Professor | 徐薇 | 数字化转型顾问

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Name	徐薇
Contact Information	xuwei_0706@fudan.edu.cn
Language ability	中文, 英语
Province	上海

Upload Avatar (500 x 500)

Name

徐薇

Contact Information

xuwei_0706@fudan.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Biomedical Sciences
Academic Background & Achievements	2006.9-2011.7 博士: 复旦大学生物医学研究院 2002.9-2006.7 学士: 浙江大学生命科学学院 2018 上海市青年科技启明星计划项目 2018 上海市卫生计生系统优秀青年医学人才培养计划 2015 中国科协首届“青年人才托举工程”
Work Experience	2021.1-至今 - 复旦大学生物医学研究院 - 研究员 2017.1-2021.1 - 复旦大学生物医学研究院 - 副研究员 2011.7-2016.12 - 复旦大学生物医学研究院 - 助理研究员
Awards	2017 中华医学科技奖二等奖，第二完成人 2016 上海市医学科技奖二等奖，第二完成人 2012 教育部自然科学一等奖，第七完成人

University/Lab Affiliation and Title

复旦大学

Faculty

Biomedical Sciences

Academic Background & Achievements

2006.9-2011.7 博士: 复旦大学生物医学研究院
2002.9-2006.7 学士: 浙江大学生命科学学院
2018 上海市青年科技启明星计划项目
2018 上海市卫生计生系统优秀青年医学人才培养计划
2015 中国科协首届“青年人才托举工程”

Work Experience

2021.1-至今 - 复旦大学生物医学研究院 - 研究员
2017.1-2021.1 - 复旦大学生物医学研究院 - 副研究员
2011.7-2016.12 - 复旦大学生物医学研究院 - 助理研究员

Awards

2017 中华医学科技奖二等奖，第二完成人
2016 上海市医学科技奖二等奖，第二完成人
2012 教育部自然科学一等奖，第七完成人

Areas of Focus	代谢物失调与疾病机制代谢物感知与信号传导代谢网络的乙酰化调控重大疾病中的氨基酸信号感知
Publications	核二羟丙酮磷酸信号营养充足和细胞周期阶段对全局组蛋白乙酰化的影响。, Zhang, J.-J., Fan, T.-T., Mao, Y.-Z., Hou, J.-L., Wang, M., Zhang, M., Lin, Y., Zhang, L., Yan, G.-Q., An, Y.-P., Yao, J., Zhang, C., Lin, P.-C., Yuan, Y.-Y., Zhao, J.-Y., Wei Xu#, and Zhao, S.-M., 2021 抑制甲硫氨酰-tRNA合成酶减少神经管缺陷和先天性心脏缺陷的发生。, Xin-Yu Mei, Da-Shi Qi, Ting Zhang, Yin Zhao, Li Jin, Junli Hou, Jianhua Wang, Yan Lin, Yu Xue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, Jianhong Ye, Richard H. Finnell, Hexige Saiyin, Hong-Yan Wang#, Jian-Yuan Zhao#, Shi-Min Zhao#, and Wei Xu#, 2020 通过可逆赖氨酸氨酰化感知和传递细胞内氨基酸信号。, Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yan-Hui Xu#, Wei Xu#, Shi-Min Zhao#, 2018 NADP+-IDH突变促进超琥珀酰化，损害线粒体呼吸并诱导抗凋亡。, Feng Li, Xiadi He, Dingwei Ye, Yan Lin, Hongxiu Yu, Cuifang Yao, Lei Huang, Jianong Zhang, Fang Wang, Sha Xu, Xiaohui Wu, Lixia Liu, Chen Yang, Jiaqi Shi, Xiaoyang He, Jie Liu, Yuanyuan Qu, Fushen Guo, Jianyuan Zhao, Wei Xu#, and Shimin Zhao#, 2015 烯酰辅酶A水合酶-1通过感知营养调节mTOR信号和凋亡。, Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu#, Shi-Min Zhao#, and Wei Xu#, 2017 丙酮酸激酶M2通过磷酸化AKT1S1激活mTORC1。, He, Chang-Liang, Yang-Yang Bian, Yu Xue, Ze-Xian Liu, Kai-Qiang Zhou, Cui-Fang Yao, Yan Lin, Han-Fa Zou, Fang-Xiu Luo, Yuan-Yuan Qu, Jian-Yuan Zhao, Ming-Liang Ye, Shi-Min Zhao and Wei Xu#, 2016 蛋白赖氨酸乙酰化通过对抗癌症来维持代谢稳态。, Xu, W., Li, Y., Liu, C. & Zhao, S., 2014 致癌代谢物2-羟基戊二酸是α-酮戊二酸依赖性双加氧酶的竞争性抑制剂。, Xu W, Hui Yang, Ying Liu, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen Frye, Yi Zhang, Yan-hui Xu, Qun-ying Lei, Kun-Liang Guan#, Shi-min Zhao#, and Yue Xiong#, 2010 蛋白赖氨酸乙酰化调节细胞代谢。, Zhao, S-M., Xu, W. , Jiang, W-Q. , Yu, W., Lin, Y., Zhang, T-F., Yao, J., Zhou, L., Zeng, Y., Li, H., Li, Y., Shi, J., An, W-L., Hancock, S. M., He, F., Qin, L-X., Chin, J. C., Yang, P-Y., Chen, X., Lei, Q-Y., Xiong, Y. # and Guan, K-L. #, 2010 胶质瘤来源的IDH1突变显著抑制IDH1催化活性并诱导HIF-1α。, Zhao, S-M., Li, Y., Xu, W. , Jiang, W-Q. *, Zha, Z-Y., Yu,

Areas of Focus

代谢物失调与疾病机制
代谢物感知与信号传导
代谢网络的乙酰化调控
重大疾病中的氨基酸信号感知

Publications

核二羟丙酮磷酸信号营养充足和细胞周期阶段对全局组蛋白乙酰化的影响。, Zhang, J.-J., Fan, T.-T., Mao, Y.-Z., Hou, J.-L., Wang, M., Zhang, M., Lin, Y., Zhang, L., Yan, G.-Q., An, Y.-P., Yao, J., Zhang, C., Lin, P.-C., Yuan, Y.-Y., Zhao, J.-Y., Wei Xu#, and Zhao, S.-M.*, 2021
抑制甲硫氨酰-tRNA合成酶减少神经管缺陷和先天性心脏缺陷的发生。, Xin-Yu Mei*, Da-Shi Qi*, Ting Zhang*, Yin Zhao*, Li Jin, Junli Hou, Jianhua Wang, Yan Lin, Yu Xue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, Jianhong Ye, Richard H. Finnell, Hexige Saiyin, Hong-Yan Wang#, Jian-Yuan Zhao#, Shi-Min Zhao#, and Wei Xu#, 2020
通过可逆赖氨酸氨酰化感知和传递细胞内氨基酸信号。, Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yan-Hui Xu#, Wei Xu#, Shi-Min Zhao#, 2018
NADP+-IDH突变促进超琥珀酰化，损害线粒体呼吸并诱导抗凋亡。, Feng Li*, Xiadi He*, Dingwei Ye*, Yan Lin, Hongxiu Yu, Cuifang Yao, Lei Huang, Jianong Zhang, Fang Wang, Sha Xu, Xiaohui Wu, Lixia Liu, Chen Yang, Jiaqi Shi, Xiaoyang He, Jie Liu, Yuanyuan Qu, Fushen Guo, Jianyuan Zhao, Wei Xu#, and Shimin Zhao#, 2015
烯酰辅酶A水合酶-1通过感知营养调节mTOR信号和凋亡。, Ya-Kun Zhang*, Yuan-Yuan Qu*, Yan Lin*, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu#, Shi-Min Zhao#, and Wei Xu#, 2017
丙酮酸激酶M2通过磷酸化AKT1S1激活mTORC1。, He, Chang-Liang*, Yang-Yang Bian*, Yu Xue, Ze-Xian Liu, Kai-Qiang Zhou, Cui-Fang Yao, Yan Lin, Han-Fa Zou, Fang-Xiu Luo, Yuan-Yuan Qu, Jian-Yuan Zhao, Ming-Liang Ye, Shi-Min Zhao and Wei Xu#, 2016
蛋白赖氨酸乙酰化通过对抗癌症来维持代谢稳态。, Xu, W., Li, Y., Liu, C. & Zhao, S., 2014
致癌代谢物2-羟基戊二酸是α-酮戊二酸依赖性双加氧酶的竞争性抑制剂。, Xu W*, Hui Yang*, Ying Liu*, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen Frye, Yi Zhang, Yan-hui Xu, Qun-ying Lei, Kun-Liang Guan#, Shi-min Zhao#, and Yue Xiong#, 2010
蛋白赖氨酸乙酰化调节细胞代谢。, Zhao, S-M., Xu, W. *, Jiang, W-Q. *, Yu, W., Lin, Y., Zhang, T-F., Yao, J., Zhou, L., Zeng, Y., Li, H., Li, Y., Shi, J., An, W-L., Hancock, S. M., He, F., Qin, L-X., Chin, J. C., Yang, P-Y., Chen, X., Lei, Q-Y., Xiong, Y. # and Guan, K-L. #, 2010
胶质瘤来源的IDH1突变显著抑制IDH1催化活性并诱导HIF-1α。, Zhao, S-M., Li, Y.*, Xu, W. *, Jiang, W-Q. *, Zha, Z-Y., Yu,

代谢物失调疾病机制感知信号传导乙酰化调控氨基酸重大疾病

赵世民 - 复旦大学

阿拉斯泰尔·默奇 - 复旦大学

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