, Xu X, Ren J, Zhao Y, Hu X, Lian Z, Men H, Pan D, Li N, Capecchi MR, Du X, Zhao Y, Wu S., 2018
- Melatonin promotes sheep Leydig cell testosterone secretion in a co-culture with Sertoli cells., Shoulong Deng et al., 2018
- Effects of AANAT overexpression on the inflammatory responses and autophagy activity in the cellular and transgenic animal levels., Jingling Tao et al., 2018
- Overexpression of Toll-like Receptor 4-linked Mitogen-activated Protein Kinase Signaling Contributes to Internalization of Escherichia coli in Sheep., Sutian Wang et al., 2018
- Dwarf chickens with low monocytes/macrophages phagocytic activity show low antibody titers but greater performance., Yitong Yuan et al., 2018
- Interferon-γ acts as a regulator in the trade-off between phagocytosis and production performance in dwarf chickens., Yitong Yuan et al., 2018
- An Alternative Method for Long-Term Culture of Chicken Embryonic Stem Cell In Vitro., Li Zhang et al., 2018
- Erratum to: Over-expression of Toll-like receptor 2 up-regulates heme oxygenase-1 expression and decreases oxidative injury in dairy goats., Shoulong Deng et al., 2017
- In vitro production of functional haploid sperm cells from male germ cells of Saanen dairy goat., Shoulong Deng et al., 2017
- Over-expression of Toll-like receptor 2 up-regulates heme oxygenase-1 expression and decreases oxidative injury in dairy goats., Shoulong Deng et al., 2017
- RNAi combining Sleeping Beauty transposon system inhibits ex vivo expression of foot-and-mouth disease virus VP1 in transgenic sheep cells., Shoulong Deng et al., 2017
- An AANAT/ASMT transgenic animal model constructed with CRISPR/Cas9 system serving as the mammary gland bioreactor to produce melatonin-enriched milk in sheep., Teng Ma et al., 2017
- Beneficial Effects of Melatonin on the In Vitro Maturation of Sheep Oocytes and Its Relation to Melatonin Receptors., Xiuzhi Tian et al., 2017
- Melatonin Promotes the In Vitro Development of Microinjected Pronuclear Mouse Embryos via Its Anti-Oxidative and Anti-Apoptotic Effects., Xiuzhi Tian et al., 2017
- The evolutionary characteristics and structural biology of Gallus toll‐like receptor 21., Hongping Wu et al., 2017
- Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system., Mingming Wu et al., 2016
- Efficient production of pronuclear embryos in breeding and nonbreeding season for generating transgenic sheep overexpressing TLR4., Yan Li et al., 2016
- Expression of recombinant human lysozyme in transgenic chicken promotes the growth of Bifidobacterium in the intestine and improves postnatal growth of chicken., Hai Wang et al., 2016
- Small interfering RNA expression inhibits avian infectious bronchitis virus replication and inflammatory response., Kun Yu et al., 2016
- Effects of seasonal changes on the ovulation rate and embryo quality in superovulated Black Suffolk ewes., Shi JM, 2015
- Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat., Yuanhong Xie et al., 2015
- Endothelial Cells Regulate Cardiac Myocyte Reorganisation Through β1-Integrin Signalling., Zhang Y et al., 2015
- A 90-day toxicology study of meat from genetically modified sheep overexpressing TLR4 in Sprague-Dawley rats., Hai Bai et al., 2015
- Melatonin reduces oxidative damage and upregulates heat shock protein 90 expression in cryopreserved human semen., Shoulong Deng et al., 2015
- Toll-Like Receptor 4 Promotes NO Synthesis by Upregulating GCHI Expression under Oxidative Stress Conditions in Sheep Monocytes/Macrophages., Shoulong Deng et al., 2015
- Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep., Shoulong Deng et al., 2015
- Tongue Epithelium Cells from shRNA Mediated Transgenic Goat Show High Resistance to Foot and Mouth Disease Virus., Wenting Li et al., 2015
- Effects of melatonin on superovulation and transgenic embryo transplantation in small-tailed han sheep (Ovis aries)., Zhang L et al., 2013
- Transgenic cloned sheep overexpressing ovine toll-like receptor 4., Shoulong Deng et al., 2013
- Four recombinant pluripotency transcriptional factors containing a protein transduction domain maintained the in vitro pluripotency of chicken embryonic stem cells., Miaoying Yu et al., 2013
Awards
- 2006: Second Prize for Scientific and Technological Progress by the Ministry of Education, for the efficient expression of recombinant human lactoferrin and α-lactalbumin in cow bioreactors
- 2005: First Prize for Scientific and Technological Progress by Beijing, for the production and rescue of high-quality breeding cattle using somatic cell cloning technology
- 2003: Second Prize for National Technological Invention, for the discovery and application research of the FSHβ gene for high litter size in pigs
