Professor | Shimin Zhao | Asia Growth Partners

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Name	Shimin Zhao
Contact Information	zhaosm@fudan.edu.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Shimin Zhao

Contact Information

zhaosm@fudan.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	1995-2000 Ph.D. in Biochemistry: Purdue University, Advisor: Ronald Somerville 1984-1988 Bachelor's in Chemistry: Beijing Normal University 2016 Leader of the Key Field Innovation Team, Ministry of Science and Technology 2015 Shanghai Leading Talent, Shanghai Municipal Organization Department 2015 Kunlun Scholar, Qinghai Provincial Department of Education 2013 Shanghai Outstanding Academic Leader, Shanghai Science and Technology Commission
Work Experience	2016/01-Present - Fudan University Affiliated Obstetrics and Gynecology Hospital - Professor 2009/01-Present - Fudan University School of Life Sciences - Professor; Fudan University Institute of Biomedical Sciences - Senior PI 2006/01-2009/01 - Fudan University Institute of Biomedical Sciences - Associate Researcher; Fudan University School of Life Sciences - Lecturer 2002/01-2005/12 - Life Sciences Inc. - Technical Director, Asia Business Director 2000/07-2002/01 - Procter & Gamble - Scientist, Global Detergent and Asia Solid Detergent Human Safety Manager 1988/09-1995/12 - Chinese Academy of Medical Sciences/Peking Union Medical College Cancer Institute - Intern/Assistant Researcher
Awards	2017 Chinese Medical Science Award Second Prize: Chinese Medical Association 2016 Shanghai Medical Science Award Second Prize: Shanghai Medical Association 2013 First Prize in Natural Science: Ministry of Education 2013 WuXi AppTec Life Chemistry Research Award: WuXi AppTec Company 2012 First Campus Science Star: Shanghai Municipal Government 2011 Top Ten Scientific Advances in China: Ministry of Science and Technology 2010 Top Ten Scientific Advances in Chinese Higher Education: Ministry of Education 2010 Tan Jiazhen Life Science Innovation Award: Shanghai Biomedical Association/Ministry of Science and Technology 2010 Meiji Dairy Life Science Research Outstanding Award: National Human Genome South Research Center

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

1995-2000 Ph.D. in Biochemistry: Purdue University, Advisor: Ronald Somerville
1984-1988 Bachelor's in Chemistry: Beijing Normal University
2016 Leader of the Key Field Innovation Team, Ministry of Science and Technology
2015 Shanghai Leading Talent, Shanghai Municipal Organization Department
2015 Kunlun Scholar, Qinghai Provincial Department of Education
2013 Shanghai Outstanding Academic Leader, Shanghai Science and Technology Commission

Work Experience

2016/01-Present - Fudan University Affiliated Obstetrics and Gynecology Hospital - Professor
2009/01-Present - Fudan University School of Life Sciences - Professor; Fudan University Institute of Biomedical Sciences - Senior PI
2006/01-2009/01 - Fudan University Institute of Biomedical Sciences - Associate Researcher; Fudan University School of Life Sciences - Lecturer
2002/01-2005/12 - Life Sciences Inc. - Technical Director, Asia Business Director
2000/07-2002/01 - Procter & Gamble - Scientist, Global Detergent and Asia Solid Detergent Human Safety Manager
1988/09-1995/12 - Chinese Academy of Medical Sciences/Peking Union Medical College Cancer Institute - Intern/Assistant Researcher

Awards

2017 Chinese Medical Science Award Second Prize: Chinese Medical Association
2016 Shanghai Medical Science Award Second Prize: Shanghai Medical Association
2013 First Prize in Natural Science: Ministry of Education
2013 WuXi AppTec Life Chemistry Research Award: WuXi AppTec Company
2012 First Campus Science Star: Shanghai Municipal Government
2011 Top Ten Scientific Advances in China: Ministry of Science and Technology
2010 Top Ten Scientific Advances in Chinese Higher Education: Ministry of Education
2010 Tan Jiazhen Life Science Innovation Award: Shanghai Biomedical Association/Ministry of Science and Technology
2010 Meiji Dairy Life Science Research Outstanding Award: National Human Genome South Research Center

Areas of Focus	Metabolite Sensing and Signal Transduction Pathogenic Mechanisms of Metabolite Signal Disorders
Publications	NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance, Li, F., He, X., Ye, D., Lin, Y., Yu, H., Yao, C., Huang, L., Zhang, J., Wang, F., Xu, S., Wu, X., Liu, L., Yang, C., Shi, J., He, X., Liu, J., Qu, Y., Guo, F., Zhao, J., Xu, W., and Zhao, S., 2015 Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1, Zhang, T., Wang, S., Lin, Y., Xu, W., Ye, D., Xiong, Y., Zhao, S., and Guan, K. L., 2012 Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases, Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S. H., Ito, S., Yang, C., Wang, P., Xiao, M. T., Liu, L. X., Jiang, W. Q., Liu, J., Zhang, J. Y., Wang, B., Frye, S., Zhang, Y., Xu, Y. H., Lei, Q. Y., Guan, K. L., Zhao, S. M., and Xiong, Y., 2011 Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase, Jiang, W., Wang, S., Xiao, M., Lin, Y., Zhou, L., Lei, Q., Xiong, Y., Guan, K. L., and Zhao, S., 2011 Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux, Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J., Li, H., Xie, L., Zhao, W., Yao, Y., Ning, Z. B., Zeng, R., Xiong, Y., Guan, K. L., Zhao, S., and Zhao, G. P., 2010

Areas of Focus

Metabolite Sensing and Signal Transduction
Pathogenic Mechanisms of Metabolite Signal Disorders

Publications

NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance, Li, F., He, X., Ye, D., Lin, Y., Yu, H., Yao, C., Huang, L., Zhang, J., Wang, F., Xu, S., Wu, X., Liu, L., Yang, C., Shi, J., He, X., Liu, J., Qu, Y., Guo, F., Zhao, J., Xu, W., and Zhao, S., 2015
Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1, Zhang, T., Wang, S., Lin, Y., Xu, W., Ye, D., Xiong, Y., Zhao, S., and Guan, K. L., 2012
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases, Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S. H., Ito, S., Yang, C., Wang, P., Xiao, M. T., Liu, L. X., Jiang, W. Q., Liu, J., Zhang, J. Y., Wang, B., Frye, S., Zhang, Y., Xu, Y. H., Lei, Q. Y., Guan, K. L., Zhao, S. M., and Xiong, Y., 2011
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase, Jiang, W., Wang, S., Xiao, M., Lin, Y., Zhou, L., Lei, Q., Xiong, Y., Guan, K. L., and Zhao, S., 2011
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux, Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J., Li, H., Xie, L., Zhao, W., Yao, Y., Ning, Z. B., Zeng, R., Xiong, Y., Guan, K. L., Zhao, S., and Zhao, G. P., 2010

Metabolite Sensing Signal Transduction Pathogenic Mechanisms Signal Disorders Metabolic Enzymes Acetylation Regulation Nutrient Sensing Tumor Metabolites Molecular Mechanisms

Wei Xu - Fudan University

Chen Ding - Fudan University

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