Professor | Guo-Liang Xu | Asia Growth Partners

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Name	Guo-Liang Xu
Contact Information	xugl@fudan.edu.cn
Language ability	Chinese, English, German
Province	Shanghai

Upload Avatar (500 x 500)

Name

Guo-Liang Xu

Contact Information

xugl@fudan.edu.cn

Language ability

Chinese, English, German

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	1989-1993 PhD: Max Planck Institute for Molecular Genetics, Germany 1985-1988 Master's: Institute of Genetics, Chinese Academy of Sciences, Beijing 1981-1985 Bachelor's: Department of Biology, Zhejiang University 2001 National Outstanding Youth Science Fund, National Natural Science Foundation
Work Experience	2017.03-Present - Fudan University - Professor, Executive Dean (Concurrent) 2001.08-Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher 2000.04-2001.07 - Columbia University Medical Center - Associate Research Scientist 1995.10-2000.03 - Department of Genetics and Development, Columbia University - Postdoctoral Fellow 1994.08-1995.09 - National University of Singapore, Life Sciences Center - Laboratory Director 1993.03-1994.07 - Max Planck Institute for Molecular Genetics, Germany - Postdoctoral Fellow
Awards	2017: Ho Leung Ho Lee Foundation Science and Technology Progress Award 2016: Shanghai Natural Science First Prize, Shanghai Municipal Government 2014: Chen Jiageng Life Science Award, Chen Jiageng Science Award Foundation 2013: TWAS Biology Award, The World Academy of Sciences

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

1989-1993 PhD: Max Planck Institute for Molecular Genetics, Germany
1985-1988 Master's: Institute of Genetics, Chinese Academy of Sciences, Beijing
1981-1985 Bachelor's: Department of Biology, Zhejiang University
2001 National Outstanding Youth Science Fund, National Natural Science Foundation

Work Experience

2017.03-Present - Fudan University - Professor, Executive Dean (Concurrent)
2001.08-Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
2000.04-2001.07 - Columbia University Medical Center - Associate Research Scientist
1995.10-2000.03 - Department of Genetics and Development, Columbia University - Postdoctoral Fellow
1994.08-1995.09 - National University of Singapore, Life Sciences Center - Laboratory Director
1993.03-1994.07 - Max Planck Institute for Molecular Genetics, Germany - Postdoctoral Fellow

Awards

2017: Ho Leung Ho Lee Foundation Science and Technology Progress Award
2016: Shanghai Natural Science First Prize, Shanghai Municipal Government
2014: Chen Jiageng Life Science Award, Chen Jiageng Science Award Foundation
2013: TWAS Biology Award, The World Academy of Sciences

Areas of Focus	Epigenetics research focusing on covalent modifications of chromatin Exploring new base modification forms and biological functions in mammalian cells Epigenetic regulatory mechanisms crucial for maintaining hematopoietic homeostasis and the development of hematological malignancies Principles of cardiac progenitor cell fate determination and strategies for addressing developmental defects and diseases in organs like the heart
Publications	Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency, Bin Chen, Ya-Rui Du, Hong Zhu, Mei-Ling Sun, Chao Wang, Yi Cheng, Haiyan Pang, Guolian Ding, Juan Gao, Yajing Tan, Xiaomei Tong, Pingping Lv, Feng Zhou, Qitao Zhan, Zhi-Mei Xu, Li Wang, Donghao Luo, Yinghui Ye, Li Jin, Songying Zhang, Yimin Zhu, Xiaona Lin, Yanting Wu, Luyang Jin, Yin Zhou, Caochong Yan, Jianzhong Sheng, Peter R. Flatt, Guo-Liang Xu & Hefeng Huang, 2022 Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development, Qin Xu, Chao Wang, Jia-Xin Zhou, Zhi-Mei Xu, Juan Gao, Peng-Fei Sui, Colum P Walsh, Hong-Bin Ji & Guo-Liang Xu, 2022 Reversal of nucleobase methylation by dioxygenases, Guo-Liang Xu, Matthias Bochtler, 2020 A vitamin-C-derived DNA modification catalysed by an algal TET homologue, Jian-Huang Xue, Guo-Dong Chen, Fuhua Hao, Hui Chen, Zhaoyuan Fang, Fang-Fang Chen, Bo Pang, Qing-Lin Yang, Xinben Wei, Qiang-Qiang Fan, Changpeng Xin, Jiaohong Zhao, Xuan Deng, Bang-An Wang, Xiao-Jie Zhang, Yueying Chu, Hui Tang, Huiyong Yin, Weimin Ma, Luonan Chen, Jianping Ding, Elmar Weinhold, Rahul M. Kohli, Wen Liu, Zheng-Jiang Zhu, Kaiyao Huang, Huiru Tang & Guo-Liang Xu, 2019 TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling, Hai-Qiang Dai, Bang-An Wang, Lu Yang, Jia-Jia Chen, Guo-Chun Zhu, Mei-Ling Sun, Hao Ge, Rui Wang, Deborah L. Chapman, Fuchou Tang, Xin Sun & Guo-Liang Xu, 2016 Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote, Fan Guo, Xianlong Li, Dan Liang, Tong Li, Ping Zhu, Hongshan Guo, Xinglong Wu, Lu Wen, Tian-Peng Gu, Colum P. Walsh, Jinsong Li, Fuchou Tang & Guo-Liang Xu, 2014 Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming, Xiao Hu, Lei Zhang, Shi-Qing Mao, Zheng Li, Jiekai Chen, Run-Rui Zhang, Hai-Ping Wu, Juan Gao, Fan Guo, Wei Liu, Gui-Fang Xu, Hai-Qiang Dai, Yujiang Geno Shi, Xianlong Li, Boqiang Hu, Fuchou Tang, Duanqing Pei & Guo-Liang Xu, 2014 Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition, Run-Rui Zhang, Qing-Yan Cui, Kiyohito Murai, Yen Ching Lim, Zachary D. Smith, Shengnan Jin, Peng Ye, Luis Rosa, Yew Kok Lee, Hai-Ping Wu, Wei Liu, Zhi-Mei Xu, Lu Yang, Yu-Qiang Ding, Fuchou Tang, Alexander Meissner, Chunming Ding, Yanhong Shi & Guo-Liang Xu, 2013 Vitamin C modulates Tet1 function during somatic cell reprogramming, Jiekai Chen, Lin Guo, Lei Zhang, Haoyu Wu, Jiaqi Yang, He Liu, Xiaoshan Wang, Xiao Hu, Tianpeng Gu, Zhiwei Zhou, Jing Liu, Jiadong Liu, Hongling Wu, Shi-Qing Mao, Kunlun Mo, Yingying Li, Keyu Lai, Jing Qi, Hongjie Yao, Guangjin Pan, Guo-Liang Xu & Duanqing Pei, 2013 Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells, Hui Yang, Linyu Shi, Bang-An Wang, Dan Liang, Cuiqing Zhong, Wei Liu, Yongzhan Nie, Jie Liu, Jing Zhao, Xiang Gao, Dangsheng Li, Guo-Liang Xu & Jinsong Li, 2012 Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA, Yu-Fei He, Bin-Zhong Li, Zheng Li, Peng Liu, Yang Wang, Qingyu Tang, Jianping Ding, Yingying Jia, Zhangcheng Chen, Lin Li, Yan Sun, Xiuxue Li, Qing Dai, Chun-Xiao Song, Kangling Zhang, Chuan He & Guo-Liang Xu, 2011 The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes, Tian-Peng Gu, Fan Guo, Hui Yang, Hai-Ping Wu, Gui-Fang Xu, Wei Liu, Zhi-Guo Xie, Linyu Shi, Xinyi He, Seung-gi Jin, Khursheed Iqbal, Yujiang Geno Shi, Zixin Deng, Piroska E. Szabó, Gerd P. Pfeifer, Jinsong Li & Guo-Liang Xu, 2011

Areas of Focus

Epigenetics research focusing on covalent modifications of chromatin
Exploring new base modification forms and biological functions in mammalian cells
Epigenetic regulatory mechanisms crucial for maintaining hematopoietic homeostasis and the development of hematological malignancies
Principles of cardiac progenitor cell fate determination and strategies for addressing developmental defects and diseases in organs like the heart

Publications

Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency, Bin Chen, Ya-Rui Du, Hong Zhu, Mei-Ling Sun, Chao Wang, Yi Cheng, Haiyan Pang, Guolian Ding, Juan Gao, Yajing Tan, Xiaomei Tong, Pingping Lv, Feng Zhou, Qitao Zhan, Zhi-Mei Xu, Li Wang, Donghao Luo, Yinghui Ye, Li Jin, Songying Zhang, Yimin Zhu, Xiaona Lin, Yanting Wu, Luyang Jin, Yin Zhou, Caochong Yan, Jianzhong Sheng, Peter R. Flatt, Guo-Liang Xu & Hefeng Huang, 2022
Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development, Qin Xu, Chao Wang, Jia-Xin Zhou, Zhi-Mei Xu, Juan Gao, Peng-Fei Sui, Colum P Walsh, Hong-Bin Ji & Guo-Liang Xu, 2022
Reversal of nucleobase methylation by dioxygenases, Guo-Liang Xu, Matthias Bochtler, 2020
A vitamin-C-derived DNA modification catalysed by an algal TET homologue, Jian-Huang Xue, Guo-Dong Chen, Fuhua Hao, Hui Chen, Zhaoyuan Fang, Fang-Fang Chen, Bo Pang, Qing-Lin Yang, Xinben Wei, Qiang-Qiang Fan, Changpeng Xin, Jiaohong Zhao, Xuan Deng, Bang-An Wang, Xiao-Jie Zhang, Yueying Chu, Hui Tang, Huiyong Yin, Weimin Ma, Luonan Chen, Jianping Ding, Elmar Weinhold, Rahul M. Kohli, Wen Liu, Zheng-Jiang Zhu, Kaiyao Huang, Huiru Tang & Guo-Liang Xu, 2019
TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling, Hai-Qiang Dai, Bang-An Wang, Lu Yang, Jia-Jia Chen, Guo-Chun Zhu, Mei-Ling Sun, Hao Ge, Rui Wang, Deborah L. Chapman, Fuchou Tang, Xin Sun & Guo-Liang Xu, 2016
Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote, Fan Guo, Xianlong Li, Dan Liang, Tong Li, Ping Zhu, Hongshan Guo, Xinglong Wu, Lu Wen, Tian-Peng Gu, Colum P. Walsh, Jinsong Li, Fuchou Tang & Guo-Liang Xu, 2014
Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming, Xiao Hu, Lei Zhang, Shi-Qing Mao, Zheng Li, Jiekai Chen, Run-Rui Zhang, Hai-Ping Wu, Juan Gao, Fan Guo, Wei Liu, Gui-Fang Xu, Hai-Qiang Dai, Yujiang Geno Shi, Xianlong Li, Boqiang Hu, Fuchou Tang, Duanqing Pei & Guo-Liang Xu, 2014
Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition, Run-Rui Zhang, Qing-Yan Cui, Kiyohito Murai, Yen Ching Lim, Zachary D. Smith, Shengnan Jin, Peng Ye, Luis Rosa, Yew Kok Lee, Hai-Ping Wu, Wei Liu, Zhi-Mei Xu, Lu Yang, Yu-Qiang Ding, Fuchou Tang, Alexander Meissner, Chunming Ding, Yanhong Shi & Guo-Liang Xu, 2013
Vitamin C modulates Tet1 function during somatic cell reprogramming, Jiekai Chen, Lin Guo, Lei Zhang, Haoyu Wu, Jiaqi Yang, He Liu, Xiaoshan Wang, Xiao Hu, Tianpeng Gu, Zhiwei Zhou, Jing Liu, Jiadong Liu, Hongling Wu, Shi-Qing Mao, Kunlun Mo, Yingying Li, Keyu Lai, Jing Qi, Hongjie Yao, Guangjin Pan, Guo-Liang Xu & Duanqing Pei, 2013
Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells, Hui Yang, Linyu Shi, Bang-An Wang, Dan Liang, Cuiqing Zhong, Wei Liu, Yongzhan Nie, Jie Liu, Jing Zhao, Xiang Gao, Dangsheng Li, Guo-Liang Xu & Jinsong Li, 2012
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA, Yu-Fei He, Bin-Zhong Li, Zheng Li, Peng Liu, Yang Wang, Qingyu Tang, Jianping Ding, Yingying Jia, Zhangcheng Chen, Lin Li, Yan Sun, Xiuxue Li, Qing Dai, Chun-Xiao Song, Kangling Zhang, Chuan He & Guo-Liang Xu, 2011
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes, Tian-Peng Gu, Fan Guo, Hui Yang, Hai-Ping Wu, Gui-Fang Xu, Wei Liu, Zhi-Guo Xie, Linyu Shi, Xinyi He, Seung-gi Jin, Khursheed Iqbal, Yujiang Geno Shi, Zixin Deng, Piroska E. Szabó, Gerd P. Pfeifer, Jinsong Li & Guo-Liang Xu, 2011

Chromatin Covalent Modifications Epigenetics Dna Methylation Embryonic Development Stem Cells Self-Renewal Differentiation Tumorigenesis Disease Mechanisms

Fei Lan - Fudan University

Hongjie Shen - Fudan University

Guo-Liang Xu - Fudan University

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