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Wenfu Tan
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, English
Anti-Tumor
Drug Activity
In Vitro
In Vivo
Evaluation
Molecular Targeted
Drug Development
Pharmacology
Cancer
Therapy
Areas of Focus
- In vitro and in vivo evaluation of anti-tumor drug activity
- Development of molecular targeted anti-tumor drugs
Work Experience
- 2017/12 - Present - Fudan University - Researcher
- 2009/7 - 2017/12 - Fudan University - Associate Researcher
- 2008/4 - 2009/4 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Associate Researcher
- 2003/10 - 2008/4 - National Institutes of Health, NIDCR - Visiting Scholar
- 2001/10 - 2003/10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Fellow
Academic Background & Achievements
- 1998/9 - 2001/6 PhD in Clinical Medicine: Tongji Medical University
- 1995/9 - 1998/6 Master's in Clinical Medicine: Hengyang Medical College
- 1990/9 - 1995/6 Bachelor's in Clinical Chinese Medicine: Hunan University of Chinese Medicine
Publications
- Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription, Liu G#, Huang W#, Wang J#, Liu X, Yang J, Zhang Y, Geng Y, Tan W*, Zhang A*, 2017
- Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand, Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W*, Tao H*, Xu F*, 2017
- Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists, Liu G#, Xue D#, Yang J#, Wang J#, Liu X, Huang W, Li J, Long YQ*, Tan W*, Zhang A*, 2016
- Twist1 and Snail link Hedgehog signaling to tumor-initiating cell-like properties and acquired chemoresistance independently of ABC transporters, Kong Y#, Peng Y#, Liu Y#, Xin H, Zhan X, Tan W*, 2015
- GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli, Zhan X, Wang J, Liu Y, Peng Y, Tan W*, 2014
