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Yihua Chen
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
Microbial Secondary Metabolism
Human Health
Antitumor Drugs
Antibiotics
Immunosuppressants
Molecular Genetics
Biochemistry
Chemistry
Bioinformatics
Drug Discovery
Areas of Focus
- Microbial Secondary Metabolism and Human Health
- Biosynthesis of Microbial Drugs
- Synthetic Biology
Work Experience
- 2011-04 to Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher
- 2006-07 to 2011-04 - University of Wisconsin-Madison - Postdoc Research Associate
Academic Background & Achievements
- 2001-09 to 2005-07 PhD: Institute of Microbiology, Chinese Academy of Sciences
- 1998-09 to 2001-06 Master's: Nanjing Agricultural University
- 1994-09 to 1998-06 Bachelor's: Nanjing Agricultural University
Publications
- Insights into the biosynthesis of septacidin L-heptosamine moiety unveils a VOC family sugar epimerase, Yihua Chen, 2023
- Characterization of three succinyl-CoA acyltransferases involved in polyketide chain assembly, Yihua Chen, 2023
- Engineering the C3N Pathway as a Short Detour for De Novo NAD + Biosynthesis in Saccharomyces cerevisiae, Yihua Chen, 2023
- Human-associated bacteria adopt an unusual route for synthesizing 3-acetylated tetramates for environmental adaptation, Yihua Chen, 2023
- Artificial intelligence accelerates the mining of bioactive small molecules from human microbiome, Yihua Chen, 2022
- Construction and heterologous expression of the di-AFN A1 biosynthetic gene cluster in Streptomyces model strains, Yihua Chen, 2022
- Discovery of novel septacidin congeners from a high yield heterologous expression strain Streptomyces albus 1597, Yihua Chen, 2022
- A conservative distribution of tridomain NDP-heptose synthetases in actinobacteria, Yihua Chen, 2022
- Synthetic robust perfect adaptation achieved by negative feedback coupling with linear weak positive feedback, Yihua Chen, 2022
- Identification of antimicrobial peptides from the human gut microbiome using deep learning, Yihua Chen, 2022
- (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine, Yihua Chen, 2022
- Artificial intelligence accelerates the mining of bioactive small molecules from human microbiome, Yihua Chen, 2022
- Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius, Yihua Chen, 2022
- Assigning the stereochemical structures of aurantinin A and B with the assistance of biosynthetic investigations, Yihua Chen, 2022
- Discovery of Brominated Alboflavusins With Anti-MRSA Activities, Yihua Chen, 2021
- Medium optimization with the response surface methodology to improve daptomycin production, Yihua Chen, 2021
- Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses, Yihua Chen, 2021
- Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis, Yihua Chen, 2021
- Comparative Microbial Profiles of Caries and Black Extrinsic Tooth Stain in Primary Dentition, Yihua Chen, 2021
- Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway, Yihua Chen, 2021
- Initiating polyketide biosynthesis by on-line methyl esterification, Yihua Chen, 2021
- Candicidin Isomer Production Is Essential for Biocontrol of Cucumber Rhizoctonia Rot by Streptomyces albidoflavus W68, Yihua Chen, 2021
- Deciphering the Biosynthesis of TDP-β-L-oleandrose in Avermectin, Yihua Chen, 2020
- Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis, Yihua Chen, 2020
- A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters, Yihua Chen, 2020
- Bioretrosynthesis of Functionalized N-Heterocycles from Glucose via One-Pot Tandem Collaborations of Designed Microbes, Yihua Chen, 2020
- De novo design of an intercellular signaling toolbox for multi-channel cell–cell communication and biological computation, Yihua Chen, 2020
- Activation of paulomycin production by exogenous gamma-butyrolactone signaling molecules in Streptomyces albidoflavus J1074, Yihua Chen, 2020
- Deciphering the Biosynthesis of TDP-beta-L-oleandrose in Avermectin, Yihua Chen, 2020
- Characterization of SepE and SepF for the N-6-Glycosylated Adenine Structure Formation in Septacidin Biosynthesis, Yihua Chen, 2020
- Activation of paulomycin production by exogenous γ-butyrolactone signaling molecules in Streptomyces albidoflavus J1074, Yihua Chen, 2020
- Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage, Yihua Chen, 2020
- Primed adaptation tolerates extensive structural and size variations of the CRISPR RNA guide in Haloarcula hispanica, Yihua Chen, 2019
- Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains, Yihua Chen, 2019
- An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters, Yihua Chen, 2019
- Advances in the formation mechanisms of L-hexoses, Yihua Chen, 2019
- Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis, Yihua Chen, 2019
- Cloning and Expression of a Nonribosomal Peptide Synthetase to Generate Blue Rose, Yihua Chen, 2019
- Characterization of a Bi-directional Promoter OtrRp Involved in Oxytetracycline Biosynthesis, Yihua Chen, 2019
- d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B, Yihua Chen, 2018
- Activation of three natural product biosynthetic gene clusters from Streptomyces lavendulae CGMCC 4.1386 by a reporter-guided strategy, Yihua Chen, 2018
- Genome sequencing and comparative genomics reveal the potential pathogenic mechanism of Cercospora sojina Hara on soybean, Yihua Chen, 2018
- Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling, Yihua Chen, 2018
- Identification and Characterization of Mycemycin Biosynthetic Gene Clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp FXJ1.235, Yihua Chen, 2018
- Extracellular aminopeptidase modulates biofilm development of Pseudomonas aeruginosa by affecting matrix exopolysaccharide and bacterial cell death, Yihua Chen, 2018
- Design and biosynthesis of dimeric alboflavusins with biaryl linkages via regiospecific C-C bond coupling, Yihua Chen, 2018
- Improvement of Paulomycin Stability by Addition of Paulic Acid, Yihua Chen, 2018
- Improvement of Paulomycin Stability by Addition of Paulic Acid, Yihua Chen, 2018
- Hexaricins, Pradimicin-like Polyketides from a Marine Sediment-Derived Streptosporangium sp and Their Antioxidant Effects, Yihua Chen, 2018
- Phosphodiesterase EdpX1 Promotes Xanthomonas oryzae pv. oryzae Virulence, Exopolysaccharide Production, and Biofilm Formation, Yihua Chen, 2018
- Secondary metabolites from Streptococcus mutans and their ecological roles in dental biofilm, Yihua Chen, 2017
- Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387, Yihua Chen, 2017
- Synthesis, characterizations and antimicrobial activities of new thiourea derivatives, Yihua Chen, 2017
- Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis, Yihua Chen, 2017
