Weijun Feng

fengweijun@fudan.edu.cn

English, Chinese, German

Shanghai

Fudan University

Biomedical Sciences

• 2005-2009 PhD: Heidelberg University
• 2003-2005 Master's: Heidelberg University
• 1996-2001 Bachelor's: Tongji Medical College, Huazhong University of Science and Technology

• 2018.06-Present - Fudan University - Young Researcher, Institute of Biomedical Sciences
• 2009.10-2018.05 - German Cancer Research Center - Postdoctoral Researcher

Dysfunction of chromatin regulators including chromatin remodeling factors and histone and DNA modification proteins can lead to various neurological diseases. My research group studies how mutations in chromatin regulators specifically lead to developmental neurological diseases. The research aims to elucidate the types of neural cells that cause these diseases and the specific functions of chromatin regulators in these cells. We use transgenic mice, human brain organoids, and primary neural cells as models, employing techniques such as mouse genetics, gene editing, and high-throughput chromatin analysis. The research findings will help us understand the pathogenesis of related diseases and provide new ideas for future clinical interventions.

• CRISPR-mediated loss of function analysis in cerebellar granule cells using in utero electroporation-based gene transfer, Feng, W., Herbst, L., Lichter, P., Pfister, S. M., Liu, H. K., & Kawauchi, D., 2018
• Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and Disease, Feng, W*., Shao, C., Liu HK., 2017
• CRISPR-engineered genome editing for the next generation neurological disease modeling, Feng, W., Liu HK., Kawauchi D., 2017
• Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme, Feng, W#., Kawauchi, D#., Korkel-Qu, H., Deng, H., Serger, E., Sieber, L., Lieberman, J.A., Jimeno-Gonzalez, S., Lambo, S., Hanna, B.S., et al., 2017
• Revealing the Hidden Powers that Fuel Adult Neurogenesis, Feng, W., and Liu, H.K., 2017
• Epigenetic regulation of neuronal fate determination: The role of CHD7, Feng, W., Liu HK., 2013
• The Chromatin Remodeler CHD7 Regulates Adult Neurogenesis via Activation of SoxC Transcription Factors, Feng, W., Khan, M.A., Bellvis, P., Zhu, Z., Bernhardt, O., Herold-Mende, C., and Liu, HK., 2013
• The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions, Xie, W., Ling, T., Zhou, Y., Feng, W., Zhu, Q., Stunnenberg, H.G., Grummt, I., and Tao, W., 2012
• PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation, Feng, W#., Yonezawa, M#., Ye, J., Jenuwein, T., and Grummt, I., 2010
• Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a, Yuan, X., Feng, W., Imhof, A., Grummt, I., and Zhou, Y., 2007