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Fei Chen
Biomedical Sciences
Fudan University
Shanghai
Language: English, Chinese
Gene Transcription
Epigenetic Regulation
Cancer
Development
Biochemistry
Genomics
Bioinformatics
Genetics
Molecular Biology
Stem Cells
Areas of Focus
- Mechanisms of gene transcription and epigenetic regulation in cancer and development
Work Experience
- 2021.12-present - Fudan University - Researcher (Outstanding Young Talent)
- 2019.12-2021.11 - Fudan University - Young Researcher
- 2018.3-2019.11 - Sloan Kettering Cancer Center - Postdoctoral Fellow
Academic Background & Achievements
- 2018 Ph.D.: Northwestern University
- 2012 Master's: Fudan University
- 2009 Bachelor's: Shandong University
- 2019 Shanghai Distinguished Professor
Publications
- R-loop dependent promoter-proximal termination maintains genome stability, Xu C#, Li C#, Chen J#, Xiong Y#, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H*, Chen FX*, 2023
- H3K4me2/3 modulate the stability of RNA polymerase II pausing, Hu S#, Song A#, Peng L#, Tang N, Qiao Z, Wang Z, Lan F, Chen FX*, 2023
- INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II, Hu S#, Peng L#, Song A#, Ji YX#, Cheng J, Wang M, Chen FX*, 2023
- Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1, Wang Z#, Song A#, Xu H#, Hu S, Tao B, Peng L, Wang J, Li J, Yu J, Wang L, Li Z, Chen X, Wang M, Chi Y, Wu J, Xu Y, Zheng H, Chen FX*, 2022
- RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex, Wang X, Qi Y, Wang Z, Wang L, Song A, Tao B, Li J, Zhao D, Zhang H, Jin Q, Jiang YZ, Chen FX*, Xu Y*, Chen X*, 2022
- SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape, Hu S#, Peng L#, Xu C#, Wang Z, Song A, and Chen FX*, 2021
- Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, Zheng H#, Qi Y#, Hu S#, Cao X#, Xu C#, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX*, Xu Y*, 2020
- Born to run: Control of RNA polymerase II transcription elongation, Chen FX, Smith ER, Shilatifard A, 2018
- PAF1 regulation of promoter-proximal pause release via enhancer activation, Chen FX, Xie P, Collings CK, Cao K, Marshall SA, Rendleman EJ, Ugarenko M, Zhang A, Shiekhattar R, Smith ER, Shiekhattar R, Zhang MQ, Shilatifard A, 2017
- PAF1, a molecular regulator of promoter-proximal pausing by RNA polymerase II, Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A, 2015
- Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide, Chen F, Gao X, Shilatifard A, 2015
- Structural insight into substrate recognition by histone demethylase LSD2/KDM1b, Chen F*, Yang H*, Dong Z*, Fang J, Wang P, Zhu T, Gong W, Fang R, Shi YG, Li Z#, Xu Y#, 2013
- LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation, Fang R*, Chen F*, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y#, Shi YG#, 2013
- Measuring Nascent Transcripts by Nascent-seq, Chen FX, Marshall SA, Deng Y, Tianjiao S, 2018
- ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer, Huang YH, Hu J, Chen F, Lecomte N, Basnet H, David CJ, Witkin MD, Allen PJ, Leach SD, Hollmann TJ, Iacobuzio-Donahue CA, Massague J, 2019
Awards
- 2018: Driskill Award for Outstanding Graduate, Northwestern University
- 2016: First Prize in Natural Science by Ministry of Education (Fifth Contributor)
