Professor | Peihua Luo | Asia Growth Partners

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Name	Peihua Luo
Contact Information	peihualuo@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Peihua Luo

Contact Information

peihualuo@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	National 'Ten Thousand Talents Program' Young Top-notch Talent Qiu Shi Young Scholar of Zhejiang University Published 37 SCI papers in journals like Cell Research and Autophagy Principal Investigator for 5 National Natural Science Foundation projects Granted 7 Chinese invention patents and 1 US PCT patent Conducted a Phase II clinical trial and received a new drug clinical approval
Work Experience	Current - Zhejiang University - Professor, Doctoral Supervisor, Deputy Director of the Drug Safety Evaluation Research Center
Awards	Second Prize of Science and Technology Progress Award by Ministry of Education Second Prize of Zhejiang Provincial Natural Science Award Second Prize of Zhejiang Provincial Science and Technology Progress Award Outstanding Young Scholar Award at the 1st and 4th International Symposium on Alternative Methods for Toxicity Testing and Translational Toxicology Outstanding Young Pharmacologist Award by the Chinese Pharmacological Society

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

National 'Ten Thousand Talents Program' Young Top-notch Talent
Qiu Shi Young Scholar of Zhejiang University
Published 37 SCI papers in journals like Cell Research and Autophagy
Principal Investigator for 5 National Natural Science Foundation projects
Granted 7 Chinese invention patents and 1 US PCT patent
Conducted a Phase II clinical trial and received a new drug clinical approval

Work Experience

Current - Zhejiang University - Professor, Doctoral Supervisor, Deputy Director of the Drug Safety Evaluation Research Center

Awards

Second Prize of Science and Technology Progress Award by Ministry of Education
Second Prize of Zhejiang Provincial Natural Science Award
Second Prize of Zhejiang Provincial Science and Technology Progress Award
Outstanding Young Scholar Award at the 1st and 4th International Symposium on Alternative Methods for Toxicity Testing and Translational Toxicology
Outstanding Young Pharmacologist Award by the Chinese Pharmacological Society

Areas of Focus	Drug Toxicology Tumor Pharmacology
Publications	Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib, Xu Z, Jin Y, Gao Z, Zeng Y, Du J, Yan H, Chen X, Ping L, Lin N, Yang B, He Q, Luo P, 2021 PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1), Luo P, Yan H, Du J, Chen X, Shao J, Zhang Y, Xu Z, Jin Y, Lin N, Yang B, He Q, 2020 s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide, Luo P, Yan H, Chen X, Zhang Y, Zhao Z, Cao J, Zhu Y, Du J, Xu Z, Zhang X, Zeng S, Yang B, Ma S, He Q, 2020 Bisdemethoxycurcumin alleviates vandetanib-induced cutaneous toxicity in vivo and in vitro through autophagy activation, Jin Y, Chen X, Gao Z, Shen X, Fu H, Pan Z, Yan H, Yang B, He Q, Xu Z, Luo P, 2021 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib, Du J, Li G, Jiang L, Zhang X, Xu Z, Yan H, Zhou Z, He Q, Yang X, Luo P, 2021 Keratinocytes apoptosis contributes to crizotinib induced-erythroderma, Hu Y, Zhang X, Zhao Z, Chen X, Zhou Z, Yang X, Yang B, He Q, Luo P, 2020 Bisdemethoxycurcumin attenuates cisplatin-induced renal injury through anti-apoptosis, anti-oxidant and anti-inflammatory, Jin F, Chen X, Yan H, Xu Z, Yang B, Luo P, He Q, 2020 ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway, Yan H, Du J, Chen X, Yang B, He Q, Yang X, Luo P, 2019 Macrophage-secreted TSLP and MMP9 promote bleomycin-induced pulmonary fibrosis, Li G, Jin F, Du J, He Q, Yang B, Luo P, 2019 HMGB1 represses the anti-cancer activity of sunitinib by governing TP53 autophagic degradation via its nucleus-to-cytoplasm transport, Luo P, Xu Z, Li G, Yan H, Zhu Y, Zhu H, Ma S, Yang B, He Q, 2018 High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity, Xu Z, Jin Y, Yan H, Gao Z, Xu B, Yang B, He Q, Shi Q, Luo P, 2018

Areas of Focus

Drug Toxicology
Tumor Pharmacology

Publications

Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib, Xu Z, Jin Y, Gao Z, Zeng Y, Du J, Yan H, Chen X, Ping L, Lin N, Yang B, He Q, Luo P, 2021
PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1), Luo P, Yan H, Du J, Chen X, Shao J, Zhang Y, Xu Z, Jin Y, Lin N, Yang B, He Q, 2020
s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide, Luo P, Yan H, Chen X, Zhang Y, Zhao Z, Cao J, Zhu Y, Du J, Xu Z, Zhang X, Zeng S, Yang B, Ma S, He Q, 2020
Bisdemethoxycurcumin alleviates vandetanib-induced cutaneous toxicity in vivo and in vitro through autophagy activation, Jin Y, Chen X, Gao Z, Shen X, Fu H, Pan Z, Yan H, Yang B, He Q, Xu Z, Luo P, 2021
Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib, Du J, Li G, Jiang L, Zhang X, Xu Z, Yan H, Zhou Z, He Q, Yang X, Luo P, 2021
Keratinocytes apoptosis contributes to crizotinib induced-erythroderma, Hu Y, Zhang X, Zhao Z, Chen X, Zhou Z, Yang X, Yang B, He Q, Luo P, 2020
Bisdemethoxycurcumin attenuates cisplatin-induced renal injury through anti-apoptosis, anti-oxidant and anti-inflammatory, Jin F, Chen X, Yan H, Xu Z, Yang B, Luo P, He Q, 2020
ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway, Yan H, Du J, Chen X, Yang B, He Q, Yang X, Luo P, 2019
Macrophage-secreted TSLP and MMP9 promote bleomycin-induced pulmonary fibrosis, Li G, Jin F, Du J, He Q, Yang B, Luo P, 2019
HMGB1 represses the anti-cancer activity of sunitinib by governing TP53 autophagic degradation via its nucleus-to-cytoplasm transport, Luo P, Xu Z, Li G, Yan H, Zhu Y, Zhu H, Ma S, Yang B, He Q, 2018
High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity, Xu Z, Jin Y, Yan H, Gao Z, Xu B, Yang B, He Q, Shi Q, Luo P, 2018

Autophagy Small Molecule Kinase Inhibitors Toxicity Mechanisms Vascular Endothelial Cells Drug Toxicity Intervention Targets Effective Strategies Cardiotoxicity Hepatotoxicity Pulmonary Toxicity

Qiaojun He - Zhejiang University

Zhifei Xu - Zhejiang University

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