Professor | Wenteng Chen | Asia Growth Partners

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Name	Wenteng Chen
Contact Information	wentengchen@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Wenteng Chen

Contact Information

wentengchen@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2008/09-2013/06 Ph.D. in Medicinal Chemistry: Zhejiang University 2004/09-2008/06 B.Sc. in Pharmacy: Xiamen University Selected for Zhejiang Province Taizhou '500 Elite Plan' Innovation Talent B Category (2017) Published over 50 SCI papers as first or corresponding author Authored 1 English monograph Granted 1 US patent, 1 European patent, 1 Hong Kong patent, and 25 Chinese patents
Work Experience	2020/01-Present - Zhejiang University - Associate Professor, Institute of Drug Discovery and Design 2013/07-2019/12 - Zhejiang University - Assistant Researcher, Institute of Drug Design and Discovery 2013/07-2015/06 - Zhejiang University - Postdoctoral Researcher, Institute of Pharmacology, Toxicology, and Biochemistry 2010/08-2011/09 - Torrey Pines Institute for Molecular Studies - Visiting Scholar
Awards	Zhejiang Province Taizhou '500 Elite Plan' Innovation Talent B Category (2017)

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2008/09-2013/06 Ph.D. in Medicinal Chemistry: Zhejiang University
2004/09-2008/06 B.Sc. in Pharmacy: Xiamen University
Selected for Zhejiang Province Taizhou '500 Elite Plan' Innovation Talent B Category (2017)
Published over 50 SCI papers as first or corresponding author
Authored 1 English monograph
Granted 1 US patent, 1 European patent, 1 Hong Kong patent, and 25 Chinese patents

Work Experience

2020/01-Present - Zhejiang University - Associate Professor, Institute of Drug Discovery and Design
2013/07-2019/12 - Zhejiang University - Assistant Researcher, Institute of Drug Design and Discovery
2013/07-2015/06 - Zhejiang University - Postdoctoral Researcher, Institute of Pharmacology, Toxicology, and Biochemistry
2010/08-2011/09 - Torrey Pines Institute for Molecular Studies - Visiting Scholar

Awards

Zhejiang Province Taizhou '500 Elite Plan' Innovation Talent B Category (2017)

Areas of Focus	Innovative Drug Development Based on Unmet Clinical Needs Development of Chemiluminescence Detection Kits Development of New Drug Synthesis Technologies
Publications	Facile access to thieno[2,3-b]thiophenes and poly-substituted thiophenes through divergent annulation of ketene 1,3-dithietanes, You Wu, Shuqi Wang, Bo Peng, Jie Cen, Yongping Yu, Wenteng Chen, 2024 Synthesis and structure-activity optimization of hydroxypyridinones against rhabdomyolysis-induced acute kidney injury, Jie Cen, Haiying Zhu, Chenggang Hong, Xi Zhang, Shuangrong Liu, BoYang, Yongping Yu, Yuanmei Wen, Ji Cao, Wenteng Chen, 2024 塞拉菌素合成新工艺研究, 钟秀文、张蕾、黄友纯、罗峰、陈仁尔、俞永平、陈文腾, 2024 Ac-L-methionine-catalyzed, nitrite-triggered cycloaddition reaction between bromide and alkyne/alkene: A step-economical reaction for modular synthesis, Shuangrong Liu, Zhimin Ying, Qi Zhu, Xiuwen Zhong, Jie Cen, You Wu, Yongping Yu, Jiaan Shao, Wenteng Chen, 2023 Targeting labile iron-mediated ferroptosis provides a potential therapeutic strategy for rhabdomyolysis-induced acute kidney injury, Haiying Zhu, Jie Cen, Chenggang Hong, Haiyang Wang, Yuanmei Wen, Qiaojun He, Yongping Yu, Ji Cao, Wenteng Chen, 2023 BF3·CH3CN promotes a formation of aryl α-O-glycosides from pyranoses: A facile approach to oligosaccharide EPS-G7, Xiuwen Zhong, Danzhi Ying, Youchun Huang, Lei Zhang, Haiyang Wang, Qi Zhu, En Chen, Yongping Yu, Wenteng Chen, 2023 Palladium (II)-catalyzed intramolecular tandem cyclization reaction for the assembly of unsymmetrical 2,6-disubstituted pyrazines, Yitong Chen, Qi Zhu, Haiyang Wang, Yongping Yu, Guolin Zhang, Wenteng Chen, 2023 Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit, Sihan Wang, Zhimin Ying, Youchun Huang, Yuting Li, Menglong Hu, Ke Kang, Haiyang Wang, Jiaan Shao, Gaoqi Wu, Yongping Yu, Yushen Du, Wenteng Chen, 2023 Rh(III)-catalyzed C-H activation/intramolecular annulation for the synthesis of N-methoxydihydropyrimidin-2-one fused heterocycles, Youchun Huang, Ke Kang, Xiuwen Zhong, Yongping Yu, Wenteng Chen, 2023 Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis, Zhaoxian Cai, Xiaotian Wu, Zijun Song, Shumin Sun, Yunxing Su, Tianyi Wang, Xihao Cheng, Yingying Yu, Chao Yu, En Chen, Wenteng Chen, Yongping Yu, Andreas Linkermann, Junxia Min, Fudi Wang, 2023 Approaches for discovery of small-molecular antivirals targeting to influenza A virus PB2 subunit, Wenteng Chen, Jiaan Shao, Zhimin Ying, Yushen Du, Yongping Yu, 2022 Boronic-acid-accelerated electrophilic activation of unprotected maltols to N-substituted hydroxypyridinones in water, Di Ke, Lei Zhang, Xiuwen Zhong, Jiaan Shao, Yongping Yu, Wenteng Chen, 2022 Group-assisted-purification chemistry strategy for the efficient assembly of cyclic fused pyridinones, Di Ke, You Wu, Lei Zhang, Jiaan Shao, Yongping Yu, Wenteng Chen, 2022 Substrate-tuned domino annulation for selective synthesis of poly-substituted benzo[f]imidazo[2,1-a][2,7]naphthyridines and 3-azaheterocyclic substituted 2-arylquinolines, Zhimin Ying, Jie Cen, Feng Luo, You Wu, Shuangrong Liu, Wenteng Chen, Jiaan Shao, Yongping Yu, 2021 Palladium-catalyzed synthesis of polysubstituted pyrazoles via ring opening reactions of 2H-azirines with hydrazones, Jiaan Shao, Ke Shu, Shuangrong Liu, Huajiang Zhu, Jiangkang Zhang, Chong Zhang, Linhui Zeng, Wenteng Chen, 2021 CN128, a new orally active hydroxypyridinone iron chelator, Wenteng Chen, Xin Yuan, Zhi Li, Zidong Lu, Sisi Kong, Huidi Jiang, Houbing Du, Xiuhong Pan, Manasi Nandi, Xiaole Kong, Kathryn Brown, Zudong Liu, Guolin Zhang, Robert C. Hider, Yongping Yu, 2020 Efficient access to fluorescent benzofuro[3,2-b]carbazoles via TFA-promoted cascade annulations of sulfur ylides, 2-hydroxy-β-nitrostyrenes and indoles, Wenteng Chen, Feng Luo, You Wu, Jie Cen, Jiaan Shao, Yongping Yu, 2020 Facile and mild access to fluorescent ladder-type indolo[3,2-a]carbazoles via cascade annulation, Shuangrong Liu, You Wu, Zhimin Ying, Feng Luo, En Chen, Wenteng Chen, Yongping Yu, 2020 Palladium-catalyzed synthesis of polysubstituted pyrazoles via ring opening reactions of 2H-azirines with hydrazones, Jiaan Shao, Ke Shu, Shuangrong Liu, Huajiang Zhu, Jiangkang Zhang, Chong Zhang, Linhui Zeng, Wenteng Chen, 2020 Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M, Jiaan Shao, Shuangrong Liu, Xingyu Liu, Youlu Pan, Wenteng Chen, 2020 Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants, Wenteng Chen, Xiao Guo, Can Zhang, Di Ke, Guolin Zhang, Yongping Yu, 2019 Sulfur ylide initiated [4 + 1]/[4 + 2] annulation reactions: A one-pot approach to dibenzofuran acrylate derivatives, Jiaan Shao, Wenteng Chen, Zhimin Ying, Shuangrong Liu, Feng Luo, Lili Ou, 2019 New β-carboline fluorophores with superior sensitivity and endoplasmic reticulum specificity for tracking ER changes, Wenteng Chen, Jiaan Shao, Yujie Huang, En Chen, Mingzhu Huang, Feng Han, Xingguang Liang, Yongping Yu, 2019 Mild and facile synthesis of formamide: reduction and functionalization of CO2 using NaBH(OAc)3 under atmospheric pressure, Huan Liu, Zhuang Nie, Jiaan Shao, Wenteng Chen, Yongping Yu, 2019 Synthesis of polyfunctional imidazoles from vinyl azides and amidine along with NHBoc as a leaving group, Pai Tang, Di Ke, Jiaan Shao, Wenteng Chen, Yongping Yu, 2019 Catalyst-free three-component sequencing approach for efficient assembly of [1, 3] oxazine N-fused imidazole-2-thiones, En Chen, Jiaan Shao, Pai Tang, Ke Shu, Wenteng Chen, Yongping Yu, 2018 Substrate-controlled synthesis of spirocyclopropylpyrazolones and bicyclic 4,5-dihydropyrazoles from 1,2-diaza-1,3-dienes with sulfur ylides, Jiaan Shao, Wenteng Chen, Menghao Zhao, Ke Shu, Huan Liu, Pai Tang, 2018 Highly efficient synthesis of polysubstituted 2-aminopyrroles via multi-component domino reactions, Jiaan Shao, Di Ke, Ke Shu, En Chen, Yongping Yu, Wenteng Chen, 2018 A Multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles via ring-opening of nitroepoxides, Xingyu Liu, Zhuang Nie, Jiaan Shao, Wenteng Chen, Yongping Yu, 2018 Highly selective and potent α4β2

Areas of Focus

Innovative Drug Development Based on Unmet Clinical Needs
Development of Chemiluminescence Detection Kits
Development of New Drug Synthesis Technologies

Publications

Facile access to thieno[2,3-b]thiophenes and poly-substituted thiophenes through divergent annulation of ketene 1,3-dithietanes, You Wu, Shuqi Wang, Bo Peng, Jie Cen, Yongping Yu, Wenteng Chen, 2024
Synthesis and structure-activity optimization of hydroxypyridinones against rhabdomyolysis-induced acute kidney injury, Jie Cen, Haiying Zhu, Chenggang Hong, Xi Zhang, Shuangrong Liu, BoYang, Yongping Yu, Yuanmei Wen, Ji Cao, Wenteng Chen, 2024
塞拉菌素合成新工艺研究, 钟秀文、张蕾、黄友纯、罗峰、陈仁尔、俞永平、陈文腾, 2024
Ac-L-methionine-catalyzed, nitrite-triggered cycloaddition reaction between bromide and alkyne/alkene: A step-economical reaction for modular synthesis, Shuangrong Liu, Zhimin Ying, Qi Zhu, Xiuwen Zhong, Jie Cen, You Wu, Yongping Yu, Jiaan Shao, Wenteng Chen, 2023
Targeting labile iron-mediated ferroptosis provides a potential therapeutic strategy for rhabdomyolysis-induced acute kidney injury, Haiying Zhu, Jie Cen, Chenggang Hong, Haiyang Wang, Yuanmei Wen, Qiaojun He, Yongping Yu, Ji Cao, Wenteng Chen, 2023
BF3·CH3CN promotes a formation of aryl α-O-glycosides from pyranoses: A facile approach to oligosaccharide EPS-G7, Xiuwen Zhong, Danzhi Ying, Youchun Huang, Lei Zhang, Haiyang Wang, Qi Zhu, En Chen, Yongping Yu, Wenteng Chen, 2023
Palladium (II)-catalyzed intramolecular tandem cyclization reaction for the assembly of unsymmetrical 2,6-disubstituted pyrazines, Yitong Chen, Qi Zhu, Haiyang Wang, Yongping Yu, Guolin Zhang, Wenteng Chen, 2023
Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit, Sihan Wang, Zhimin Ying, Youchun Huang, Yuting Li, Menglong Hu, Ke Kang, Haiyang Wang, Jiaan Shao, Gaoqi Wu, Yongping Yu, Yushen Du, Wenteng Chen, 2023
Rh(III)-catalyzed C-H activation/intramolecular annulation for the synthesis of N-methoxydihydropyrimidin-2-one fused heterocycles, Youchun Huang, Ke Kang, Xiuwen Zhong, Yongping Yu, Wenteng Chen, 2023
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis, Zhaoxian Cai, Xiaotian Wu, Zijun Song, Shumin Sun, Yunxing Su, Tianyi Wang, Xihao Cheng, Yingying Yu, Chao Yu, En Chen, Wenteng Chen, Yongping Yu, Andreas Linkermann, Junxia Min, Fudi Wang, 2023
Approaches for discovery of small-molecular antivirals targeting to influenza A virus PB2 subunit, Wenteng Chen, Jiaan Shao, Zhimin Ying, Yushen Du, Yongping Yu, 2022
Boronic-acid-accelerated electrophilic activation of unprotected maltols to N-substituted hydroxypyridinones in water, Di Ke, Lei Zhang, Xiuwen Zhong, Jiaan Shao, Yongping Yu, Wenteng Chen, 2022
Group-assisted-purification chemistry strategy for the efficient assembly of cyclic fused pyridinones, Di Ke, You Wu, Lei Zhang, Jiaan Shao, Yongping Yu, Wenteng Chen, 2022
Substrate-tuned domino annulation for selective synthesis of poly-substituted benzo[f]imidazo[2,1-a][2,7]naphthyridines and 3-azaheterocyclic substituted 2-arylquinolines, Zhimin Ying, Jie Cen, Feng Luo, You Wu, Shuangrong Liu, Wenteng Chen, Jiaan Shao, Yongping Yu, 2021
Palladium-catalyzed synthesis of polysubstituted pyrazoles via ring opening reactions of 2H-azirines with hydrazones, Jiaan Shao, Ke Shu, Shuangrong Liu, Huajiang Zhu, Jiangkang Zhang, Chong Zhang, Linhui Zeng, Wenteng Chen, 2021
CN128, a new orally active hydroxypyridinone iron chelator, Wenteng Chen, Xin Yuan, Zhi Li, Zidong Lu, Sisi Kong, Huidi Jiang, Houbing Du, Xiuhong Pan, Manasi Nandi, Xiaole Kong, Kathryn Brown, Zudong Liu, Guolin Zhang, Robert C. Hider, Yongping Yu, 2020
Efficient access to fluorescent benzofuro[3,2-b]carbazoles via TFA-promoted cascade annulations of sulfur ylides, 2-hydroxy-β-nitrostyrenes and indoles, Wenteng Chen, Feng Luo, You Wu, Jie Cen, Jiaan Shao, Yongping Yu, 2020
Facile and mild access to fluorescent ladder-type indolo[3,2-a]carbazoles via cascade annulation, Shuangrong Liu, You Wu, Zhimin Ying, Feng Luo, En Chen, Wenteng Chen, Yongping Yu, 2020
Palladium-catalyzed synthesis of polysubstituted pyrazoles via ring opening reactions of 2H-azirines with hydrazones, Jiaan Shao, Ke Shu, Shuangrong Liu, Huajiang Zhu, Jiangkang Zhang, Chong Zhang, Linhui Zeng, Wenteng Chen, 2020
Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M, Jiaan Shao, Shuangrong Liu, Xingyu Liu, Youlu Pan, Wenteng Chen, 2020
Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants, Wenteng Chen, Xiao Guo, Can Zhang, Di Ke, Guolin Zhang, Yongping Yu, 2019
Sulfur ylide initiated [4 + 1]/[4 + 2] annulation reactions: A one-pot approach to dibenzofuran acrylate derivatives, Jiaan Shao, Wenteng Chen, Zhimin Ying, Shuangrong Liu, Feng Luo, Lili Ou, 2019
New β-carboline fluorophores with superior sensitivity and endoplasmic reticulum specificity for tracking ER changes, Wenteng Chen, Jiaan Shao, Yujie Huang, En Chen, Mingzhu Huang, Feng Han, Xingguang Liang, Yongping Yu, 2019
Mild and facile synthesis of formamide: reduction and functionalization of CO2 using NaBH(OAc)3 under atmospheric pressure, Huan Liu, Zhuang Nie, Jiaan Shao, Wenteng Chen, Yongping Yu, 2019
Synthesis of polyfunctional imidazoles from vinyl azides and amidine along with NHBoc as a leaving group, Pai Tang, Di Ke, Jiaan Shao, Wenteng Chen, Yongping Yu, 2019
Catalyst-free three-component sequencing approach for efficient assembly of [1, 3] oxazine N-fused imidazole-2-thiones, En Chen, Jiaan Shao, Pai Tang, Ke Shu, Wenteng Chen, Yongping Yu, 2018
Substrate-controlled synthesis of spirocyclopropylpyrazolones and bicyclic 4,5-dihydropyrazoles from 1,2-diaza-1,3-dienes with sulfur ylides, Jiaan Shao, Wenteng Chen, Menghao Zhao, Ke Shu, Huan Liu, Pai Tang, 2018
Highly efficient synthesis of polysubstituted 2-aminopyrroles via multi-component domino reactions, Jiaan Shao, Di Ke, Ke Shu, En Chen, Yongping Yu, Wenteng Chen, 2018
A Multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles via ring-opening of nitroepoxides, Xingyu Liu, Zhuang Nie, Jiaan Shao, Wenteng Chen, Yongping Yu, 2018
Highly selective and potent α4β2

Drug Development Clinical Needs Chemiluminescence Detection Kits Drug Synthesis Innovative Drugs Clinical Trials Pharmaceutical Chemistry Antiviral Drugs Cancer Treatment

Yuan Gao - Fudan University

Yongping Yu - Zhejiang University

Wenteng Chen - Zhejiang University

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