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Lei Chen
Life Sciences / Medical / Biology
Peking University
Beijing
Language: Chinese, English
Metabolic Diseases
Cardiovascular Diseases
Membrane Proteins
Ion Channels
Structural Biology
Biochemistry
Cell Biology
Biophysics
Electrophysiology
Protein Mechanisms
Areas of Focus
- Mechanisms of important proteins related to metabolic and cardiovascular diseases, especially membrane proteins such as ion channels
Work Experience
- 2010-2016 - Oregon Health & Science University - Postdoctoral Researcher
- 2016-present - Academy for Advanced Interdisciplinary Studies, Peking University - Researcher, Doctoral Supervisor
Academic Background & Achievements
- 2001-2005 Bachelor's Degree: Tsinghua University, Department of Biological Sciences and Technology
- 2005-2010 Ph.D.: Tsinghua University, School of Life Sciences
Publications
- Structural basis for the binding of DNP and purine nucleotides onto UCP1, Y. Kang and L. Chen, 2023
- Functional dissection of KATP channel structures reveals the importance of a conserved interface, Y. Yang and L. Chen, 2023
- The inhibition mechanism of the SUR2A-containing K(ATP) channel by a regulatory helix, D. Ding, T. Hou, M. Wei, J. X. Wu and L. Chen, 2023
- Structures of human SGLT in the occluded state reveal conformational changes during sugar transport, W. Cui, Y. Niu, Z. Sun, R. Liu and L. Chen, 2023
- NO binds to the distal site of haem in the fully activated soluble guanylate cyclase, R. Liu, Y. Kang and L. Chen, 2023
- Structure of human phagocyte NADPH oxidase in the resting state, R. Liu, K. Song, J. X. Wu, X. P. Geng, L. Zheng, X. Gao, H. Peng and L. Chen, 2022
- Structural mechanism of SGLT1 inhibitors, Y. Niu, W. Cui, R. Liu, S. Wang, H. Ke, X. Lei and L. Chen, 2022
- Identification of ASPDH as a novel NAADP-binding protein, X. He, Y. Kang and L. Chen, 2022
- Structural identification of riluzole-binding site on human TRPC5, Y. Yang, M. Wei and L. Chen, 2022
- Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide, M. Wang, J. X. Wu and L. Chen, 2022
- Structural identification of vasodilator binding sites on the SUR2 subunit, D. Ding, J. X. Wu, X. Duan, S. Ma, L. Lai and L. Chen, 2022
- Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides, M. Wang, J. X. Wu, D. Ding and L. Chen, 2022
- Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex, Y. Kang and L. Chen, 2022
- A co-expression vector for baculovirus-mediated protein expression in mammalian cells, W. Guo, M. Wang and L. Chen, 2022
- Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites, W. Guo, Q. Tang, M. Wei, Y. Kang, J. X. Wu and L. Chen, 2022
- Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter, Y. Niu, R. Liu, C. Guan, Y. Zhang, Z. Chen, S. Hoerer, H. Nar and L. Chen, 2021
- Activation mechanism of human soluble guanylate cyclase by stimulators and activators, R. Liu, Y. Kang and L. Chen, 2021
- Structural basis for human TRPC5 channel inhibition by two distinct inhibitors, K. Song, M. Wei, W. Guo, L. Quan, Y. Kang, J. X. Wu and L. Chen, 2021
- Structures of human dual oxidase 1 complex in low-calcium and high-calcium states, J. X. Wu, R. Liu, K. Song and L. Chen, 2021
- Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor, C. Guan, Y. Niu, S. C. Chen, Y. Kang, J. X. Wu, K. Nishi, C. C. Y. Chang, T. Y. Chang, T. Luo and L. Chen, 2020
- Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex, Y. Kang, J. X. Wu and L. Chen, 2020
- Recent Progress on The Studies of OSCA/TMEM63 Family Ion Channels, J. X. Wu and L. Chen, 2020
- Structural insights into the mechanism of human soluble guanylate cyclase, Y. Kang, R. Liu, J. X. Wu and L. Chen, 2019
- Recent progress in structural studies on canonical TRP ion channels, W. Guo and L. Chen, 2019
- The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel, D. Ding, M. Wang, J. X. Wu, Y. Kang and L. Chen, 2019
- Structure of the mechanosensitive OSCA channels, M. Zhang, D. Wang, Y. Kang, J. X. Wu, F. Yao, C. Pan, Z. Yan, C. Song and L. Chen, 2018
- Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels, J. X. Wu, D. Ding, M. Wang, Y. Kang, X. Zeng and L. Chen, 2018
- Structure of the receptor-activated human TRPC6 and TRPC3 ion channels, Q. Tang, W. Guo, L. Zheng, J. X. Wu, M. Liu, X. Zhou, X. Zhang and L. Chen, 2018
- Structure of a Pancreatic ATP-Sensitive Potassium Channel, N. Li, J. X. Wu, D. Ding, J. Cheng, N. Gao and L. Chen, 2017
- Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states, K. L. Durr, L. Chen, R. A. Stein, R. De Zorzi, I. M. Folea, T. Walz, H. S. McHaourab and E. Gouaux, 2014
- X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism, L. Chen, K. L. Durr and E. Gouaux, 2014
- Conserved regulatory elements in AMPK, L. Chen, F. J. Xin, J. Wang, J. Hu, Y. Y. Zhang, S. Wan, L. S. Cao, C. Lu, P. Li, S. F. Yan, D. Neumann, U. Schlattner, B. Xia, Z. X. Wang and J. W. Wu, 2013
- AMP-activated protein kinase undergoes nucleotide-dependent conformational changes, L. Chen, J. Wang, Y. Y. Zhang, S. F. Yan, D. Neumann, U. Schlattner, Z. X. Wang and J. W. Wu, 2012
- Structural insight into the autoinhibition mechanism of AMP-activated protein kinase, L. Chen, Z. H. Jiao, L. S. Zheng, Y. Y. Zhang, S. T. Xie, Z. X. Wang and J. W. Wu, 2009
