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Lulu Hu
Biomedical Sciences
Fudan University
Shanghai
Language: English, Chinese
Epigenome
Transcriptome
Single-Base Resolution
Low-Cost
Cfdna
Dna Methylation
Rna M6A
Quantitative Analysis
Clinical Application
User-Friendly
Single-Cell
Dna 5Hmc
Sequencing
Neural Cells
Brain Science
Brain Diseases
Dna Modification
Cell Clustering
Practical Tool
Research
Rna Subcellular Localization
Apex-Seq
Plasmid Overexpression
Lentivirus Infection
Cell State
In Situ Amplification
Membrane-Less Organelles
P-Body
Nuclear Speckle
Stress Granule
Cell Membrane
Glycosylation
Rna
Membrane Proteins
P62
Autophagy Receptor
Rna Regulation
Detection Technology
Binding Proteins
Detailed Function
Areas of Focus
- Development of low-cost, single-base resolution epigenome and transcriptome detection technology
- Single-cell DNA 5hmC sequencing technology
- New technology for detecting RNA subcellular localization
- Research on glycosylated RNA on the cell membrane surface
Work Experience
- 2020.11-present - Fudan University - Researcher
- 2015.2-2020.9 - University of Chicago - Postdoctoral Fellow
Academic Background & Achievements
- 2009.9-2014.6 Ph.D.: Fudan University, Institute of Biomedical Sciences
- 2005.9-2009.6 Bachelor's: Soochow University, School of Life Sciences
Publications
- Ascorbic Acid Reprograms Epigenome and Epitranscriptome by Reducing Fe (III) in the Catalytic Cycle of Dioxygenases, Weizhi He, Xiaotong Yin, Chu Xu, Xiangyue Liu, Yue Huang, Caiguang Yang, Yanhui Xu, and Lulu Hu, 2023
- m6A-SAC-seq for quantitative whole transcriptome m6A profiling, Ruiqi Ge, Chang Ye, Yong Peng, Qing Dai, Yutao Zhao, Shun Liu, Pingluan Wang, Lulu Hu, Chuan He, 2023
- m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome, Hu L, Liu S, Peng Y, Ge R, Su R, Senevirathne C, Harada BT, Dai Q, Wei J, Zhang L, Hao Z, Luo L, Wang H, Wang Y, Luo M, Chen M, Chen J, He C, 2022
- Detection of m6A RNA modifications at single-nucleotide resolution using m6A-selective allyl chemical labeling and sequencing, Yong Peng, Hanzhe Meng, Ruiqi Ge, Shun Liu, Mengjie Chen, Chuan He, Lulu Hu, 2022
- Quantitative and single nucleotide RNA m6 A detection technology boosts clinical research based on tissue and cell free RNA modification, Lulu Hu, 2022
- Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites, Hu L, Liu Y, Han S, Yang L, Cui X, Gao Y, Dai Q, Lu X, Kou X, Zhao Y, Sheng W, Gao S, He X, He C, 2019
- Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA, Zhang LS, Liu C, Ma H, Dai Q, Sun HL, Luo G, Zhang Z, Zhang L, Hu L, Dong X, He C, 2019
- TET-mediated epimutagenesis of the Arabidopsis thaliana methylome, Ji L, Jordan WT, Shi X, Hu L, He C, Schmitz RJ, 2018
- Epigenetic DNA Modification N6-Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing, Wang W, Xu L, Hu L, Chong J, He C, Wang D, 2017
- A computational investigation on the substrate preference of ten-eleven-translocation 2 (TET2), Lu J, Hu L, Cheng J, Fang D, Wang C, Yu K, Jiang H, Cui Q, Xu Y, Luo C, 2016
- Detecting hepatocellular carcinoma in blood, Hu L, He C, 2015
- Structural insight into substrate preference for TET-mediated oxidation, Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y, 2015
- Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation, Hu L, Li Z, Cheng J, Rao Q, Gong W, Liu M, Shi YG, Zhu J, Wang P, Xu Y, 2013
- Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2, Hu L, Li Z, Wang P, Lin Y, Xu Y, 2011
- PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression, Rajakumara E, Wang Z, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y, 2011
- Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans, Yang Y, Hu L, Wang P, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen CD, Xu Y, 2010
Awards
- Excellent Ph. D of Fudan University and Shanghai City (2014): Detail
- Graduate Star of Scientific Research of Fudan University (2014): Detail
- Chicago Fellow Award (2015-2017): Detail
- The Chicago Biomedical Consortium (CBC) fellowship (2016-2017): Detail
- Leukemia & Lymphoma Society Special Fellow (2017-2020): Detail
