Professor | Wenfu Tan | Asia Growth Partners

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Name	Wenfu Tan
Contact Information	{'en': 'Email: wftan@@fudan.edu.cn\\nPhone: 021-51980039', 'zh': '电子邮件：wftan@@fudan.edu.cn\\n电话：021-51980039', 'de': 'E-Mail: wftan@@fudan.edu.cn\\nTelefon: 021-51980039'}
Language ability	Chinese, English
Province	Shanghai

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Name

Wenfu Tan

Contact Information

{'en': 'Email: wftan@@fudan.edu.cn\\nPhone: 021-51980039', 'zh': '电子邮件：wftan@@fudan.edu.cn\\n电话：021-51980039', 'de': 'E-Mail: wftan@@fudan.edu.cn\\nTelefon: 021-51980039'}

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1998/9 - 2001/6 PhD in Clinical Medicine: Tongji Medical University 1995/9 - 1998/6 Master's in Clinical Medicine: Hengyang Medical College 1990/9 - 1995/6 Bachelor's in Clinical Chinese Medicine: Hunan University of Chinese Medicine
Work Experience	2017/12 - Present - Fudan University - Researcher 2009/7 - 2017/12 - Fudan University - Associate Researcher 2008/4 - 2009/4 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Associate Researcher 2003/10 - 2008/4 - National Institutes of Health, NIDCR - Visiting Scholar 2001/10 - 2003/10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Fellow

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1998/9 - 2001/6 PhD in Clinical Medicine: Tongji Medical University
1995/9 - 1998/6 Master's in Clinical Medicine: Hengyang Medical College
1990/9 - 1995/6 Bachelor's in Clinical Chinese Medicine: Hunan University of Chinese Medicine

Work Experience

2017/12 - Present - Fudan University - Researcher
2009/7 - 2017/12 - Fudan University - Associate Researcher
2008/4 - 2009/4 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Associate Researcher
2003/10 - 2008/4 - National Institutes of Health, NIDCR - Visiting Scholar
2001/10 - 2003/10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Fellow

Areas of Focus	In vitro and in vivo evaluation of anti-tumor drug activity Development of molecular targeted anti-tumor drugs
Publications	Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription, Liu G#, Huang W#, Wang J#, Liu X, Yang J, Zhang Y, Geng Y, Tan W, Zhang A, 2017 Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand, Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F, 2017 Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists, Liu G#, Xue D#, Yang J#, Wang J#, Liu X, Huang W, Li J, Long YQ, Tan W, Zhang A, 2016 Twist1 and Snail link Hedgehog signaling to tumor-initiating cell-like properties and acquired chemoresistance independently of ABC transporters, Kong Y#, Peng Y#, Liu Y#, Xin H, Zhan X, Tan W, 2015 GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli, Zhan X, Wang J, Liu Y, Peng Y, Tan W, 2014

Areas of Focus

In vitro and in vivo evaluation of anti-tumor drug activity
Development of molecular targeted anti-tumor drugs

Publications

Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription, Liu G#, Huang W#, Wang J#, Liu X, Yang J, Zhang Y, Geng Y, Tan W*, Zhang A*, 2017
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand, Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W*, Tao H*, Xu F*, 2017
Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists, Liu G#, Xue D#, Yang J#, Wang J#, Liu X, Huang W, Li J, Long YQ*, Tan W*, Zhang A*, 2016
Twist1 and Snail link Hedgehog signaling to tumor-initiating cell-like properties and acquired chemoresistance independently of ABC transporters, Kong Y#, Peng Y#, Liu Y#, Xin H, Zhan X, Tan W*, 2015
GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli, Zhan X, Wang J, Liu Y, Peng Y, Tan W*, 2014

Anti-Tumor Drug Activity In Vitro In Vivo Evaluation Molecular Targeted Drug Development Pharmacology Cancer Therapy

Yingxia Li - Fudan University

Weili Zhao - Fudan University

Wei Xie - Zhejiang University

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