Professor | Ke-Wu Zeng | Asia Growth Partners

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Name	Ke-Wu Zeng
Contact Information	ZKW@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Ke-Wu Zeng

Contact Information

ZKW@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Work Experience	2024.01-2028.12 - National Natural Science Foundation of China - Project Leader 2023.01-2025.12 - Beijing Natural Science Foundation - Project Leader 2022.01-2025.12 - National Natural Science Foundation of China - Project Leader 2020.01-2023.12 - National Natural Science Foundation of China - Project Leader 2018.01-2021.12 - National Natural Science Foundation of China - Project Leader 2019.12-2022.12 - Ministry of Science and Technology Key R&D Program - Sub-project Leader 2019.12-2021.12 - Ministry of Science and Technology Key R&D Program - Sub-project Leader 2014.01-2016.12 - National Natural Science Foundation of China - Project Leader
Awards	2023: Chinese Association of Traditional Chinese Medicine Science and Technology Award - Young and Middle-aged Innovation Talent Award 2023: Chinese Ethnic Medicine Association Science and Technology Award First Prize (Second Contributor) 2023: Chinese Association of Traditional Chinese Medicine - 2022 Top Ten Academic Advances in Traditional Chinese Medicine 2019: Ministry of Education High-level Talent Program Youth Project Selected 2019: Chinese Pharmacological Society - Young Pharmacologist Award 2016: Peking University Green Leaf Biomedical Outstanding Young Scholar Award 2014: Huaxia Medical Science and Technology Award Second Prize (Third Contributor) 2013: Chinese and Western Medicine Science and Technology Award Second Prize (Third Contributor) 2013: Higher Education Scientific Research Outstanding Achievement Award Second Prize (Third Contributor)

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Work Experience

2024.01-2028.12 - National Natural Science Foundation of China - Project Leader
2023.01-2025.12 - Beijing Natural Science Foundation - Project Leader
2022.01-2025.12 - National Natural Science Foundation of China - Project Leader
2020.01-2023.12 - National Natural Science Foundation of China - Project Leader
2018.01-2021.12 - National Natural Science Foundation of China - Project Leader
2019.12-2022.12 - Ministry of Science and Technology Key R&D Program - Sub-project Leader
2019.12-2021.12 - Ministry of Science and Technology Key R&D Program - Sub-project Leader
2014.01-2016.12 - National Natural Science Foundation of China - Project Leader

Awards

2023: Chinese Association of Traditional Chinese Medicine Science and Technology Award - Young and Middle-aged Innovation Talent Award
2023: Chinese Ethnic Medicine Association Science and Technology Award First Prize (Second Contributor)
2023: Chinese Association of Traditional Chinese Medicine - 2022 Top Ten Academic Advances in Traditional Chinese Medicine
2019: Ministry of Education High-level Talent Program Youth Project Selected
2019: Chinese Pharmacological Society - Young Pharmacologist Award
2016: Peking University Green Leaf Biomedical Outstanding Young Scholar Award
2014: Huaxia Medical Science and Technology Award Second Prize (Third Contributor)
2013: Chinese and Western Medicine Science and Technology Award Second Prize (Third Contributor)
2013: Higher Education Scientific Research Outstanding Achievement Award Second Prize (Third Contributor)

Areas of Focus	Natural Product Chemical Biology New Technologies for Drug Target Discovery Creation of New Drugs from Natural Products
Publications	Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease, Yan-Hang Wang, Xin Chen, Yi-Zhen Bai, Peng Gao, Zhuo Yang, Qaing Guo, Ying-Yuan Lu, Jiao Zheng, Dan Liu, Jun Yang, Peng-Fei Tu, Ke-Wu Zeng, 2024 Allosteric activation of transglutaminase 2 via inducing an 'open' conformation for osteoblast differentiation, Zhuo Yang, Xiao-Wen Zhang, Fang-Fang Zhuo, Ting-Ting Liu, Qian-Wei Luo, Yong-Zhe Zheng, Li L, Heng Yang, Yi-Chi Zhang, Yan-Hang Wang, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2023 Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy, Xiao-Wen Zhang, Na Feng, Yan-Chen Liu, Qiang Guo, Jing-Kang Wang, Yi-Zhen Bai, Xiao-Ming Ye, Zhuo Yang, Heng Yang, Yang Liu, Mi-Mi Yang, Yan-Hang Wang, Xiao-Meng Shi, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2022 Carbon quantum dots-based nanozyme from coffee induces cancer cell ferroptosis to activate antitumor immunity, Lu Yao, Mei-Mei Zhao, Qian-Wei Luo, Yi-Chi Zhang, Ting-Ting Liu, Zhuo Yang, Min Liao, Peng-Fei Tu, Ke-Wu Zeng, 2022 Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy, Li-Xi Liao, Xiao-Min Song, Li-Chao Wang, Hai-Ning Lv, Jin-Feng Chen, Dan Liu, Ge Fu, Ming-Bo Zhao, Yong Jiang, Ke-Wu Zeng, Peng-Fei Tu, 2017 Allosteric regulation of IGF2BP1 as a novel strategy for the activation of tumor immune microenvironment, Yang Liu, Qiang Guo, Heng Yang, Xiao-Wen Zhang, Na Feng, Jing-Kang Wang, Ting-Ting Liu, Ke-Wu Zeng, Peng-Fei Tu, 2022 Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification, Qiang Guo, Yi-Chi Zhang, Wei Wang, Yu-Qi Wang, Yang Liu, Zhuo Yang, Mei-Mei Zhao, Na Feng, Yan-Hang Wang, Xiao-Wen Zhang, Heng Yang, Ting-Ting Liu, Lun-Yong Shi, Xiao-Meng Shi, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2022 Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy, Ting-Ting Liu, Heng Yang, Fang-Fang Zhuo, Zhuo Yang, Mei-Mei Zhao, Qiang Guo, Yang Liu, Dan Liu, Ke-Wu Zeng, Peng-Fei Tu, 2022 Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase, Xiaoqing Zhou, Shaoyang Zhao, Tingting Liu, Lu Yao, Meimei Zhao, Xiaoming Ye, Xiaowen Zhang, Qiang Guo, Pengfei Tu, Kewu Zeng, 2022 Gold nanoparticle-based photo-cross-linking strategy for cellular target identification of supercomplex molecular systems, Lu Yao, Min Liao, Jing-Kang Wang, Jing Wang, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2022

Areas of Focus

Natural Product Chemical Biology
New Technologies for Drug Target Discovery
Creation of New Drugs from Natural Products

Publications

Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease, Yan-Hang Wang, Xin Chen, Yi-Zhen Bai, Peng Gao, Zhuo Yang, Qaing Guo, Ying-Yuan Lu, Jiao Zheng, Dan Liu, Jun Yang, Peng-Fei Tu, Ke-Wu Zeng, 2024
Allosteric activation of transglutaminase 2 via inducing an 'open' conformation for osteoblast differentiation, Zhuo Yang, Xiao-Wen Zhang, Fang-Fang Zhuo, Ting-Ting Liu, Qian-Wei Luo, Yong-Zhe Zheng, Li L, Heng Yang, Yi-Chi Zhang, Yan-Hang Wang, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2023
Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy, Xiao-Wen Zhang, Na Feng, Yan-Chen Liu, Qiang Guo, Jing-Kang Wang, Yi-Zhen Bai, Xiao-Ming Ye, Zhuo Yang, Heng Yang, Yang Liu, Mi-Mi Yang, Yan-Hang Wang, Xiao-Meng Shi, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2022
Carbon quantum dots-based nanozyme from coffee induces cancer cell ferroptosis to activate antitumor immunity, Lu Yao, Mei-Mei Zhao, Qian-Wei Luo, Yi-Chi Zhang, Ting-Ting Liu, Zhuo Yang, Min Liao, Peng-Fei Tu, Ke-Wu Zeng, 2022
Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy, Li-Xi Liao, Xiao-Min Song, Li-Chao Wang, Hai-Ning Lv, Jin-Feng Chen, Dan Liu, Ge Fu, Ming-Bo Zhao, Yong Jiang, Ke-Wu Zeng, Peng-Fei Tu, 2017
Allosteric regulation of IGF2BP1 as a novel strategy for the activation of tumor immune microenvironment, Yang Liu, Qiang Guo, Heng Yang, Xiao-Wen Zhang, Na Feng, Jing-Kang Wang, Ting-Ting Liu, Ke-Wu Zeng, Peng-Fei Tu, 2022
Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification, Qiang Guo, Yi-Chi Zhang, Wei Wang, Yu-Qi Wang, Yang Liu, Zhuo Yang, Mei-Mei Zhao, Na Feng, Yan-Hang Wang, Xiao-Wen Zhang, Heng Yang, Ting-Ting Liu, Lun-Yong Shi, Xiao-Meng Shi, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2022
Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy, Ting-Ting Liu, Heng Yang, Fang-Fang Zhuo, Zhuo Yang, Mei-Mei Zhao, Qiang Guo, Yang Liu, Dan Liu, Ke-Wu Zeng, Peng-Fei Tu, 2022
Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase, Xiaoqing Zhou, Shaoyang Zhao, Tingting Liu, Lu Yao, Meimei Zhao, Xiaoming Ye, Xiaowen Zhang, Qiang Guo, Pengfei Tu, Kewu Zeng, 2022
Gold nanoparticle-based photo-cross-linking strategy for cellular target identification of supercomplex molecular systems, Lu Yao, Min Liao, Jing-Kang Wang, Jing Wang, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2022

Natural Products Chemical Biology Drug Discovery Biotechnology Pharmacology Therapeutics Molecular Biology Biochemistry Medicinal Chemistry Biomedical Research

Ying Chen - Fudan University

Tingbo Ding - Fudan University

Ji-Bin Dong - Fudan University

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