Professor | Aili Fan | Asia Growth Partners

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Name	Aili Fan
Contact Information	fanaili@bjmu.edu.cn
Language ability	Chinese, German, English
Province	Beijing

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Name

Aili Fan

Contact Information

fanaili@bjmu.edu.cn

Language ability

Chinese, German, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2011.9-2015.7 PhD in Pharmacy and Biotechnology: University of Marburg, Germany 2009.9-2011.7 Master's in Natural Product Chemistry: Peking University 2005.9-2009.7 Bachelor's in Pharmacy: Peking University
Work Experience	2020.12- Associate Researcher - Peking University 2015.9-2020.11 Associate Professor - Beijing University of Chemical Technology 2015.10-2017.8 Assistant Researcher - Institute of Microbiology, Chinese Academy of Sciences

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2011.9-2015.7 PhD in Pharmacy and Biotechnology: University of Marburg, Germany
2009.9-2011.7 Master's in Natural Product Chemistry: Peking University
2005.9-2009.7 Bachelor's in Pharmacy: Peking University

Work Experience

2020.12- Associate Researcher - Peking University
2015.9-2020.11 Associate Professor - Beijing University of Chemical Technology
2015.10-2017.8 Assistant Researcher - Institute of Microbiology, Chinese Academy of Sciences

Areas of Focus	Discovery of marine natural products based on biosynthesis and synthetic biology Analysis of biosynthetic pathways and catalytic mechanisms of key enzymes in marine natural products Biomanufacturing of active drug source molecules based on heterologous expression/metabolic regulation
Publications	Biosynthesis of epipyrone A reveals a highly specific membrane-bound fungal C-glycosyltransferase for pyrone galactosylation, Fan, Aili; Zhong, B.; Liu, D.; Lu, Y.; Wu, M.; Jin, H.; Shi, X.-M.; Ren, J.; Zhang, B.; Su, X.-d.; Ma, M.; Li, S.-M.; and Lin, W., 2024 Brominated depsidones with antibacterial effects from a deep-sea-derived fungus Spiromastix sp., Huang, Z.; Liu, D.; Chen, S.; Ren, J.; Gao, C.; Li, Z.; Fan, A.; and Lin, W., 2024 Concise biosynthesis of tropone-containing spiromaterpenes by a sesquiterpene cyclase and a multifunctional P450 from a deep-sea-derived Spiromastix sp. fungus, Liu, J.; Guo, X.; Guo, X.; Zhong, B.; Wang, T.; Liu, D.; Jin, H.; Ren, J.; Liu, Z.; Gao, J.; Li, S. M.; Fan, A.; Lin, W., 2022 Sclerotiamides C–H, notoamides from a marine gorgonian-derived fungus with cytotoxic activities, Guo, X.; Meng, Q.; Liu, J.; Wu, J.; Jia, H.; Liu, D.; Gu, Y.; Liu, J.; Huang, J.; Fan, A.; Lin, W., 2022 ThpacC acts as a positive regulator of homodimericin A biosynthesis and antifungal activities of Trichoderma harzianum 3.9236, Wu, M.; Wei, H.; Ma, K.; Cui, P.; Zhu, S.; Lai, D.; Ren, J.; Wang, W.; Fan, A.; Lin, W.; Su, H., 2021 Rapid colonization and biodegradation of untreated commercial polyethylene wrap by a new strain of Bacillus velezensis C5, Liu, X.; Zhang, Y.; Sun, Q.; Liu, Z.; Zhao, Y.; Fan, A.; Su, H., 2021 Epigenetic manipulation to trigger production of guaiane-type sesquiterpenes from a marine-derived Spiromastix sp. fungus with antineuroinflammatory effects, Guo, X.; Meng, Q.; Niu, S.; Liu, J.; Guo, X.; Sun, Z.; Liu, D.; Gu, Y.; Huang, J.; Fan, A.; Lin, W., 2021 Recombinant protein production in the filamentous fungus Trichoderma, Wei, H.; Wu, M.; Fan, A.; Su, H., 2021 Enhanced resistance of Trichoderma harzianum LZDX-32-08 to hygromycin B induced by sea salt, Yu, X.; Wei, H.; Liu, X.; Liu, D.; Fan, A.; Su, H., 2020 Enhancing robustness of aerobic granule sludge under low C/N ratios with addition of kitchen wastewater, Wang, L.; Yu, X.; Xiong, W.; Li, P.; Wang, S.; Fan, A.; Su, H., 2020 Reinvestigation of the substrate specificity of a reverse prenyltransferase NotF from Aspergillus sp. MF297-2, Yang, K.; Li, S.-M.; Liu, X.; Fan, A., 2020 Unequivocal identification of two-bond heteronuclear correlations in natural products at nanomole scale by i-HMBC, Wang, Y.; Fan, A.; Cohen, R.D.; Dal Poggetto, G.; Huang, Z.; Yang, H.; Martin, G.E.; Sherer, E.C.; Reibarkh, M.; and Wang, X., 2023 Oxepinamide F biosynthesis involves enzymatic D-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration, Zheng, L.; Wang, H.; Fan, A.; Li, S. M., 2020 Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi, Li, W.; Fan, A.; Wang, L.; Zhang, P.; Liu, Z.; An, Z.; Yin, W.-B., 2018 Deletion of a histone acetyltransferase leads to the pleiotropic activation of natural products in Metarhizium robertsii, Fan, A.; Mi, W.; Liu, Z.; Zeng, G.; Zhang, P.; Hu, Y.; Fang, W.; Yin, W.-B., 2017

Areas of Focus

Discovery of marine natural products based on biosynthesis and synthetic biology
Analysis of biosynthetic pathways and catalytic mechanisms of key enzymes in marine natural products
Biomanufacturing of active drug source molecules based on heterologous expression/metabolic regulation

Publications

Biosynthesis of epipyrone A reveals a highly specific membrane-bound fungal C-glycosyltransferase for pyrone galactosylation, Fan, Aili; Zhong, B.; Liu, D.; Lu, Y.; Wu, M.; Jin, H.; Shi, X.-M.; Ren, J.; Zhang, B.; Su, X.-d.; Ma, M.; Li, S.-M.; and Lin, W., 2024
Brominated depsidones with antibacterial effects from a deep-sea-derived fungus Spiromastix sp., Huang, Z.; Liu, D.; Chen, S.; Ren, J.; Gao, C.; Li, Z.; Fan, A.; and Lin, W., 2024
Concise biosynthesis of tropone-containing spiromaterpenes by a sesquiterpene cyclase and a multifunctional P450 from a deep-sea-derived Spiromastix sp. fungus, Liu, J.; Guo, X.; Guo, X.; Zhong, B.; Wang, T.; Liu, D.; Jin, H.; Ren, J.; Liu, Z.; Gao, J.; Li, S. M.; Fan, A.; Lin, W., 2022
Sclerotiamides C–H, notoamides from a marine gorgonian-derived fungus with cytotoxic activities, Guo, X.; Meng, Q.; Liu, J.; Wu, J.; Jia, H.; Liu, D.; Gu, Y.; Liu, J.; Huang, J.; Fan, A.; Lin, W., 2022
ThpacC acts as a positive regulator of homodimericin A biosynthesis and antifungal activities of Trichoderma harzianum 3.9236, Wu, M.; Wei, H.; Ma, K.; Cui, P.; Zhu, S.; Lai, D.; Ren, J.; Wang, W.; Fan, A.; Lin, W.; Su, H., 2021
Rapid colonization and biodegradation of untreated commercial polyethylene wrap by a new strain of Bacillus velezensis C5, Liu, X.; Zhang, Y.; Sun, Q.; Liu, Z.; Zhao, Y.; Fan, A.; Su, H., 2021
Epigenetic manipulation to trigger production of guaiane-type sesquiterpenes from a marine-derived Spiromastix sp. fungus with antineuroinflammatory effects, Guo, X.; Meng, Q.; Niu, S.; Liu, J.; Guo, X.; Sun, Z.; Liu, D.; Gu, Y.; Huang, J.; Fan, A.; Lin, W., 2021
Recombinant protein production in the filamentous fungus Trichoderma, Wei, H.; Wu, M.; Fan, A.; Su, H., 2021
Enhanced resistance of Trichoderma harzianum LZDX-32-08 to hygromycin B induced by sea salt, Yu, X.; Wei, H.; Liu, X.; Liu, D.; Fan, A.; Su, H., 2020
Enhancing robustness of aerobic granule sludge under low C/N ratios with addition of kitchen wastewater, Wang, L.; Yu, X.; Xiong, W.; Li, P.; Wang, S.; Fan, A.; Su, H., 2020
Reinvestigation of the substrate specificity of a reverse prenyltransferase NotF from Aspergillus sp. MF297-2, Yang, K.; Li, S.-M.; Liu, X.; Fan, A., 2020
Unequivocal identification of two-bond heteronuclear correlations in natural products at nanomole scale by i-HMBC, Wang, Y.; Fan, A.; Cohen, R.D.; Dal Poggetto, G.; Huang, Z.; Yang, H.; Martin, G.E.; Sherer, E.C.; Reibarkh, M.; and Wang, X., 2023
Oxepinamide F biosynthesis involves enzymatic D-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration, Zheng, L.; Wang, H.; Fan, A.; Li, S. M., 2020
Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi, Li, W.; Fan, A.; Wang, L.; Zhang, P.; Liu, Z.; An, Z.; Yin, W.-B., 2018
Deletion of a histone acetyltransferase leads to the pleiotropic activation of natural products in Metarhizium robertsii, Fan, A.; Mi, W.; Liu, Z.; Zeng, G.; Zhang, P.; Hu, Y.; Fang, W.; Yin, W.-B., 2017

Marine Natural Products Biosynthesis Synthetic Biology Key Enzymes Catalytic Mechanisms Heterologous Expression Metabolic Regulation Biomanufacturing Drug Source Molecules Active Compounds

Guang-Lei Ma - Zhejiang University

Ma Ming - Peking University

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