Professor | Wei Xu | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Wei Xu
Contact Information	xuwei_0706@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Wei Xu

Contact Information

xuwei_0706@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	2006.9-2011.7 PhD: Fudan University, Institute of Biomedical Sciences 2002.9-2006.7 Bachelor's: Zhejiang University, School of Life Sciences 2018 Shanghai Youth Science and Technology Star Program 2018 Shanghai Health and Family Planning System Excellent Young Medical Talent Training Program 2015 China Association for Science and Technology's First 'Youth Talent Support Project'
Work Experience	2021.1-Present - Fudan University, Institute of Biomedical Sciences - Researcher 2017.1-2021.1 - Fudan University, Institute of Biomedical Sciences - Associate Researcher 2011.7-2016.12 - Fudan University, Institute of Biomedical Sciences - Assistant Researcher
Awards	2017 Chinese Medical Science Award Second Prize, Second Contributor 2016 Shanghai Medical Science Award Second Prize, Second Contributor 2012 Ministry of Education Natural Science First Prize, Seventh Contributor

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

2006.9-2011.7 PhD: Fudan University, Institute of Biomedical Sciences
2002.9-2006.7 Bachelor's: Zhejiang University, School of Life Sciences
2018 Shanghai Youth Science and Technology Star Program
2018 Shanghai Health and Family Planning System Excellent Young Medical Talent Training Program
2015 China Association for Science and Technology's First 'Youth Talent Support Project'

Work Experience

2021.1-Present - Fudan University, Institute of Biomedical Sciences - Researcher
2017.1-2021.1 - Fudan University, Institute of Biomedical Sciences - Associate Researcher
2011.7-2016.12 - Fudan University, Institute of Biomedical Sciences - Assistant Researcher

Awards

2017 Chinese Medical Science Award Second Prize, Second Contributor
2016 Shanghai Medical Science Award Second Prize, Second Contributor
2012 Ministry of Education Natural Science First Prize, Seventh Contributor

Areas of Focus	Metabolite Imbalance and Disease Mechanisms Metabolite Sensing and Signaling Acetylation Regulation of Metabolic Networks Amino Acid Signal Sensing in Major Diseases
Publications	Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation., Zhang, J.-J., Fan, T.-T., Mao, Y.-Z., Hou, J.-L., Wang, M., Zhang, M., Lin, Y., Zhang, L., Yan, G.-Q., An, Y.-P., Yao, J., Zhang, C., Lin, P.-C., Yuan, Y.-Y., Zhao, J.-Y., Wei Xu#, and Zhao, S.-M., 2021 Inhibiting Methionyl-tRNA synthetase reduces neural tube defects and congenital heart defects onsets., Xin-Yu Mei, Da-Shi Qi, Ting Zhang, Yin Zhao, Li Jin, Junli Hou, Jianhua Wang, Yan Lin, Yu Xue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, Jianhong Ye, Richard H. Finnell, Hexige Saiyin, Hong-Yan Wang#, Jian-Yuan Zhao#, Shi-Min Zhao#, and Wei Xu#, 2020 Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations., Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yan-Hui Xu#, Wei Xu#, Shi-Min Zhao#, 2018 NADP+-IDH mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance., Feng Li, Xiadi He, Dingwei Ye, Yan Lin, Hongxiu Yu, Cuifang Yao, Lei Huang, Jianong Zhang, Fang Wang, Sha Xu, Xiaohui Wu, Lixia Liu, Chen Yang, Jiaqi Shi, Xiaoyang He, Jie Liu, Yuanyuan Qu, Fushen Guo, Jianyuan Zhao, Wei Xu#, and Shimin Zhao#, 2015 Enoyl-CoA Hydratase-1 Regulates mTOR Signaling and Apoptosis by Sensing Nutrients., Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu#, Shi-Min Zhao#, and Wei Xu#, 2017 Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1., He, Chang-Liang, Yang-Yang Bian, Yu Xue, Ze-Xian Liu, Kai-Qiang Zhou, Cui-Fang Yao, Yan Lin, Han-Fa Zou, Fang-Xiu Luo, Yuan-Yuan Qu, Jian-Yuan Zhao, Ming-Liang Ye, Shi-Min Zhao and Wei Xu#, 2016 Protein lysine acetylation guards metabolic homeostasis to fight against cancer., Xu, W., Li, Y., Liu, C. & Zhao, S., 2014 Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases., Xu W, Hui Yang, Ying Liu, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen Frye, Yi Zhang, Yan-hui Xu, Qun-ying Lei, Kun-Liang Guan#, Shi-min Zhao#, and Yue Xiong#, 2010 Regulation of cellular metabolism by protein lysine acetylation., Zhao, S-M., Xu, W. , Jiang, W-Q. , Yu, W., Lin, Y., Zhang, T-F., Yao, J., Zhou, L., Zeng, Y., Li, H., Li, Y., Shi, J., An, W-L., Hancock, S. M., He, F., Qin, L-X., Chin, J. C., Yang, P-Y., Chen, X., Lei, Q-Y., Xiong, Y. # and Guan, K-L. #, 2010 Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α., Zhao, S-M., Li, Y., Xu, W. , Jiang, W-Q. *, Zha, Z-Y., Yu, W., Li, Z-Q., Gong, L-L., Peng, Y-J., Ding, J-P., Lei, Q-Y., Guan, K-L.#, and Xiong, Y. #, 2009

Areas of Focus

Metabolite Imbalance and Disease Mechanisms
Metabolite Sensing and Signaling
Acetylation Regulation of Metabolic Networks
Amino Acid Signal Sensing in Major Diseases

Publications

Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation., Zhang, J.-J., Fan, T.-T., Mao, Y.-Z., Hou, J.-L., Wang, M., Zhang, M., Lin, Y., Zhang, L., Yan, G.-Q., An, Y.-P., Yao, J., Zhang, C., Lin, P.-C., Yuan, Y.-Y., Zhao, J.-Y., Wei Xu#, and Zhao, S.-M.*, 2021
Inhibiting Methionyl-tRNA synthetase reduces neural tube defects and congenital heart defects onsets., Xin-Yu Mei*, Da-Shi Qi*, Ting Zhang*, Yin Zhao*, Li Jin, Junli Hou, Jianhua Wang, Yan Lin, Yu Xue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, Jianhong Ye, Richard H. Finnell, Hexige Saiyin, Hong-Yan Wang#, Jian-Yuan Zhao#, Shi-Min Zhao#, and Wei Xu#, 2020
Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations., Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yan-Hui Xu#, Wei Xu#, Shi-Min Zhao#, 2018
NADP+-IDH mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance., Feng Li*, Xiadi He*, Dingwei Ye*, Yan Lin, Hongxiu Yu, Cuifang Yao, Lei Huang, Jianong Zhang, Fang Wang, Sha Xu, Xiaohui Wu, Lixia Liu, Chen Yang, Jiaqi Shi, Xiaoyang He, Jie Liu, Yuanyuan Qu, Fushen Guo, Jianyuan Zhao, Wei Xu#, and Shimin Zhao#, 2015
Enoyl-CoA Hydratase-1 Regulates mTOR Signaling and Apoptosis by Sensing Nutrients., Ya-Kun Zhang*, Yuan-Yuan Qu*, Yan Lin*, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu#, Shi-Min Zhao#, and Wei Xu#, 2017
Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1., He, Chang-Liang*, Yang-Yang Bian*, Yu Xue, Ze-Xian Liu, Kai-Qiang Zhou, Cui-Fang Yao, Yan Lin, Han-Fa Zou, Fang-Xiu Luo, Yuan-Yuan Qu, Jian-Yuan Zhao, Ming-Liang Ye, Shi-Min Zhao and Wei Xu#, 2016
Protein lysine acetylation guards metabolic homeostasis to fight against cancer., Xu, W., Li, Y., Liu, C. & Zhao, S., 2014
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases., Xu W*, Hui Yang*, Ying Liu*, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen Frye, Yi Zhang, Yan-hui Xu, Qun-ying Lei, Kun-Liang Guan#, Shi-min Zhao#, and Yue Xiong#, 2010
Regulation of cellular metabolism by protein lysine acetylation., Zhao, S-M., Xu, W. *, Jiang, W-Q. *, Yu, W., Lin, Y., Zhang, T-F., Yao, J., Zhou, L., Zeng, Y., Li, H., Li, Y., Shi, J., An, W-L., Hancock, S. M., He, F., Qin, L-X., Chin, J. C., Yang, P-Y., Chen, X., Lei, Q-Y., Xiong, Y. # and Guan, K-L. #, 2010
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α., Zhao, S-M., Li, Y.*, Xu, W. *, Jiang, W-Q. *, Zha, Z-Y., Yu, W., Li, Z-Q., Gong, L-L., Peng, Y-J., Ding, J-P., Lei, Q-Y., Guan, K-L.#, and Xiong, Y. #, 2009

Metabolite Imbalance Disease Mechanism Sensing Signaling Acetylation Regulation Amino Acid Major Diseases

Shimin Zhao - Fudan University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us