Lifang Hu
hulifang@nwpu.edu.cn
Chinese, English
Shaanxi
Northwestern Polytechnical University
Life Science
  • 2009/4-2013/12: PhD in Human-Machine and Environmental Engineering, Northwestern Polytechnical University
  • 2006/9-2009/3: Master of Engineering in Biomedical Engineering, Northwestern Polytechnical University
  • 2002/9-2006/6: Bachelor of Science in Biology, Shaanxi Normal University
  • Guided 5 undergraduate students to complete their thesis, 1 received the Excellent Undergraduate Thesis Award at Northwestern Polytechnical University
  • 2013/12-2015/12: Postdoctoral Researcher, School of Life Sciences, Northwestern Polytechnical University
  • 2016/01-2019/12: Assistant Professor, School of Life Sciences, Northwestern Polytechnical University
  • 2019/12-present: Associate Professor, School of Life Sciences, Northwestern Polytechnical University
  • 2018: Outstanding Young Teacher Award, Northwestern Polytechnical University
  • 2018: Young Excellent Paper Award, Shaanxi Society of Cell Biology
  • 2016: Young Paper Encouragement Award, Shaanxi Society of Cell Biology
  • 2014: Third Prize in Young Excellent Paper, Shaanxi Society of Cell Biology
  • 2014: Outstanding Paper Award for Young Scientists, Committee on Space Research (COSPAR)
Bone Metabolic Diseases
Cellular Senescence
Biomechanics
  • Ellagic acid inhibits CDK12 to increase osteoblast differentiation and alleviate osteoporosis in hindlimb-unloaded and ovariectomized mice, Lifang Hu, Zixiang Wu, Kang Ru, Wenjuan Zhang, Xia Xu, Shuyu Liu, Hua Liu, Yunxia Jia, Shujing Liang, Zhihao Chen, Airong Qian, 2023
  • MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm, Lifang Hu, Chong Yin, Dong Chen, Zixiang Wu, Shujing Liang, Yu Zhang, Zizhan Huang, Shuyu Liu, Xia Xu, Zhihao Chen, Yi Zhang, Airong Qian, 2021
  • Piezo channels: awesome mechanosensitive structures in cellular mechanotransduction and their role in bone, Lifang Hu, Xia Xu, Shuyu Liu, Hua Liu, Kang Ru, Yunxian Jia, Zixiang Wu, Shujing Liang, Zarnaz Khan, Zhihao Chen, Airong Qian, 2021
  • miR-138-5p negatively regulates osteoblast differentiation through inhibiting β-catenin under simulated microgravity in MC3T3-E1 cells, Lifang Hu, Zhihao Chen, Yan Zhang, Fan Zhao, Chong Yin, Chaofei Yang, Ying Huai, Shujing Liang, Shuyu Liu, Xia Xu, Zixiang Wu, Ye Tian, Yu Li, 2021
  • Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli, Lifang Hu, Zhihao Chen, Fan Zhao, Chao Liang, Dijie Li, Yan Zhang, Chong Yin, Lei Chen, Luyao Wang, Xiao Lin, Peihong Su, Jianhua Ma, Chaofei Yang, Ye Tian, Wenjuan Zhang, Yu Li, Songlin Peng, Weiyi Chen, Ge Zhang, Airong Qian, 2020
  • The Application of MSCs-Derived Extracellular Vesicles in Bone Disorders: Novel Cell-Free Therapeutic Strategy, Lifang Hu, Shuyu Liu, Xia Xu, Shujing Liang, Zhihao Chen, Yan Zhang, Airong Qian, 2020
  • CDK12: A Potent Target and Biomarker for Human Cancer Therapy, Lifang Hu, Shujing Liang, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian, 2020
  • Recombinant irisin prevents the reduction of osteoblast differentiation induced by simulated microgravity through increasing β-catenin expression, Lifang Hu, Zhihao Chen, Yan Zhang, Fan Zhao, Chong Yin, Chaofei Yang, Xue Wang, Zixiang Wu, Shujing Liang, Dijie Li, Xiao Lin, Ye Tian, Yu Li, Airong Qian, 2020
  • Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells, Lifang Hu, Abdul Qadir, Shujing Liang, Zixiang Wu, Zhihao Chen, Airong Qian, 2020
  • MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells, Lifang Hu, Zixiang Wu, Shujing Liang, Wenyu Kuai, Airong Qian, 2019
  • Mammalian plakins, giant cytolinkers: versatile biological functions and roles in cancer, Lifang Hu, Zizhan Huang, Zixiang Wu, Arshad Ali, Airong Qian, 2018
  • Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment, Lifang Hu, Chong Yin, Fan Zhao, Arshad Ali, Jianhua Ma, Airong Qian, 2018
  • Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis, Lifang Hu, Peihong Su, Chong Yin, Runzhi Li, Kun Yan, Zhihao Chen, Dijie Li, Ge Zhang, Liping Wang, Zhiping Miao, Airong Qian, Cory J. Xian, 2018
  • MACF1, versatility in tissue-specific function and in human disease, Lifang Hu, Yunyun Xiao, Zhipeng Xiong, Fan Zhao, Chong Yin, Yan Zhang, Peihong Su, Dijie Li, Zhihao Chen, Xiaoli Ma, Ge Zhang, Airong Qian, 2017
  • Isoforms, structures, and functions of versatile spectraplakin MACF1, Lifang Hu, Peihong Su, Runzhi Li, Chong Yin, Yan Zhang, Peng Shang, Tuanmin Yang, Airong Qian, 2016
  • Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells, Lifang Hu, Peihong Su, Runzhi Li, Kun Yan, Zhihao Chen, Peng Shang, Airong Qian, 2015
  • Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition, Lifang Hu, Jingbao Li, Airong Qian, Fei Wang, Peng Shang, 2015
  • Response and adaptation of bone cells to simulated microgravity, Lifang Hu, Runzhi Li, Peihong Su, Yasir Arfat, Ge Zhang, Peng Shang, Airong Qian, 2014
  • Inhibitory effect of simulated microgravity on differentiating preosteoblasts, Lifang Hu, Airong Qian, Yang Wang, Shengmeng Di, Peng Shang, 2013
  • Spectraplakins, versatile roles in physiology and pathology, Airong Qian, Lifang Hu, 2017
  • MACF1 overexpression by transfecting the 21-kbp large plasmid PEGFP-C1A-ACF7 promotes osteoblast differentiation and bone formation, Yan Zhang, Chong Yin, Lifang Hu, Zhihao Chen, Fan Zhao, Dijie Li, Jianhua Ma, Xiaoli Ma, Peihong Su, Wuxia Qiu, Chaofei Yang, Pai Wang, Siyu Li, Ge Zhang, Liping Wang, Airong Qian, Cory J. Xian, 2018
  • Mechanical unloading reduces microtubule actin crosslinking factor 1 expression to inhibit β-catenin signaling and osteoblast proliferation, Chong Yin, Yan Zhang, Lifang Hu, Ye Tian, Zhihao Chen, Dijie Li, Fan Zhao, Peihong Su, Xiaoli Ma, Ge Zhang, Zhiping Miao, Liping Wang, Airong Qian, Cory J. Xian, 2018
  • MACF1对成骨细胞微丝骨架和细胞力学性能的调节作用, 胡丽芳,吴自祥,丛晓岚,Mitchel Alioscha-Perez,王哲,蒋冬梅,骞爱荣, Hichem Sahli, 2020
  • 不同分化阶段的成骨细胞对强磁重力环境的响应, 胡丽芳,骞爱荣,李迪杰,李京宝,商澎, 2013
  • 骨硬化蛋白与骨代谢, 胡丽芳,骞爱荣,商澎, 2011
  • Vinculin在细胞响应力学刺激中的作用, 胡丽芳,骞爱荣,商
Osteoporosis Bone Formation Cell Aging Mechanotransduction Biomechanical Signaling Osteoblast Differentiation Microgravity Cellular Structure Molecular Pathways Mechanical Stress

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