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Ke-Wu Zeng
Pharmaceutical Sciences
Peking University
Beijing
Language: Chinese, English
Natural Products
Chemical Biology
Drug Discovery
Biotechnology
Pharmacology
Therapeutics
Molecular Biology
Biochemistry
Medicinal Chemistry
Biomedical Research
Areas of Focus
- Natural Product Chemical Biology
- New Technologies for Drug Target Discovery
- Creation of New Drugs from Natural Products
Work Experience
- 2024.01-2028.12 - National Natural Science Foundation of China - Project Leader
- 2023.01-2025.12 - Beijing Natural Science Foundation - Project Leader
- 2022.01-2025.12 - National Natural Science Foundation of China - Project Leader
- 2020.01-2023.12 - National Natural Science Foundation of China - Project Leader
- 2018.01-2021.12 - National Natural Science Foundation of China - Project Leader
- 2019.12-2022.12 - Ministry of Science and Technology Key R&D Program - Sub-project Leader
- 2019.12-2021.12 - Ministry of Science and Technology Key R&D Program - Sub-project Leader
- 2014.01-2016.12 - National Natural Science Foundation of China - Project Leader
Publications
- Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease, Yan-Hang Wang, Xin Chen, Yi-Zhen Bai, Peng Gao, Zhuo Yang, Qaing Guo, Ying-Yuan Lu, Jiao Zheng, Dan Liu, Jun Yang, Peng-Fei Tu, Ke-Wu Zeng, 2024
- Allosteric activation of transglutaminase 2 via inducing an 'open' conformation for osteoblast differentiation, Zhuo Yang, Xiao-Wen Zhang, Fang-Fang Zhuo, Ting-Ting Liu, Qian-Wei Luo, Yong-Zhe Zheng, Li L, Heng Yang, Yi-Chi Zhang, Yan-Hang Wang, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2023
- Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy, Xiao-Wen Zhang, Na Feng, Yan-Chen Liu, Qiang Guo, Jing-Kang Wang, Yi-Zhen Bai, Xiao-Ming Ye, Zhuo Yang, Heng Yang, Yang Liu, Mi-Mi Yang, Yan-Hang Wang, Xiao-Meng Shi, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2022
- Carbon quantum dots-based nanozyme from coffee induces cancer cell ferroptosis to activate antitumor immunity, Lu Yao, Mei-Mei Zhao, Qian-Wei Luo, Yi-Chi Zhang, Ting-Ting Liu, Zhuo Yang, Min Liao, Peng-Fei Tu, Ke-Wu Zeng, 2022
- Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy, Li-Xi Liao, Xiao-Min Song, Li-Chao Wang, Hai-Ning Lv, Jin-Feng Chen, Dan Liu, Ge Fu, Ming-Bo Zhao, Yong Jiang, Ke-Wu Zeng, Peng-Fei Tu, 2017
- Allosteric regulation of IGF2BP1 as a novel strategy for the activation of tumor immune microenvironment, Yang Liu, Qiang Guo, Heng Yang, Xiao-Wen Zhang, Na Feng, Jing-Kang Wang, Ting-Ting Liu, Ke-Wu Zeng, Peng-Fei Tu, 2022
- Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification, Qiang Guo, Yi-Chi Zhang, Wei Wang, Yu-Qi Wang, Yang Liu, Zhuo Yang, Mei-Mei Zhao, Na Feng, Yan-Hang Wang, Xiao-Wen Zhang, Heng Yang, Ting-Ting Liu, Lun-Yong Shi, Xiao-Meng Shi, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2022
- Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy, Ting-Ting Liu, Heng Yang, Fang-Fang Zhuo, Zhuo Yang, Mei-Mei Zhao, Qiang Guo, Yang Liu, Dan Liu, Ke-Wu Zeng, Peng-Fei Tu, 2022
- Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase, Xiaoqing Zhou, Shaoyang Zhao, Tingting Liu, Lu Yao, Meimei Zhao, Xiaoming Ye, Xiaowen Zhang, Qiang Guo, Pengfei Tu, Kewu Zeng, 2022
- Gold nanoparticle-based photo-cross-linking strategy for cellular target identification of supercomplex molecular systems, Lu Yao, Min Liao, Jing-Kang Wang, Jing Wang, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng, 2022
Awards
- 2023: Chinese Association of Traditional Chinese Medicine Science and Technology Award - Young and Middle-aged Innovation Talent Award
- 2023: Chinese Ethnic Medicine Association Science and Technology Award First Prize (Second Contributor)
- 2023: Chinese Association of Traditional Chinese Medicine - 2022 Top Ten Academic Advances in Traditional Chinese Medicine
- 2019: Ministry of Education High-level Talent Program Youth Project Selected
- 2019: Chinese Pharmacological Society - Young Pharmacologist Award
- 2016: Peking University Green Leaf Biomedical Outstanding Young Scholar Award
- 2014: Huaxia Medical Science and Technology Award Second Prize (Third Contributor)
- 2013: Chinese and Western Medicine Science and Technology Award Second Prize (Third Contributor)
- 2013: Higher Education Scientific Research Outstanding Achievement Award Second Prize (Third Contributor)
