Professor | Tengfei Xu | Asia Growth Partners

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Name	Tengfei Xu
Contact Information	tfxu@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Tengfei Xu

Contact Information

tfxu@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2018 PhD: University of Chinese Academy of Sciences 2018-2021 Postdoctoral Research: Nanyang Technological University, Singapore Published over 20 papers in SCI journals as first or corresponding author Received the Second Prize of Jilin Province Science and Technology Progress Award Recognized as a High-Level Overseas Talent in Shenzhen
Work Experience	2018-2021 - Nanyang Technological University, Singapore - Postdoctoral Researcher Current - Zhejiang University - Distinguished Researcher, Doctoral Supervisor
Awards	Second Prize of Jilin Province Science and Technology Progress Award High-Level Overseas Talent in Shenzhen

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2018 PhD: University of Chinese Academy of Sciences
2018-2021 Postdoctoral Research: Nanyang Technological University, Singapore
Published over 20 papers in SCI journals as first or corresponding author
Received the Second Prize of Jilin Province Science and Technology Progress Award
Recognized as a High-Level Overseas Talent in Shenzhen

Work Experience

2018-2021 - Nanyang Technological University, Singapore - Postdoctoral Researcher
Current - Zhejiang University - Distinguished Researcher, Doctoral Supervisor

Awards

Second Prize of Jilin Province Science and Technology Progress Award
High-Level Overseas Talent in Shenzhen

Areas of Focus	Analysis of Traditional Chinese Medicine Components Identification of Traditional Chinese Medicine Targets Proteomics Metabolomics Chemical Proteomics
Publications	Uncovering SOD3 and GPX4 as new targets of Benzo [α] pyrene-induced hepatotoxicity through Metabolomics and Chemical Proteomics, Yanwei Wang, Jiahui Zhao, Yipeng Xu, Cimin Tao, Jie Tong, Yingjie Luo, Yong Chen, Xuesong Liu, Tengfei Xu, 2023 Machine learning screening based strategy for the synthesis of a molecularly imprinted ionic liquid polymer for specific adsorption of perfluorooctanoic acid, Yiwei Zhang, Yingjie Luo, Jie Tong, Xuesong Liu, Yong Chen, Tengfei Xu, 2023 A Q-marker screening strategy based on ADME studies and systems biology for Chinese herbal medicine, taking Qianghuo Shengshi decoction in treating rheumatoid arthritis as an example, Jiao Wang, Cimin Tao, Guangzheng Xu, Jiawei Ling, Jie Tong, Bey-Hing Goh, Yipeng Xu, Linghui Qian, Yong Chen, Xuesong Liu, Yongjiang Wu, Tengfei Xu, 2023 Network pharmacology and metabolomics elucidate the underlying mechanisms of Venenum Bufonis in the treatment of colorectal cancer, Tao Cimin, Wang Jiao, Gu Zhilei, Ni Hongfei, Luo Yingjie, Ling Jiawei, Chen Yong, Wu Yongjiang, Liu Xuesong, Zhou Yuan, Tengfei Xu, 2023 Non-destructive detection of polysaccharides and moisture in Ganoderma lucidum using near-infrared spectroscopy and machine learning algorithm, Hongfei Ni, Weiliang Fu, Jing Wei, Yiwei Zhang, Dan Chen, Jie Tong, Yong Chen, Xuesong Liu, Yingjie Luo, Tengfei Xu, 2023 Exploration of the anti-inflammatory mechanism of Lanqin oral solution based on the network pharmacology analysis optimized by Q-markers selection, Hui Ma, Weiliang Fu, Hengyuan Yu, Youdong Xu, Lulu Xiao, Yiwei Zhang, Yongjiang Wu, Xuesong Liu, Yong Chen, Tengfei Xu, 2023 Feasibility of NIR spectral calibration transfer algorithm based on optimized feature variables to predict tobacco samples in different states, Yingrui Geng, Hongfei Ni, Huanchao Shen, Hui Wang, Jizhong Wu, Keyu Pan, Yongjiang Wu, Yong Chen, Yingjie Luo, Tengfei Xu, Xuesong Liu, 2023 PKM2-mediated neuronal hyperglycolysis enhances risk of Parkinson's disease in diabetic rats, Ya Zhao #, Yanwei Wang #, Yuying Wu, Cimin Tao, Rui Xu, Yong Chen, Linghui Qian, Tengfei Xu, Xiaoyuan Lian, 2023 Neisseria species as pathobionts in bronchiectasis, Liang Li#, Micheál Mac Aogáin#, Tengfei Xu#, Jaggi Tavleen Kaur, Chan Louisa L. Y. Qu, Jing, Wei Lan, Liao Shumin, Cheng Hong Sheng, Keir Holly R., Dicker Alison J., De Yun Wang, Koh, Mariko Siyue, Ong, Thun How, Lim, Albert Yick Hou, Abisheganaden, John A., Low, Teck Boon, Hassan, Tidi Maharani, Long Xiang, Wark Peter A. B., Oliver Brian, Drautz-Moses Daniela I., Schuster Stephan C., Tan Nguan Soon, Fang Mingliang, Chalmers James D., Chotirmall Sanjay H., 2022 Exploring the Absorption Mechanisms of Imidazolium-Based Ionic Liquids to Epigallocatechin Gallate, Luo, Y., Zhang, Y., Tao, C., Ni, H., Liu, X., Chen, Y., Wu, Y., Song, H., & Xu, T., 2022 Synthesis of Tropine-Based Functionalized Acidic Ionic Liquids and Catalysis of Esterification, Ni, H., Zhang, Y., Zong, C., Hou, Z., Song, H., Chen, Y., Liu, X., Xu, T., Luo, Y., 2022 Metabolomics and In Silico Docking-Directed Discovery of Small-Molecule Enzyme Targets, Xu T, Zhao H, Wang M, Chow A, Fang M., 2021 Single Cell Metabolite Detection Using Inertial Microfluidics-Assisted Ion Mobility Mass Spectrometry, Zhang L, Xu T, Zhang J, Wong SCC, Ritchie M, Hou HW, et al., 2021 System Biology-Guided Chemical Proteomics to Discover Protein Targets of Monoethylhexyl Phthalate in Regulating Cell Cycle, Xu T, Chen L, Lim YT, Zhao H, Chen H, Chen MW, et al., 2021 Streamlined MRM method transfer between instruments assisted with HRMS matching and retention-time prediction, Yang JJ, Han Y, Mah CH, Wanjaya E, Peng B, Xu TF, et al., 2020 A Novel Mechanism of Monoethylhexyl Phthalate in Lipid Accumulation via Inhibiting Fatty Acid Beta-Oxidation on Hepatic Cells, Xu T, Lim YT, Chen L, Zhao H, Low JH, Xia Y, et al., 2020 Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects, Liu M, Jia S, Dong T, Zhao F, Xu T, Yang Q, et al., 2020 A wide-targeted urinary and serum metabolomics strategy reveals the effective substance of the Wu-tou decoction, Cheng X, Xu T, Pi Z, Liu S, Song F, Liu Z., 2020 Effects of the ambient fine particulate matter (PM2.5) exposure on urinary metabolic profiles in rats using UPLC-Q-TOF-MS, Zhang L#, Xu T#, Pi Z, Zheng M, Song F, Liu Z., 2019 Chemical Isotope Labeling Exposome (CIL-EXPOSOME): One High-Throughput Platform for Human Urinary Global Exposome Characterization, Jia S, Xu T, Huan T, Chong M, Liu M, Fang W, et al., 2019 Benzophenone used as the photochemical reagent for pinpointing C=C locations in unsaturated lipids through shotgun and liquid chromatography-mass spectrometry approaches, Xu T, Pi ZF, Liu S, Song FR, Liu ZQ., 2018 Chemical Profiling Combined with 'Omics' Technologies (CP-Omics): a Strategy to Understand the Compatibility Mechanisms and Simplify Herb Formulas in Traditional Chinese Medicines, Xu T, Pi ZF, Liu S, Song FR, Liu ZQ., 2017 Systematically characterize the absorbed effective substances of Wutou Decoction and their metabolic pathways in rat plasma using UHPLC-Q-TOF-MS combined with a target network pharmacological analysis, Xu T, Li SZ, Sun YF, Pi ZF, Liu S, Song FR, et al., 2017 A study on the effective substance of the Wu-tou formula based on the metabonomic method using UPLC-Q-TOF-HDMS, Xu T, Liu S, Zhao JD, Feng GF, Pi ZF, Song FR, et al., 2015 Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines, Xu T, Liu S, Meng LL, Pi ZF, Song FR, Liu ZQ., 2016 A non-target urinary and serum metabolomics strategy reveals therapeutical mechanism of Radix Astragali on adjuvant-induced arthritis rats, Xu T, Feng GF, Zhao B, Zhao JD, Pi ZF, Liu S, et al., 2017

Areas of Focus

Analysis of Traditional Chinese Medicine Components
Identification of Traditional Chinese Medicine Targets
Proteomics
Metabolomics
Chemical Proteomics

Publications

Uncovering SOD3 and GPX4 as new targets of Benzo [α] pyrene-induced hepatotoxicity through Metabolomics and Chemical Proteomics, Yanwei Wang, Jiahui Zhao, Yipeng Xu, Cimin Tao, Jie Tong, Yingjie Luo, Yong Chen, Xuesong Liu, Tengfei Xu*, 2023
Machine learning screening based strategy for the synthesis of a molecularly imprinted ionic liquid polymer for specific adsorption of perfluorooctanoic acid, Yiwei Zhang, Yingjie Luo, Jie Tong, Xuesong Liu*, Yong Chen, Tengfei Xu*, 2023
A Q-marker screening strategy based on ADME studies and systems biology for Chinese herbal medicine, taking Qianghuo Shengshi decoction in treating rheumatoid arthritis as an example, Jiao Wang, Cimin Tao, Guangzheng Xu, Jiawei Ling, Jie Tong, Bey-Hing Goh, Yipeng Xu, Linghui Qian, Yong Chen, Xuesong Liu, Yongjiang Wu, Tengfei Xu*, 2023
Network pharmacology and metabolomics elucidate the underlying mechanisms of Venenum Bufonis in the treatment of colorectal cancer, Tao Cimin, Wang Jiao, Gu Zhilei, Ni Hongfei, Luo Yingjie, Ling Jiawei, Chen Yong, Wu Yongjiang, Liu Xuesong, Zhou Yuan, Tengfei Xu*, 2023
Non-destructive detection of polysaccharides and moisture in Ganoderma lucidum using near-infrared spectroscopy and machine learning algorithm, Hongfei Ni, Weiliang Fu, Jing Wei, Yiwei Zhang, Dan Chen, Jie Tong, Yong Chen, Xuesong Liu*, Yingjie Luo*, Tengfei Xu*, 2023
Exploration of the anti-inflammatory mechanism of Lanqin oral solution based on the network pharmacology analysis optimized by Q-markers selection, Hui Ma, Weiliang Fu, Hengyuan Yu, Youdong Xu, Lulu Xiao, Yiwei Zhang, Yongjiang Wu, Xuesong Liu, Yong Chen*, Tengfei Xu*, 2023
Feasibility of NIR spectral calibration transfer algorithm based on optimized feature variables to predict tobacco samples in different states, Yingrui Geng, Hongfei Ni, Huanchao Shen, Hui Wang, Jizhong Wu, Keyu Pan, Yongjiang Wu, Yong Chen, Yingjie Luo, Tengfei Xu, Xuesong Liu*, 2023
PKM2-mediated neuronal hyperglycolysis enhances risk of Parkinson's disease in diabetic rats, Ya Zhao #, Yanwei Wang #, Yuying Wu, Cimin Tao, Rui Xu, Yong Chen, Linghui Qian, Tengfei Xu*, Xiaoyuan Lian*, 2023
Neisseria species as pathobionts in bronchiectasis, Liang Li#, Micheál Mac Aogáin#, Tengfei Xu#, Jaggi Tavleen Kaur, Chan Louisa L. Y. Qu, Jing, Wei Lan, Liao Shumin, Cheng Hong Sheng, Keir Holly R., Dicker Alison J., De Yun Wang, Koh, Mariko Siyue, Ong, Thun How, Lim, Albert Yick Hou, Abisheganaden, John A., Low, Teck Boon, Hassan, Tidi Maharani, Long Xiang, Wark Peter A. B., Oliver Brian, Drautz-Moses Daniela I., Schuster Stephan C., Tan Nguan Soon, Fang Mingliang, Chalmers James D., Chotirmall Sanjay H., 2022
Exploring the Absorption Mechanisms of Imidazolium-Based Ionic Liquids to Epigallocatechin Gallate, Luo, Y., Zhang, Y., Tao, C., Ni, H., Liu, X., Chen, Y., Wu, Y., Song, H., & Xu, T.*, 2022
Synthesis of Tropine-Based Functionalized Acidic Ionic Liquids and Catalysis of Esterification, Ni, H., Zhang, Y., Zong, C., Hou, Z., Song, H., Chen, Y., Liu, X., Xu, T.*, Luo, Y.*, 2022
Metabolomics and In Silico Docking-Directed Discovery of Small-Molecule Enzyme Targets, Xu T, Zhao H, Wang M, Chow A, Fang M., 2021
Single Cell Metabolite Detection Using Inertial Microfluidics-Assisted Ion Mobility Mass Spectrometry, Zhang L, Xu T, Zhang J, Wong SCC, Ritchie M, Hou HW, et al., 2021
System Biology-Guided Chemical Proteomics to Discover Protein Targets of Monoethylhexyl Phthalate in Regulating Cell Cycle, Xu T, Chen L, Lim YT, Zhao H, Chen H, Chen MW, et al., 2021
Streamlined MRM method transfer between instruments assisted with HRMS matching and retention-time prediction, Yang JJ, Han Y, Mah CH, Wanjaya E, Peng B, Xu TF, et al., 2020
A Novel Mechanism of Monoethylhexyl Phthalate in Lipid Accumulation via Inhibiting Fatty Acid Beta-Oxidation on Hepatic Cells, Xu T, Lim YT, Chen L, Zhao H, Low JH, Xia Y, et al., 2020
Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects, Liu M, Jia S, Dong T, Zhao F, Xu T, Yang Q, et al., 2020
A wide-targeted urinary and serum metabolomics strategy reveals the effective substance of the Wu-tou decoction, Cheng X, Xu T, Pi Z, Liu S, Song F, Liu Z., 2020
Effects of the ambient fine particulate matter (PM2.5) exposure on urinary metabolic profiles in rats using UPLC-Q-TOF-MS, Zhang L#, Xu T#, Pi Z, Zheng M, Song F, Liu Z., 2019
Chemical Isotope Labeling Exposome (CIL-EXPOSOME): One High-Throughput Platform for Human Urinary Global Exposome Characterization, Jia S, Xu T, Huan T, Chong M, Liu M, Fang W, et al., 2019
Benzophenone used as the photochemical reagent for pinpointing C=C locations in unsaturated lipids through shotgun and liquid chromatography-mass spectrometry approaches, Xu T, Pi ZF, Liu S, Song FR, Liu ZQ., 2018
Chemical Profiling Combined with 'Omics' Technologies (CP-Omics): a Strategy to Understand the Compatibility Mechanisms and Simplify Herb Formulas in Traditional Chinese Medicines, Xu T, Pi ZF, Liu S, Song FR, Liu ZQ., 2017
Systematically characterize the absorbed effective substances of Wutou Decoction and their metabolic pathways in rat plasma using UHPLC-Q-TOF-MS combined with a target network pharmacological analysis, Xu T, Li SZ, Sun YF, Pi ZF, Liu S, Song FR, et al., 2017
A study on the effective substance of the Wu-tou formula based on the metabonomic method using UPLC-Q-TOF-HDMS, Xu T, Liu S, Zhao JD, Feng GF, Pi ZF, Song FR, et al., 2015
Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines, Xu T, Liu S, Meng LL, Pi ZF, Song FR, Liu ZQ., 2016
A non-target urinary and serum metabolomics strategy reveals therapeutical mechanism of Radix Astragali on adjuvant-induced arthritis rats, Xu T, Feng GF, Zhao B, Zhao JD, Pi ZF, Liu S, et al., 2017

Traditional Chinese Medicine Component Analysis Target Identification Proteomics Metabolomics Chemical Proteomics Fingerprinting Pk-Pd Studies Efficacy Evaluation Neurodegenerative Diseases

Ping Yang - Fudan University

Haiyan Zhu - Fudan University

Hong Liang - Peking University

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