Professor | Fei Lan | Asia Growth Partners

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Name	Fei Lan
Contact Information	fei_lan@fudan.edu.cn
Language ability	English, Chinese
Province	Shanghai

Upload Avatar (500 x 500)

Name

Fei Lan

Contact Information

fei_lan@fudan.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	2002-2008 PhD: Harvard University, Department of Cell and Developmental Biology 1999-2002 Master's: Fudan University, Shanghai Medical College, Former Cancer Research Institute 1995-1999 Bachelor's: Fudan University, School of Life Sciences, Department of Biochemistry 2019 National Outstanding Youth Science Fund, NSFC 2016 Shanghai Outstanding Academic Leader, Shanghai Science and Technology Commission 2012 Shanghai Higher Education Institutions Distinguished Professor, Shanghai Municipal Education Commission
Work Experience	2012.12-Present - Fudan University, Institute of Biomedical Sciences/Affiliated Zhongshan Hospital - Researcher 2008.2-2012.12 - Constellation Pharmaceuticals, USA - Researcher
Awards	2017: Zhongyuan Concord Life Medicine Innovation Breakthrough Award, Zhongyuan Concord Foundation, University of Chinese Academy of Sciences 2017: Top Ten Medical Advances in China (Basic Category), China Science News Agency, People's Daily Online 2016: Tang Jiazheng Life Science Award (Innovation Award), Shanghai Biomedical Industry Association 2016: Shanghai 'Outstanding Academic Leader', Shanghai Science and Technology Commission

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

2002-2008 PhD: Harvard University, Department of Cell and Developmental Biology
1999-2002 Master's: Fudan University, Shanghai Medical College, Former Cancer Research Institute
1995-1999 Bachelor's: Fudan University, School of Life Sciences, Department of Biochemistry
2019 National Outstanding Youth Science Fund, NSFC
2016 Shanghai Outstanding Academic Leader, Shanghai Science and Technology Commission
2012 Shanghai Higher Education Institutions Distinguished Professor, Shanghai Municipal Education Commission

Work Experience

2012.12-Present - Fudan University, Institute of Biomedical Sciences/Affiliated Zhongshan Hospital - Researcher
2008.2-2012.12 - Constellation Pharmaceuticals, USA - Researcher

Awards

2017: Zhongyuan Concord Life Medicine Innovation Breakthrough Award, Zhongyuan Concord Foundation, University of Chinese Academy of Sciences
2017: Top Ten Medical Advances in China (Basic Category), China Science News Agency, People's Daily Online
2016: Tang Jiazheng Life Science Award (Innovation Award), Shanghai Biomedical Industry Association
2016: Shanghai 'Outstanding Academic Leader', Shanghai Science and Technology Commission

Areas of Focus	Epigenetic regulation mechanisms in pluripotent stem cells Histone methylation regulation and recognition mechanisms in epigenetics
Publications	BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer–promoter activity and maintains pluripotency, Niu, C., Wang, S., Guo, J., Wei, X., Jia, M., Chen, Z., Gong, W., Qin, Y., Wang, X., Zhi, X., Lu, M., Chen, S., Gu, M., Zhang, J., Han, J.-D. J., Lan, F., and Meng, D, 2021 Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth, Rong, B., Zhang, Q., Wan, J., Xing, S., Dai, R., Li, Y., Cai, J., Xie, J., Song, Y., Chen, J., Zhang, L., Yan, G., Zhang, W., Gao, H., Han, J.-D. J., Qu, Q., Ma, H., Tian, Y., and Lan, F., 2020 Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection, Wan, J., Xing, S., Ding, L., Wang, Y., Gu, C., Wu, Y., Rong, B., Li, C., Wang, S., Chen, K., He, C., Zhu, D., Yuan, S., Qiu, C., Zhao, C., Nie, L., Gao, Z., Jiao, J., Zhang, X., Wang, X., Ying, T., Wang, H., Xie, Y., Lu, Y., Xu, J., and Lan, F., 2020 Refined Spatial-temporal Epigenomic Profiling Reveals Intrinsic Connection between PRDM9-mediated H3K4me3 and the Fate of Double-stranded Breaks, Yao Chen, Ruitu Lv, Bowen Rong, Yuxuan Zheng, Zhen Lin, Ruofei Dai, Xi Zhang, Nannan Xie, Siqing Wang, Fuchou Tang, Fei Lan and Ming-Han Tong, 2020 DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation, Wenqi Xu, Jiahui Li, Bowen Rong, Bin Zhao, Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo, Hongjie Shen, Feizhen Wu, Fei Lan, 2019 HNF1B-mediated repression of SLUG is suppressed by EZH2 in aggressive prostate cancer, Jianqing Wang, Chenxi He, Peng Gao, Siqing Wang, Ruitu Lv, Huihui Zhou, Qidong Zhou, Ke Zhang, Jian Sun, Caibin Fan, Guanxiong Ding and Fei Lan, 2019 Mettl17, a Regulator of Mitochondrial Ribosomal RNA Modifications, Is Required for the Translation of Mitochondrial Coding Genes, Zhennan Shi, Siyuan Xu, Shenghui Xing, Ke Yao, Lei Zhang, Luxi Xue, Bisi Miao, Peng Zhou, Ming Wang, Guoquan Yan, Pengyuan Yang, Jing Liu, Zeping Hu, Fei Lan, 2019 H3K14me3 Genomic Distributions and its regulation by KDM4 family demethylases, Zhao B, Xu W, Rong B, Chen G, Ye X, Dai R, Li W, Chen J, Cai J, Song L, Luo ZQ, Zeng R, Shi Y, Han JJ, Lan F, 2018 The histone methyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice, Zuo X, Rong B, Li L, Lv R, Lan F, Tong MH, 2018 Histone lysine demethylases in mammalian embryonic development, Shen H, Xu W, Lan F, 2017 Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency, Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F, Shi Y, 2016 Suppression of Enhancer Over-activation by a RACK7-Histone Demethylase Complex, Shen H, Xu W, Guo R, Rong B, Gu L, Wang Z, He C, Zheng L, Hu X, Shao Z-M, Yang PY, Wu FZ, Shi YG, Shi Y, Lan F, 2016 Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria, Yang L, Lian X, Zhang W, Guo J, Wang Q, Li Y, Chen Y, Yin X, Yang P, Lan F, He QY, Zhang G, Wang T, 2015 Histone H3.3 and Cancer: a potential reader connection, Lan F, Shi Y, 2015 BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing, Guo R, Zheng LJ, Park JW, Xu WQ, Chen H, Qiu JS, Lv RT, Wang ZT, Yang PY, Wu FZ, Shi XB, Fu XD, Shi X, Shi YG, Xing Y, Lan F, Shi Y, 2014 Mechanisms involved in the regulation of histone lysine demethylases, Lan F, Nottke AC, Shi Y, 2008 A histone H3 lysine 27 demethylase regulates animal posterior development, Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y, 2007 Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression, Lan F, Collins RE, De Cegli R, Alpatov R, Horton JR, Shi X, Gozani O, Cheng X, Shi Y, 2007 S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription, Lan F, Zaratiegui M, Villén J, Vaughn MW, Verdel A, Huarte M, Shi Y, Gygi SP, Moazed D, Martienssen RA, Shi Y, 2007 The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases, Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y, 2007 Regulation of LSD1 histone demethylase activity by its associated factors, Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y, 2005 Histone demethylation mediated by the nuclear amine oxidase homolog LSD1, Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y, 2004

Areas of Focus

Epigenetic regulation mechanisms in pluripotent stem cells
Histone methylation regulation and recognition mechanisms in epigenetics

Publications

BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer–promoter activity and maintains pluripotency, Niu, C., Wang, S., Guo, J., Wei, X., Jia, M., Chen, Z., Gong, W., Qin, Y., Wang, X., Zhi, X., Lu, M., Chen, S., Gu, M., Zhang, J., Han, J.-D. J., Lan, F.*, and Meng, D*, 2021
Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth, Rong, B., Zhang, Q., Wan, J., Xing, S., Dai, R., Li, Y., Cai, J., Xie, J., Song, Y., Chen, J., Zhang, L., Yan, G., Zhang, W., Gao, H., Han, J.-D. J., Qu, Q., Ma, H., Tian, Y.*, and Lan, F.*, 2020
Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection, Wan, J., Xing, S., Ding, L., Wang, Y., Gu, C., Wu, Y., Rong, B., Li, C., Wang, S., Chen, K., He, C., Zhu, D., Yuan, S., Qiu, C., Zhao, C., Nie, L., Gao, Z., Jiao, J., Zhang, X., Wang, X., Ying, T., Wang, H., Xie, Y.*, Lu, Y.*, Xu, J.*, and Lan, F.*, 2020
Refined Spatial-temporal Epigenomic Profiling Reveals Intrinsic Connection between PRDM9-mediated H3K4me3 and the Fate of Double-stranded Breaks, Yao Chen, Ruitu Lv, Bowen Rong, Yuxuan Zheng, Zhen Lin, Ruofei Dai, Xi Zhang, Nannan Xie, Siqing Wang, Fuchou Tang*, Fei Lan* and Ming-Han Tong*, 2020
DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation, Wenqi Xu, Jiahui Li, Bowen Rong, Bin Zhao, Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo, Hongjie Shen*, Feizhen Wu*, Fei Lan*, 2019
HNF1B-mediated repression of SLUG is suppressed by EZH2 in aggressive prostate cancer, Jianqing Wang*, Chenxi He, Peng Gao, Siqing Wang, Ruitu Lv, Huihui Zhou, Qidong Zhou, Ke Zhang, Jian Sun, Caibin Fan, Guanxiong Ding* and Fei Lan*, 2019
Mettl17, a Regulator of Mitochondrial Ribosomal RNA Modifications, Is Required for the Translation of Mitochondrial Coding Genes, Zhennan Shi, Siyuan Xu, Shenghui Xing, Ke Yao, Lei Zhang, Luxi Xue, Bisi Miao, Peng Zhou, Ming Wang, Guoquan Yan, Pengyuan Yang, Jing Liu, Zeping Hu*, Fei Lan*, 2019
H3K14me3 Genomic Distributions and its regulation by KDM4 family demethylases, Zhao B, Xu W, Rong B, Chen G, Ye X, Dai R, Li W, Chen J, Cai J, Song L, Luo ZQ, Zeng R, Shi Y, Han JJ, Lan F*, 2018
The histone methyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice, Zuo X, Rong B, Li L, Lv R, Lan F*, Tong MH*, 2018
Histone lysine demethylases in mammalian embryonic development, Shen H, Xu W, Lan F*, 2017
Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency, Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F*, Shi Y*, 2016
Suppression of Enhancer Over-activation by a RACK7-Histone Demethylase Complex, Shen H, Xu W, Guo R, Rong B, Gu L, Wang Z, He C, Zheng L, Hu X, Shao Z-M, Yang PY, Wu FZ, Shi YG, Shi Y*, Lan F*, 2016
Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria, Yang L, Lian X, Zhang W, Guo J, Wang Q, Li Y, Chen Y, Yin X, Yang P, Lan F*, He QY*, Zhang G*, Wang T*, 2015
Histone H3.3 and Cancer: a potential reader connection, Lan F*, Shi Y*, 2015
BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing, Guo R, Zheng LJ, Park JW, Xu WQ, Chen H, Qiu JS, Lv RT, Wang ZT, Yang PY, Wu FZ, Shi XB, Fu XD, Shi X, Shi YG, Xing Y*, Lan F*, Shi Y*, 2014
Mechanisms involved in the regulation of histone lysine demethylases, Lan F*, Nottke AC*, Shi Y, 2008
A histone H3 lysine 27 demethylase regulates animal posterior development, Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y, 2007
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression, Lan F, Collins RE, De Cegli R, Alpatov R, Horton JR, Shi X, Gozani O, Cheng X, Shi Y, 2007
S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription, Lan F, Zaratiegui M, Villén J, Vaughn MW, Verdel A, Huarte M, Shi Y, Gygi SP, Moazed D, Martienssen RA, Shi Y, 2007
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases, Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y, 2007
Regulation of LSD1 histone demethylase activity by its associated factors, Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y, 2005
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1, Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y, 2004

Pluripotent Stem Cells Epigenetics Histone Methylation Gene Regulation Disease Mechanisms Tumor Metastasis Histone Variants Mrna Splicing Chromatin Methylation

Guo-Liang Xu - Fudan University

Hongjie Shen - Fudan University

Guo-Liang Xu - Fudan University

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