Professor | Xiaochun Dong | Asia Growth Partners

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Name	Xiaochun Dong
Contact Information	xcdong@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Xiaochun Dong

Contact Information

xcdong@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2004.9-2007.6: Ph.D. in Medicinal Chemistry, Fudan University 2000.9-2003.6: Master's in Medicinal Chemistry, Fudan University 1993.9-1997.6: Bachelor's in Chemistry, East China Normal University
Work Experience	2013.12-Present: Associate Professor, Department of Medicinal Chemistry, Fudan University 2008.9-2009.9: Postdoctoral Researcher, Department of Medicinal Chemistry, University of Minnesota 1997.7-2013.11: Assistant/Instructor, Department of Medicinal Chemistry, Fudan University

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2004.9-2007.6: Ph.D. in Medicinal Chemistry, Fudan University
2000.9-2003.6: Master's in Medicinal Chemistry, Fudan University
1993.9-1997.6: Bachelor's in Chemistry, East China Normal University

Work Experience

2013.12-Present: Associate Professor, Department of Medicinal Chemistry, Fudan University
2008.9-2009.9: Postdoctoral Researcher, Department of Medicinal Chemistry, University of Minnesota
1997.7-2013.11: Assistant/Instructor, Department of Medicinal Chemistry, Fudan University

Areas of Focus	Research on small molecule anti-tumor drugs based on molecular targeting, tumor signaling pathways, and immune-related lead compounds Research on organic drug synthesis methods
Publications	Discovery of Subcellular-Targeted Aza-BODIPY Photosensitizers for Efficient Photodynamic Antitumor Therapy, Chang Liu, Xin Ji, Zhiliang Yu, Shaohui Zhang, Rong Zhang, Weili Zhao, Xiaochun Dong, 2023 A series of meso amide BODIPY based lysosome-targeting fluorescent probe with high photostability and sensitivity, Li Ruan, Junping Bai, Xin Ji, Weili Zhao, Xiaochun Dong, 2022 Access to Pyridinyl or Pyridinium Aza-BODIPYs with Tunable Near-Infrared Fluorescence through ICT from 4-Pyridinyl Pyrroles, Chang Liu, Yue Jin, Xin Ji, Weili Zhao, Xiaochun Dong, 2022 Water-soluble near-infrared fluorescent heptamethine dye for lymphatic mapping applications, Shaohui Zhang, Xin Ji, Rong Zhang, Weili Zhao, Xiaochun Dong, 2022 Discovery of Meso-(meta-Pyridinium) BODIPY Photosensitizers: In Vitro and In Vivo Evaluations for Antimicrobial Photodynamic Therapy, Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li, Xiaochun Dong, Weili Zhao, 2021 Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy, Zhiliang Yu, Junliang Zhou, Xin Ji, Guangyu Lin, Shuang Xu, Xiaochun Dong, Weili Zhao, 2020 Anchoring BODIPY photosensitizers enable pan-microbial photo-inactivation, Kedan Gu, Guangyu Lin, Yuanxing Zhu, Xin Ji, Jiyang Li, Xiaochun Dong, Weili Zhao, 2020 Design, Synthesis and Biological Evaluation of Novel1,2,5-Oxadiazol-3-Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1(IDO1) Inhibitors, Zhifeng Xia, Yanyang Nan, Chang Liu, Guangyu Lin, Kedan Gu, Cheng Chen, Weili Zhao, Dianwen Ju, Xiaochun Dong, 2020 L-4, a well-tolerated and orally active inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against medulloblastoma in vitro and in vivo, Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao, Xiaochun Dong, Xiongwen Zhang, 2019 Overcoming the Resistance mechanisms of Smoothened inhibitors, Xiaochun Dong, Chenglin Wang, Zhongjian Chen, Weili Zhao, 2018 Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors, Chenglin Wang, Mingfei Zhu, Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang, Xiaochun Dong, 2018 Water -Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos, Xiuhong Lu, Zhongjian Chen, Xiaochun Dong, Weili Zhao, 2018 Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors, Xiuhong Lu, Yuanqiu Peng, Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao, Wenfu Tan, Xiaochun Dong, 2017

Areas of Focus

Research on small molecule anti-tumor drugs based on molecular targeting, tumor signaling pathways, and immune-related lead compounds
Research on organic drug synthesis methods

Publications

Discovery of Subcellular-Targeted Aza-BODIPY Photosensitizers for Efficient Photodynamic Antitumor Therapy, Chang Liu, Xin Ji, Zhiliang Yu, Shaohui Zhang, Rong Zhang, Weili Zhao, Xiaochun Dong, 2023
A series of meso amide BODIPY based lysosome-targeting fluorescent probe with high photostability and sensitivity, Li Ruan, Junping Bai, Xin Ji, Weili Zhao, Xiaochun Dong, 2022
Access to Pyridinyl or Pyridinium Aza-BODIPYs with Tunable Near-Infrared Fluorescence through ICT from 4-Pyridinyl Pyrroles, Chang Liu, Yue Jin, Xin Ji, Weili Zhao, Xiaochun Dong, 2022
Water-soluble near-infrared fluorescent heptamethine dye for lymphatic mapping applications, Shaohui Zhang, Xin Ji, Rong Zhang, Weili Zhao, Xiaochun Dong, 2022
Discovery of Meso-(meta-Pyridinium) BODIPY Photosensitizers: In Vitro and In Vivo Evaluations for Antimicrobial Photodynamic Therapy, Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li, Xiaochun Dong, Weili Zhao, 2021
Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy, Zhiliang Yu, Junliang Zhou, Xin Ji, Guangyu Lin, Shuang Xu, Xiaochun Dong, Weili Zhao, 2020
Anchoring BODIPY photosensitizers enable pan-microbial photo-inactivation, Kedan Gu, Guangyu Lin, Yuanxing Zhu, Xin Ji, Jiyang Li, Xiaochun Dong, Weili Zhao, 2020
Design, Synthesis and Biological Evaluation of Novel1,2,5-Oxadiazol-3-Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1(IDO1) Inhibitors, Zhifeng Xia, Yanyang Nan, Chang Liu, Guangyu Lin, Kedan Gu, Cheng Chen, Weili Zhao, Dianwen Ju, Xiaochun Dong, 2020
L-4, a well-tolerated and orally active inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against medulloblastoma in vitro and in vivo, Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao, Xiaochun Dong, Xiongwen Zhang, 2019
Overcoming the Resistance mechanisms of Smoothened inhibitors, Xiaochun Dong, Chenglin Wang, Zhongjian Chen, Weili Zhao, 2018
Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors, Chenglin Wang, Mingfei Zhu, Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang, Xiaochun Dong, 2018
Water -Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos, Xiuhong Lu, Zhongjian Chen, Xiaochun Dong, Weili Zhao, 2018
Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors, Xiuhong Lu, Yuanqiu Peng, Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao, Wenfu Tan, Xiaochun Dong, 2017

Molecular Targeting Tumor Signaling Pathways Immune-Related Small Molecule Anti-Tumor Drugs Lead Compounds Organic Synthesis Drug Synthesis Medicinal Chemistry Research

Yu Sun - Fudan University

Wenteng Chen - Zhejiang University

Xin Wang - Peking University

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