Upload Avatar (500 x 500)
Weili Zhao
Pharmaceutical Sciences
Fudan University
Shanghai
Language: English, Chinese, German
Anti-Tumor
Small Molecule
Targeted Drugs
Organic Synthesis
Fluorescent Probes
Sensors
Drug Development
Photodynamic Therapy
Bioimaging
Chemical Research
Areas of Focus
- Research on anti-tumor small molecule targeted drugs
- Organic synthesis methods
- Fluorescent probes and sensors
Work Experience
- 2009.04-Present - Fudan University - Researcher, Doctoral Supervisor
- 2005.11-2009.03 - Roche R&D (China) Co., Ltd. - Deputy Director, Director of Drug Development
- 2002.10-2005.11 - Swiss Federal Institute of Technology Zurich - 'Wissenschaftlicher Mitarbeiter'
- 1990.07-1994.07 - Henan University - Assistant Lecturer, Lecturer
Academic Background & Achievements
- 1998.10-2002.10 Postdoctoral: Swiss Federal Institute of Technology Zurich
- 1998.07-1998.10 Postdoctoral: California Institute of Technology
- 1997.07-1998.07 Visiting Scholar: University of California, Irvine
- 1994.07-1997.07 Ph.D.: Institute of Photographic Chemistry, Chinese Academy of Sciences
- 1987.07-1990.07 M.Sc.: Institute of Photographic Chemistry, Chinese Academy of Sciences
- 1983.07-1987.07 B.Sc.: Department of Chemistry, Wuhan University
Publications
- Discovery of an Amino Acid-Modified Near-Infrared Aza-BODIPY Photosensitizer as an Immune Initiator for Potent Photodynamic Therapy in Melanoma, Zhiliang Yu, Hong Wang, Zhongjian Chen, Xiaochun Dong, Weili Zhao*, Yuling Shi*, Quangang Zhu*, 2022
- Development of environment-insensitive and highly emissive BODIPYs via installation of N, N’-dialkylsubstituted amide at meso position, Junping Bai, Junliang Zhou, Xin Ji, Nannan Wang, Xiaochun Dong*, Wei Wu*, Weili Zhao*, 2022
- Near-infrared fluorophores with absolute aggregation-caused quenching and negligible fluorescence re-illumination for in vivo bioimaging of nanocarriers, Yifan Cai, Xin Ji, Yunsen Zhang, Chang Liu, Zichen Zhang, Yongjiu Lv, Xiaochun Dong, Haisheng He, Jianping Qi, Yi Lu, Defang Ouyang*, Weili Zhao*, Wei Wu*, 2022
- Accurate and sensitive probing of onset of micellization based on absolute aggregation-caused quenching effect, Haisheng He, Chang Liu, Jiang Ming, Yongjiu Lv, Jianping Qi, Yi Lu, Xiaochun Dong, Weili Zhao*, Wei Wu*, 2022
- Discovery of meso-(meta-pyridinium) BODIPY photosensitizers: In vitro and in vivo evaluations for antimicrobial photodynamic therapy, Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li*, Xiaochun Dong*,Weili Zhao*, 2021
- Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy, Zhiliang Yu, Junliang Zhou, Xin Ji, Guangyu Lin, Shuang Xu, Xiaochun Dong*, Weili Zhao*, 2020
- Anchoring BODIPY photosensitizers enable pan-microbial photoinactivation, Kedan Gu, Guangyu Lin, Yuanxing Zhu, Xin Ji, Jiyang Li*, Xiaochun Dong*, Weili Zhao*, 2020
- Azetidine-Containing Heterospirocycles Enhance the Performance of Fluorophores, Junliang Zhou, Xianfeng Lin, Xin Ji, Shuang Xu, Chang Liu, Xiaochun Dong*, Weili Zhao*, 2020
- Response to Comment on “Water-Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability Superoxide Detection in Live Cells and in Zebrafish Embryos”, Xiuhong Lu, Guangyu Lin, Xiaochun Dong*, Weili Zhao*, Zhongjian Chen*, 2019
- Fluorescent probe for sensitive discrimination of Hcy and Cys/GSH in living cells via dual-emission, Shuang Xu, Junliang Zhou, Xiaochun Dong*, Weili Zhao*, Quangang Zhu*, 2019
- Visualizing Nitric Oxide in Mitochondria and Lysosomes of Living Cells with N-Nitrosation of BODIPY-based Fluorescent Probes, Zhiliang Yu, Junliang Zhou, Xiaochun Dong*, Weili Zhao*, Zhongjian Chen*, 2019
- Pyridinium substituted BODIPY as NIR fluorescent probe for simultaneous sensing of hydrogen sulphide/glutathione and cysteine/homocysteine, Jian Zhang, Xin Ji, Junliang Zhou, Zhongjian Chen*, Xiaochun Dong*, Weili Zhao*, 2018
- Water-Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos, Xiuhong Lu, Zhongjian Chen*, Xiaochun Dong*, Weili Zhao*, 2018
- Overcoming the resistance mechanisms of Smoothened inhibitors, Xiaochun Dong, Chenglin Wang, Zhongjian Chen*, Weili Zhao*, 2018
- A mitochondria-targeted turn-on fuorescent probe for the detection of glutathione in living cells, Jian Zhang, Xiaolong Bao, Junliang Zhou, Fangfang Peng, Hang Ren, Xiaochun Dong*, Weili Zhao*, 2016
- A multi-functional probe to discriminate Lys, Arg, His, Cys, Hcy and GSH from common amino acids, Xiuhong Lu, Wen Wang, Qian Dong, Xiaolong Bao, Xianfeng Lin, Weixing Zhang, Xiaochun Dong*, Weili Zhao*, 2015
