Professor | 陈飞 | 数字化转型顾问

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Name	陈飞
Contact Information	feixchen@fudan.edu.cn
Language ability	英语, 中文
Province	上海

Upload Avatar (500 x 500)

Name

陈飞

Contact Information

feixchen@fudan.edu.cn

Language ability

英语, 中文

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Biomedical Sciences
Academic Background & Achievements	2018 博士: 美国西北大学 2012 硕士: 复旦大学 2009 学士: 山东大学 2019 上海高校特聘教授
Work Experience	2021.12-至今 - 复旦大学 - 研究员（青年杰出人才） 2019.12-2021.11 - 复旦大学 - 青年研究员 2018.3-2019.11 - 斯隆凯特琳癌症中心 - 博士后
Awards	2018: 西北大学医学院优秀毕业生（Driskill Award） 2016: 教育部自然科学一等奖（第五完成人）

University/Lab Affiliation and Title

复旦大学

Faculty

Biomedical Sciences

Academic Background & Achievements

2018 博士: 美国西北大学
2012 硕士: 复旦大学
2009 学士: 山东大学
2019 上海高校特聘教授

Work Experience

2021.12-至今 - 复旦大学 - 研究员（青年杰出人才）
2019.12-2021.11 - 复旦大学 - 青年研究员
2018.3-2019.11 - 斯隆凯特琳癌症中心 - 博士后

Awards

2018: 西北大学医学院优秀毕业生（Driskill Award）
2016: 教育部自然科学一等奖（第五完成人）

Areas of Focus	癌症和发育中基因转录和表观遗传调控的机制
Publications	R-loop dependent promoter-proximal termination maintains genome stability, Xu C#, Li C#, Chen J#, Xiong Y#, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H, Chen FX, 2023 H3K4me2/3 modulate the stability of RNA polymerase II pausing, Hu S#, Song A#, Peng L#, Tang N, Qiao Z, Wang Z, Lan F, Chen FX, 2023 INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II, Hu S#, Peng L#, Song A#, Ji YX#, Cheng J, Wang M, Chen FX, 2023 Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1, Wang Z#, Song A#, Xu H#, Hu S, Tao B, Peng L, Wang J, Li J, Yu J, Wang L, Li Z, Chen X, Wang M, Chi Y, Wu J, Xu Y, Zheng H, Chen FX, 2022 RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex, Wang X, Qi Y, Wang Z, Wang L, Song A, Tao B, Li J, Zhao D, Zhang H, Jin Q, Jiang YZ, Chen FX, Xu Y, Chen X, 2022 SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape, Hu S#, Peng L#, Xu C#, Wang Z, Song A, and Chen FX, 2021 Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, Zheng H#, Qi Y#, Hu S#, Cao X#, Xu C#, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX, Xu Y, 2020 Born to run: Control of RNA polymerase II transcription elongation, Chen FX, Smith ER, Shilatifard A, 2018 PAF1 regulation of promoter-proximal pause release via enhancer activation, Chen FX, Xie P, Collings CK, Cao K, Marshall SA, Rendleman EJ, Ugarenko M, Zhang A, Shiekhattar R, Smith ER, Shiekhattar R, Zhang MQ, Shilatifard A, 2017 PAF1, a molecular regulator of promoter-proximal pausing by RNA polymerase II, Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A, 2015 Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide, Chen F, Gao X, Shilatifard A, 2015 Structural insight into substrate recognition by histone demethylase LSD2/KDM1b, Chen F, Yang H, Dong Z, Fang J, Wang P, Zhu T, Gong W, Fang R, Shi YG, Li Z#, Xu Y#, 2013 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation, Fang R, Chen F, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y#, Shi YG#, 2013 Measuring Nascent Transcripts by Nascent-seq, Chen FX, Marshall SA, Deng Y, Tianjiao S, 2018 ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer, Huang YH, Hu J, Chen F, Lecomte N, Basnet H, David CJ, Witkin MD, Allen PJ, Leach SD, Hollmann TJ, Iacobuzio-Donahue CA, Massague J, 2019

Areas of Focus

癌症和发育中基因转录和表观遗传调控的机制

Publications

R-loop dependent promoter-proximal termination maintains genome stability, Xu C#, Li C#, Chen J#, Xiong Y#, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H*, Chen FX*, 2023
H3K4me2/3 modulate the stability of RNA polymerase II pausing, Hu S#, Song A#, Peng L#, Tang N, Qiao Z, Wang Z, Lan F, Chen FX*, 2023
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II, Hu S#, Peng L#, Song A#, Ji YX#, Cheng J, Wang M, Chen FX*, 2023
Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1, Wang Z#, Song A#, Xu H#, Hu S, Tao B, Peng L, Wang J, Li J, Yu J, Wang L, Li Z, Chen X, Wang M, Chi Y, Wu J, Xu Y, Zheng H, Chen FX*, 2022
RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex, Wang X, Qi Y, Wang Z, Wang L, Song A, Tao B, Li J, Zhao D, Zhang H, Jin Q, Jiang YZ, Chen FX*, Xu Y*, Chen X*, 2022
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape, Hu S#, Peng L#, Xu C#, Wang Z, Song A, and Chen FX*, 2021
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, Zheng H#, Qi Y#, Hu S#, Cao X#, Xu C#, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX*, Xu Y*, 2020
Born to run: Control of RNA polymerase II transcription elongation, Chen FX, Smith ER, Shilatifard A, 2018
PAF1 regulation of promoter-proximal pause release via enhancer activation, Chen FX, Xie P, Collings CK, Cao K, Marshall SA, Rendleman EJ, Ugarenko M, Zhang A, Shiekhattar R, Smith ER, Shiekhattar R, Zhang MQ, Shilatifard A, 2017
PAF1, a molecular regulator of promoter-proximal pausing by RNA polymerase II, Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A, 2015
Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide, Chen F, Gao X, Shilatifard A, 2015
Structural insight into substrate recognition by histone demethylase LSD2/KDM1b, Chen F*, Yang H*, Dong Z*, Fang J, Wang P, Zhu T, Gong W, Fang R, Shi YG, Li Z#, Xu Y#, 2013
LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation, Fang R*, Chen F*, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y#, Shi YG#, 2013
Measuring Nascent Transcripts by Nascent-seq, Chen FX, Marshall SA, Deng Y, Tianjiao S, 2018
ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer, Huang YH, Hu J, Chen F, Lecomte N, Basnet H, David CJ, Witkin MD, Allen PJ, Leach SD, Hollmann TJ, Iacobuzio-Donahue CA, Massague J, 2019

基因转录表观遗传调控癌症发育生物化学基因组学生物信息学遗传学分子生物学干细胞

贺福初 - 复旦大学

贺林 - 复旦大学

Area of Focus
遗传学 | 心理健康 | 基因组学 | 营养 | 药理学 | Dna | 计算 | 疾病 | 研究 | 科学

阿拉斯泰尔·默奇 - 复旦大学

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