Biosynthesis pathways of medicinal natural products Key enzyme discovery and catalytic mechanisms in biosynthesis of active components in traditional Chinese medicine Genome-driven discovery of lead structures and synthetic biology manufacturing
Biosynthesis of octacosamicin A: uncommon starter/extender units and product releasing via intermolecular amidation, Yanghui Liao, Xue-Jiao Wang, Guang-Lei Ma, Hartono Candra, Sean Lee Qiu En, Zhao-Xun Liang, 2024
Structurally diverse terpenoids and their DRAK2 inhibitory activities: A follow-up study on the vulnerable conifer Pseudotsuga forrestii, Peng-Jun Zhou, Ting Huang, Guang-Lei Ma, Ze-Yu Zhao, Zhe-Lu Jiang, Yi Zang, Juan Xiong, Jia Li, Jin-Feng Hu, 2024
Streptomyces sungeiensis SD3 as a microbial chassis for the heterologous production of secondary metabolites, Sean Qiu En Lee, Guang-Lei Ma, Hartono Candra, Srashti Khandelwal, Li Mei Pang, Zhen Jie Low, Qing Wei Cheang, and Zhao-Xun Liang, 2024
Unprecedented spirodioxynaphthalenes from the endophytic fungus Phyllosticta ligustricola HDF-L-2 derived from the endangered conifer Pseudotsuga gaussenii, Hao-Wei Chen, Chun-Xiao Jiang, Guang-Lei Ma, Xi-Ying Wu, Wei Jiang, Jiyang Li, Yi Zang, Jia Li, Juan Xiong, Jin-Feng Hu, 2023
Forrestiacids E–K: Further [4+2]-type triterpene–diterpene hybrids as potential ACL inhibitors from the vulnerable conifer Pseudotsuga forrestii, Peng-Jun Zhou, Ting Huang, Guang-Lei Ma, Ying-Peng Tong, Wen-Xue Chen, Yi Zang, Juan Xiong, Jia Li, Jin-Feng Hu, 2023
Antibacterial and antibiofilm efficacy of the preferred fractions and compounds from Euphorbia humifusa (herba euphorbiae humifusae) against Staphylococcus aureus, Xiying Wu; Guang-Lei Ma; Hao-Wei Chen; Ze-Yu Zhao; Zi-Ping Zhu; Juan Xiong; Guo-Xun Yang; Jin-Feng Hu, 2023
Characterization of the biosynthetic gene cluster and shunt products yields insights into the biosynthesis of balmoralmycin, Guang-Lei Ma; Lingyi Xin; Yanghui Liao; Zhi-Soon Chong; Hartono Candra; Li Mei Pang; Sean Qiu En Lee; Martin Muthee Gakuubi; Siew Bee Ng; Zhao-Xun Liang, 2022
Enaminone formation drives the coupling of biosynthetic pathways to generate cyclic lipopeptides, Hartono Candra; Guang-Lei Ma (co-first); Sean Lee Qiu En; Zhao-Xun Liang, 2022
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities, Wei Jiang, Ze-Yu Zhao, Ying-Peng Tong, Guang-Lei Ma, Yi Zang, Ezzat EA Osman, Ze-Xin Jin, Juan Xiong, Jia Li, Jin-Feng Hu, 2022
CRISPR/Cas9 RNP-assisted validation of palmarumycin biosynthetic gene cluster in Lophiotrema sp. F6932, Martin Muthee Gakuubi, Kuan Chieh Ching, Madhaiyan Munusamy, Mario Wibowo, Chun Teck Lim, Guang-Lei Ma, Zhao-Xun Liang, Yoganathan Kanagasundaram, Siew Bee Ng, 2022
Structurally diverse glycosides of secoiridoid, bisiridoid, and triterpene-bisiridoid conjugates from the flower buds of two Caprifoliaceae plants and their ATP-citrate lyase inhibitory activities, Jiang Wan, Chun-Xiao Jiang, Yu Tang, Guang-Lei Ma, Ying-Peng Tong, Ze-Xin Jin, Yi Zang, Ezzat EA Osman, Jia Li, Juan Xiong, Jin-Feng Hu, 2022
Biosynthesis of tasikamides via pathway coupling and diazonium-mediated hydrazone formation, Guang-Lei Ma; Hartono Candra; Li Mei Pang; Juan Xiong; Yichen Ding; Hoa Thi Tran; Zhen Jie Low; Hong Ye; Min Liu; Jie Zheng; Mingliang Fang; Bin Cao; Zhao-Xun Liang, 2022
Pathway retrofitting yields insights into the biosynthesis of anthraquinone-fused enediynes, Guang-Lei Ma; Hoa Thi Tran; Zhen Jie Low; Hartono Candra; Li Mei Pang; Qing Wei Cheang; Mingliang Fang; Zhao-Xun Liang, 2021
Cytotoxic secondary metabolites from the vulnerable conifer Cephalotaxus oliveri and its associated endophytic fungus Alternaria alternate Y-4-2, Guang-Lei Ma; Nan Guo; Xi-Ling Wang; Junmin Li; Ze-Xin Jin; Yuqiao Han; Su-Zhen Dong; Juan Xiong; Jin-Feng Hu, 2020
Taming the flagellar motor of pseudomonads with a nucleotide messenger, Guang-Lei Ma; Hartono Chandra; Zhao-Xun Liang, 2020
Sungeidines from a non-canonical enediyne biosynthetic pathway, Zhen Jie Low; Guang-Lei Ma (co-first); Hoa Thi Tran; Yike Zou; Juan Xiong; Limei Pang;Selbi Nuryyeva; Hong Ye; Jin-Feng Hu; K. N. Houk; Zhao-Xun Liang, 2020
Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin, Zhen Jie Low; Juan Xiong; Ying Xie; Guang-Lei Ma (co-first); Howard Saw; Hoa Thi Tran; Soo Lin Wong; Li Mei Pang; July Fong; Peng Lu; Jin-Feng Hu; Yang Liang; Yansong Miao; Zhao-Xun Liang, 2020
Simultaneous identification of characteristic components in HPLC-PDA-ELSD fingerprint profile of Ginkgo biloba leaves extract, Guang-Lei Ma; Jiang Wan; Juan Xiong; Guo-Xun Yang; Jin-Feng Hu, 2019
LC-MS guided isolation and dereplication of Lycopodium alkaloids from Lycopodium cernuum var. sikkimense of different geographical origins, Yu Tang, Na Li, Yike Zou, Yanran Ai, Guang-Lei Ma, Ezzat EA Osman, Juan Xiong, Junmin Li, Ze-Xin Jin, Jin-Feng Hu, 2019
Advanced natural products chemistry research in China between 2015 and 2017, Guo-Xun Yang; Guang-Lei Ma; Hao Li; Ting Huang; Juan Xiong; Jin-Feng Hu, 2018
Structurally Diverse Sesquiterpenoids from the endangered ornamental Plant Michelia shiluensis, Juan Xiong, Li-Jun Wang, Jianchang Qian, Pei-Pei Wang, Xue-Jiao Wang, Guang-Lei Ma, Huaqiang Zeng, Jia Li, Jin-Feng Hu, 2018
LC-MS guided isolation of sinodamines A and B: Chimonanthine-type alkaloids from the endangered ornamental plant Sinocalycanthus chinensis, Guang-Lei Ma; Juan Xiong; Ezzat E.A. Osman; Ting Huang; Guo-Xun Yang; Jin-Feng Hu, 2018
Two new bisabolane-type sesquiterpenoids from Curcuma longa, Chao Huang, Yu Tang, Ting Huang, Lijun Wang, Wei Jiang, Guanglei Ma, Juan Xiong, Jinfeng Hu, 2018
Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis, Juan Xiong, Xi-Ying Wu, Pei-Pei Wang, Choiwan Lau, Hui Fan, Guang-Lei Ma, Yu Tang, Jia Li, Jin-Feng Hu, 2018
Anti-neuroinflammatory diterpenoids from the endangered conifer Podocarpus imbricatus, Chang-Ling Hu, Juan Xiong, Chen-Xi Xiao, Yu Tang, Guang-Lei Ma, Jiang Wan, Jin-Feng Hu, 2018
Camellianols A–G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana, Juan Xiong, Jiang Wan, Jie Ding, Pei-Pei Wang, Guang-Lei Ma, Jia Li, Jin-Feng Hu, 2017
Diterpenoids from the needles and twigs of the cultivated endangered pine Pinus kwangtungensis and their PTP1B inhibitory effects, Chang-Ling Hu, Juan Xiong, Pei-Pei Wang, Guang-Lei Ma, Yu Tang, Guo-Xun Yang, Jia Li, Jin-Feng Hu, 2017
Biginkgosides A-I, unexpected minor dimeric flavonol diglycosidic truxinate and truxillate esters from Ginkgo biloba leaves and their antineuroinflammatory and neuroprotective activities, Guang-Lei Ma; Juan Xiong; Guo-Xun Yang; Li-Long Pan; Chang-Ling Hu; Wei Wang; Hui Fan; Qiu-Hua Zhao; Hai-Yan Zhang; Jin-Feng Hu, 2016
Salicifoxazines A and B, new cytotoxic tetrahydro-1,2-oxazinecontaining tryptamine-derived alkaloids from the leaves of Chimonanthus salicifolius, Guang-Lei Ma; Guo-Xun Yang; Juan Xiong; Wen-Liang Cheng; Ke-Jun Cheng; Jin-Feng Hu, 2015
Leonurosides A–D: Steroid N-acetylglucosaminides from the fruits of Leonurus japonicus, Miao Ye; Guang-Lei Ma; Jing-Jing Su; Juan Xiong; Jin-Feng Hu, 2014
Chloranthones A-D: Minor and unprecedented dinor‐eudesmenes from Chloranthus elatior, Shu‐Ting Liu, Juan Xiong, Yu Tang, Wen‐Xuan Wang, Van‐Binh Bui, Guang‐Lei Ma, Ya Huang, Yun Zhao, Guo‐Xun Yang, Jin‐Feng Hu, 2014
Casuarinines A–J, lycodine-type alkaloids from Lycopodiastrum casuarinoides, Yu Tang, Yan Fu, Juan Xiong, Ming Li, Guang-Lei Ma, Guo-Xun Yang, Bang-Guo Wei, Yun Zhao, Hai-Yan Zhang, Jin-Feng Hu, 2013
Keywords
BiosynthesisNatural ProductsMedicinalEnzymesCatalysisTraditional Chinese MedicineGenomicsLead StructuresSynthetic BiologyManufacturing
