Professor | 董肖椿 | 数字化转型顾问

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Name	董肖椿
Contact Information	xcdong@fudan.edu.cn
Language ability	中文, 英语
Province	上海

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Name

董肖椿

Contact Information

xcdong@fudan.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2004.9-2007.6：复旦大学药学院药物化学专业，博士 2000.9-2003.6：复旦大学药学院药物化学专业，硕士 1993.9-1997.6：华东师范大学化学系化学专业，学士
Work Experience	2013.12-至今：复旦大学药学院药物化学教研室，副教授 2008.9-2009.9：美国明尼苏达大学药学院药物化学系，博士后 1997.7-2013.11：复旦大学药学院药物化学教研室，助教/讲师

University/Lab Affiliation and Title

复旦大学

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2004.9-2007.6：复旦大学药学院药物化学专业，博士
2000.9-2003.6：复旦大学药学院药物化学专业，硕士
1993.9-1997.6：华东师范大学化学系化学专业，学士

Work Experience

2013.12-至今：复旦大学药学院药物化学教研室，副教授
2008.9-2009.9：美国明尼苏达大学药学院药物化学系，博士后
1997.7-2013.11：复旦大学药学院药物化学教研室，助教/讲师

Areas of Focus	基于分子靶向、肿瘤信号通路及免疫相关小分子抗肿瘤药物先导化合物研究有机药物合成方法研究
Publications	Discovery of Subcellular-Targeted Aza-BODIPY Photosensitizers for Efficient Photodynamic Antitumor Therapy, Chang Liu, Xin Ji, Zhiliang Yu, Shaohui Zhang, Rong Zhang, Weili Zhao, Xiaochun Dong, 2023 A series of meso amide BODIPY based lysosome-targeting fluorescent probe with high photostability and sensitivity, Li Ruan, Junping Bai, Xin Ji, Weili Zhao, Xiaochun Dong, 2022 Access to Pyridinyl or Pyridinium Aza-BODIPYs with Tunable Near-Infrared Fluorescence through ICT from 4-Pyridinyl Pyrroles, Chang Liu, Yue Jin, Xin Ji, Weili Zhao, Xiaochun Dong, 2022 Water-soluble near-infrared fluorescent heptamethine dye for lymphatic mapping applications, Shaohui Zhang, Xin Ji, Rong Zhang, Weili Zhao, Xiaochun Dong, 2022 Discovery of Meso-(meta-Pyridinium) BODIPY Photosensitizers: In Vitro and In Vivo Evaluations for Antimicrobial Photodynamic Therapy, Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li, Xiaochun Dong, Weili Zhao, 2021 Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy, Zhiliang Yu, Junliang Zhou, Xin Ji, Guangyu Lin, Shuang Xu, Xiaochun Dong, Weili Zhao, 2020 Anchoring BODIPY photosensitizers enable pan-microbial photo-inactivation, Kedan Gu, Guangyu Lin, Yuanxing Zhu, Xin Ji, Jiyang Li, Xiaochun Dong, Weili Zhao, 2020 Design, Synthesis and Biological Evaluation of Novel1,2,5-Oxadiazol-3-Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1(IDO1) Inhibitors, Zhifeng Xia, Yanyang Nan, Chang Liu, Guangyu Lin, Kedan Gu, Cheng Chen, Weili Zhao, Dianwen Ju, Xiaochun Dong, 2020 L-4, a well-tolerated and orally active inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against medulloblastoma in vitro and in vivo, Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao, Xiaochun Dong, Xiongwen Zhang, 2019 Overcoming the Resistance mechanisms of Smoothened inhibitors, Xiaochun Dong, Chenglin Wang, Zhongjian Chen, Weili Zhao, 2018 Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors, Chenglin Wang, Mingfei Zhu, Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang, Xiaochun Dong, 2018 Water -Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos, Xiuhong Lu, Zhongjian Chen, Xiaochun Dong, Weili Zhao, 2018 Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors, Xiuhong Lu, Yuanqiu Peng, Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao, Wenfu Tan, Xiaochun Dong, 2017

Areas of Focus

基于分子靶向、肿瘤信号通路及免疫相关小分子抗肿瘤药物先导化合物研究
有机药物合成方法研究

Publications

Discovery of Subcellular-Targeted Aza-BODIPY Photosensitizers for Efficient Photodynamic Antitumor Therapy, Chang Liu, Xin Ji, Zhiliang Yu, Shaohui Zhang, Rong Zhang, Weili Zhao, Xiaochun Dong, 2023
A series of meso amide BODIPY based lysosome-targeting fluorescent probe with high photostability and sensitivity, Li Ruan, Junping Bai, Xin Ji, Weili Zhao, Xiaochun Dong, 2022
Access to Pyridinyl or Pyridinium Aza-BODIPYs with Tunable Near-Infrared Fluorescence through ICT from 4-Pyridinyl Pyrroles, Chang Liu, Yue Jin, Xin Ji, Weili Zhao, Xiaochun Dong, 2022
Water-soluble near-infrared fluorescent heptamethine dye for lymphatic mapping applications, Shaohui Zhang, Xin Ji, Rong Zhang, Weili Zhao, Xiaochun Dong, 2022
Discovery of Meso-(meta-Pyridinium) BODIPY Photosensitizers: In Vitro and In Vivo Evaluations for Antimicrobial Photodynamic Therapy, Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li, Xiaochun Dong, Weili Zhao, 2021
Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy, Zhiliang Yu, Junliang Zhou, Xin Ji, Guangyu Lin, Shuang Xu, Xiaochun Dong, Weili Zhao, 2020
Anchoring BODIPY photosensitizers enable pan-microbial photo-inactivation, Kedan Gu, Guangyu Lin, Yuanxing Zhu, Xin Ji, Jiyang Li, Xiaochun Dong, Weili Zhao, 2020
Design, Synthesis and Biological Evaluation of Novel1,2,5-Oxadiazol-3-Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1(IDO1) Inhibitors, Zhifeng Xia, Yanyang Nan, Chang Liu, Guangyu Lin, Kedan Gu, Cheng Chen, Weili Zhao, Dianwen Ju, Xiaochun Dong, 2020
L-4, a well-tolerated and orally active inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against medulloblastoma in vitro and in vivo, Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao, Xiaochun Dong, Xiongwen Zhang, 2019
Overcoming the Resistance mechanisms of Smoothened inhibitors, Xiaochun Dong, Chenglin Wang, Zhongjian Chen, Weili Zhao, 2018
Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors, Chenglin Wang, Mingfei Zhu, Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang, Xiaochun Dong, 2018
Water -Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos, Xiuhong Lu, Zhongjian Chen, Xiaochun Dong, Weili Zhao, 2018
Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors, Xiuhong Lu, Yuanqiu Peng, Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao, Wenfu Tan, Xiaochun Dong, 2017

分子靶向肿瘤信号通路免疫相关小分子抗肿瘤药物先导化合物有机合成药物合成药物化学研究

孙域 - 复旦大学

陈建忠 - 浙江大学

Area of Focus
药物化学 | 药物设计 | 先导化合物 | 优化 | 构效关系 | 药理学 | 合成 | 评价 | 大麻素受体 | 激动剂

陈文腾 - 浙江大学

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