2006-2011: Ph.D. in Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2002-2006: Bachelor's in Biotechnology, Guangxi University
Young Changjiang Scholar of the Ministry of Education
Outstanding Youth of the National Natural Science Foundation
Youth Chief Scientist of the National Key R&D Program of the Ministry of Science and Technology
High-level Overseas Innovative Talent of Zhejiang Province
International Young Chemical Biologist Award
Fok Ying Tung Young Teacher Award of the Ministry of Education
Graduate Student Mentor Award of Zhejiang University School of Pharmacy
2023-present: Tenured Associate Professor, Group Leader, Doctoral Supervisor, Zhejiang University School of Pharmacy
2016-2023: Tenure-track Researcher, Group Leader, Doctoral Supervisor, Zhejiang University School of Pharmacy
2014-2016: Postdoctoral Researcher, University of Southern California, Biology and Chemistry
2011-2014: Postdoctoral Researcher, Scripps Research Institute, Structural and Computational Biology
2022-present: Adjunct Professor, Second Affiliated Hospital of Zhejiang University School of Medicine
2020-2021: Deputy Director, Zhejiang University Hangzhou International Science and Innovation Center
2019-present: Director, Zhejiang University-Moscow Institute of Physics and Technology Joint Research Center for Structural Biology and Drug Discovery
2018-present: Member, Analytical Pharmacology Professional Committee, Chinese Pharmacological Society
2017-2022: Director, Precision Drug Target Structure Research Center, Zhejiang University Hangzhou Innovation Institute of Medicine
2017-present: Board Member, International Chemical Biology Society
Young Changjiang Scholar of the Ministry of Education
Outstanding Youth of the National Natural Science Foundation
Youth Chief Scientist of the National Key R&D Program of the Ministry of Science and Technology
High-level Overseas Innovative Talent of Zhejiang Province
International Young Chemical Biologist Award
Fok Ying Tung Young Teacher Award of the Ministry of Education
Graduate Student Mentor Award of Zhejiang University School of Pharmacy
Research
Structural Biology Pharmacology Chemical Biology
Structural Insights into Angiotensin Receptor Signaling Modulation by Balanced and Biased Agonists, Dongqi Zhang, Yongfeng Liu, Saheem A. Zaidi, Lingyi Xu, Yuting Zhan, Anqi Chen, Jiangtao Guo, Xi-Ping Huang, Bryan L. Roth, Vsevolod Katritch, Vadim Cherezov, Haitao Zhang, 2023
Structures of Human Gastrin-Releasing Peptide Receptors Bound to Antagonist and Agonist for Cancer and Itch Therapy, Shuman Peng, Yuting Zhan, Dongqi Zhang, Lu Ren, Anqi Chen, Zhou-Feng Chen, Haitao Zhang, 2023
Heterodimerization of human UDP-glucuronosyltransferase (UGT) 1A9 and UGT2B7 alters their glucuronidation activities, Jia Xue, Jiayi Yin, Jing Nie, Huidi Jiang, Haitao Zhang, Su Zeng, 2023
Function and structure of bradykinin receptor 2 for drug Discovery, Jinkang Shen, Haitao Zhang, 2023
Structural basis for recognition of antihistamine drug by human histamine receptor, Xueqian Peng, Linlin Yang, Zixuan Liu, Siyi Lou, Shiliu Mei, Meiling Li, Zhong Chen, Haitao Zhang, 2022
Cryo-EM structures of human bradykinin receptor-Gq proteins complexes, Jinkang Shen, Dongqi Zhang, Yao Fu, Anqi Chen, Xiaoli Yang, Haitao Zhang, 2022
Integrate thermostabilized fusion protein apocytochrome b562RIL and N-glycosylation mutations: A novel approach to heterologous expression of human UDP-glucuronosyltransferase (UGT) 2B7, Jia Xue, Haitao Zhang, Su Zeng, 2022
Structures of EBI2 shed light on the treatment of autoimmune diseases, Jinkang Shen, Haitao Zhang, 2022
Structural insights into ligand recognition and activation of angiotensin receptors, Haitao Zhang, Aleksandra Luginina, Alexey Mishin, Mithu Baidya, Arun K Shukla, Vadim Cherezov, 2021
Isolation and characterization of charge variants of infliximab biosimilar HS626, Junjie Yuan, Dong Gao, Feng Hu, Yang Shi, Zhenhua Wu, Chuanqin Hu, Xiaodong Huang, Weijie Fang, Haitao Zhang, Haibin Wang, 2021
Structural basis for selectivity and diversity in angiotensin II receptors, Haitao Zhang, Gye Won Han, Alexander Batyuk, Andrii Ishchenko, Kate L. White, Nilkanth Patel, Anastasiia Sadybekov, Beata Zamlynny, Michael T. Rudd, Kaspar Hollenstein, Alexandra Tolstikova, Thomas A. White, Mark S. Hunter, Uwe Weierstall, Wei Liu, Kerim Babaoglu, Eric L. Moore, Ryan D. Katz, Jennifer M. Shipman, Margarita Garcia-Calvo, Sujata Sharma, Payal Sheth, Stephen M. Soisson, Raymond C. Stevens, Vsevolod Katritch, Vadim Cherezov, 2017
Serial femtosecond crystallography datasets from G protein-coupled receptors, Thomas A. White, Anton Barty, Wei Liu, Andrii Ishchenko, Haitao Zhang, Cornelius Gati, Nadia A. Zatsepin, Shibom Basu, Dominik Oberthür, Markus Metz, Kenneth R. Beyerlein, Chun Hong Yoon, Oleksandr M. Yefanov, Daniel James, Dingjie Wang, Marc Messerschmidt, Jason E. Koglin, Sébastien Boutet, Uwe Weierstall, Vadim Cherezov, 2016
Structural basis for bifunctional peptide recognition at human delta-Opioid receptor, Gustavo Fenalti, Nadia A Zatsepin, Cecilia Betti, Patrick Giguere, Gye Won Han, Andrii Ishchenko, Wei Liu, Karel Guillemyn, Haitao Zhang, Daniel James, Dingjie Wang, Uwe Weierstall, John C H Spence, Sébastien Boutet, Marc Messerschmidt, Garth J Williams, Cornelius Gati, Oleksandr M Yefanov, Thomas A White, Dominik Oberthuer, Markus Metz, Chun Hong Yoon, Anton Barty, Henry N Chapman, Shibom Basu, Jesse Coe, Chelsie E Conrad, Raimund Fromme, Petra Fromme, Dirk Tourwe, Peter W Schiller, Bryan L Roth, Steven Ballet, Vsevolod Katritch, Raymond C Stevens, Vadim Cherezov, 2015
Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography, Haitao Zhang, Hamiyet Unal, Cornelius Gati, Gye Won Han, Wei Liu, Nadia A. Zatsepin, Daniel James, Dingjie Wang, Garrett Nelson, Uwe Weierstall, Michael R. Sawaya, Qingping Xu, Marc Messerschmidt, Garth J. Williams, Sebastien Boutet, Oleksandr M. Yefanov, Thomas A. White, Chong Wang, Andrii Ishchenko, Kalyan C. Tirupula, Russell Desnoyer, Jesse Coe, Chelsie E. Conrad, Petra Fromme, Raymond C. Stevens, Vsevolod Katritch, Sadashiva S. Karnik, Vadim Cherezov, 2015
Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor, Haitao Zhang, Hamiyet Unal, Russell Desnoyer, Gye Won Han, Nilkanth Patel, Vsevolod Katritch, Sadashiva S. Karnik, Vadim Cherezov, Raymond C. Stevens, 2015
Exploring NAG-thiazoline and its derivatives as inhibitors of chitinolytic beta-acetylglucosaminidases, Tian Liu, Meng Xia, Haitao Zhang, Hao Zhou, Jing Wang, Xu Shen, Qing Yang, 2015
(+)-Rutamarin as a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis in insulin-resistant mice, Yu Zhang, Haitao Zhang, Xin-gang Yao, Hong Shen, Jing Chen, Chenjing Li, Lili Chen, Mingyue Zheng, Jiming Ye, Lihong Hu, Xu Shen, Hualiang Jiang, 2012
Structural basis for retinoic X receptor repression on the tetramer, Haitao Zhang, Lili Chen, Jing Chen, Hualiang Jiang, Xu Shen, 2011
Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor, Haitao Zhang, Rong Zhou, Li Li, Jing Chen, Lili Chen, Chenjing Li, Hong Ding, Liang Yu, Lihong Hu, Hualiang Jiang, Xu Shen, 2011
Keywords
Protein StructureDrug DiscoveryMolecular MechanismsBiomolecular InteractionsPharmacodynamicsPharmacokineticsChemical ProbesBiochemical AssaysTherapeutic TargetsSignal Transduction
Area of Focus
Drug Discovery | Pharmacology | Clinical Trials | New Drug Development | Pharmaceutical Research | Medicinal Chemistry | Biotechnology | Pharmacokinetics | Pharmacodynamics | Therapeutics
