Professor | Jia-Yu Liao | Asia Growth Partners

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Name	Jia-Yu Liao
Contact Information	jyliao@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Jia-Yu Liao

Contact Information

jyliao@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2012.8-2016.9 PhD in Organic Chemistry: National University of Singapore 2008.9-2012.6 Bachelor's in Pharmacy: Zhejiang University
Work Experience	2019.6-Present - Zhejiang University, College of Pharmaceutical Sciences - Distinguished Researcher 2018.5-2019.5 - Novartis Pharmaceuticals Technology Co., Ltd., Suzhou - Senior Scientist 2017.8-2018.5 - National University of Singapore, Department of Chemistry - Postdoctoral Researcher 2016.5-2016.11 - National University of Singapore, Department of Chemistry - Research Assistant

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2012.8-2016.9 PhD in Organic Chemistry: National University of Singapore
2008.9-2012.6 Bachelor's in Pharmacy: Zhejiang University

Work Experience

2019.6-Present - Zhejiang University, College of Pharmaceutical Sciences - Distinguished Researcher
2018.5-2019.5 - Novartis Pharmaceuticals Technology Co., Ltd., Suzhou - Senior Scientist
2017.8-2018.5 - National University of Singapore, Department of Chemistry - Postdoctoral Researcher
2016.5-2016.11 - National University of Singapore, Department of Chemistry - Research Assistant

Areas of Focus	Synthesis Methodology and Biological Activity of Heterocyclic Compounds Drug Design, Synthesis, and Structure-Activity Relationship AI-Assisted Drug Discovery
Publications	Atroposelective synthesis of eight-membered lactam-bridged N-arylindoles via stepwise cut-and-sew strategy, Ling-Fei Tao, Fen Huang, Xin Zhao, Linghui Qian, Jia-Yu Liao, 2023 The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics, Linghui Qian, Xuefen Lin, Xue Gao, Rizwan Ullah Khan, Jia-Yu Liao, Shubo Du, Jingyan Ge, Su Zeng, Shao Q. Yao, 2023 Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality, Fen Huang, Ling-Fei Tao, Jiyong Liu, Linghui Qian, Jia-Yu Liao, 2023 pH-Triggered cancer-targeting polymers: From extracellular accumulation to intracellular release, Rizwan Ullah Khan, Jinning Shao, Jia-Yu Liao, Linghui Qian, 2023 Sensitive Imaging of Cellular RNA via Cascaded Proximity-Induced Fluorogenic Reactions, Zhiyan Chen, Wen-Tao Wang, Wenchao Wang, Jinsong Huang, Jia-Yu Liao, Su Zeng, Linghui Qian, 2022 Torsional Strain-Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers, Zhang-Hong Luo, Wen-Tao Wang, Tian-Yi Tang, Sen Zhang, Fen Huang, Dan Hu, Ling-Fei Tao, Linghui Qian, Jia-Yu Liao, 2022 Catalytic Asymmetric [3+3] Cycloaddition of Activated Isocyanides with Azomethine Imines, Ling-Fei Tao, Linghui Qian, Jia-Yu Liao, 2022 Simultaneous Construction of C-N Axial and Central Chirality via Silver-Catalyzed Desymmetrizative [3+2] Cycloaddition of Prochiral N‑Aryl Maleimides with Activated Isocyanides, Sen Zhang, Zhang-Hong Luo, Wen-Tao Wang, Linghui Qian, Jia-Yu Liao, 2022 Cooperative catalysis-enabled C-N bond cleavage of biaryl lactams with activated isocyanides, Wen-Tao Wang, Sen Zhang, Ling-Fei Tao, Zi-Qi Pan, Linghui Qian, Jia-Yu Liao, 2022 Introducing… profile, Jia-Yu Liao, 2022 Diastereo- and Enantioselective Silver-Catalyzed [3+3] Cycloaddition and Kinetic Resolution of Azomethine Imines with Activated Isocyanides, Ling-Fei Tao, Sen Zhang, Fen Huang, Wen-Tao Wang, Zhang-Hong Luo, Linghui Qian, Jia-Yu Liao, 2022 Prediction of Maximum Absorption Wavelength Using Deep Neural Networks, Jinning Shao, Yue Liu, Jiaqi Yan, Ze-Yi Yan, Yangyang Wu, Zhongying Ru, Jia-Yu Liao, Xiaoye Miao, Linghui Qian, 2022 In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s, Yulong Kong, Kui Zeng, Ying Zhang, Jinning Shao, Jiaqi Yan, Jia-Yu Liao, Wenchao Wang, Xiaoyang Dai, Qinjie Weng, Shao Q. Yao, Su Zeng, Linghui Qian, 2022 Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides, Linghui Qian, Ling-Fei Tao, Wen-Tao Wang, Ehtesham Jameel, Zhang-Hong Luo, Tao Zhang, Yu Zhao, Jia-Yu Liao, 2021 Isocyanides: Promising Species in Bioorthogonal Labeling of Biomolecules, Yuchen Zhu, Jia-Yu Liao, Linghui Qian, 2021 Cobalt-Catalyzed Enantioselective Hydroboration/Cyclization of 1,7-Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers, Caizhi Wu, Jiayu Liao, Shaozhong Ge, 2019 Divergent, Enantioselective Synthesis of Pyrroles, 3H-Pyrroles and Bicyclic Imidazolines by Ag- or P-Catalyzed [3+2] Cycloaddition of Allenoates with Activated Isocyanides, Germaine Pui Yann Kok, Pan-Lin Shao, Jia-Yu Liao, Siti Nur Fairuz Bte Sheikh Ismail, Weijun Yao, Yixin Lu, Yu Zhao, 2018 Catalyst-Enabled Scaffold Diversity: Highly Chemo- and Stereoselective Synthesis of Tricyclic Ketals and Triarylmethanes, Jia-Yu Liao, Qijian Ni, Yu Zhao, 2017 Three-Component Reactions of Isocyanoacetates, Amines and 3-Formylchromones Initiated by an Unexpected aza-Michael Addition, Jia-Yu Liao, Wei Jie Yap, Ji'En Wu, Ming Wah Wong, Yu Zhao, 2017 Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3+2] Cyclization of Allenoates with Activated Isocyanides, Jia-Yu Liao, Pan-Lin Shao, Yu Zhao, 2015 Highly Diastereo- and Enantioselective Silver-Catalyzed Double [3+2] Cyclization of α-Imino Esters with Isocyanoacetate, Pan-Lin Shao, Jia-Yu Liao, Yee Ann Ho, Yu Zhao, 2014 Comparison of Three Methods on Assay for Vitamin A: UV, NP-HPLC and RP-HPLC, Linghui Qian, Jiayu Liao, Yani Li, Xiaofan Mo, Li Ma, Tongwei Yao, 2012

Areas of Focus

Synthesis Methodology and Biological Activity of Heterocyclic Compounds
Drug Design, Synthesis, and Structure-Activity Relationship
AI-Assisted Drug Discovery

Publications

Atroposelective synthesis of eight-membered lactam-bridged N-arylindoles via stepwise cut-and-sew strategy, Ling-Fei Tao, Fen Huang, Xin Zhao, Linghui Qian, Jia-Yu Liao, 2023
The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics, Linghui Qian, Xuefen Lin, Xue Gao, Rizwan Ullah Khan, Jia-Yu Liao, Shubo Du, Jingyan Ge, Su Zeng, Shao Q. Yao, 2023
Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality, Fen Huang, Ling-Fei Tao, Jiyong Liu, Linghui Qian, Jia-Yu Liao, 2023
pH-Triggered cancer-targeting polymers: From extracellular accumulation to intracellular release, Rizwan Ullah Khan, Jinning Shao, Jia-Yu Liao, Linghui Qian, 2023
Sensitive Imaging of Cellular RNA via Cascaded Proximity-Induced Fluorogenic Reactions, Zhiyan Chen, Wen-Tao Wang, Wenchao Wang, Jinsong Huang, Jia-Yu Liao, Su Zeng, Linghui Qian, 2022
Torsional Strain-Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers, Zhang-Hong Luo, Wen-Tao Wang, Tian-Yi Tang, Sen Zhang, Fen Huang, Dan Hu, Ling-Fei Tao, Linghui Qian, Jia-Yu Liao, 2022
Catalytic Asymmetric [3+3] Cycloaddition of Activated Isocyanides with Azomethine Imines, Ling-Fei Tao, Linghui Qian, Jia-Yu Liao, 2022
Simultaneous Construction of C-N Axial and Central Chirality via Silver-Catalyzed Desymmetrizative [3+2] Cycloaddition of Prochiral N‑Aryl Maleimides with Activated Isocyanides, Sen Zhang, Zhang-Hong Luo, Wen-Tao Wang, Linghui Qian, Jia-Yu Liao, 2022
Cooperative catalysis-enabled C-N bond cleavage of biaryl lactams with activated isocyanides, Wen-Tao Wang, Sen Zhang, Ling-Fei Tao, Zi-Qi Pan, Linghui Qian, Jia-Yu Liao, 2022
Introducing… profile, Jia-Yu Liao, 2022
Diastereo- and Enantioselective Silver-Catalyzed [3+3] Cycloaddition and Kinetic Resolution of Azomethine Imines with Activated Isocyanides, Ling-Fei Tao, Sen Zhang, Fen Huang, Wen-Tao Wang, Zhang-Hong Luo, Linghui Qian, Jia-Yu Liao, 2022
Prediction of Maximum Absorption Wavelength Using Deep Neural Networks, Jinning Shao, Yue Liu, Jiaqi Yan, Ze-Yi Yan, Yangyang Wu, Zhongying Ru, Jia-Yu Liao, Xiaoye Miao, Linghui Qian, 2022
In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s, Yulong Kong, Kui Zeng, Ying Zhang, Jinning Shao, Jiaqi Yan, Jia-Yu Liao, Wenchao Wang, Xiaoyang Dai, Qinjie Weng, Shao Q. Yao, Su Zeng, Linghui Qian, 2022
Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides, Linghui Qian, Ling-Fei Tao, Wen-Tao Wang, Ehtesham Jameel, Zhang-Hong Luo, Tao Zhang, Yu Zhao, Jia-Yu Liao, 2021
Isocyanides: Promising Species in Bioorthogonal Labeling of Biomolecules, Yuchen Zhu, Jia-Yu Liao, Linghui Qian, 2021
Cobalt-Catalyzed Enantioselective Hydroboration/Cyclization of 1,7-Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers, Caizhi Wu, Jiayu Liao, Shaozhong Ge, 2019
Divergent, Enantioselective Synthesis of Pyrroles, 3H-Pyrroles and Bicyclic Imidazolines by Ag- or P-Catalyzed [3+2] Cycloaddition of Allenoates with Activated Isocyanides, Germaine Pui Yann Kok, Pan-Lin Shao, Jia-Yu Liao, Siti Nur Fairuz Bte Sheikh Ismail, Weijun Yao, Yixin Lu, Yu Zhao, 2018
Catalyst-Enabled Scaffold Diversity: Highly Chemo- and Stereoselective Synthesis of Tricyclic Ketals and Triarylmethanes, Jia-Yu Liao, Qijian Ni, Yu Zhao, 2017
Three-Component Reactions of Isocyanoacetates, Amines and 3-Formylchromones Initiated by an Unexpected aza-Michael Addition, Jia-Yu Liao, Wei Jie Yap, Ji'En Wu, Ming Wah Wong, Yu Zhao, 2017
Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3+2] Cyclization of Allenoates with Activated Isocyanides, Jia-Yu Liao, Pan-Lin Shao, Yu Zhao, 2015
Highly Diastereo- and Enantioselective Silver-Catalyzed Double [3+2] Cyclization of α-Imino Esters with Isocyanoacetate, Pan-Lin Shao, Jia-Yu Liao, Yee Ann Ho, Yu Zhao, 2014
Comparison of Three Methods on Assay for Vitamin A: UV, NP-HPLC and RP-HPLC, Linghui Qian, Jiayu Liao, Yani Li, Xiaofan Mo, Li Ma, Tongwei Yao, 2012

Heterocyclic Compounds Synthesis Biological Activity Drug Design Structure-Activity Relationship Ai Drug Discovery Medicinal Chemistry Organic Synthesis

Xian Zeng - Fudan University

Yi-Fei Qi - Fudan University

Rong Sheng - Zhejiang University

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