2004-2009 PhD: Jilin University, Department of Organic Chemistry
2000-2004 Bachelor's: Jilin University, Polymer Materials and Engineering
Chief Young Scientist of the 14th Five-Year National Key R&D Program
Guangdong Provincial Natural Science Foundation Outstanding Youth Fund Recipient
2019-present - South China Agricultural University - Professor
2017-2017 - National Natural Science Foundation Committee - Seconded to Planning Bureau
2014-2015 - University of California, San Francisco - Visiting Scholar
2013-2018 - South China Agricultural University - Associate Professor, Young Professor
2009-2013 - South China Agricultural University - Lecturer
2014 Guangdong Provincial Science and Technology Award First Prize: Development and Application of Veterinary Raw Drugs and Preparations
Research
Design, synthesis, and activity mechanism of antibacterial, anti-inflammatory, and bio-antioxidant molecules
Antibacterial activity and synergistic antibiotic mechanism of phenolic compounds against methicillin-resistant Staphylococcus aureus, Dingyi Shen, Songpo Duan, Yuhan Hu, Jintong Liang, Youzhi Tang, 2022
Design, synthesis, antibacterial activity evaluation and molecular docking study of pleuromutilin derivatives bearing amide side chains, Zhuo-Qi Zhang, Jie Liu, Guang-Yu Zhang, Bo Li, Kang Li, Zhen Jin, Xu Bai, You-Zhi Tang, 2022
In vitro and in vivo Antibacterial Activity, Toxicity and Resistance Analysis of Pleuromutilin Derivative Z33 against Methicillin-Resistant Staphylococcus aureus, Yuhan Hu, Fang Chen, Kexin Zhou, Zhe Zhang, Fei Li, Jianfeng Zhang, Youzhi Tang, Zhen Jin, 2022
Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups, Qi Wang, Jie Liu, Zi-Dan Zhou, Ke-Xin Zhou, Fei Li, Qi-Wen Zhang, Shou-Kai Wang, Wei Wang, Zhen Jin, You-Zhi Tang, 2022
Aesculetin exhibited anti-inflammatory activities through inhibiting NF-кB and MAPKs pathway in vitro and in vivo, Shou-Kai Wang, Ting-Xiao Chen, Wei Wang, Ling Ling Xu, Yu-Qing Zhang, Zhen Jin, You-Bin Liu, You-Zhi Tang, 2022
Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing 4-aminothiophenol linker as promising antibacterial agents, Fei Chai, Jun Wang, Ke-Xin Zhou, Shou-Kai Wang, Ya-Hong Liu, Zhen Jin, You-Zhi Tang, 2022
Semisynthetic Pleuromutilin Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus by targeting 50S Ribosomal Subunit, Xiao Wang, Rui Wang, Zhao-Sheng Zhang, Guang-Yu Zhang, Zhen Jin, Rong Shen, Dan Du, You-Zhi Tang, 2022
Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection, Han-Qing Fang, Jie Zeng, Shou-Kai Wang, Xiao Wang, Fang Chen, Bo Li, Jie Liu, Zhen Jin, Ya-Hong Liu, You-Zhi Tang, 2022
A click chemistry approach to pleuromutilin derivatives, evaluation of anti-MRSA activity and elucidation of binding mode by surface plasmon resonance and molecular docking, Zhe Zhang, Zhao-Sheng Zhang, Xiao Wang, Gao-Lei Xi, Zhen Jin, You-Zhi Tang, 2021
Design, synthesis and biological evaluation of pleuromutilin-Schiff base hybrids as potent anti-MRSA agents in vitro and in vivo, Bo Li, Zhe Zhang, Jian-Feng Zhang, Jie Liu, Xiang-Yi Zuo, Fang Chen, Guang-Yu Zhang, Han-Qing Fang, Zhen Jin, You-Zhi Tang, 2021
Antibacterial activity of a promising antibacterial agent: 22-(4-(2-(4-Nitrophenyl-piperazin-1-yl)-acetyl)-piperazin-1-yl)-22-deoxypleuromutilin, Xiang-Yi Zuo, Hong Gao, Mei-Ling Gao, Zhen Jin, You-Zhi Tang, 2021
Design, synthesis, in vitro and in vivo evaluation against MRSA and molecular docking studies of novel pleuromutilin derivatives bearing 1, 3, 4-oxadiazole linker, Jie Liu, Guang-Yu Zhang, Zhe Zhang, Bo Li, Fei Chai, Qi Wang, Zi-Dan Zhou, Ling-Ling Xu, Shou-Kai Wang, Zhen Jin, You-Zhi Tang, 2021
Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome, Si-Yu Huang, Xiao Wang, Ding-Yi Shen, Fang Chen, Guang-Yu Zhang, Zhe Zhang, Kang Li, Zhen Jin, Dan Du, You-Zhi Tang, 2021
Rapid detection of the New Delhi metallo-β-lactamase (NDM) gene by recombinase polymerase amplification, Xiao Wang, Ling-Ling Xu, Xiang-Yi Zuo, Jia-Wen Lin, Zhen Jin, Rong Shen, Dan Du, You-Zhi Tang, 2021
Design, synthesis and biological evaluation of novel pleuromutilin derivatives containing piperazine and 1,2,3-triazole linker, Guang-Yu Zhang, Zhe Zhang, Kang Li, Jie Liu, Bo Li, Zhen Jin, Ya-Hong Liu, You-Zhi Tang, 2020
Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness, Aparna Sundaram, Chun Chen, Nilgun Isik Reed, Sean Liu, Seul Ki Yeon, Joel McIntosh, You-Zhi Tang, Hyunjun Yang, Marc Adler, Richard Beresis, Ian B. Seiple, Dean Sheppard, William F. DeGrado, Hyunil Jo, 2020
Synergistic effect of a pleuromutilin derivative with tetracycline against Streptococcus suis in vitro and in the neutropenic thigh infection model, Fang Chen, Meng-Chao Wei, Yi-Dan Luo, Zhen Jin, You-Zhi Tang, 2020
Design, synthesis and biological activities of novel pleuromutilin derivatives with a substituted triazole moiety as potent antibacterial agents, Zhe Zhang, Kang Li, Guang-Yu Zhang, You-Zhi Tang, Zhen Jin, 2020
Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties, Wei Wang, Ru-Feng Yue, Zhen Jin, Li-Min He, Rong Shen, Dan Du, You-Zhi Tang, 2020
Antibacterial Activity and Pharmacokinetic Profile of a Promising Antibacterial Agent: 22-(2-Amino-phenylsulfanyl)-22-Deoxypleuromutilin, Xiangyi Zuo, Xi Fang, Zhaosheng Zhang, Zhen Jin, Gaolei Xi, Yahong Liu, Youzhi Tang, 2020
Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing acetamine phenyl linker, Zhen Jin, Le Wang, Hong Gao, Ying-Hui Zhou, Ya-Hong Liu, You-Zhi Tang, 2019
Synthesis and antibacterial activities of novel pleuromutilin derivatives bearing an aminothiophenol moiety, Zhao-Sheng Zhang, Yun-Zhen Huang, Jian Luo, Zhen Jin, Ya-Hong Liu, You-Zhi Tang, 2018
Synthesis and antibacterial activity against MRSA of pleuromutilin derivatives possessing a mercaptoethylamine linker, Zhao-Sheng Zhang, Yun-Zhen Huang, Jian Luo, Bing-Feng Wang, Zhen Jin, Ya-Hong Liu, You-Zhi Tang, 2018
De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles, Shao-Qing Zhang, Marco Chino, Lijun Liu, Youzhi Tang, Xiaozhen Hu, William F. DeGrado, Angela Lombardi, 2018
Inhibition of pro-inflammatory mediators in RAW264.7 cells by 7-Hydroxyflavone and 7,8-Dihydroxyflavone, Zhen Jin, Yao-Zhi Yang, Jian-Xin Chen, You-Zhi Tang, 2017
Design, synthesis and antibacterial evaluation of novel pleuromutilin derivatives possessing piperazine linker, Mei-Ling Gao, Jie Zeng, Xi Fang, Jian Luo, Zhen Jin, Ya-Hong Liu, You-Zhi Tang, 2017
