Professor | Yingxia Li | Asia Growth Partners

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Name	Yingxia Li
Contact Information	liyx417@fudan.edu.cn
Language ability	Chinese, Japanese
Province	Shanghai

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Name

Yingxia Li

Contact Information

liyx417@fudan.edu.cn

Language ability

Chinese, Japanese

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1982.09-1989.07 Bachelor's/Master's: Shandong Ocean University, Chemistry 1993.09-1999.06 PhD: Qingdao Ocean University, Pharmacy 1995.10-1998.04 Exchange PhD Student: Osaka University, Japan
Work Experience	1989.08-1998.12 - Qingdao Ocean University - Assistant/ Lecturer/ Associate Professor 2001.12-2009.05 - Ocean University of China - Professor 2009.06-Present - Fudan University - Professor
Awards	Shanghai Outstanding Academic Leader

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1982.09-1989.07 Bachelor's/Master's: Shandong Ocean University, Chemistry
1993.09-1999.06 PhD: Qingdao Ocean University, Pharmacy
1995.10-1998.04 Exchange PhD Student: Osaka University, Japan

Work Experience

1989.08-1998.12 - Qingdao Ocean University - Assistant/ Lecturer/ Associate Professor
2001.12-2009.05 - Ocean University of China - Professor
2009.06-Present - Fudan University - Professor

Awards

Shanghai Outstanding Academic Leader

Areas of Focus	Structure-based drug design and optimization, mainly including anti-tumor and metabolic regulatory small molecule drugs Optimization of druggability based on active natural products
Publications	Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma, Chang, Qi; Li, Jiayi; Deng, Yue; Zhou, Ruilin; Wang, Bingwei; Wang, Yujie; Zhang, Mingming; Huang, Xun; Li, Yingxia, 2024 Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation, He, Yulong; Li, Shunyi; Zhu, Yueyue; Wang, Yujie; Chen, Yuqi; Zhang, Deqiang; Wang, Heyao; Li, Yingxia, 2023 Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim, Wang, Xianyang; Wang, Yujie; Zhu, Yueyue; Lei, Xinsheng; Zhang, Mingming; Li, Yingxia, 2022 Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines, Liu, Ruiqi; Yang, Hong; Chen, Zonglong; Zhou, Kaixin; Shi, Qiongyu; Li, Jiayi; Huang, Yuting; Huang, Xun; Li, Yingxia, 2022 Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells, Chen, Zonglong; Li, Jiayi; Yang, Hong; He, Yulong; Shi, Qiongyu; Chang, Qi; Liu, Ruiqi; Huang, Xun; Li, Yingxia, 2022 Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors, Gao, Dingding; Jin, Nan; Fu, Yixian; Zhu, Yueyue; Wang, Yujie; Wang, Ting; Chen, Yuehong; Zhang, Mingming; Xiao, Qiang; Huang, Min; Li, Yingxia, 2021 Synthesis and biological evaluation of novel cabazitaxel analogues, Ren, Sumei; Zhang, Minmin; Wang, Yujie; Guo, Jia; Wang, Junfei; Li, Yingxia; Ding, Ning, 2021 Palladium-Catalysed C(sp3)-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids, Liu, Yichu; Wang, Yibing; Dai, Wenhao; Huang, Wei; Li, Yingxia; Liu, Hong, 2020

Areas of Focus

Structure-based drug design and optimization, mainly including anti-tumor and metabolic regulatory small molecule drugs
Optimization of druggability based on active natural products

Publications

Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma, Chang, Qi; Li, Jiayi; Deng, Yue; Zhou, Ruilin; Wang, Bingwei; Wang, Yujie; Zhang, Mingming; Huang, Xun; Li, Yingxia, 2024
Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation, He, Yulong; Li, Shunyi; Zhu, Yueyue; Wang, Yujie; Chen, Yuqi; Zhang, Deqiang; Wang, Heyao; Li, Yingxia, 2023
Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim, Wang, Xianyang; Wang, Yujie; Zhu, Yueyue; Lei, Xinsheng; Zhang, Mingming; Li, Yingxia, 2022
Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines, Liu, Ruiqi; Yang, Hong; Chen, Zonglong; Zhou, Kaixin; Shi, Qiongyu; Li, Jiayi; Huang, Yuting; Huang, Xun; Li, Yingxia, 2022
Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells, Chen, Zonglong; Li, Jiayi; Yang, Hong; He, Yulong; Shi, Qiongyu; Chang, Qi; Liu, Ruiqi; Huang, Xun; Li, Yingxia, 2022
Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors, Gao, Dingding; Jin, Nan; Fu, Yixian; Zhu, Yueyue; Wang, Yujie; Wang, Ting; Chen, Yuehong; Zhang, Mingming; Xiao, Qiang; Huang, Min; Li, Yingxia, 2021
Synthesis and biological evaluation of novel cabazitaxel analogues, Ren, Sumei; Zhang, Minmin; Wang, Yujie; Guo, Jia; Wang, Junfei; Li, Yingxia; Ding, Ning, 2021
Palladium-Catalysed C(sp3)-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids, Liu, Yichu; Wang, Yibing; Dai, Wenhao; Huang, Wei; Li, Yingxia; Liu, Hong, 2020

Drug Design Optimization Anti-Tumor Metabolic Regulation Small Molecule Drugs Natural Products Druggability Structure-Based Pharmacology Chemistry

Wenfu Tan - Fudan University

Wei Xie - Zhejiang University

Meihua Yu - Fudan University

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