2008/09-2013/06 Ph.D. in Medicinal Chemistry: Zhejiang University
2004/09-2008/06 B.Sc. in Pharmacy: Xiamen University
Achievement: Selected for Zhejiang Province Taizhou '500 Elite Plan' Innovation Talent B Category (2017)
2020/01-Present - Zhejiang University - Associate Professor, Institute of Drug Discovery and Design
2013/07-2019/12 - Zhejiang University - Assistant Researcher, Institute of Drug Design and Discovery
2013/07-2015/06 - Zhejiang University - Postdoctoral Researcher, Institute of Pharmacology, Toxicology, and Biochemistry
2010/08-2011/09 - Torrey Pines Institute for Molecular Studies - Visiting Scholar
Graduate National Scholarship (2012)
Zhejiang Province Outstanding Graduate (2013)
Zhejiang Province Taizhou '500 Elite Plan' Innovation Talent B Category (2017)
Research
Innovative Drug Development Based on Unmet Clinical Needs Development of Chemiluminescence Detection Kits Development of New Drug Synthesis Technologies
Facile access to thieno[2,3-b]thiophenes and poly-substituted thiophenes through divergent annulation of ketene 1,3-dithietanes, You Wu, Shuqi Wang, Bo Peng, Jie Cen, Yongping Yu, Wenteng Chen, 2024
Synthesis and structure-activity optimization of hydroxypyridinones against rhabdomyolysis-induced acute kidney injury, Jie Cen, Haiying Zhu, Chenggang Hong, Xi Zhang, Shuangrong Liu, BoYang, Yongping Yu, Yuanmei Wen, Ji Cao, Wenteng Chen, 2024
塞拉菌素合成新工艺研究, 钟秀文、张蕾、黄友纯、罗峰、陈仁尔、俞永平、陈文腾, 2024
Ac-L-methionine-catalyzed, nitrite-triggered cycloaddition reaction between bromide and alkyne/alkene: A step-economical reaction for modular synthesis, Shuangrong Liu, Zhimin Ying, Qi Zhu, Xiuwen Zhong, Jie Cen, You Wu, Yongping Yu, Jiaan Shao, Wenteng Chen, 2023
Targeting labile iron-mediated ferroptosis provides a potential therapeutic strategy for rhabdomyolysis-induced acute kidney injury, Haiying Zhu, Jie Cen, Chenggang Hong, Haiyang Wang, Yuanmei Wen, Qiaojun He, Yongping Yu, Ji Cao, Wenteng Chen, 2023
BF3·CH3CN promotes a formation of aryl α-O-glycosides from pyranoses: A facile approach to oligosaccharide EPS-G7, Xiuwen Zhong, Danzhi Ying, Youchun Huang, Lei Zhang, Haiyang Wang, Qi Zhu, En Chen, Yongping Yu, Wenteng Chen, 2023
Palladium (II)-catalyzed intramolecular tandem cyclization reaction for the assembly of unsymmetrical 2,6-disubstituted pyrazines, Yitong Chen, Qi Zhu, Haiyang Wang, Yongping Yu, Guolin Zhang, Wenteng Chen, 2023
Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit, Sihan Wang, Zhimin Ying, Youchun Huang, Yuting Li, Menglong Hu, Ke Kang, Haiyang Wang, Jiaan Shao, Gaoqi Wu, Yongping Yu, Yushen Du, Wenteng Chen, 2023
Rh(III)-catalyzed C-H activation/intramolecular annulation for the synthesis of N-methoxydihydropyrimidin-2-one fused heterocycles, Youchun Huang, Ke Kang, Xiuwen Zhong, Yongping Yu, Wenteng Chen, 2023
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis, Zhaoxian Cai, Xiaotian Wu, Zijun Song, Shumin Sun, Yunxing Su, Tianyi Wang, Xihao Cheng, Yingying Yu, Chao Yu, En Chen, Wenteng Chen, Yongping Yu, Andreas Linkermann, Junxia Min, Fudi Wang, 2023
Approaches for discovery of small-molecular antivirals targeting to influenza A virus PB2 subunit, Wenteng Chen, Jiaan Shao, Zhimin Ying, Yushen Du, Yongping Yu, 2022
Boronic-acid-accelerated electrophilic activation of unprotected maltols to N-substituted hydroxypyridinones in water, Di Ke, Lei Zhang, Xiuwen Zhong, Jiaan Shao, Yongping Yu, Wenteng Chen, 2022
Group-assisted-purification chemistry strategy for the efficient assembly of cyclic fused pyridinones, Di Ke, You Wu, Lei Zhang, Jiaan Shao, Yongping Yu, Wenteng Chen, 2022
Substrate-tuned domino annulation for selective synthesis of poly-substituted benzo[f]imidazo[2,1-a][2,7]naphthyridines and 3-azaheterocyclic substituted 2-arylquinolines, Zhimin Ying, Jie Cen, Feng Luo, You Wu, Shuangrong Liu, Wenteng Chen, Jiaan Shao, Yongping Yu, 2021
Palladium-catalyzed synthesis of polysubstituted pyrazoles via ring opening reactions of 2H-azirines with hydrazones, Jiaan Shao, Ke Shu, Shuangrong Liu, Huajiang Zhu, Jiangkang Zhang, Chong Zhang, Linhui Zeng, Wenteng Chen, 2021
CN128, a new orally active hydroxypyridinone iron chelator, Wenteng Chen, Xin Yuan, Zhi Li, Zidong Lu, Sisi Kong, Huidi Jiang, Houbing Du, Xiuhong Pan, Manasi Nandi, Xiaole Kong, Kathryn Brown, Zudong Liu, Guolin Zhang, Robert C. Hider, Yongping Yu, 2020
Efficient access to fluorescent benzofuro[3,2-b]carbazoles via TFA-promoted cascade annulations of sulfur ylides, 2-hydroxy-β-nitrostyrenes and indoles, Wenteng Chen, Feng Luo, You Wu, Jie Cen, Jiaan Shao, Yongping Yu, 2020
Facile and mild access to fluorescent ladder-type indolo[3,2-a]carbazoles via cascade annulation, Shuangrong Liu, You Wu, Zhimin Ying, Feng Luo, En Chen, Wenteng Chen, Yongping Yu, 2020
Palladium-catalyzed synthesis of polysubstituted pyrazoles via ring opening reactions of 2H-azirines with hydrazones, Jiaan Shao, Ke Shu, Shuangrong Liu, Huajiang Zhu, Jiangkang Zhang, Chong Zhang, Linhui Zeng, Wenteng Chen, 2020
Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M, Jiaan Shao, Shuangrong Liu, Xingyu Liu, Youlu Pan, Wenteng Chen, 2020
Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants, Wenteng Chen, Xiao Guo, Can Zhang, Di Ke, Guolin Zhang, Yongping Yu, 2019
New β-carboline fluorophores with superior sensitivity and endoplasmic reticulum specificity for tracking ER changes, Wenteng Chen, Jiaan Shao, Yujie Huang, En Chen, Mingzhu Huang, Feng Han, Xingguang Liang, Yongping Yu, 2019
Mild and facile synthesis of formamide: reduction and functionalization of CO2 using NaBH(OAc)3 under atmospheric pressure, Huan Liu, Zhuang Nie, Jiaan Shao, Wenteng Chen, Yongping Yu, 2019
Synthesis of polyfunctional imidazoles from vinyl azides and amidine along with NHBoc as a leaving group, Pai Tang, Di Ke, Jiaan Shao, Wenteng Chen, Yongping Yu, 2019
Catalyst-free three-component sequencing approach for efficient assembly of [1, 3] oxazine N-fused imidazole-2-thiones, En Chen, Jiaan Shao, Pai Tang, Ke Shu, Wenteng Chen, Yongping Yu, 2018
Substrate-controlled synthesis of spirocyclopropylpyrazolones and bicyclic 4,5-dihydropyrazoles from 1,2-diaza-1,3-dienes with sulfur ylides, Jiaan Shao, Wenteng Chen, Menghao Zhao, Ke Shu, Huan Liu, Pai Tang, 2018
Highly efficient synthesis of polysubstituted 2-aminopyrroles via multi-component domino reactions, Jiaan Shao, Di Ke, Ke Shu, En Chen, Yongping Yu, Wenteng Chen, 2018
A Multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles via ring-opening of nitroepoxides, Xingyu Liu, Zhuang Nie, Jiaan Shao, Wenteng Chen, Yongping Yu, 2018
Highly selective and potent α4β2 nAChR antagonist inhibits nicotine self-administration and reinstatement in rats, Jinhua Wu, Andrea Cippitelli, Yaohong Zhang, Ginamarie Debevec, Jennifer Schoch, Akihiko Ozawa, Yongping Yu, Huan Liu, Wenteng Chen, Richard A. Houghten, Gregory S. Welmaker, Marc A. Giulianotti, Lawrence Toll, 2017
KI-mediated radical multi-functionalization of
Keywords
Drug DevelopmentClinical NeedsChemiluminescenceDetection KitsDrug SynthesisInnovative DrugsClinical TrialsPharmaceutical ResearchChemical StrategiesLead Compounds
Area of Focus
Drug Discovery | Pharmacology | Clinical Trials | New Drug Development | Pharmaceutical Research | Medicinal Chemistry | Biotechnology | Pharmacokinetics | Pharmacodynamics | Therapeutics
Area of Focus
Precision Oncology | Cancer Treatment | Targeted Therapy | Clinical Trials | Big Data | Data Mining | Translational Medicine | Drug Development | Pharmacology | Biomedical Research
