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Aili Fan
Pharmaceutical Sciences
Peking University
Beijing
Language: Chinese, German, English
Marine Natural Products
Biosynthesis
Synthetic Biology
Key Enzymes
Catalytic Mechanisms
Heterologous Expression
Metabolic Regulation
Biomanufacturing
Drug Source Molecules
Active Compounds
Areas of Focus
- Discovery of marine natural products based on biosynthesis and synthetic biology
- Analysis of biosynthetic pathways and catalytic mechanisms of key enzymes in marine natural products
- Biomanufacturing of active drug source molecules based on heterologous expression/metabolic regulation
Work Experience
- 2020.12- Associate Researcher - Peking University
- 2015.9-2020.11 Associate Professor - Beijing University of Chemical Technology
- 2015.10-2017.8 Assistant Researcher - Institute of Microbiology, Chinese Academy of Sciences
Academic Background & Achievements
- 2011.9-2015.7 PhD in Pharmacy and Biotechnology: University of Marburg, Germany
- 2009.9-2011.7 Master's in Natural Product Chemistry: Peking University
- 2005.9-2009.7 Bachelor's in Pharmacy: Peking University
Publications
- Biosynthesis of epipyrone A reveals a highly specific membrane-bound fungal C-glycosyltransferase for pyrone galactosylation, Fan, Aili; Zhong, B.; Liu, D.; Lu, Y.; Wu, M.; Jin, H.; Shi, X.-M.; Ren, J.; Zhang, B.; Su, X.-d.; Ma, M.; Li, S.-M.; and Lin, W., 2024
- Brominated depsidones with antibacterial effects from a deep-sea-derived fungus Spiromastix sp., Huang, Z.; Liu, D.; Chen, S.; Ren, J.; Gao, C.; Li, Z.; Fan, A.; and Lin, W., 2024
- Concise biosynthesis of tropone-containing spiromaterpenes by a sesquiterpene cyclase and a multifunctional P450 from a deep-sea-derived Spiromastix sp. fungus, Liu, J.; Guo, X.; Guo, X.; Zhong, B.; Wang, T.; Liu, D.; Jin, H.; Ren, J.; Liu, Z.; Gao, J.; Li, S. M.; Fan, A.; Lin, W., 2022
- Sclerotiamides C–H, notoamides from a marine gorgonian-derived fungus with cytotoxic activities, Guo, X.; Meng, Q.; Liu, J.; Wu, J.; Jia, H.; Liu, D.; Gu, Y.; Liu, J.; Huang, J.; Fan, A.; Lin, W., 2022
- ThpacC acts as a positive regulator of homodimericin A biosynthesis and antifungal activities of Trichoderma harzianum 3.9236, Wu, M.; Wei, H.; Ma, K.; Cui, P.; Zhu, S.; Lai, D.; Ren, J.; Wang, W.; Fan, A.; Lin, W.; Su, H., 2021
- Rapid colonization and biodegradation of untreated commercial polyethylene wrap by a new strain of Bacillus velezensis C5, Liu, X.; Zhang, Y.; Sun, Q.; Liu, Z.; Zhao, Y.; Fan, A.; Su, H., 2021
- Epigenetic manipulation to trigger production of guaiane-type sesquiterpenes from a marine-derived Spiromastix sp. fungus with antineuroinflammatory effects, Guo, X.; Meng, Q.; Niu, S.; Liu, J.; Guo, X.; Sun, Z.; Liu, D.; Gu, Y.; Huang, J.; Fan, A.; Lin, W., 2021
- Recombinant protein production in the filamentous fungus Trichoderma, Wei, H.; Wu, M.; Fan, A.; Su, H., 2021
- Enhanced resistance of Trichoderma harzianum LZDX-32-08 to hygromycin B induced by sea salt, Yu, X.; Wei, H.; Liu, X.; Liu, D.; Fan, A.; Su, H., 2020
- Enhancing robustness of aerobic granule sludge under low C/N ratios with addition of kitchen wastewater, Wang, L.; Yu, X.; Xiong, W.; Li, P.; Wang, S.; Fan, A.; Su, H., 2020
- Reinvestigation of the substrate specificity of a reverse prenyltransferase NotF from Aspergillus sp. MF297-2, Yang, K.; Li, S.-M.; Liu, X.; Fan, A., 2020
- Unequivocal identification of two-bond heteronuclear correlations in natural products at nanomole scale by i-HMBC, Wang, Y.; Fan, A.; Cohen, R.D.; Dal Poggetto, G.; Huang, Z.; Yang, H.; Martin, G.E.; Sherer, E.C.; Reibarkh, M.; and Wang, X., 2023
- Oxepinamide F biosynthesis involves enzymatic D-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration, Zheng, L.; Wang, H.; Fan, A.; Li, S. M., 2020
- Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi, Li, W.; Fan, A.; Wang, L.; Zhang, P.; Liu, Z.; An, Z.; Yin, W.-B., 2018
- Deletion of a histone acetyltransferase leads to the pleiotropic activation of natural products in Metarhizium robertsii, Fan, A.; Mi, W.; Liu, Z.; Zeng, G.; Zhang, P.; Hu, Y.; Fang, W.; Yin, W.-B., 2017
