1987 - Bachelor's in Chemistry: Hangzhou University
2000/2-2002/2 - Postdoctoral Research: Torrey Pines Institute for Molecular Studies, USA
2004/6-Present - Zhejiang University College of Pharmaceutical Sciences - Professor, Doctoral Supervisor
2002/3-2004/6 - Torrey Pines Institute for Molecular Studies, USA - Senior Researcher
Research
Innovative Drug Development
Palladium-Catalyzed H/D Exchange Reaction with 8-Aminoquinoline as the Directing Group: Access to ortho-Selective Deuterated Aromatic Acids and β-Selective Deuterated Aliphatic Acids, Donghong Zhao, Haofan Luo, Binhui Chen, Wenteng Chen, Guolin Zhang, Yongping Yu, 2018
Catalyst-free three-component sequencing approach for efficient assembly of [1, 3] oxazine N-fused imidazole-2-thiones, En Chen, Jiaan Shao, Pai Tang, Ke Shu, Wenteng Chen, Yongping Yu, 2018
A Multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles via ring-opening of nitroepoxides, Xingyu Liu, Zhuang Nie, Jiaan Shao, Wenteng Chen, Yongping Yu, 2018
A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation, Jiaan Shao, Richard A. Houghten, Colette T. Dooley, Margret Cazares, Jay P. McLaughlin, Shainnel O. Eans, Michelle L. Ganno, Michelle R. Hoot, Marc A. Giulianotti, Yongping Yu, 2017
KI-mediated radical multi-functionalization of vinyl azides: a one-pot and efficient approach to β-keto sulfones and α-halo-β-keto sulfones, Wenteng Chen, Xingyu Liu, En Chen, Binhui Chen, Jiaan Shao, Yongping Yu, 2017
A three-component one-pot synthesis of penta-substituted pyrroles via ring opening of α-nitroepoxides, Donghong Zhao, Yue Zhu, Shanshan Guo, Wenteng Chen, Guolin Zhang, Yongping Yu, 2017
MnIII-catalyzed Phosphorylation of Vinyl Azides: The synthesis of ß-keto phosphine oxides, Pai Tang, Can Zhang, Binhui Chen, Wenteng Chen, Yongping Yu, 2017
One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles, Shanshan Guo, Donghong Zhao, Yue, Zhu, Yongping Yu, Wenteng Chen, Guolin Zhang, 2017
Facile, efficient synthesis of polysubstituted thiazoles via anitroepoxides and thioureas, Donghong Zhao, Shanshan Guo, Xiao Guo, Guolin Zhang, Yongping Yu, 2016
A flavonoid compound promotes neuronal differentiation of embryonic stem cells via PPAR-β modulating mitochondrial energy metabolism, Yuqin Mei, Zongfu Pan, Wenteng Chen, Minhua Xu, Danyan Zhu, Yongping Yu, Yijia Lou, 2016
6-Oxooxazolidine-quinazolines as noncovalent inhibitors with the potential to target mutant forms of EGFR, Jiaan Shao, En Chen, Ke Shu, Wenteng Chen, Guolin Zhang, Yongping Yu, 2016
Base-mediated synthesis of highly functionalized 2-aminonicotinonitriles from α-keto vinyl azides and α, α-dicyanoalkenes, Ke Shu, Jiaan Shao, Hong Li, Binhui Chen, Pai Tang, Xingyu Liu, Wenteng Chen, Yongping Yu, 2016
Selective access to 4-substituted-2-aminothiazoles and 4-substituted-5-thiocyano-2-aminothiazoles from vinyl azides and potassium thiocyanate switched by palladium and iron catalysts, Binhui Chen, Shanshan Guo, Xiao Guo, Guolin Zhang, Yongping Yu, 2015
Tuning the Annulation Reactivity of Vinyl Azides and carbazates: A divergent synthesis of aza-pyrimidinones and imidazoles, Jiaan Shao, Xingyu Liu, Ke Shu, Pai Tang, Jing Luo, Wenteng Chen, Yongping Yu, 2015
Mn(II)-catalyzed synthesis of benzo[f]indole-4,9-diones via vinyl azides and 2- hydroxynaphthoquinone, Shanshan Guo, Binhui Chen, Xiao Guo, Guolin Zhang, Yongping Yu, 2015
Synthesis of polysubstituted 4-aminopyrazoles and 4-hydroxypyrazoles from vinyl azides and hydrazines, Wei Huang, Shen Liu, Binhui Chen, Xiao Guo, Yongping Yu, 2015
Synthesis of poly-functionalized imidazoles via vinyl azides annulation, Jing Luo, Wenteng Chen, Jiaan Shao, Xingyu Liu, Ke Shu, Pai Tang, Yongping Yu, 2015
Highly efficient and eco-friendly protocol to functionalized imidazoles via ring-opening of α-nitro epoxides, Xiao Guo, Jiaan Shao, HuanLiu, Binhui Chen, Wenteng Chen, Yongping Yu, 2015
One-pot three-component strategy for functionalized 2‑aminoimidazoles via ring opening of α-nitro epoxides, Xiao Guo, Wenteng Chen, Binhui Chen, Wei Huang, Weixing Qi, Guolin Zhang, Yongping Yu, 2015
Vinyl azides as versatile synthons for the synthesis of nitrogen-containing heterocycles, Hangcheng Ni, Guolin Zhang, Yongping Yu, 2015
Iron (II)-promoted synthesis of 2-aminothiazoles via C-N bond formation from vinyl azides and potassium thiocyanate, Guolin Zhang, Binhui Chen, Xiao Guo, Shanshan Guo, Yongping Yu, 2015
Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and d opioid receptor antagonist activities, Miao Hu, Marc A. Giulianotti, Jay P. McLaughlin, Jiaan Shao, Ginamarie Debevec, Laura E. Maida, Phaedra Geer, Margaret Cazares, Jaime Misler, Ling Li, Colette Dooley, Michelle L. Ganno, Shainnel O. Eans, Elisa Mizrachi, Radleigh G. Santos, Austin B. Yongye, Richard A. Houghten, Yongping Yu, 2015
A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles, Guangxin Xia, Wenteng Chen, Jing Zhang, Jiaan Shao, Yong Zhang, Wei Huang, Leduo Zhang, Weixing Qi, Xing Sun, Bojun Li, Zhixiong Xiang, Chen Ma, Jia Xu, Hailin Deng, Yufeng Li, Ping Li, Hong Miao, Jiansheng Han, Yanjun Liu, Jingkang Shen, Yongping Yu, 2014
[3+3] annulation of allylic phosphoryl-stabilized carbanions/phosphorus ylides and vinyl azides: a practice strategy for synthesis of polyfunctionalized anilines, Shen Liu, Wenteng Chen, Jing Luo, Yongping Yu, 2014
Facile preparation of 3, 5-disubstituted-4-aminothiophene-2-carbaldehyde from a novel unexpected domino reaction of vinyl azides and 1, 4-dithiane-2, 5-diol, Binhui Chen, Hangcheng Ni, Xiao Guo, Guolin Zhang, Yongping Yu, 2014
The prevention of titanium-particle-induced osteolysis by OA-14 through the suppression of the p38 signaling pathway and inhibition of osteoclastogenesis, Bo Tian, Tao, Jiang, Zhanying Shao, Zanjing Zhai, Haowei Li, Qiming Fan, Xuqiang Liu, Zhengxiao Ouyang, Tingting Tang, Qing Jiang, Minghao Zheng, Kerong Dai, An Qi, Yongping Yu, Zhenan Zhu, 2014
OA10 Is a Novel p38alpha Mitogen-Activated Protein Kinase Inhibitor That Suppresses Osteoclast Differentiation and Bone Resorption, Tao Jiang, An Qin, ZhanYing Shao, Bo Tian, Zanjing Zhai, Haowei Li, Zhenan Zhu, Kerong Dai, Minghao Zheng, Yongping Yu, Qing Jiang, 2014
OA-4 Inhibits Osteoclast Formation and Bone Resorption via Suppressing RANKL Induced P38 Signaling Pathway, Bo Tian, An Qin, Zhanying Shao, Tao Jiang, Zanjing Zhai, Haowei Li, Tingting Tang, Qing Jiang, Kerong. Dai, Minghao Zheng, Yongping Yu, Zhenan Zhu, 2014
Facile, efficient synthesis of polyfunctionalized 2-aminoimidazoles via vinyl azides and cyanamide, Shen Liu, Jiaan Shao, Xiao Guo, Jing Luo, Menghao Zhao, Guolin Zhang, Yongping Yu, 2014
Generation of insulin-producing cells from rat mesenchymal stem cells using an aminopyrrole derivative XW4.4, Jingfeng Ouyang, Wei Huang, Wanwan Yu, Wei Xiong, Ramanjaneya V.R. Mula, Hongbin Zou, Yongping Yu, 2014
Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies, Jinhua Wu, Yaohong Zhang, Laura E. Maida, Radleigh G. Santos, Gregory S. Welmaker, Travis M. LaVoi, Adel Nefzi, Yongping Yu, Richard A. Houghten, Lawrence Toll, Marc A. Giulianotti, 2013
Regioselective 6-detrimethylsilylation of per-O-TMS-protected carbohydrates in the presence of ammonium acetate, Yanli Cui, Zhaodong Cheng, Jianwei Mao, Yongping Yu, 2013
Area of Focus
Precision Oncology | Cancer Treatment | Targeted Therapy | Clinical Trials | Big Data | Data Mining | Translational Medicine | Drug Development | Pharmacology | Biomedical Research
Area of Focus
Lipid-Based Nano Drug Delivery | Tumor-Targeted Drugs | Radionuclide Tracing | Pharmaceutical Research | Nanotechnology | Drug Delivery Systems | Cancer Treatment | Biomedical Engineering | Pharmacology | Therapeutics
