Weining Niu
Life Science
Northwestern Polytechnical University
Shaanxi
Language: Chinese, English
Contact
Sulfur Metabolism H2S Cellular Energy Cancer Research Drug Screening Biocatalysis Pharmaceutical Intermediates Enzyme Production Medical Diagnostics Industrial Preparation
Areas of Focus
  • Cellular sulfur/H2S metabolism and its impact on cellular energy metabolism
  • Cellular sulfur/H2S metabolism and cancer mechanism research and drug screening
  • Biocatalytic synthesis of pharmaceutical intermediates; industrial preparation of enzymes for medical diagnostics
Work Experience
  • 2006.11–2009.02 - Postdoctoral Researcher, School of Life Sciences, Northwestern Polytechnical University
  • 2009.03–2019.06 - Lecturer, Associate Professor, School of Life Sciences, Northwestern Polytechnical University
  • 2012.08–2013.08 - Visiting Scholar, Department of Biochemistry, University of Michigan Medical School, USA
  • 2019.07-present - Professor, Northwestern Polytechnical University
Academic Background & Achievements
  • 1998 - Bachelor in Veterinary Medicine: Shanxi Agricultural University
  • 2003 - Master in Biochemistry and Molecular Biology: Northwest A&F University
  • 2006 - PhD in Biochemical Engineering: Beijing University of Chemical Technology
Publications
  • Hydrogen sulfide from cysteine desulfurase, not 3-mercaptopyruvate sulfurtransferase, contributes to sustaining cell growth and bioenergetics in E. coli under anaerobic conditions, Niu WN*, 2019
  • Allosteric control of human cystathionine β-synthase activity by a redox active disulfide bond, Niu WN*, 2018
  • Antitumor effect of sikokianin C, a selective cystathionine β-synthase inhibitor, against human colon cancer in vitro and in vivo, Niu WN*, 2018
  • Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe, Niu WN*, 2017
  • S-Glutathionylation Enhances Human Cystathionine-β- synthase Activity Under Oxidative Stress Conditions, Niu WN, Banerjee R*, 2015
Awards
  • 2015 Shaanxi Province Science and Technology Third Prize (First Completer)
  • 2014 Xi'an City Science and Technology Second Prize (First Completer)
  • Northwestern Polytechnical University 'Soaring Star'
  • Northwestern Polytechnical University 'Outstanding Young Teacher'
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