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Hui Shi
Animal Sciences
Zhejiang University
Zhejiang
Language: English, Chinese
Animal
Digestive Organs
Development
Diseases
Zebrafish
Liver
Neuroblastoma
Gene Expression
Cell Models
Mechanisms
Areas of Focus
- Development and diseases of animal digestive organs
Work Experience
- 2014-2020 - Postdoctoral Researcher - Harvard Medical School, Dana-Farber Cancer Institute
Academic Background & Achievements
- 2009 - Bachelor's Degree in Veterinary Medicine: Zhejiang University
- 2014 - Ph.D. in Agriculture: Zhejiang University
- Postdoctoral Research: Harvard Medical School, Dana-Farber Cancer Institute
Publications
- ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression, Shi H*, Tao T*, Abraham BJ, Durbin AD, Zimmerman MW, Kadoch C, Look AT., 2020
- Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors, Tao T*, Shi H*, Wang M, Perez-Atayde AR, London WB, Gutierrez A, Lemos B, Durbin AD, Look AT., 2020
- LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors, Tao T*, Shi H*, Mariani L, Abraham BJ, Durbin AD, Zimmerman MW, Powers JT, Missios P, Ross KN, Perez-Atayde AR, Bulyk ML, Young RA, Daley GQ, Look AT., 2020
- The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma, Tao T*, Sondalle SB*, Shi H*, Zhu S, Perez-Atayde AR, Peng J, Baserga SJ, Look AT., 2017
- A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function, Shi H, Tao T, Huang D, Ou Z, Chen J, Peng J., 2015
- Def defines a nucleolar pathway that leading p53 to proteasome-independent degradation, Tao T*, Shi H*, Guan Y, Huang D, Chen Y, Lane DP, Chen J, Peng J., 2013
- Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish, Tao T*, Shi H*, Huang D, Peng J., 2013
- Targeting ganglioneuromas with mTOR inhibitors, Tao T, Shi H, Durbin AD, Look AT., 2021
- Capn3 depletion causes Chk1 and Wee1 accumulation and disrupts synchronization of cell cycle reentry during liver regeneration after partial hepatectomy, Chen F, Huang D, Shi H, Wang Y, Peng J., 2020
- PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components, Ma Z, Zhu P, Shi H, Guo L, Zhang Q, Chen Y, Chen S, Zhang Z, Peng J, Chen J., 2019
- Loss of ATRX cooperates with p53-Deficiency to promote the development of sarcomas and other malignancies, Oppel F*, Tao T*, Shi H, Ross KN, Zimmerman MW, He S, Tong G, Aster JC, Look AT., 2019
- Sas10 controls ribosome biogenesis by stabilizing Mpp10 and delivering the Mpp10-Imp3-Imp4 complex to nucleolus, Zhao S, Chen Y, Chen F, Huang D, Shi H, Lo LJ, Chen J, Peng J., 2019
- Phosphorylation of Def regulates nucleolar p53 turnover and cell-cycle progression through Def recruitment of Calpain3, Guan Y, Huang D, Chen F, Gao C, Tao T, Shi H, Zhao S, Liao Z, Lo L, Wang Y, Chen J, Peng J., 2016
- The role of mesodermal signals during liver organogenesis in zebrafish, Niu X, Shi H, Peng J., 2010
