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Yangming Wang
Life Sciences / Medical / Biology
Peking University
Beijing
Language: Chinese, English
Stem Cells
Rna
Cell Biology
Molecular Biology
Genetics
Biochemistry
Bioinformatics
Sequencing
Gene Editing
Disease Models
Areas of Focus
- Stem Cell Biology
- RNA Biology
Work Experience
- 2000.7 – 2001.6 - Peking University, School of Life Sciences - Technician
- 2006.3 – 2010.12 - University of California, San Francisco - Postdoctoral Researcher, Advisor: Robert H. Blelloch
- 2011.1 – 2018.8 - Peking University, Institute of Molecular Medicine - Researcher (Assistant Professor)
- 2018.9 – 2021.1 - Peking University, Institute of Molecular Medicine - Researcher (Associate Professor)
- 2021.1 – Present - Peking University, School of Future Technology - Researcher (Professor)
Academic Background & Achievements
- 1996-2000 Bachelor's Degree: Peking University, School of Life Sciences
- 2001-2006 Ph.D.: University of Illinois at Urbana-Champaign, Advisor: Scott K. Silverman
- Achievement: Established miRNA knockout mouse embryonic stem cell lines
- Achievement: Discovered miR-290 and miR-302 families regulating embryonic stem cell functions
- Achievement: Invented miRNA-activated CRISPR-Cas9 gene editing system
Publications
- Highly reproducible and cost-effective one-pot organoid differentiation using a novel platform based on PF-127 triggered spheroid assembly, Zhang, X.S., Xie, G., Ma, H., Ding, S., Wu, Y.X., Fei, Y., Cheng, Q., Huang, Y. and *Wang, Y., 2023
- DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing, #Mi, L., #Shi, M., Li, Y.X., Xie, G., Rao, X., Wu, D., Cheng, A., Niu, M., Xu, F., Yu, Y., Gao, N., Wei, W., Wang, X. and *Wang, Y., 2023
- Klf17 promotes human naive pluripotency through repressing MAPK3 and ZIC2, Wang, S.H., Hao, J., Zhang, C., Duan, F.F., Chiu, Y.T., Shi, M., Huang, X., Yang, J., *Cao, H. and *Wang, Y., 2022
- Acidic pH transiently prevents the silencing of self-renewal and dampens microRNA function in embryonic stem cells, *Guo, W., Wang, S., Zhang, X., Shi, M., Duan, F., Hao, J., Gu, K., Quan, L., Wu, Y., Liang Z. and *Wang, Y., 2021
- Monitoring the promoter activity of long noncoding RNAs and stem cell differentiation through knock-in of sgRNA flanked by tRNA in an intron, Zhao, Y.T. and *Wang, Y., 2021
- DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program, #Yan, Y.L, #Zhang, C., Hao, J., Wang, X.L., Ming, J., Mi, L., Na, J., Hu, X. and *Wang，Y., 2019
- A microRNA-inducible CRISPR-Cas9 platform serves as a microRNA sensor and cell-type-specific genome regulation tool, #Wang, X.W., #Hu, L.F., Hao, J., Liao, L.Q., Chiu, Y.T., Shi, M. and *Wang，Y., 2019
- A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells, #Li, Y.P., #Duan, F.F., Zhao, Y.T., Gu, K.L., Liao, L.Q., Su, H.B., Hao, J., Zhang, K., Yang, N. and *Wang，Y., 2019
- DGCR8-independent stable microRNA expression strategy reveals important functions of miR-290 and miR-183~182 families in mouse embryonic stem cells, Wang, X.W., Hao, J., Guo, W.T., Liao, L.Q., Huang, S., Guo, X., Bao, X., Esteban, M.A. and *Wang, Y., 2017
- Pluripotency Associated miR-290/302 Family of microRNAs Promote the Dismantling of Naive Pluripotency, #Gu, K.L., #Zhang, Q., #Yan, Y., #Li, T.T., Duan, F.F., Hao, J., Wang, X.W., Shi, M., Wu, D.R., Guo, W.T., *Wang, Y., 2016
Awards
- National Outstanding Youth Fund Recipient
