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Jia-Yu Liao
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, English
Heterocyclic Compounds
Synthesis
Biological Activity
Drug Design
Structure-Activity Relationship
Ai
Drug Discovery
Medicinal Chemistry
Organic Synthesis
Areas of Focus
- Synthesis Methodology and Biological Activity of Heterocyclic Compounds
- Drug Design, Synthesis, and Structure-Activity Relationship
- AI-Assisted Drug Discovery
Work Experience
- 2019.6-Present - Zhejiang University, College of Pharmaceutical Sciences - Distinguished Researcher
- 2018.5-2019.5 - Novartis Pharmaceuticals Technology Co., Ltd., Suzhou - Senior Scientist
- 2017.8-2018.5 - National University of Singapore, Department of Chemistry - Postdoctoral Researcher
- 2016.5-2016.11 - National University of Singapore, Department of Chemistry - Research Assistant
Academic Background & Achievements
- 2012.8-2016.9 PhD in Organic Chemistry: National University of Singapore
- 2008.9-2012.6 Bachelor's in Pharmacy: Zhejiang University
Publications
- Atroposelective synthesis of eight-membered lactam-bridged N-arylindoles via stepwise cut-and-sew strategy, Ling-Fei Tao, Fen Huang, Xin Zhao, Linghui Qian, Jia-Yu Liao, 2023
- The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics, Linghui Qian, Xuefen Lin, Xue Gao, Rizwan Ullah Khan, Jia-Yu Liao, Shubo Du, Jingyan Ge, Su Zeng, Shao Q. Yao, 2023
- Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality, Fen Huang, Ling-Fei Tao, Jiyong Liu, Linghui Qian, Jia-Yu Liao, 2023
- pH-Triggered cancer-targeting polymers: From extracellular accumulation to intracellular release, Rizwan Ullah Khan, Jinning Shao, Jia-Yu Liao, Linghui Qian, 2023
- Sensitive Imaging of Cellular RNA via Cascaded Proximity-Induced Fluorogenic Reactions, Zhiyan Chen, Wen-Tao Wang, Wenchao Wang, Jinsong Huang, Jia-Yu Liao, Su Zeng, Linghui Qian, 2022
- Torsional Strain-Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers, Zhang-Hong Luo, Wen-Tao Wang, Tian-Yi Tang, Sen Zhang, Fen Huang, Dan Hu, Ling-Fei Tao, Linghui Qian, Jia-Yu Liao, 2022
- Catalytic Asymmetric [3+3] Cycloaddition of Activated Isocyanides with Azomethine Imines, Ling-Fei Tao, Linghui Qian, Jia-Yu Liao, 2022
- Simultaneous Construction of C-N Axial and Central Chirality via Silver-Catalyzed Desymmetrizative [3+2] Cycloaddition of Prochiral N‑Aryl Maleimides with Activated Isocyanides, Sen Zhang, Zhang-Hong Luo, Wen-Tao Wang, Linghui Qian, Jia-Yu Liao, 2022
- Cooperative catalysis-enabled C-N bond cleavage of biaryl lactams with activated isocyanides, Wen-Tao Wang, Sen Zhang, Ling-Fei Tao, Zi-Qi Pan, Linghui Qian, Jia-Yu Liao, 2022
- Introducing… profile, Jia-Yu Liao, 2022
- Diastereo- and Enantioselective Silver-Catalyzed [3+3] Cycloaddition and Kinetic Resolution of Azomethine Imines with Activated Isocyanides, Ling-Fei Tao, Sen Zhang, Fen Huang, Wen-Tao Wang, Zhang-Hong Luo, Linghui Qian, Jia-Yu Liao, 2022
- Prediction of Maximum Absorption Wavelength Using Deep Neural Networks, Jinning Shao, Yue Liu, Jiaqi Yan, Ze-Yi Yan, Yangyang Wu, Zhongying Ru, Jia-Yu Liao, Xiaoye Miao, Linghui Qian, 2022
- In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s, Yulong Kong, Kui Zeng, Ying Zhang, Jinning Shao, Jiaqi Yan, Jia-Yu Liao, Wenchao Wang, Xiaoyang Dai, Qinjie Weng, Shao Q. Yao, Su Zeng, Linghui Qian, 2022
- Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides, Linghui Qian, Ling-Fei Tao, Wen-Tao Wang, Ehtesham Jameel, Zhang-Hong Luo, Tao Zhang, Yu Zhao, Jia-Yu Liao, 2021
- Isocyanides: Promising Species in Bioorthogonal Labeling of Biomolecules, Yuchen Zhu, Jia-Yu Liao, Linghui Qian, 2021
- Cobalt-Catalyzed Enantioselective Hydroboration/Cyclization of 1,7-Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers, Caizhi Wu, Jiayu Liao, Shaozhong Ge, 2019
- Divergent, Enantioselective Synthesis of Pyrroles, 3H-Pyrroles and Bicyclic Imidazolines by Ag- or P-Catalyzed [3+2] Cycloaddition of Allenoates with Activated Isocyanides, Germaine Pui Yann Kok, Pan-Lin Shao, Jia-Yu Liao, Siti Nur Fairuz Bte Sheikh Ismail, Weijun Yao, Yixin Lu, Yu Zhao, 2018
- Catalyst-Enabled Scaffold Diversity: Highly Chemo- and Stereoselective Synthesis of Tricyclic Ketals and Triarylmethanes, Jia-Yu Liao, Qijian Ni, Yu Zhao, 2017
- Three-Component Reactions of Isocyanoacetates, Amines and 3-Formylchromones Initiated by an Unexpected aza-Michael Addition, Jia-Yu Liao, Wei Jie Yap, Ji'En Wu, Ming Wah Wong, Yu Zhao, 2017
- Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3+2] Cyclization of Allenoates with Activated Isocyanides, Jia-Yu Liao, Pan-Lin Shao, Yu Zhao, 2015
- Highly Diastereo- and Enantioselective Silver-Catalyzed Double [3+2] Cyclization of α-Imino Esters with Isocyanoacetate, Pan-Lin Shao, Jia-Yu Liao, Yee Ann Ho, Yu Zhao, 2014
- Comparison of Three Methods on Assay for Vitamin A: UV, NP-HPLC and RP-HPLC, Linghui Qian, Jiayu Liao, Yani Li, Xiaofan Mo, Li Ma, Tongwei Yao, 2012
