Professor | Yan Niu | Asia Growth Partners

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Name	Yan Niu
Contact Information	yanniu@bjmu.edu.cn
Language ability	Chinese, English, German
Province	Beijing

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Name

Yan Niu

Contact Information

yanniu@bjmu.edu.cn

Language ability

Chinese, English, German

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2021.12-Present: Associate Professor, Doctoral Supervisor, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University 2015.9-2016.9: Visiting Scholar, Department of Chemical Biology and Pharmacology, University of Konstanz, Germany 2013.8-2021.12: Associate Professor, Master's Supervisor, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University 2007.8-2013.7: Lecturer, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University 2002.9-2007.7: Ph.D. in Chemical Biology, School of Pharmaceutical Sciences, Peking University 1998.9-2002.7: Bachelor's in Pharmacy, School of Pharmaceutical Sciences, Peking University
Work Experience	2021.12-Present - Peking University - Associate Professor, Doctoral Supervisor 2015.9-2016.9 - University of Konstanz - Visiting Scholar 2013.8-2021.12 - Peking University - Associate Professor, Master's Supervisor 2007.8-2013.7 - Peking University - Lecturer
Awards	2023: Peking University Health Science Center Teaching Excellence Award 2019: Peking University Green Leaf Biomedical Outstanding Young Scholar Award 2017: Excellence Award, 17th Young Teachers' Teaching Basic Skills Competition (Medical Category), Peking University 2010: Second Prize, Outstanding Class Advisor, Peking University

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2021.12-Present: Associate Professor, Doctoral Supervisor, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University
2015.9-2016.9: Visiting Scholar, Department of Chemical Biology and Pharmacology, University of Konstanz, Germany
2013.8-2021.12: Associate Professor, Master's Supervisor, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University
2007.8-2013.7: Lecturer, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University
2002.9-2007.7: Ph.D. in Chemical Biology, School of Pharmaceutical Sciences, Peking University
1998.9-2002.7: Bachelor's in Pharmacy, School of Pharmaceutical Sciences, Peking University

Work Experience

2021.12-Present - Peking University - Associate Professor, Doctoral Supervisor
2015.9-2016.9 - University of Konstanz - Visiting Scholar
2013.8-2021.12 - Peking University - Associate Professor, Master's Supervisor
2007.8-2013.7 - Peking University - Lecturer

Awards

2023: Peking University Health Science Center Teaching Excellence Award
2019: Peking University Green Leaf Biomedical Outstanding Young Scholar Award
2017: Excellence Award, 17th Young Teachers' Teaching Basic Skills Competition (Medical Category), Peking University
2010: Second Prize, Outstanding Class Advisor, Peking University

Areas of Focus	Discovery and optimization of lead compounds Structure-based drug design and chemical synthesis Structure-activity relationship studies of active small molecules
Publications	Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes, Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Mopei Wang, Liangren Zhang, Thomas Brunner, Ping Xu, Yan Niu, 2022 Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules, Xiaona Li, Zirui Lü, Cong Wang, Kebin Li, Fengrong Xu, Ping Xu, Yan Niu, 2021 Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway inhibitors, Zirui Lü, Xiaona Li, Kebin Li, Cong Wang, Tingting Du, Wei Huang, Ming Ji, Changhong Li, Fengrong Xu, Ping Xu, Yan Niu, 2021 Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome, Sun Q, Zhou T, Xi D, Li X, Lü Z, Xu F, Wang C, Niu Y, Xu P, 2020 Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening, Dandan Xi, Yan Niu, Hongyue Li, Stefan M. Noha, Veronika Temml, Daniela Schuster, Chao Wang, Fengrong Xu, Ping Xu, 2019 Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents, Jing Sun, Yan Niu, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Hongwei Jin, Yihong Peng, Lei Liang, Ping Xu, 2016 Nitazoxanide reduces inflammation and bone erosion in mice with collagen-induced arthritis via inhibiting the JAK2/STAT3 and NF-κB pathways in fibroblast-like synoviocytes, Li C, Wang F, Han Y, Zhai J, Jin Y, Liu R, Niu Y, Yao Z, Zhao J, 2024 Phosphorylation of enteroviral 2Apro at Ser/Thr125 benefits its proteolytic activity and viral pathogenesis, Wang Y, Zou W, Niu Y, Wang S, Chen B, Xiong R, Zhang P, Luo Z, Wu Y, Fan C, Zhong Z, Xu P, Peng Y, 2023 Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis, Chang-hong Li, Zi-rui Lü, Zhen-da Zhao, Xin-yu Wang, Hui-jie Leng, Yan Niu, Mo-pei Wang, 2021 Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain, P. Ripani, J. Delp, K. Bode, M. E. Delgado, L. Dietrich, V. M. Betzler, Y. Niu, G. von Scheven, T. U. Mayer, M. Leist, T. Brunner, 2020 Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors, Xiufeng Xu, Peng Lü, Junjie Wang, Fengrong Xu, Lei Liang, Chao Wang, Yan Niu, Ping Xu, 2019 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies, Gang Yan, Lina Hao, Yan Niu, Wenjie Huang, Wei Wang, Fengrong Xu, Lei Liang, Chao Wang, Hongwei Jin, Ping Xu, 2017 Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors, Qi Sun, Bo Xu, Yan Niu, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin, Ping Xu, 2015 4-Oxo-1,4-dihydroquinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies, Peng Liu, Yan Niu, Chao Wang, Qi Sun, Yaya Zhai, Jiapei Yu, Jing Sun, Fengrong Xu, Gang Yan, Wenjie Huang, Lei Liang, Ping Xu, 2014 Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents, Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu, Yun Wu, Xin Wang, Yihong Peng, Jing Sun, Lei Liang, Ping Xu, 2013 Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors, Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu, 2013 Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors, Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun, Ping Xu, 2012 The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies, Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang, Ping Xu, 2012 Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline, Dong Wang, Liguo Yang, Jingjing Su, Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu, 2011 Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase, Yan Niu, Yuehua Wang, Xiaomin Zou, Xiaoming Yang, Chao Ma, Yang Lü, Bo Zhou, Yue Yuan, Guanhua Du, Ping Xu, 2010 A novel derivative of xanomeline improves fear cognition in aged mice, Wen Si, Xuliang Zhang, Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao, 2010 Enhancement of memory function in aged mice by a novel derivative of xanomeline, Yihui Cui, Dong Wang, Wen Si, Wen Lu, Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao, 2008

Areas of Focus

Discovery and optimization of lead compounds
Structure-based drug design and chemical synthesis
Structure-activity relationship studies of active small molecules

Publications

Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes, Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Mopei Wang, Liangren Zhang, Thomas Brunner, Ping Xu, Yan Niu, 2022
Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules, Xiaona Li, Zirui Lü, Cong Wang, Kebin Li, Fengrong Xu, Ping Xu, Yan Niu, 2021
Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway inhibitors, Zirui Lü, Xiaona Li, Kebin Li, Cong Wang, Tingting Du, Wei Huang, Ming Ji, Changhong Li, Fengrong Xu, Ping Xu, Yan Niu, 2021
Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome, Sun Q, Zhou T, Xi D, Li X, Lü Z, Xu F, Wang C, Niu Y, Xu P, 2020
Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening, Dandan Xi, Yan Niu, Hongyue Li, Stefan M. Noha, Veronika Temml, Daniela Schuster, Chao Wang, Fengrong Xu, Ping Xu, 2019
Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents, Jing Sun, Yan Niu, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Hongwei Jin, Yihong Peng, Lei Liang, Ping Xu, 2016
Nitazoxanide reduces inflammation and bone erosion in mice with collagen-induced arthritis via inhibiting the JAK2/STAT3 and NF-κB pathways in fibroblast-like synoviocytes, Li C, Wang F, Han Y, Zhai J, Jin Y, Liu R, Niu Y, Yao Z, Zhao J, 2024
Phosphorylation of enteroviral 2Apro at Ser/Thr125 benefits its proteolytic activity and viral pathogenesis, Wang Y, Zou W, Niu Y, Wang S, Chen B, Xiong R, Zhang P, Luo Z, Wu Y, Fan C, Zhong Z, Xu P, Peng Y, 2023
Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis, Chang-hong Li, Zi-rui Lü, Zhen-da Zhao, Xin-yu Wang, Hui-jie Leng, Yan Niu, Mo-pei Wang, 2021
Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain, P. Ripani, J. Delp, K. Bode, M. E. Delgado, L. Dietrich, V. M. Betzler, Y. Niu, G. von Scheven, T. U. Mayer, M. Leist, T. Brunner, 2020
Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors, Xiufeng Xu, Peng Lü, Junjie Wang, Fengrong Xu, Lei Liang, Chao Wang, Yan Niu, Ping Xu, 2019
2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies, Gang Yan, Lina Hao, Yan Niu, Wenjie Huang, Wei Wang, Fengrong Xu, Lei Liang, Chao Wang, Hongwei Jin, Ping Xu, 2017
Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors, Qi Sun, Bo Xu, Yan Niu, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin, Ping Xu, 2015
4-Oxo-1,4-dihydroquinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies, Peng Liu, Yan Niu, Chao Wang, Qi Sun, Yaya Zhai, Jiapei Yu, Jing Sun, Fengrong Xu, Gang Yan, Wenjie Huang, Lei Liang, Ping Xu, 2014
Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents, Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu, Yun Wu, Xin Wang, Yihong Peng, Jing Sun, Lei Liang, Ping Xu, 2013
Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors, Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu, 2013
Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors, Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun, Ping Xu, 2012
The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies, Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang, Ping Xu, 2012
Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline, Dong Wang, Liguo Yang, Jingjing Su, Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu, 2011
Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase, Yan Niu, Yuehua Wang, Xiaomin Zou, Xiaoming Yang, Chao Ma, Yang Lü, Bo Zhou, Yue Yuan, Guanhua Du, Ping Xu, 2010
A novel derivative of xanomeline improves fear cognition in aged mice, Wen Si, Xuliang Zhang, Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao, 2010
Enhancement of memory function in aged mice by a novel derivative of xanomeline, Yihui Cui, Dong Wang, Wen Si, Wen Lu, Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao, 2008

Lead Compounds Optimization Drug Design Chemical Synthesis Structure-Activity Relationship Active Small Molecules Medicinal Chemistry Pharmacology Biochemistry Target-Based

Renxiao Wang - Fudan University

Ying Chen - Fudan University

Tingbo Ding - Fudan University

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