Professor | Alastair Murchie | Asia Growth Partners

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Name	Alastair Murchie
Contact Information	aihm@fudan.edu.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Alastair Murchie

Contact Information

aihm@fudan.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	1990.09-1994.06 PhD: University of Dundee, Biochemistry and Molecular Biology (Supervisor: David Lilley) 1981.09-1984.06 Bachelor's: University of Manchester, Chemistry 2015 Key International (Regional) Cooperation Research Project, National Natural Science Foundation
Work Experience	2005.03-Present - Fudan University, Institute of Biomedical Sciences - Professor 2003.12-2005.02 - Pasteur Institute, Paris, France - Chief R&D, Ariana pharmac 1998.07-2003.02 - Ribotargets, Cambridge, UK - Chief R&D 1994.09-1998.06 - University of Dundee, UK - Postdoctoral and Senior Researcher, Department of Biochemistry
Awards	White Magnolia Memorial Award (2015): Shanghai

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

1990.09-1994.06 PhD: University of Dundee, Biochemistry and Molecular Biology (Supervisor: David Lilley)
1981.09-1984.06 Bachelor's: University of Manchester, Chemistry
2015 Key International (Regional) Cooperation Research Project, National Natural Science Foundation

Work Experience

2005.03-Present - Fudan University, Institute of Biomedical Sciences - Professor
2003.12-2005.02 - Pasteur Institute, Paris, France - Chief R&D, Ariana pharmac
1998.07-2003.02 - Ribotargets, Cambridge, UK - Chief R&D
1994.09-1998.06 - University of Dundee, UK - Postdoctoral and Senior Researcher, Department of Biochemistry

Awards

White Magnolia Memorial Award (2015): Shanghai

Areas of Focus	Research on advanced structures and biological functions of nucleic acids, including: discovery, structure, and function of riboswitch RNA and novel ribozyme RNA, and their impact on gene expression and regulation, RNA modification and its biological functions, research on RNA epigenetics in diseases and stem cells. Regulation of antibiotic resistance gene expression by interactions between non-coding RNA and small molecules.
Publications	The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences, Hengyi Jiang, Yanqing Gao, Lei Zhang, Dongrong Chen, Jianhua Gan, Alastair I H Murchie, 2021 The function of twister ribozyme variants in non-LTR retrotransposition in Schistosoma mansoni, Getong Liu, Hengyi Jiang, Wenxia Sun, Jun Zhang, Dongrong Chen, Alastair I H Murchie, 2021 Aminoglycoside antibiotics can inhibit or activate twister ribozyme cleavage, Jun Zhang, Getong Liu, Wenxia Sun, Dongrong Chen, Alastair I H Murchie, 2020 Interactions between the 5' UTR mRNA of the spe2 gene and spermidine regulate translation in S. pombe, Wenxia Sun, Xuhui Zhang, Dongrong Chen, Alastair I H Murchie, 2020 Aminoglycoside riboswitch control of the expression of integron associated aminoglycoside resistance adenyltransferases, Jun Zhang, Getong Liu, Xuhui Zhang, Yaowen Chang, Shasha Wang, Weizhi He, Wenxia Sun, Dongrong Chen, Alastair I H Murchie, 2020 Interactions between SAM and the 5' UTR mRNA of the sam1 gene regulate translation in S. pombe, Xuhui Zhang, Wenxia Sun, Dongrong Chen, Alastair I H Murchie, 2020 Integron-Derived Aminoglycoside-Sensing Riboswitches Control Aminoglycoside Acetyltransferase Resistance Gene Expression, Shasha Wang, Weizhi He, Wenxia Sun, Jun Zhang, Yaowen Chang, Dongrong Chen, Alastair I H Murchie, 2019 Osmium tetroxide as a probe of RNA structure, Jing Zhang, Danbin Li, Jun Zhang, Dongrong Chen, Alastair I H Murchie, 2017 Substrate recognition and modification by the nosiheptide resistance methyltransferase, Sitao Yin, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2015 An aminoglycoside sensing riboswitch controls the expression of aminoglycoside resistance acetyltransferase and adenyltransferases, Dongrong Chen, Alastair I H Murchie, 2014 Riboswitch regulation of aminoglycoside resistance acetyl and adenyl transferases, Xu Jia, Jing Zhang, Wenxia Sun, Weizhi He, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2013 Riboswitch control of induction of aminoglycoside resistance acetyl and adenyl-transferases, Weizhi He, Xuhui Zhang, Jun Zhang, Xu Jia, Jing Zhang, Wenxia Sun, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2013 Riboswitch control of aminoglycoside antibiotic resistance, Xu Jia, Jing Zhang, Wenxia Sun, Weizhi He, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2013 Targeting mitochondrial transcription in fission yeast with ETB, an inhibitor of HSP60, the chaperone that binds to the mitochondrial transcription factor Mtf1, Wenxia Sun, Li Wang, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2012 A novel function of the mitochondrial transcription factor Mtf1 in fission yeast; Mtf1 regulates the nuclear transcription of srk1, Wenxia Sun, Zhe Wang, Hengyi Jiang, Jing Zhang, Jürg Bähler, Dongrong Chen, Alastair I H Murchie, 2011 The global transcriptional response of fission yeast to hydrogen sulfide, Xu Jia, Weizhi He, Alastair I H Murchie, Dongrong Chen, 2011 Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe, Hengyi Jiang, Wenxia Sun, Zhe Wang, Jing Zhang, Dongrong Chen, Alastair I H Murchie, 2011 Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus, Huirong Yang, Zhe Wang, Yan Shen, Ping Wang, Xu Jia, Liang Zhao, Pei Zhou, Rui Gong, Ze Li, Ying Yang, Dongrong Chen, Alastair I H Murchie, 2010

Areas of Focus

Research on advanced structures and biological functions of nucleic acids, including: discovery, structure, and function of riboswitch RNA and novel ribozyme RNA, and their impact on gene expression and regulation, RNA modification and its biological functions, research on RNA epigenetics in diseases and stem cells.
Regulation of antibiotic resistance gene expression by interactions between non-coding RNA and small molecules.

Publications

The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences, Hengyi Jiang, Yanqing Gao, Lei Zhang, Dongrong Chen, Jianhua Gan, Alastair I H Murchie, 2021
The function of twister ribozyme variants in non-LTR retrotransposition in Schistosoma mansoni, Getong Liu, Hengyi Jiang, Wenxia Sun, Jun Zhang, Dongrong Chen, Alastair I H Murchie, 2021
Aminoglycoside antibiotics can inhibit or activate twister ribozyme cleavage, Jun Zhang, Getong Liu, Wenxia Sun, Dongrong Chen, Alastair I H Murchie, 2020
Interactions between the 5' UTR mRNA of the spe2 gene and spermidine regulate translation in S. pombe, Wenxia Sun, Xuhui Zhang, Dongrong Chen, Alastair I H Murchie, 2020
Aminoglycoside riboswitch control of the expression of integron associated aminoglycoside resistance adenyltransferases, Jun Zhang, Getong Liu, Xuhui Zhang, Yaowen Chang, Shasha Wang, Weizhi He, Wenxia Sun, Dongrong Chen, Alastair I H Murchie, 2020
Interactions between SAM and the 5' UTR mRNA of the sam1 gene regulate translation in S. pombe, Xuhui Zhang, Wenxia Sun, Dongrong Chen, Alastair I H Murchie, 2020
Integron-Derived Aminoglycoside-Sensing Riboswitches Control Aminoglycoside Acetyltransferase Resistance Gene Expression, Shasha Wang, Weizhi He, Wenxia Sun, Jun Zhang, Yaowen Chang, Dongrong Chen, Alastair I H Murchie, 2019
Osmium tetroxide as a probe of RNA structure, Jing Zhang, Danbin Li, Jun Zhang, Dongrong Chen, Alastair I H Murchie, 2017
Substrate recognition and modification by the nosiheptide resistance methyltransferase, Sitao Yin, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2015
An aminoglycoside sensing riboswitch controls the expression of aminoglycoside resistance acetyltransferase and adenyltransferases, Dongrong Chen, Alastair I H Murchie, 2014
Riboswitch regulation of aminoglycoside resistance acetyl and adenyl transferases, Xu Jia, Jing Zhang, Wenxia Sun, Weizhi He, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2013
Riboswitch control of induction of aminoglycoside resistance acetyl and adenyl-transferases, Weizhi He, Xuhui Zhang, Jun Zhang, Xu Jia, Jing Zhang, Wenxia Sun, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2013
Riboswitch control of aminoglycoside antibiotic resistance, Xu Jia, Jing Zhang, Wenxia Sun, Weizhi He, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2013
Targeting mitochondrial transcription in fission yeast with ETB, an inhibitor of HSP60, the chaperone that binds to the mitochondrial transcription factor Mtf1, Wenxia Sun, Li Wang, Hengyi Jiang, Dongrong Chen, Alastair I H Murchie, 2012
A novel function of the mitochondrial transcription factor Mtf1 in fission yeast; Mtf1 regulates the nuclear transcription of srk1, Wenxia Sun, Zhe Wang, Hengyi Jiang, Jing Zhang, Jürg Bähler, Dongrong Chen, Alastair I H Murchie, 2011
The global transcriptional response of fission yeast to hydrogen sulfide, Xu Jia, Weizhi He, Alastair I H Murchie, Dongrong Chen, 2011
Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe, Hengyi Jiang, Wenxia Sun, Zhe Wang, Jing Zhang, Dongrong Chen, Alastair I H Murchie, 2011
Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus, Huirong Yang, Zhe Wang, Yan Shen, Ping Wang, Xu Jia, Liang Zhao, Pei Zhou, Rui Gong, Ze Li, Ying Yang, Dongrong Chen, Alastair I H Murchie, 2010

Nucleic Acids Riboswitch Rna Ribozyme Rna Gene Expression Gene Regulation Rna Modification Biological Functions Rna Epigenetics Diseases Stem Cells Non-Coding Rna Small Molecules Antibiotic Resistance Regulation Rna Interactions Molecular Biology Biochemistry Drug Resistance Genetics

Lin He - Fudan University

Fei Chen - Fudan University

Su-Ling Liu - Fudan University

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