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Yingxia Li
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, Japanese
Drug Design
Optimization
Anti-Tumor
Metabolic Regulation
Small Molecule Drugs
Natural Products
Druggability
Structure-Based
Pharmacology
Chemistry
Areas of Focus
- Structure-based drug design and optimization, mainly including anti-tumor and metabolic regulatory small molecule drugs
- Optimization of druggability based on active natural products
Work Experience
- 1989.08-1998.12 - Qingdao Ocean University - Assistant/ Lecturer/ Associate Professor
- 2001.12-2009.05 - Ocean University of China - Professor
- 2009.06-Present - Fudan University - Professor
Academic Background & Achievements
- 1982.09-1989.07 Bachelor's/Master's: Shandong Ocean University, Chemistry
- 1993.09-1999.06 PhD: Qingdao Ocean University, Pharmacy
- 1995.10-1998.04 Exchange PhD Student: Osaka University, Japan
Publications
- Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma, Chang, Qi; Li, Jiayi; Deng, Yue; Zhou, Ruilin; Wang, Bingwei; Wang, Yujie; Zhang, Mingming; Huang, Xun; Li, Yingxia, 2024
- Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation, He, Yulong; Li, Shunyi; Zhu, Yueyue; Wang, Yujie; Chen, Yuqi; Zhang, Deqiang; Wang, Heyao; Li, Yingxia, 2023
- Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim, Wang, Xianyang; Wang, Yujie; Zhu, Yueyue; Lei, Xinsheng; Zhang, Mingming; Li, Yingxia, 2022
- Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines, Liu, Ruiqi; Yang, Hong; Chen, Zonglong; Zhou, Kaixin; Shi, Qiongyu; Li, Jiayi; Huang, Yuting; Huang, Xun; Li, Yingxia, 2022
- Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells, Chen, Zonglong; Li, Jiayi; Yang, Hong; He, Yulong; Shi, Qiongyu; Chang, Qi; Liu, Ruiqi; Huang, Xun; Li, Yingxia, 2022
- Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors, Gao, Dingding; Jin, Nan; Fu, Yixian; Zhu, Yueyue; Wang, Yujie; Wang, Ting; Chen, Yuehong; Zhang, Mingming; Xiao, Qiang; Huang, Min; Li, Yingxia, 2021
- Synthesis and biological evaluation of novel cabazitaxel analogues, Ren, Sumei; Zhang, Minmin; Wang, Yujie; Guo, Jia; Wang, Junfei; Li, Yingxia; Ding, Ning, 2021
- Palladium-Catalysed C(sp3)-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids, Liu, Yichu; Wang, Yibing; Dai, Wenhao; Huang, Wei; Li, Yingxia; Liu, Hong, 2020
Awards
- Shanghai Outstanding Academic Leader
