Professor | Wei Xie | Asia Growth Partners

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Name	Wei Xie
Contact Information	xie_wei@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Wei Xie

Contact Information

xie_wei@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2007 - Bachelor's Degree: Shandong University 2013 - PhD: Institute of Biophysics, Chinese Academy of Sciences Developed small molecule inhibitors targeting cGAS and novel STING agonists
Work Experience	2013-2016 - Tianjin University - Lecturer 2016-2021 - Memorial Sloan Kettering Cancer Center - Postdoctoral Researcher 2021-Present - Zhejiang University - Researcher, Doctoral Supervisor
Awards	National High-Level Overseas Young Talent

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2007 - Bachelor's Degree: Shandong University
2013 - PhD: Institute of Biophysics, Chinese Academy of Sciences
Developed small molecule inhibitors targeting cGAS and novel STING agonists

Work Experience

2013-2016 - Tianjin University - Lecturer
2016-2021 - Memorial Sloan Kettering Cancer Center - Postdoctoral Researcher
2021-Present - Zhejiang University - Researcher, Doctoral Supervisor

Awards

National High-Level Overseas Young Talent

Areas of Focus	Pharmacology of anti-infection/anti-tumor drugs based on nucleic acid recognition mechanisms Intelligent molecular intervention and mechanism of action of important drug targets related to nucleic acids in immunity and infection Drug discovery and molecular mechanisms
Publications	Advances in structure-guided mechanisms impacting on the cGAS-STING innate immune pathway, Chen KX, Liao JL, Patel DJ, Xie W, 2023 Arabinose- and xylose-modified analogs of 2′, 3′-cGAMP act as STING agonists, Xie W, Lama L, Yang XJ, Kuryavyi V, Bhattacharya S, Nudelman I, Yang GL, Ouerfelli O, Glickman JF, Jones RA, Tuschl T, Patel DJ, 2023 细胞核内液-液相分离作为抗肿瘤药物靶点的研究进展, 陈维浩, 谭采薇, 赵青威, 谢伟, 2023 Structure-based mechanisms of 2'3'-cGAMP intercellular transport in the cGAS–STING immune pathway, Xie W, Patel DJ, 2023 cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans, Patel DJ, Yu Y, Xie W, 2023 A ‘warhorse-shaped’ topology adopted by the m6A RNA writer complex, Xie W, Patel DJ, 2023 Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells, Nguyenla X, Wehri E, Dis EV, Biering S, Yamashiro LH, Zhu C, Stroumza J, Dugast-Darzacq C, Graham TGW, Wang XT, Jockusch S, Tao CJ, Chien M, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Russo JJ, Ju JY, Näär AM, Stanley S, Schaletzky J, 2022 A structural platform for B cell receptor signaling, Xie W, Wucherpfennig K, Patel DJ, 2022 Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture, Wang XT, Sacramento CQ, Jockusch S, Chaves OA, Tao CJ, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TM, Ju JY, 2022 The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites, Riward CM, Tong XR, Xie W, Abel S, Orchard LM, Daher W, Patel DJ, Llinás M, Le Roch KG, Kafsack B, 2022 m6A mRNA catalyzes a phase-separated nuclear body that controls differentiation, Cheng Y, Xie W, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, Nguyen DT, Barin E, Velleca A, Rohwetter T, Patel DJ, Jaffrey SR, Kharas MG, 2021 In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, et al., 2021 DNA-driven condensation assembles the meiotic DNA break machinery, Bouuaert CC, Pu S, Wang J, Oger C, Daccache D, Xie W, Patel DJ, Keeney S, 2021 Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex, Xie W, Wang S, Wang J, de la Cruz MJ, Xu G, Scaltriti M, Patel DJ, 2021 The Card1 nuclease provides defence during type III CRISPR immunity, Rostøl JT, Xie W, Kuryavyi V, Maguin P, Kao K, Froom R, Patel DJ, Marraffini LA, 2021 In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates, Ma W, Zhen G, Xie W, Mayr C, 2021 Structure-function analysis of microRNA 3′-end trimming by Nibbler, Xie W, Sowemimo I, Hayashi R, Wang J, Burkard TR, Brennecke J, Ameres SL, Patel DJ, 2020 Keeping innate immune response in check: when cGAS meets the nucleosome, Xie W, Patel DJ, 2020 Structure–function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex, Jia N, Xie W, de la Cruz MJ, Eng ET, Patel DJ, 2020 REV7 has a dynamic adaptor region to accommodate small GTPase RAN/Shigella IpaB ligands, and its activity is regulated by RanGTP/GDP switch, Wang X, Pernicone N, Pertz L, Hua DP, Zhang TQ, Listovsky T, Xie W, 2019 The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation, Batki J, Schnabl J, Wang J, Handler D, Andreev VI, Stieger CE, Novatchkova M, Lampersberger L, Kauneckaite K, Xie W, Karl M, Patel DJ, Brennecke J, 2019 Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia, Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG, 2019 Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation, Xie W, Lama L, Adura C, Glickman JF, Tuschl T, Patel DJ, 2019 Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression, Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano K, Hashizume S, Aida J, Imaeda T, Okamato R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinkwe P, Glickman JF, Patel DJ, Tuschl T, 2019 TRF2 binds branched DNA to safeguard telomere integrity, Schmutz I, Timashev L, Xie W, Patel DJ, de Lange T, 2017 Structural studies of the periplasmic portion of the diguanylate cyclase CdgH from Vibrio cholerae, Xu M, Wang YZ, Yang XA, Jiang T, Xie W, 2017 A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro, Wang D, Chen C, Liu S, Zhou H, Yang K, Zhao Q, Ji X, Chen C, Xie W, Wang ZF, Mi LZ, Yang HT, 2017 The conformational changes of Zika virus methyltransferase upon converting SAM to SAH, Zhou H, Wang F, Wang H, Chen C, Zhang T, Han X, Wang D, Chen C, Wu C, Xie W, Wang ZF, Zhang L, Wang L, Yang HT, 2017 The crystal structure of Zika virus helicase: basis for antiviral drug design, Tian H, Ji X, Yang X, Xie W, Yang K, Chen C, Wu C, Chi H, Mu Z, Wang ZF, Yang HT, 2016 Structural basis of Zika virus helicase in recognizing its substrates, Tian H, Ji X, Yang X, Zhang Z, Lu Z, Yang K, Chen C, Zhao Q, Chi H, Mu Z, Xie W, Wang Z, Lou H, Yang HT, Rao ZH, 2016 Structural insight into the assembly of human anti-HIV dynamin-like protein MxB/Mx2, Xu B, Kong J, Wang X, Wei W, Xie W, Yu XF, 2015 Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid, Kong J, Xu B, Wei W, Wang X, Xie W, Yu XF, 2014 Structural insights into the assembly of human translesion polymerase complexes, Xie W, Yang X, Xu M, Jiang T, 2012 Structure and functional implications of the human Rad9-Hus1-Rad1 cell cycle checkpoint complex, Xu M, Bai L, Gong Y, Xie W, Hang H, Jiang T, 2009

Areas of Focus

Pharmacology of anti-infection/anti-tumor drugs based on nucleic acid recognition mechanisms
Intelligent molecular intervention and mechanism of action of important drug targets related to nucleic acids in immunity and infection
Drug discovery and molecular mechanisms

Publications

Advances in structure-guided mechanisms impacting on the cGAS-STING innate immune pathway, Chen KX, Liao JL, Patel DJ, Xie W, 2023
Arabinose- and xylose-modified analogs of 2′, 3′-cGAMP act as STING agonists, Xie W, Lama L, Yang XJ, Kuryavyi V, Bhattacharya S, Nudelman I, Yang GL, Ouerfelli O, Glickman JF, Jones RA, Tuschl T, Patel DJ, 2023
细胞核内液-液相分离作为抗肿瘤药物靶点的研究进展, 陈维浩, 谭采薇, 赵青威, 谢伟, 2023
Structure-based mechanisms of 2'3'-cGAMP intercellular transport in the cGAS–STING immune pathway, Xie W, Patel DJ, 2023
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans, Patel DJ, Yu Y, Xie W, 2023
A ‘warhorse-shaped’ topology adopted by the m6A RNA writer complex, Xie W, Patel DJ, 2023
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells, Nguyenla X, Wehri E, Dis EV, Biering S, Yamashiro LH, Zhu C, Stroumza J, Dugast-Darzacq C, Graham TGW, Wang XT, Jockusch S, Tao CJ, Chien M, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Russo JJ, Ju JY, Näär AM, Stanley S, Schaletzky J, 2022
A structural platform for B cell receptor signaling, Xie W, Wucherpfennig K, Patel DJ, 2022
Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture, Wang XT, Sacramento CQ, Jockusch S, Chaves OA, Tao CJ, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TM, Ju JY, 2022
The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites, Riward CM, Tong XR, Xie W, Abel S, Orchard LM, Daher W, Patel DJ, Llinás M, Le Roch KG, Kafsack B, 2022
m6A mRNA catalyzes a phase-separated nuclear body that controls differentiation, Cheng Y, Xie W, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, Nguyen DT, Barin E, Velleca A, Rohwetter T, Patel DJ, Jaffrey SR, Kharas MG, 2021
In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, et al., 2021
DNA-driven condensation assembles the meiotic DNA break machinery, Bouuaert CC, Pu S, Wang J, Oger C, Daccache D, Xie W, Patel DJ, Keeney S, 2021
Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex, Xie W, Wang S, Wang J, de la Cruz MJ, Xu G, Scaltriti M, Patel DJ, 2021
The Card1 nuclease provides defence during type III CRISPR immunity, Rostøl JT, Xie W, Kuryavyi V, Maguin P, Kao K, Froom R, Patel DJ, Marraffini LA, 2021
In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates, Ma W, Zhen G, Xie W, Mayr C, 2021
Structure-function analysis of microRNA 3′-end trimming by Nibbler, Xie W, Sowemimo I, Hayashi R, Wang J, Burkard TR, Brennecke J, Ameres SL, Patel DJ, 2020
Keeping innate immune response in check: when cGAS meets the nucleosome, Xie W, Patel DJ, 2020
Structure–function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex, Jia N, Xie W, de la Cruz MJ, Eng ET, Patel DJ, 2020
REV7 has a dynamic adaptor region to accommodate small GTPase RAN/Shigella IpaB ligands, and its activity is regulated by RanGTP/GDP switch, Wang X, Pernicone N, Pertz L, Hua DP, Zhang TQ, Listovsky T, Xie W, 2019
The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation, Batki J, Schnabl J, Wang J, Handler D, Andreev VI, Stieger CE, Novatchkova M, Lampersberger L, Kauneckaite K, Xie W, Karl M, Patel DJ, Brennecke J, 2019
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia, Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG, 2019
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation, Xie W, Lama L, Adura C, Glickman JF, Tuschl T, Patel DJ, 2019
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression, Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano K, Hashizume S, Aida J, Imaeda T, Okamato R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinkwe P, Glickman JF, Patel DJ, Tuschl T, 2019
TRF2 binds branched DNA to safeguard telomere integrity, Schmutz I, Timashev L, Xie W, Patel DJ, de Lange T, 2017
Structural studies of the periplasmic portion of the diguanylate cyclase CdgH from Vibrio cholerae, Xu M, Wang YZ, Yang XA, Jiang T, Xie W, 2017
A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro, Wang D, Chen C, Liu S, Zhou H, Yang K, Zhao Q, Ji X, Chen C, Xie W, Wang ZF, Mi LZ, Yang HT, 2017
The conformational changes of Zika virus methyltransferase upon converting SAM to SAH, Zhou H, Wang F, Wang H, Chen C, Zhang T, Han X, Wang D, Chen C, Wu C, Xie W, Wang ZF, Zhang L, Wang L, Yang HT, 2017
The crystal structure of Zika virus helicase: basis for antiviral drug design, Tian H, Ji X, Yang X, Xie W, Yang K, Chen C, Wu C, Chi H, Mu Z, Wang ZF, Yang HT, 2016
Structural basis of Zika virus helicase in recognizing its substrates, Tian H, Ji X, Yang X, Zhang Z, Lu Z, Yang K, Chen C, Zhao Q, Chi H, Mu Z, Xie W, Wang Z, Lou H, Yang HT, Rao ZH, 2016
Structural insight into the assembly of human anti-HIV dynamin-like protein MxB/Mx2, Xu B, Kong J, Wang X, Wei W, Xie W, Yu XF, 2015
Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid, Kong J, Xu B, Wei W, Wang X, Xie W, Yu XF, 2014
Structural insights into the assembly of human translesion polymerase complexes, Xie W, Yang X, Xu M, Jiang T, 2012
Structure and functional implications of the human Rad9-Hus1-Rad1 cell cycle checkpoint complex, Xu M, Bai L, Gong Y, Xie W, Hang H, Jiang T, 2009

Nucleic Acid Recognition Anti-Infection Anti-Tumor Pharmacology Immune Response Drug Targets Molecular Intervention Mechanism Of Action Drug Discovery Molecular Mechanisms

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